The Changing Pattern of Serum Prostate Specific Antigen in Patients with Benign Prostatic Hyperplasia after Combined Treatment with Finasteride and alpha-blockers: the 3 Year Follow-up Data / 대한비뇨기과학회지
Korean Journal of Urology
; : 372-376, 2006.
Article
em Ko
| WPRIM
| ID: wpr-99404
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: Some recent studies have demonstrated that finasteride, a well- known 5alpha-reductase inhibitor, can decrease prostate specific antigen (PSA) by approximately 50% during the first 1 year of treatment. We investigated how long-term treatment with finasteride and alpha-blockers impacts on the serum PSA level of men whose final diagnosis was benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: In a retrospective trial, we evaluated a total of 293 men with lower urinary tract symptoms (LUTS) that were suggestive of BPH. These men were divided into two treatment groups: group A was treated with alpha-blockers and group C was treated with a combination of finasteride and alpha-blocker. Comparisons of the two groups were performed by using independent t-tests. The changes in the PSA concentrations from baseline to the time of the final measurements were determined by repeated measures of ANOVA. RESULTS: There was no significant difference in the baseline PSA between the two groups. A statistically significant reduction in the PSA levels was observed at 2 years in C group (p0.05). In group A, the repeatedly measured PSA levels were 2.67, 2.40, 2.41 and 2.42, respectively. In C group, these were 3.22, 2.09, 1.81 and 1.71 respectively. CONCLUSIONS: Our data showed that there was no clinically significant effect of long term treatment with alpha-blocker on the PSA levels. However, finasteride had significant effect on the serum PSA level during first two years of treatment.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Oxirredutases
/
Próstata
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Hiperplasia Prostática
/
Estudos Retrospectivos
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Seguimentos
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Antígeno Prostático Específico
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Finasterida
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Antagonistas Adrenérgicos
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Diagnóstico
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Sintomas do Trato Urinário Inferior
Tipo de estudo:
Diagnostic_studies
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Observational_studies
/
Prognostic_studies
Limite:
Humans
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Male
Idioma:
Ko
Revista:
Korean Journal of Urology
Ano de publicação:
2006
Tipo de documento:
Article