Effects of resistance-aerobic exercise on glycolipid metabolism and cardiovascular events in the patients of prediabetes mellitus / 中国医师进修杂志

ABSTRACT

Objective:To investigate the effects of resistance-aerobic exercise on glycolipid metabolism and cardiovascular disease (CVD) in the patients of prediabetes mellitus (PDM).Methods:A total of 88 patients with PDM diagnosed and treated in Yuyao Maternal and Child Health Care Hospital from February to October 2020 were selected and divided into the observation group and the control group according to the random number table method, with 44 patients in each group. The control group adopted aerobic exercise, and the observation group adopted resistance-aerobic exercise. The changes of blood sugar, lipid levels, blood pressure, body mass index (BMI) and waist-to-hip ratio (WHR) were compared after treatment. According to the Framingham Risk Score (FRS), the 10-year incidence probability of CVD was calculated.Results:After treatment, the levels of fasting plasma glucose (FPG), 2 h postprandial blood glucose (2 h PG), glycosylated hemoglobin (HbA 1c), insulin resistance index (HOMA-IR) in the observation group were lower than those in the control group (5.32 ± 0.54) mmol/L vs. (5.57 ± 0.60) mmol/L, (7.10 ± 1.07) mmol/L vs. (7.58 ± 1.02) mmol/L, (5.64 ± 0.36)% vs. (5.82 ± 0.40)%, 2.54 ± 0.56 vs. 2.89 ± 0.75, there were statistical differences ( P<0.05). After treatment, the levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL-C) in the observation group were lower than those in the control group, and high density lipoprotein (HDL-C) was higher than that in the control group (4.80 ± 0.62) mmol/L vs. (5.14 ± 0.74) mmol/L, (1.50 ± 0.62) mmol/L vs. (1.80 ± 0.70)mmol/L, (2.80 ± 0.52) mmol/L vs. (3.04 ± 0.59) mmol/L, (1.90 ± 0.44) mmol/L vs. (1.72 ± 0.40) mmol/L, there were statistical differences ( P<0.05). After the treatment, the systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the observation group were lower than those in the control group (128.42 ± 13.74) mmHg (1 mmHg = 0.133 kPa) vs. (134.98 ± 14.56) mmHg, (74.64 ± 8.02) mmHg vs.(78.25 ± 8.53) mmHg ( P<0.05); the BMI and WHR in the observation group were lower than those in the control group (23.28 ± 1.66) kg/m 2 vs. (24.15 ± 2.02) kg/m 2, 0.84 ± 0.05 vs. 0.86 ± 0.03, P<0.05. The FRS score and 10-year incidence of CVD in the observation group were significantly lower than those in the control group [(12.15 ± 1.52) scores vs.(12.84 ± 1.59) scores, (6.42 ± 1.52)% vs. (7.23 ± 1.79)%, P<0.05. Conclusions:The effect of resistance-aerobic exercise on PDM is obvious, which can significantly improve glycolipid metabolism and reduce the risk of CVD.