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2.
Annals of Phytomedicine-an International Journal ; 10:56-62, 2021.
Article in English | Web of Science | ID: covidwho-2072560

ABSTRACT

COVID-19 is an infectious disease which was originated in Wuhan (China) and is declared a pandemic by the World Health Organization. Functional foods are gaining popularity as they have been boosting immunity and capable to fight against various diseases including the COVID-19. Functional foods are categorized under the type of food products that possess physiological benefits. These foods are essential for health and help in improving one's health by preventing and curing several chronic diseases. This study has been conducted to evaluate the consumer's awareness and their knowledge of functional foods and their health benefits. A survey method was employed using a set of questions to assess consumer's knowledge and awareness. The scientific goal of this study was to increase awareness in the population about the advantages of these foods. The survey was conducted online on sample size of 301 participants for functional foods and, the data thus obtained was magnificent. The majority of the participants were either students or working professionals. More than half of the participants knew functional foods and were regular consumers. This survey gave an idea about what people think of the new emerging foods, their health claims, and their consumption during COVID-19, therefore, moving towards a healthy future.

3.
American Journal of Transplantation ; 22(Supplement 3):404, 2022.
Article in English | EMBASE | ID: covidwho-2063367

ABSTRACT

Purpose: The OPTN DTAC, a multidisciplinary group, evaluates potential donor derived transmission events (PDDTE) to assess the likelihood of disease transmission. Method(s): Retrospective study of PDDTE cases reported to the OPTN between 01/20 and 12/20. DTAC reviewed cases using a standardized classification algorithm. Result(s): During 2020, there were 18,318 donors and 37,583 unique recipients. DTAC reviewed 261/427 PDDTE from donor (111) or recipient (150) findings. 64/261 (25%) donors had proven/probable transmission (P/P Tr) of infection, malignancies or other to 84/206 (41%) exposed recipients [figure]. 12 involved living donors. Infection occurred with 44/64 P/P cases affecting 63 recipients. Viruses were most frequent P/P infections with 29 recipients having P/P Tr from 19 donors. COVID-19 PDDTE represented 11% (29/261) of all cases reviewed involving 29 donors and 15 lung and 76 non-lung recipients. One lung recipient had P/P Tr and died;none of the non-lung recipients developed P/P Tr. For bacteria, 20 recipients had P/P Tr from 14 donors. Deaths from infection (N=10) occurred at a median of 20 days (5-89 days). Attributable death was highest for fungal (4/12, 33%) and bacterial infections (6/20, 30%). 7 donors with malignancies were classified as P/P impacting 15 recipients with 1 attributable death. 53 non-infection, non-malignancy PDDTE were reported;13 resulted in P/P Tr to 14 recipients. Conclusion(s): Although P/P events remain rare, 1/4 reviewed cases resulted in unanticipated P/P Tr. This is a conservative estimate due to passive reporting and empiric interventions. In 29 COVID-19 PDDTE only 1 lung recipient had P/P Tr. The DTAC continues to evaluate PDDTE to maximize organ use and minimize the risk of transmission. (Table Presented).

4.
American Journal of Transplantation ; 22(Supplement 3):333, 2022.
Article in English | EMBASE | ID: covidwho-2063353

ABSTRACT

Purpose: Decision to transplant organs from SARS-CoV-2 NAT+ donors(N+D) balances risk of donor-derived infection with the scarcity of available organs to meet the needs of waitlisted candidates. Method(s): OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC) reports on the use of organs from N+D from the onset of required SARS-CoV-2 lower respiratory tract(LRT) testing for lung donors (May 27, 2021) through August 31, 2021. OPTN data were analyzed for donors with a positive LRT or upper respiratory tract (URT) test reported in DonorNet discrete data fields (N+D), compared with donors who did not have positive LRT or URT in the discrete data fields (N-D). Result(s): Organs were recovered from 120 N+D (all OPTN Regions and 40/57 OPOs (70%)). Median donor age was 42 (IQR: 32-52) for N+D and 43 (30-56) for N-D. There was a greater proportion of DCD N+D than N-D (37.5% vs 28.3%, p=0.04). Underlying COD of anoxia and other were different (N+D 31.7%, 16.7% vs N-D 48%, 2.7%, respectively). Transplanted N+D and N-D did not differ by KDPI, LDRI or LVEF for kidney(KT), liver(LT) or heart(HT), respectively (Table 1). Median time from donor admission to first reported test (any result) was 0 and 4 days for URT and LRT, respectively. N+D recovery occurred a median of 2 (IQR: 1-6) days from last positive test. 246 organs (152KT, 50LT, 22HT, 22other) were transplanted from 107 N+D compared to 8969 organs from 3348 N-D. Recipients from N+D and N-D were similar in age, MELD/PELD (LT) and medical urgency status (HT). Median time from listing to transplant similar for N+D for all organs. The match run sequence number for final acceptor was higher for N+D for all organ types (Table 2). Median length of stay was similar for N+D and N-D for KT and LT (5d and 12-13d, respectively). For HT, median stay was shorter for N+D (30 vs 34d). For N+D, 3 of 50 LT died within 30d of transplant. During this timeframe, no PDDTEs were reported for any N+D at the time of transplant. Conclusion(s): N+D and N-D were similar in terms organ quality characteristics. Recipients receiving organs from N+D had higher match run sequence numbers, suggesting use of organs from N+D is not widespread across centers;however, with small numbers, this data will need to be verified. We cannot assess the relatedness of the three early mortality events in N+D recipients to donor or recipient characteristics. However, these data highlight the importance of ongoing outcome review of N+D recipients. (Figure Presented).

5.
Futuristic Trends for Sustainable Development and Sustainable Ecosystems ; : 104-125, 2022.
Article in English | Scopus | ID: covidwho-2024506

ABSTRACT

COVID-19 has various symptoms, and they are cold, cough, mild or high fever, and breathing problems for severe cases. In addition, it is in talk that diabetes, chronic obstructive pulmonary disease (COPD), cardiovascular, asthma, and many diseases invite the virus. Machine learning and data analysis are considered best for predicting approaches for finding various aspects of the effect of the virus. In this chapter, the authors deal with symptoms that have been recorded in the dataset and try to find which pre-defined symptoms are considered effective or responsible in positive case of infection by coronavirus. The dataset has been taken from Kaggle. As the dataset is categorical in nature, the authors use correlation and logistic regression analysis to find the symptoms that prevail in the patient and have caused the infection in them. This is also about dimensionality reduction and feature selection where they are reducing the available features based on regression. © 2022, IGI Global.

6.
7th International Congress on Information and Communication Technology, ICICT 2022 ; 465:267-281, 2023.
Article in English | Scopus | ID: covidwho-2014035

ABSTRACT

The COVID-19 pandemic has hit the global humanity adversely. The developing country like India which has 17.7% of the total world population lacks the healthcare infrastructure but trying to lead the battle from the front with its available healthcare infrastructure and great care for patients. The global data also suggests that India has outperformed so many developed countries in caring its population. This study is an attempt to gauge the perceived service quality of patients regarding the healthcare services on HEALTHQUAL model. The primary study was conducted among 138 patients who received the healthcare services during devastating second wave of COVID-19 at Pacific Medical College and Hospital, Udaipur (India). For the correlation was calculated between the improvement of care and the HEALTHQUAL dimensions, namely empathy, safety, tangibility, and efficiency. AMOS was also applied for analyzing the data. The results clearly indicate the high relationship between the improvement of care and the HEALTHQUAL dimensions, namely empathy, safety, tangibility, and efficiency. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

7.
Indian Journal of Critical Care Medicine ; 26:S70-S71, 2022.
Article in English | EMBASE | ID: covidwho-2006360

ABSTRACT

Aim and background: Cases of thrombotic thrombocytopenia induced by coronavirus disease 2019 (COVID-19) vaccines have been reported recently. Herein, we describe hemophagocytic lymphohistiocytosis (HLH) following COVID-19 vaccination. Case report: A 35-year-old male, chronic alcoholic, 3 years into abstinence received first dose Covishield vaccine. He started developing a fever, testicular pain, diminished sensorium requiring invasive ventilation, and decreased urine output 4 days after getting vaccinated. Initial workup for NCCT brain and HRCT chest was normal, tropical fever panel was negative, cultures for blood and endotracheal aspirate were sterile, liver and renal functions showed mild derangement, CSF study was normal. Ultrasound examination of the abdomen revealed mild hepatosplenomegaly, mild testicular swelling, and suprainguinal lymphadenopathy, with no focus of infection. Subsequently, he developed bicytopenia with haemoglobin 9.0 g/dL and platelet counts 50 × 109/L, ferritin 2130 μg/L, triglyceride 353 mg/dL, and decreased fibrinogen 1.41 g/L. Bone marrow as well as lymph node biopsy showed haemophagocytosis with engulfment of neutrophils, lymphocytes, and normoblasts making HLH a likely diagnosis. Soluble CD25 and NK cell function could not be performed. Extensive evaluation was done to look into the etiology of HLH. SARS-CoV-2 reverse transcriptase-polymerase chain reaction (RT-PCR) test was negative. RT-PCR test for Epstein-Barr virus (EBV), influenza A (H1N1, H3N2), influenza B, cytomegalovirus (CMV) performed from endotracheal aspirate (ETA) was negative. Similarly, the RT-PCR test from serum samples for EBV, Parvo B-19, CMV, and from CSF sample for EBV, Parvo B-19, CMV, and HSV-1 was negative. Hepatitis B, C, and HIV serologies were negative. Culture and sensitivity repeated from blood, ETA and urine was sterile. Autoimmune panel including complements levels were negative. Peripheral smear, bone marrow, and lymph node biopsy were normal and did not reveal abnormal or malignant cells. He had persistent fevers to 38.6°C during the first 6 days of his admission, with a rise in his ferritin to 1950 μg/L. The patient received steroids but not etoposide. By the 8th day, his fevers resolved, with improvement in his lethargy and malaise. Two weeks later, his ferritin had reduced to 510 μg/L, platelet count rose to 180 × 109/L, and repeat ultrasound abdomen demonstrated resolution of his splenomegaly. In our patient, there was no clear precipitant of HLH other than the Covishield vaccine. There was no evidence of an infection or malignancy. Due to our patient's clinical stability, resolution of symptoms, and improvement of HLH parameters he did not require HLH specific therapy. It is unclear if he had a pre-existing genetic predisposition to HLH as genetic testing is pending, however, it is unlikely as he has reached the age of 35 and suffered from previous viral infections without developing HLH.

8.
International Journal of Health Sciences ; 6:11150-11160, 2022.
Article in English | Scopus | ID: covidwho-1989166

ABSTRACT

Background: People's mental health has been impacted by the novel corona virus COVID 19. According to studies, a significant percentage of people who have recovered from the infection have mental health problems. The research was carried out on people who had recovered from COVID 19 in the previous year. Participants were contacted a month after being discharged from the hospital and encouraged to complete a questionnaire that included the DASS and IES scales. Anxiety, depression, stress, and post-traumatic stress disorder were all examined in the results (PTSD). Those with scores that indicated severe levels were encouraged to see a psychiatrist for proper treatment and therapy. The results of the DASS revealed that 2.5 percent of the participants had scores indicative of severe stress, 25.3 percent had scores indicative of severe anxiety, and 7.3 percent had scores indicative of severe depression. According to the results of the IES, 15.1 percent of the participants said the event had a significant impact on their mental health, and 17.2 percent of the participants had scores that indicated the presence of post-traumatic stress disorder symptoms. There is a strong link between IES scores and the severity of lung involvement. Conclusion: People who have recovered from COVID 19 are at risk for anxiety, depression, and post-traumatic stress disorder (PTSD). © 2022 Universidad Tecnica de Manabi. All Rights Reserved.

9.
British Journal of Dermatology ; 186(6):e245, 2022.
Article in English | EMBASE | ID: covidwho-1956713

ABSTRACT

A 73-year-old man presented with left shin ulceration two weeks after receiving his first dose of the Oxford-AstraZeneca vaccine. Within 24 h of vaccination, the patient became generally unwell with fever and headache. On the third day after vaccination, he developed left shin erythema and blistering, which rapidly ulcerated. This formed two superficial ulcers with a necrotic base and a violaceous edge on the lateral aspect of his left shin, measuring approximately 2 cm × 3 cm. He had a background of atrial fibrillation and ischemic cardiomyopathy, and had been on several longstanding medications including apixaban. Blood tests revealed normal clotting, full blood count, liver and renal function. The differential diagnosis included pyoderma gangrenosum, vasculitic ulceration, and a cutaneous adverse drug reaction to vaccination. A punch biopsy was obtained from the edge of an ulcer, which revealed microthrombi within blood vessels, an ischemic epidermis, and fat necrosis of subcutaneous tissue. The patient experienced slow healing of ulceration with topical clobetasol propionate 0.05%, neomycin sulphate and nystatin ointment, and compression bandaging treatment. To our knowledge, this is the first reported case of cutaneous thrombosis associated with skin necrosis following Oxford/AstraZeneca vaccination. Recently there have been concerns related to reports of thrombotic events at atypical sites (including cerebral and splanchnic vascular beds) associated with thrombocytopenia following Oxford/ AstraZeneca vaccination (Greinacher A, Thiele T, Warkentin TE et al. Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination. N Engl J Med 2021;384: 2092-101). These findings extend the range of atypically located thromboses associated with COVID-19 vaccination and reinforce the necessity for physicians to be vigilant for signs and symptoms related to thromboses at atypical sites in recently vaccinated patients.

10.
International Journal of Technology ; 13(3):633-642, 2022.
Article in English | Scopus | ID: covidwho-1934710

ABSTRACT

Indonesia is attempting to rebuild the entire country's condition to the "New Normal" era during the COVID-19 pandemic. One of the emerging technologies with significant potential for dealing with the crisis is Immersive Technology (ImTech). In Indonesia, there is a growing demand for immersive technologies such as Virtual Reality (VR), Augmented Reality (AR), and Mixed Reality (MR). The Indonesian government is actively prioritizing digitalization implementation in various sectors to stimulate a post-COVID-19 recovery. This study aims to map the current and potential future applications of ImTech in Indonesia about dealing with the "New Normal" following the COVID-19 pandemic. A systematic literature review (SLR) was used to analyze the publications for a thorough understanding of the existing ImTech applications in Indonesia. According to 50 papers, the ontology of current ImTech applications in Indonesia is produced, focusing on four sectors (medical, industry, tourism, and education). As indicated by the growth of "start-ups" relating to this technological application, Indonesia has enormous potential to adopt ImTech. The future application of this technology is discussed on the industrial sector. © 2022. International Journal of Technology. All Rights Reserved.

11.
European Stroke Journal ; 7(1 SUPPL):355, 2022.
Article in English | EMBASE | ID: covidwho-1928135

ABSTRACT

Background: During the second wave of COVID-19, India suffered from a catastrophic outburst of cases and rapid transmission of disease due to the highly infectious delta strain (B.1.617.2). Patients infected with this strain underwent prolonged hospitalisations, suffered from severe symptoms. A sudden surge of fungal infections, primarily Mucormycosis was observed. Methods: We conducted a case-control study to study various risk factors and form of intracranial involvement in cases of Mucormycosis. Results: Study included 121 patients in total;out of which 61 were Mucormycosis patients with prior COVID-19 infection. 30 out of 61 Mucormycosis patients had intracranial involvement with majority having stroke in the form of the either infarct (10 patients, 34%);or haemorrhage (3 patients, 10%) and thrombosis of artery involvement (8 patients, 29%). Other intracranial form of involvement was abscess (6 patients, 20%) and meningitis (2 patients, 7%). The most frequent type of infarcts were lacunar infarcts and the most common location of infarcts were middle cerebral artery (MCA) or anterior cerebral artery (ACA). Patients were treated with administration of Amphotericin B and Posaconazole. Telephonic follow-up was conducted after a time period of about 90 days and their health condition was recorded on basis of modified ranking scale (mRS). Out of the 30 Mucormycosis infection patients displaying the occurrence of stroke, 10 patients could not survive. q Conclusion: Intracranial Mucormycosis in COVID19 patients presenting with stroke were observed frequently and had mortality in about one-third cases.

12.
European Stroke Journal ; 7(1 SUPPL):179-180, 2022.
Article in English | EMBASE | ID: covidwho-1928109

ABSTRACT

Background: The world was witness to a pandemic never experienced by this generation. The call to arms was answered by each branch of medicine, each fighting separate wars. The war, we as neurologists faced was the “Battle for the Vessels”. Health care workers are a precious resource in Low-Middle-Income-Countries. Hence, exposure to a covidpositive patient for a “full hour” during thrombolysis, isn't warranted. Hence Tenecteplase use which fits the bill “ideally” and “literally” was analysed in this study against Alteplase in strokes with covid-positivity. We analyse the factors which affect their action and the role covid had, in each scenario. Methods: This is an ambi-spective observational study of 37 patients in an apex tertiary-care centre in India. Routine stroke variables were assessed including follow-up imaging, functional outcomes at 3 months. The results were also analysed with the thrombolysis data from covidnegative individuals too in the same period. Results: Among the covid-positive patients 62.16% patients received tenecteplase while 37.83% received alteplase. Although the baseline characteristics were similar, the time-metrics for thrombolysis were significantly favourable in the tenecteplase arm. The median-hospital stay was shorter in the tenecteplase group as was the in-hospital mortality. On follow-up at 3 months, the median mRS-score was significantly favourable in the tenecteplase group. Conclusions: Thrombolysis during the pandemic has been a challenge in many ways especially in resource limited settings. This study shows that there needs to be a conscious and judicial transition towards tenecteplase during the pandemic, where healthcare workers are a precious resource too.

13.
American Journal of Respiratory and Critical Care Medicine ; 205(1), 2022.
Article in English | EMBASE | ID: covidwho-1927833

ABSTRACT

Lungs in COVID-19 patients produce lipid mediators measured in bronchoalveolar lavage fluid (BALF), notably thromboxane B2 (TxB2) >> prostaglandin E2 > prostaglandin D2 (PGD2).1 High levels of TxA2 metabolites in BALF from COVID-19 associated ARDS,1 and systemically in non- ICU COVID-19 patients2,3 led us to propose a critical role for TxA2 prostanoid receptors (TPr) in COVID-19 respiratory distress. We hypothesized that TxA2/TPr signaling in airways, pulmonary microvasculature, and veins contributes to pulmonary edema and hypoxemia in COVID-19 pneumonia. TPr signaling contracts intrapulmonary veins with 10-fold higher potency than arteries.4 High concentrations of TxA2 impede pulmonary venous blood flow, increase microvascular pressure, and force fluid into alveoli.4 TPr signaling also activates platelets and triggers tissue factor expression on monocytes, which may contribute to thrombosis in COVID-19. A TPr antagonist was previously reported to decrease pulmonary capillary pressure by selectively reducing post-capillary resistance in patients with acute lung injury.5 PGD2 stimulation of Dprostanoid receptor 2 (DPr2, aka CRTH2) suppresses interferon lambda (IFN-λ) transcription in the upper respiratory tract in response to respiratory viruses. PGD2/DPr2 antagonism boosts local IFN- λ antiviral responses and limits viral replication.6 Antagonism of TxA2/TPr and PGD2/DPr2 signaling has been proposed for antiviral, antithrombotic and immunomodulatory action in COVID- 19.7 Ramatroban is an oral, dual receptor antagonist of TxA2/TPr and PGD2/DPr2 and a potential candidate for chemoprophylaxis and treatment of COVID-19.1,7 With well-established safety, ramatroban has been used since 2000 in Japan for the treatment of allergic rhinitis.8 We report here a small case series of four consecutive outpatients with COVID-19 with new onset or worsening respiratory distress and hypoxemia who were treated with oral ramatroban (Baynas®, Bayer Yakuhin, Japan). Summarized below, ramatroban afforded rapid improvement in respiratory distress and hypoxemia, followed by complete recovery, successfully avoiding hospitalization. Conclusion: Four consecutive outpatients with COVID-19 were treated with ramatroban. Improvement within hours was followed by gradual complete recovery, thereby avoiding hospitalization. As a safe, oral drug, ramatroban merits clinical trials for both outpatients and hospitalized patients with SARS-CoV-2 infection and COVID-19.

14.
Neurology ; 98(18 SUPPL), 2022.
Article in English | EMBASE | ID: covidwho-1925215

ABSTRACT

Objective: To study the cause of prolonged altered sensorium following cessation of sedation in mechanically ventilated patients Background: Patients with severe COVID-19 are at risk of thrombotic complications such as deep vein thrombosis, pulmonary thromboembolism, myocardial infarction and stroke. The incidence of strokes following COVID-19 is reported to be around 1.2%. There has been an increased incidence of large vessel strokes, especially, in young patients without any known risk factors in patients with COVID-19. Design/Methods: We report four cases of stroke diagnosed following neuroimaging in patients with severe COVID-19 Acute respiratory distress syndrome (ARDS). Results: All the patients were receiving supportive treatment and mechanical ventilation at the time of diagnosis of stroke. All patients received sedation and paralytics during mechanical ventilation. Poor response to stimulation and inability to wake up after sedation had worn off prompted neuroimaging in these patients, which revealed stroke. Incidentally, all these patients had hypernatremia at the time of diagnosis of stroke. Conclusions: This case series suggests that stroke should be considered in all COVID-19 patients who continue to have altered sensorium even after the cessation of sedation.

15.
British Journal of Dermatology ; 186(6):E245-E245, 2022.
Article in English | Web of Science | ID: covidwho-1885203
16.
Fertility and Sterility ; 116(3 SUPPL):e300, 2021.
Article in English | EMBASE | ID: covidwho-1880218

ABSTRACT

OBJECTIVE: To determine online tools and applications for scientific education in andrology during the COVID-19 pandemic. MATERIALS AND METHODS: Amid the COVID-19 pandemic and its ensuing restrictions, the American Center for Reproductive Medicine (ACRM) at Cleveland Clinic, organized several fully virtual programs, namely, the Online Summer Mentorship in Scientific Writing (June - August 2020, 28 participants) and Online Training in Assisted Reproductive Technology (ART) (December 2020 - March 2021, 2444 participants). ACRM adapted its annual training programs to an entirely virtual platform, which was achieved using online communication tools such as WhatsApp, Dropbox, Instagram, Facebook, LinkedIn, Cisco WebEx, and email correspondence. To determine the perception of the participants towards the use of such tools in the organization and delivery of these online training programs, the participants answered surveys at the end of each program. This study reports the results obtained from 2472 respondents of these surveys. RESULTS: In terms of preference for online communication platforms between students, mentors and management, the 28 participants of the inaugural Online Summer Mentorship program rated their applications usage preference as WhatsApp (32.1%), Google Meet (28.6%), Skype (17.9%), e-mail (14.3%) and Zoom (7.1%). Similarly, more than 80% of the 2,444 participants of the Online Training in ART program rated the sharing of information using the various electronic platforms as either very good or excellent. Here, the preferred platform appeared to be WhatsApp, with a rating of 86% compared to Dropbox (85%), or Cisco WebEx (81%). A total of 58.1% of the participants strongly agreed that WhatsApp was used effectively to share detailed information and materials about the course. CONCLUSIONS: Among the various communication applications and tools used for the ACRM online programs during the COVID-19 pandemic, WhatsApp appeared to be one of the preferred tools by the participants for networking and collaborations. This study provides an example of utilization of online tools and applications to support organization and continuity in scientific education in Andrology, amidst the physical distancing and travel restrictions imposed during the current COVID-19 pandemic. IMPACT STATEMENT: Routinely used online communication tools are valuable and accessible resources for delivery of knowledge, organization of training programs and sharing of data in academic and scientific education in Andrology during the COVID-19 pandemic.

17.
American Journal of Respiratory and Critical Care Medicine ; 205:2, 2022.
Article in English | English Web of Science | ID: covidwho-1880217
18.
International Management Conference, IMC 2021 ; : 117-129, 2022.
Article in English | Scopus | ID: covidwho-1826311

ABSTRACT

Consumer behaviour is the key to the success of a business. In the current economic context, it is the survival of a business. The novel coronavirus has created an incredibly difficult situation in the business climate today. Business has faced lot of new challenges like closure of import and export due to international boarder close, shutdown of brick and mortar businesses, big malls and home isolation of people. Many companies faced closures, with many employees laid off and many were given less salary. Our consumption pattern also changed on a massive scale. The availability of goods was the main concern, which led to some panic buying of essential items, in bulk. Consumers’ behaviour and perception got changed, as an impact of this unprecedented pandemic. This paper, in this context, aims to analyse the perception, attitude, sentiments and buying behaviour of consumers of Odisha during the COVID-19 lockdown period (i.e. from March to October, 2020). Further, it aims to study the change of media consumption habits of the consumers. This study tries to infer how COVID-19 lockdown changed the behaviour of consumers in Odisha over 8 months and what would be future implications. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

19.
International Symposium on Medical Robotics (ISMR) ; 2021.
Article in English | Web of Science | ID: covidwho-1819835

ABSTRACT

During the COVID-19 pandemic, the lives of healthcare professionals are at significant threat because of the enormous workload and cross-infection risk. Ultrasound (US) imaging plays a vital role in the diagnosis and follow-up of COVID-19 patients;however, it requires a close-physical contact by the sonographer. In this context, this paper presents a Telerobotic Ultrasound (TR-US) system for complete remote control of the US probe, thereby preventing direct physical contact between patients and sonographers. The system consists of a 6-DOF robot arm at the remote site and a haptic device at the doctor's site. The control architecture precisely transmits the intended position and orientation of the US probe to the remote location for transversal and sagittal plane scanning. This architecture, when integrated with an admittance controller-based force modulation and feedback transmission, enables the radiologists to obtain high-quality images for diagnosis. The advantages and effectiveness of the system are demonstrated by conducting in-vivo feasibility study at AIIMS, Delhi, for imaging abdomen organs (liver, spleen, kidneys, bladders). The system provides image quality equivalent to a manually-guided probe, can identify various pathology and reports high acceptability among volunteers and doctors from a questionnaire survey.

20.
Egyptian Journal of Radiology and Nuclear Medicine ; 53(1), 2022.
Article in English | EMBASE | ID: covidwho-1817311

ABSTRACT

Background: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was declared a pandemic by the World Health Organization on 11 March 2020 has been reported in most countries around the world since its origins in Wuhan, China. As of September 2021, there have been over 229 million cases of COVID-19 reported worldwide, with over 4.7 million COVID-19–associated deaths. Body: The devastating second wave of the COVID-19 pandemic in India has seen a rise in various extrapulmonary manifestations. One of key components in the pathogenesis of COVID-19 is downregulation of ACE-2, which is expressed on many organs and counterbalances the pro-inflammatory effects of ACE/angiotensin-II axis. This leads to influx of inflammatory cells into alveoli, increased vascular permeability and activation of prothrombotic mediators. Imaging findings such as ground glass opacities, interlobular septal thickening, vascular dilatation and pulmonary thrombosis correlate well with the pathogenesis. Conclusion: We hypothesize that the systemic complications of COVID-19 are caused by either direct viral invasion or effect of cytokine storm leading to inflammation and thrombosis or a combination of both. Gaining insights into pathobiology of SARS-CoV-2 will help understanding the various multisystemic manifestations of COVID-19. To date, only a few articles have been published that comprehensively describe the pathophysiology of COVID-19 along with its various multisystemic imaging manifestations.

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