Lack of the Association between Microsatellite Polymorphism in Toll-like Receptor 2 Gene and Development of COPD / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 367-374, 2005.
Artigo
em Coreano
| WPRIM
| ID: wpr-99076
ABSTRACT
BACKGROUND:
The fact that only 10-20% of chronic cigarette smokers develop chronic obstructive pulmonary disease (COPD) reflects the presence of genetic factors associated with the susceptibility to COPD. Recently, it was reported that the surfactant protein A increases the secretion of matrix metalloprotease 9, which degrades extracellular matrices of the lung, through a Toll-like receptor 2 (TLR2). In this context, possible role of TLR2 in the pathogenesis of COPD was postulated, and a functional dinucleotide repeat polymorphism in intron II of TLR2 was evaluated for any association with COPD.METHOD:
Male patients with COPD and male smokers with a normal pulmonary function were enrolled in this study. The number of Guanine-Thymine repeats in intron II of the TLR2 gene were counted. Because the distributions of the repeats were trimodal, the alleles were classified into three subclasses, 12-16 repeats short (S) alleles; 17-22 repeats medium length (M) alleles; and 23-27 repeats long (L) alleles.RESULT:
125 male patients with COPD and 144 age- and gender-matched blood donors with a normal lung function were enrolled. There were no differences in the distribution of each allele subclass (S, M and L) between the COPD and control group (p=0.75). The frequencies of the genotypes with and without each allele subclass in the COPD and control group were similar.CONCLUSION:
A microsatellite polymorphism in intron II of TLR2 gene was not associated with the development of COPD in Koreans.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doadores de Sangue
/
Íntrons
/
Repetições de Microssatélites
/
Repetições de Dinucleotídeos
/
Predisposição Genética para Doença
/
Doença Pulmonar Obstrutiva Crônica
/
Proteína A Associada a Surfactante Pulmonar
/
Alelos
/
Receptores Toll-Like
/
Receptor 2 Toll-Like
Limite:
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Tuberculosis and Respiratory Diseases
Ano de publicação:
2005
Tipo de documento:
Artigo
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