Chromatographic Determination of the Absolute Configuration in Sanjoinine A That Increases Nitric Oxide Production
Biomolecules & Therapeutics
;
: 566-572, 2023.
Artigo
em Inglês
| WPRIM
| ID: wpr-999703
ABSTRACT
A chiral derivatization strategy with phenylglycine methyl ester (PGME) was employed to develop a straightforward method to determine the absolute configurations of N,N-dimethyl amino acids. The PGME derivatives were analyzed using liquid chromatography-mass spectrometry to identify the absolute configurations of various N,N-dimethyl amino acids based on their elution time and order. The established method was applied to assign the absolute configuration of the N,N-dimethyl phenylalanine in sanjoinine A (4), a cyclopeptide alkaloid isolated from Zizyphi Spinosi Semen widely used as herbal medicine for insomnia. Sanjoinine A displayed production of nitric oxide (NO) in LPS-activated RAW 264.7 cells.
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DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Inglês
Revista:
Biomolecules & Therapeutics
Ano de publicação:
2023
Tipo de documento:
Artigo
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