Analysis of risk assessment and screening results of lung cancer among residents in 3 cities of Shanxi Province from 2014 to 2018 / 肿瘤研究与临床

ABSTRACT

Objective:To investigate the risk of lung cancer and screening results of residents in 3 cities of Shanxi Province from 2014 to 2018.Methods:Cluster random sampling method was used to select permanent residents from 3 cities (Taiyuan, Jincheng and Yangquan) in Shanxi Province from January 2014 to December 2018 for lung cancer risk assessment. People at high risk of lung cancer were screened by low-dose spiral CT. The screening results were analyzed and the influencing factors of lung cancer occurrence were analyzed by unconditional logistic regression.Results:184 539 people were included in the survey, and 36 790 people (19.94%) were at high risk of lung cancer. The detection rate of high-risk of lung cancer in men was higher than that in women [29.76% (25 690/184 539) vs. 11.30% (1 100/184 539), χ2 = 10.44, P = 0.001]. A total of 12 660 people (34.41%) at high risk of lung cancer participated in clinical screening, and 3 038 people (24.00%) were positive in clinical screening for lung cancer. There were no statistical differences in the positive rate of clinical screening among people at high risk of lung cancer with different gender, nationality, education, marital status, occupation, history of harmful substance exposure, coal burning, clean heating, indoor oil fumes, and history of pulmonary tuberculosis (all P > 0.05). There were statistical differences in the positive rate of clinical screening among people at high risk of lung cancer with different age, smoking, drinking, drinking tea, physical exercise, exposure time of second-hand smoke, living environment air pollution, history of emphysema, history of pneumoconiosis, family history of lung cancer, mental depression, and history of trauma (all P < 0.05). Logistic regression analysis showed that age ≥ 50 years old, smoking, exposure to second-hand smoke for 1-14 years, living environment air pollution, history of emphysema, family history of lung cancer, and mental depression were the risk factors for positive clinical screening in people at high risk of lung cancer (all P < 0.05), and physical exercise was the protective factor for positive clinical screening in people at high risk of lung cancer ( P < 0.05). Conclusions:The screening rate of people at high risk of lung cancer in 3 cities of Shanxi Province needs to be improved. The detection rate of intrapulmonary nodules in people at high risk of lung cancer is mainly affected by age, smoking, exposure time of second-hand smoke, family history of lung cancer, history of emphysema and other factors.