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Research and Practice in Thrombosis and Haemostasis Conference ; 6(Supplement 1), 2022.
Article in English | EMBASE | ID: covidwho-2128255


Background: Pulmonary embolism (PE) is the third most common cause of cardiovascular death with a case fatality rate of 10% at 30 days. COVID-19 is associated with systemic inflammation and abnormal coagulation profile leading to an increased thromboembolic risk. Reported incidence of PE among COVID-19 patients is highly variable and mainly short-term studies are present in literature. Aim(s): Evaluatethe impact of COVID-19 on incidence and clinical, laboratoristic and radiological characteristics of PE over a 24-month period Methods: We conducted an observational cross-sectional study on all patients diagnosed with PE in one of the seven hospitals of the Azienda Socio Sanitaria Territoriale Sette Laghi, during a 24 month period, going from 12 months before (pre-COVID period) up to 12 months after (COVID period) February 21st 2020, day of first diagnosed italian case of COVID-19. Data were collected on clinical, laboratoristic and radiological characteristics and Non-COVID- 19 patients were compared to COVID-19 patients. Result(s): 489 patients with acute PE were identified: 217 in the pre-COVID period and 272 in the COVID period of whom 50 patients had COVID-19. The prevalence of PE in hospitalized patients with COVID-19 was 1.1% (50/4568). In patients with PE and COVID-19, male sex was more common (72% vs 42%;p-value < 0.01), D-Dimer values were significantly higher (> 9000 mcg/L in 50% of them vs 28% among non-COVID patients;p-value: 0.002), median Troponin T level was lower (32 ng/ml vs 14.5 ng/ml,;p-value: 0.02), distal obstruction was more common (68.4% vs 48% p-value: 0.03). Conclusion(s): Incidence of PE has significantly increased after the onset of pandemic (55 more cases;20%). Male sex appears to be a risk factor for PE in COVID-19 patients. Despite the high procoagulant profile of COVID-19 patients, our study found a predominantly distal distribution of PE and events appear to have lower severity indicators as compared to non-COVID- 19 patients. (Figure Presented).