Further Characterization of Activin A-induced IgA Response in Murine B Lymphocytes
Immune Network
; : 133-137, 2009.
Article
em En
| WPRIM
| ID: wpr-99214
Biblioteca responsável:
WPRO
ABSTRACT
We have recently shown that activin A, a member of TGF-beta superfamily, stimulates mouse B cells to express IgA isotype but other isotypes. In the present study, we further characterized effects of activin A on B cell growth and IgA expression. We found that activin A did not have effect on LPS-stimulated cell viability. In parallel, CFSE staining analysis revealed that activin A did not alter cell division. An increase of IgA secretion by activin A was completely abrogated by anti-activin A Ab but not by anti-TGFbeta1 Ab. In the same conditions, no other isotypes are significantly affected by each antibody treatment. Finally, activin A, as similar to TGF-beta1, increased IgA secretion by mesenteric lymph node cells. These results suggest that activin A can specifically stimulate IgA response, independent of TGF-beta in the gut.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Succinimidas
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Imunoglobulina A
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Linfócitos B
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Divisão Celular
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Sobrevivência Celular
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Fator de Crescimento Transformador beta
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Ativinas
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Fator de Crescimento Transformador beta1
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Fluoresceínas
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Linfonodos
Limite:
Animals
Idioma:
En
Revista:
Immune Network
Ano de publicação:
2009
Tipo de documento:
Article