Intestinal microecology and sepsis / 中国小儿急救医学

ABSTRACT

Sepsis is a common critical illness in PICU, with high morbidity and mortality.As the pathogenesis is still not well defined, the clinical management of sepsis can be tricky.The gastrointestinal tract is currently considered as one of the most susceptible organs in the early stages of sepsis, and intestinal microecology plays important roles in the development, progression and prognosis of this disease.There is a closely relationship between intestinal flora dysbiosis/translocation and sepsis.They interact with each other, and ultimately leading to multi-organ dysfunction.In this review, we provided a brief summary of intestinal microecological changes and its pathogenesis in sepsis, as well as the progress of treatment.