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1.
Journal of Applied Pharmaceutical Science ; 12(1):001-028, 2022.
Article in English | Scopus | ID: covidwho-1703120

ABSTRACT

The novel human coronavirus (CoV) 2019, similar to previous severe acute respiratory syndrome corona virus-1 outbreaks, has posed the unprecedented challenges that have shaped global action on preventive and easy to employ measures and policies, including regular disinfection. There is an indiscriminate use of antimicrobial agents, which may pose toxicity to humans, environmental hazards, and, in some cases, development antiviral drug resistance. This review comprehensively highlights the physical and chemical countermeasures applied to prevent various CoV infections and their potential toxicity on humans and the environment, as well as the danger of developing drug resistance. Literature information was sourced from PubMed, ScienceDirect, Embase, MEDLINE, and China National Knowledge Infrastructure databases using Google Scholars and Free Full PDF as search engines. Articles written in the English language were retrieved and included in the study. Researches covering the literature on physical and chemical severe acute respiratory syndrome corona virus-2 preventive measures, their toxicity, and possible ways of developing drug resistance were also discussed. The literature review reveals that physical inactivation under the influence of temperature, humidity, and light, especially ultraviolet-C radiation, has proven effective in reducing the spread of CoV infections. Similarly, chemical countermeasures such as the use of alcohol- and iodine-based disinfecting agents have demonstrated inhibitory potentials of the viruses on surfaces depending on nature, dose, and exposure time. The inactivation occurs through the interference of these agents with the lipid envelope, thereby disrupting the viral activity. A vast majority of the antimicrobial agents are reported to contain corrosive chemicals that are toxic to humans, especially children, and the environment. The toxicity is due to the unhealthy accumulation and pollution caused by the inappropriate disposal of biomedical waste. This study showed that chemicals might have long-term effects on public health, such as reproductive disorders, chronic obstructive pulmonary disease, cancers, skin damage, and central nervous system impairment. Therefore, further research on long-term preventive alternatives such as the formulation of these agents with natural products as active ingredients is necessary to mitigate the effects of alcohol- and iodine-based chemicals on humans and the environment. © 2022. Sani Yahaya Najib et al.

2.
Bangladesh Journal of Medical Science ; 20(4):897-910, 2021.
Article in English | Web of Science | ID: covidwho-1314549

ABSTRACT

Background: Hydroxychloroquine(HCQ), one of the repurposed drugs in COVID-19, has several known cardiovascular(CVS) toxicities. Methods: VigiBase data were used to analyze the reported ADEs linked to HCQ. The data were analyzed based on age, gender, and seriousness of ADEs at the System Organ Classification level and the individual Preferred Term level. Results: The majority were above 18 years(91.6%) and from Europe(41.6%). A total of 5,315 ADEs were associated with HCQ use in COVID-19. Of these, 918 ADEs were attributed to CVS and reported from 773 patients. Grossly, CVS ADEs were associated with concomitant use of HCQ and azithromycin(AZM), and only 40 ADEs were solely due to HCQ. The majority were serious (69.3%) and resolved afterward (51%). In CVS ADEs, there were 366 cardiac disorders, 38 vascular disorders, and 514 ADEs under investigation. Among the cardiac disorders, palpitation was the most typical (N=65), followed by bradycardia(N=44) and tachycardia(N=33). Among arrhythmias, QT prolongation (N=469), atrial fibrillation (N=25), and ventricular tachycardia(N=16) were common. The odds of developing serious CVS ADEs increased with age, patients aged 45-64 years(OR=1.75;p=0.015) and >65 years(OR=1.93, p=0.003) as compared to younger ones. Conclusion: Hydroxychloroquine with known CVS toxicities and increased risk with co-administering AZM makes physicians cautious while prescribing in COVID-19 patients.

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