Characteristics, cellular and molecular mechanisms of renal aging and nutritional intervention strategies / 中华老年医学杂志

ABSTRACT

Renal aging is a gradual process of degenerative changes in tissue structure and physiological function and is closely related to the occurrence and development of acute kidney injury(AKI)and chronic kidney disease(CKD). The cellular and molecular mechanisms of renal aging mainly include cellular senescence and reduced autophagy, and are regulated by nutritional factors.Promoting reasonable and moderate energy-and protein-restricted diets, strengthening the supervision of food additives and preservatives, cultivating safety awareness of residents, and strictly controlling the daily salt intake are potential nutritional intervention strategies to prevent and delay renal aging.Given the limited number of studies, there is an urgent need to further explore the effectiveness of the above strategies to provide a new evidence-based approach to formulating precise and feasible personalized nutritional intervention programs.