Research progress on the relationship between insulin resistance and cardiovascular disease in type 2 diabetes mellitus / 公共卫生与预防医学

ABSTRACT

Insulin resistance is one of the main contributors to the pathogenesis of type 2 diabetes mellitus, which reduces the sensitivity of target tissues to insulin and increases the compensatory secretion of islet cells, leading to chronic hyperinsulinemia and inducing vascular endothelial cell dysfunction. Insulin resistance is also the pathological basis of a series of cardiovascular diseases such as hypertension, coronary heart disease and heart failure secondary to type 2 diabetes mellitus. Analyzing the relationship between insulin resistance and cardiovascular disease in type 2 diabetes mellitus can provide new ideas for the prevention and treatment of type 2 diabetes mellitus complicated with cardiovascular disease.