Mechanism and application progress of MF59 adjuvant in influenza vaccine / 中国生物制品学杂志

ABSTRACT

@#Influenza vaccination is the most effective route to prevent influenza virus transmission,and adding adjuvant to influenza vaccines not only enhances the body immune response but also saves the antigen dose.In addition to the classic aluminum adjuvant,MF59 adjuvant is the second one on the market and has been widely used as adjuvant in human vaccine,which not only has an ability to induce antibody equivalent to that of aluminum adjuvant,but can induce cellular immune response,recruit immune cells,and improve the effectiveness of vaccine.In this review,the mechanism of action and current application progress of MF59 adjuvant in influenza vaccine was described,and the further development of MF59adjuvant research was put forward.