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1.
Indian Journal of Medical Research ; 13:13, 2022.
Article in English | MEDLINE | ID: covidwho-2163898

ABSTRACT

Background & objectives: The oropharyngeal (OP) and nasopharyngeal (NP) swab samples are the most recommended clinical specimens for detecting SARS-CoV-2 in an individual through the quantitative real-time reverse-transcriptase-polymerase chain reaction (rRT-PCR) method. The primary objective of this study was to compare the performance of NP and OP swabs for the diagnosis of COVID-19 among 2250 concomitant samples (1125 NP + 1125 OP) using rRT-PCR test.

2.
Inflammopharmacology ; 30(6): 2411-2415, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-2048378

ABSTRACT

Coronavirus disease 2019 (Covid-19) is caused by severe acute respiratory syndrome type 2 (SARS-CoV-2). Covid-19 is characterized by hyperinflammation, oxidative stress, and multi-organ injury (MOI) such as acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Covid-19 is mainly presented with respiratory manifestations; however, extra-pulmonary manifestations may also occur. Extra-pulmonary manifestations of Covid-19 are numerous including: neurological, cardiovascular, renal, endocrine, and hematological complications. Notably, a cluster of differentiation 26 (CD26) or dipeptidyl peptidase-4 (DPP-4) emerged as a new receptor for entry of SARS-CoV-2. Therefore, DPP-4 inhibitors like sitagliptin could be effective in treating Covid-19. Hence, we aimed in the present critical review to assess the potential role of sitagliptin in Covid-19. DPP-4 inhibitors are effective against the increased severity of SARS-CoV-2 infections. Moreover, DPP-4 inhibitors inhibit the interaction between DPP-4 and scaffolding proteins which are essential for endosome formation and replication of SARS-CoV-2. Therefore, sitagliptin through attenuation of the inflammatory signaling pathway and augmentation of stromal-derived factor-1 (SDF-1) may decrease the pathogenesis of SARS-CoV-2 infection and could be a possible therapeutic modality in treating Covid-19 patients. In conclusion, the DPP-4 receptor is regarded as a potential receptor for the binding and entry of SARS-CoV-2. Inhibition of these receptors by the DPP-4 inhibitor, sitagliptin, can reduce the pathogenesis of the infection caused by SARS-CoV-2 and their associated activation of the inflammatory signaling pathways.


Subject(s)
COVID-19 , Dipeptidyl-Peptidase IV Inhibitors , Humans , COVID-19/drug therapy , SARS-CoV-2 , Sitagliptin Phosphate/pharmacology , Sitagliptin Phosphate/therapeutic use , Dipeptidyl-Peptidase IV Inhibitors/pharmacology , Dipeptidyl-Peptidase IV Inhibitors/therapeutic use , Lung
3.
Gesundheitswesen ; 84(08/09):885-885, 2022.
Article in German | Web of Science | ID: covidwho-2031850
4.
Applied Mathematics and Information Sciences ; 16(5):729-737, 2022.
Article in English | Scopus | ID: covidwho-2025973

ABSTRACT

In this article, we introduce a numerical study for a spatio temporal bi-modal of covid-19 mathematical model. The temporal only model consists of a system of five ordinary differential equations and spatio-temporal model consists of a system of five partial differential equations in time and space. We will discuss the stability region to get good selection of parameters. Also, we will apply the effective method of centeral finite difference (CFD) and study stability and consistency of this scheme then we will discuss the graphical numerical results of the presented models and the behavior of this model. © 2022. NSP Natural Sciences Publishing Cor.

5.
Naunyn Schmiedebergs Arch Pharmacol ; 395(12): 1463-1475, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-2007127

ABSTRACT

Coronavirus disease 2019 (COVID-19) is a current pandemic disease caused by a novel severe acute respiratory syndrome coronavirus virus respiratory type 2 (SARS-CoV-2). SARS-CoV-2 infection is linked with various neurological manifestations due to cytokine-induced disruption of the blood brain barrier (BBB), neuroinflammation, and peripheral neuronal injury, or due to direct SARS-CoV-2 neurotropism. Of note, many repurposed agents were included in different therapeutic protocols in the management of COVID-19. These agents did not produce an effective therapeutic eradication of SARS-CoV-2, and continuing searching for novel anti-SARS-CoV-2 agents is a type of challenge nowadays. Therefore, this study aimed to review the potential anti-inflammatory and antioxidant effects of citicoline in the management of COVID-19.


Subject(s)
COVID-19 , Humans , COVID-19/drug therapy , SARS-CoV-2 , Cytidine Diphosphate Choline , Pandemics , Blood-Brain Barrier
6.
3rd International Conference on Control, Instrumentation and Mechatronics Engineering, CIM 2022 ; 921 LNEE:213-226, 2022.
Article in English | Scopus | ID: covidwho-1971639

ABSTRACT

Online food delivery is the latest trend to hit the world. This trend has increased rapidly in recent years as a result of the COVID-19 pandemic, which struck at once changing the country’s economic landscape. Therefore, motorcycles and mobile phones with high data access and battery storage capacity are used mainly involving identifying the place of delivery. Due to the widespread and frequent use of cellular phones in tracking the position of food delivery then causing the cellular phone battery storage will be depleted and require recharging the phone which involves a long time. This in turn will cause delays in the food delivery procedure. The development of a Thermoelectric Generator system using the Internet of Things (IoT) for energy harvesting is very important. Given that the development method is based on the differential temperature on the exhaust chamber of the motorcycle and heatsink to solve the problem of charging a cellular phone on a motorcycle. The process of developing this system requires control over the voltage capacity as well as the ability to monitor it online through the Internet of Things system. The development of this system revealed that large temperature difference rates produce high electrical voltages to 10 V with power rates up to 206 mW. It also shows that the quantity of TEG will affect the rate of voltage increase and the value of power produced in direct proportion as the quantity of TEG increases. In conclusion, the benefits of temperature changes will generate reusable energy for daily use. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

7.
Electronic Journal of e-Learning ; 20(4):360-373, 2022.
Article in English | Scopus | ID: covidwho-1965127

ABSTRACT

The sudden and prolonged disruption to learning caused by the COVID-19 pandemic has exposed the vulnerabilities of traditional higher education and revealed the need for a rapid transformation. Lessons from the pandemic have made it clear that the future of higher education will rely heavily on e-learning and the agility of institutions to seamlessly transition between face-to-face, blended/hybrid, and fully online learning. As institutions begin their post-pandemic planning, the online experiences of different groups of learners during the pandemic offer valuable insight into what is working and what isn’t. Consequently, this study explored the effect of gender and discipline (STEM/non-STEM) on students’ perceptions of (1) course design, (2) assessment, (3) student behavior, (4) instructor behavior, and (5) tools and technologies during forced online learning. Additionally, the researchers investigated the effect of gender and discipline on students’ overall satisfaction with remote learning and explored the influence of students’ perceptions on satisfaction. Study participants were 1, 825 undergraduates at eight universities in Qatar. Using the QLT evaluation rubric, the researchers adapted a 27-item survey to measure students’ perceptions of key aspects of quality online teaching and learning and to gauge overall satisfaction. Using a SEM approach, study results showed that (1) male students had more positive perceptions of instructor behavior, assessment, and tools and technologies compared to females, (2) males were more satisfied overall with their remote learning experiences, (3) students in STEM disciplines had significantly more negative perceptions of all the aspects of online learning explored in the study, (4) students in STEM disciplines were significantly less satisfied overall with remote learning, and (5) students’ perceptions of tools and technologies, assessment, and course design most influenced their overall satisfaction. This study also considers the unique cultural context in Qatar when interpreting results, particularly in regards to women. These findings have important implications for faculty development and post-pandemic planning in higher education in general and the Gulf in particular. © The Authors.

8.
New Emirates Medical Journal ; 3(1):79-85, 2022.
Article in English | Scopus | ID: covidwho-1910814

ABSTRACT

Background: COVID-19 has a significant impact on lives worldwide. Owing to the adverse effect of this pandemic, there has been a major shift from in-person learning activities to virtual learning. Different methods of virtual learning or e-learning, such as online classes and webinars, have emerged rapidly. Objective: The aim of this study is to identify the perceptions of healthcare professionals regarding e-learning during the COVID-19 pandemic. Methods: An online survey was conducted using Microsoft Forms sent via a text link to mobile phones and emails to healthcare professionals. The questionnaire had multiple-choice questions and five-point scaling to determine perceptions about virtual learning. Data in the form of responses were collected, analyzed, and summarized as mean ± standard deviation and percentage. Results: Responses were received from a total of 410 participants, out of which 240 (58.54%) were females, and 170 (41.46%) were males. Among all participants, 294 (71.71%) were doctors. A vast majority of participants (90%) attended online webinar/e-conferences since the pandemic. The mobile phone was the most commonly used device for e-learning. More than half of the participants opined that in-person meetings are more effective than virtual meetings. In terms of medical learning, 40.48% of participants believed that virtual conferences are more convenient compared to conventional in-person attendance. According to 42.2% of participants, lack of personal interaction in virtual meetings affected their ability to acquire knowledge and experience. Conclusion: Our survey demonstrated the acceptance of virtual learning by healthcare professionals as a new learning method. The majority of participants seem willing to adapt to this new medium. © 2022 Hamad et al.

9.
Frontline Gastroenterol ; 13(6): 547-548, 2022.
Article in English | MEDLINE | ID: covidwho-1891858
10.
Biochemical and Cellular Archives ; 22(1):1075-1092, 2022.
Article in English | CAB Abstracts | ID: covidwho-1848276

ABSTRACT

Campylobacteriosis is one of the most well-characterized bacterial foodborne infections worldwide, the species are the most common zoonotic pathogens. Chicken and chicken products are known to be the major sources of Campylobacter infection in humans. Campylobacter species represent one of the most common causes of bacterial diarrheal illness worldwide, it is the main cause of bacterial gastrointestinal infections occurring at any age, but it peaks in children and young adults. This study aims to investigate the presence and prevalence of Campylobacter bacteria in humans and chicken and aims for determination the extent of the contamination of this bacteria. The study involved two parts;the first part designed for isolation Campylobacter species from chickens which were alive, while the second part was about isolation Campylobacter species from human stool samples for different ages. The current study based on analysis of three hundred and fifty (350) stool samples taken from humans with different ages. The patients samples were collected from Al-Batool Teaching Hospital for Maternity and Pediatric, Baquba Teaching Hospital and Central Health Laboratories in Diyala, these patients were had vary clinical aspects like : (diarrhea, Fever, nausea, vomiting, abdominal pain and cramp, fatigue and muscle pain). On the other hand, one hundred seventy five (175) stool samples of chicken which they apparently had diarrhea were collected randomly from different areas of Diyala Governorate. The collection of both humans and chicken samples were during 2020 - 2021. The analysis of 350 samples of patients their ages ranged from 3 months to 59 years showed that the mean +or- SD of age was 24.5 +or- 14.3 years. The most predominant age group was 20-29 years (26.9%), while the lowest age group was 50-59 years (4.9%). Regarding the gender, 151 (43.1%) of the included patients were male and 199 (56.9%) were female. Patients included in the current study were collected from four districts of Diyala province. The highest collection rate was from Baquba district 217(62.0%), while the lowest collection rate was from Baladrooz district 18 (5.1%). the distribution of clinical signs and symptoms of included patients. Persistent diarrhea forming the predominance of signs 179 (51.1%), followed by watery diarrhea 55 (15.7%), while the least sign was vomiting 1(3%). Furthermore, 15 (4.3%) of patients showed all that signs and symptoms. The signs and symptoms were : diarrhea was found in 194 (55.4%) patients, followed by watery diarrhea in 77 (22.0%) patients. Fever was found in 30 (8.6%) patients. The least sign was nausea which was found in 15 (4.3%) patients. Abdominal pain and cramps were detected in 22 (6.3%) patients. Out of 350 stool specimens submitted for bacteriological culture, 62 (17.7%) were positive versus 288 (82.3%) were negative. Among the 62-culture positive, 13 specimens yield Campylobacter growth, so the campylobacter detection rate among human specimens was 3.7%. The isolated Campylobacter were as follow;11(3.1%) were Campylobacter jejuni, one (0.3%) was Campylobacter coli, one (0.3%) was undifferentiated campylobacter. On the other hand, 58 (16.6%) of the specimens yield bacterial growth other than Campylobacter, as follows: E. coli was detected in 28 (8.0%), Proteus Spp. was detected in 12 (3.4%), H. pylori was detected in 10 (2.9%) and Klebsiella Spp. was detected in 8 (2.3%). The remaining specimens 279 (79.7%) yield no growth. The results of the PCR technique revealed that 8 (2.38%) specimens were positive for Campylobacter, while the majority 335 (95.7%) were negative and 7(2.0%) of the specimens were not done. While the analysis of 175 chicken fecal samples taken from chickens were mainly suffering from diarrhea showed that the distribution of chickens according to their ages in days showed predominance was those 30-39 (40.6%) days old. It is clear that the majority of specimens (74.3%) were collected from Baquba districts. The results showed that specimens collected Al- Muqdadiya district farms had yielded the high

11.
Pakistan Journal of Medical and Health Sciences ; 15(12):3749-3751, 2021.
Article in English | EMBASE | ID: covidwho-1668123

ABSTRACT

Objective: The purpose of this research is to see how coronavirus affects people with cirrhosis, a type of chronic liver disease. Study Design: Retrospective/observational Place and Duration: Conducted at Khyber Teaching Hospital Peshawar, during from April 2021 to Oct 2021. Methodology: This study included 100 covid-19 individuals of both genders with or without chronic liver disease. There were two groups of patients. Group I (50 patients with cirrhosis) and Group II (without cirrhosis 50 patients). The mortality outcomes of the two groups were compared. SPSS 25.0 was used to analyze all of the data. Results: There were 31 (62%) males and 19 (38%) were females with mean age 43.31±=7.61 years in group I while in group II 32 (64%) and 18 (36%) patients were males and females with mean age 46.01±5.23 years. Patients with cirrhosis died at a higher rate than those without it, with a p-value of 0.0001 (34 percent vs. 10%). Conclusion: Patients with cirrhosis who also had coronavirus illness had a higher incidence of poor outcomes.

12.
British Journal of Surgery ; 108(SUPPL 7):vii42, 2021.
Article in English | EMBASE | ID: covidwho-1585073

ABSTRACT

Aims: Pilonidal sinus disease (PSD) is a significant cause of morbidity. The purpose of this systematic review and meta-analysis is to determine the totality of evidence regarding the effectiveness of Local Anaesthesia (LA) when compared to spinal or general anaesthesia in individuals undergoing definitive surgery for PSD. Methods: A systematic review of literature was conducted. Studies included randomized controlled trials comparing LA with other anesthetics and non-randomized studies focusing on ambulatory procedure of excising pilonidal sinus aiming wound closure, all performed under local anesthetics. We used Cochrane risk of bias tool. The statistical analysis was done using Revman and Excel. Results: Four original RCTs and 10 observational studies were included, with a total of 1801 patients. There was no significant difference in operative time between the groups Patients in the local anaesthetic group experienced less pain than those in other group, lower rates of anaesthetic related complications, early return to work and increased satisfaction. However, the mode of anaesthesia used had no relation with recurrence. Conclusion: Our findings support the use of LA in adult patients undergoing definitive surgical treatment for PSD. We aggregate the published evidence to demonstrate clear benefits clinically, patients' preference, and economic benefits. Patient selection, and adequate dose of local anaesthetic, is the key. In the context of the current COVID-19 pandemic, novel care pathways need to be developed in all medical fields, and we would propose that surgery for Pilonidal Sinus Disease under local anaesthesia should now be the default.

13.
Front Public Health ; 9: 781827, 2021.
Article in English | MEDLINE | ID: covidwho-1581107

ABSTRACT

COVID-19 (SARS-CoV-2) was declared as a global pandemic by the World Health Organization (WHO) in February 2020. This led to previously unforeseen measures that aimed to curb its spread, such as the lockdown of cities, districts, and international travel. Various researchers and institutions have focused on multidimensional opportunities and solutions in encountering the COVID-19 pandemic. This study focuses on mental health and sentiment validations caused by the global lockdowns across the countries, resulting in a mental disability among individuals. This paper discusses a technique for identifying the mental state of an individual by sentiment analysis of feelings such as anxiety, depression, and loneliness caused by isolation and pauses to the normal chains of operations in daily life. The research uses a Neural Network (NN) to resolve and extract patterns and validate threshold trained datasets for decision making. This technique was used to validate 2,173 global speech samples, and the resulting accuracy of mental state and sentiments are identified with 93.5% accuracy in classifying the behavioral patterns of patients suffering from COVID-19 and pandemic-influenced depression.


Subject(s)
COVID-19 , Pandemics , Attitude , Communicable Disease Control , Depression/diagnosis , Depression/epidemiology , Humans , Neural Networks, Computer , SARS-CoV-2 , Speech
14.
International Journal of Financial Engineering ; 8(1):22, 2021.
Article in English | Web of Science | ID: covidwho-1559668

ABSTRACT

COVID-19 and the worldwide lockdown left life in worse condition in which people struggle to meet their livelihood. People are concerned about their lives, jobs, savings, and investments. This paper had analyzed the changes in the mutual fund industry in India due to the virus outbreak from December 2019 to May 2020. A sample of 25 equity-oriented direct growth funds has been considered for this study to analyze their performance along with the sector-wise differences. The results show that the value of majority of the funds had plunged, while some funds had rebounded during the period.

15.
Jcpsp-Journal of the College of Physicians and Surgeons Pakistan ; 31(7):S109-S111, 2021.
Article in English | Web of Science | ID: covidwho-1543110

ABSTRACT

Wuhan, the capital of China's Hubei province, was recognised in December 2019 as the centre of an outbreak of an unknown originator of pneumonia. Intense concentrations of illness spread throughout China and, ultimately, globally. Consequently, on 7th January, 2020, Chinese researchers identified a case of severe acute respiratory syndrome coronavirus (SARS-CoV-2) in an affected person in Wuhan as the cause. Symptoms of SARS-CoV-2 vary from mild (fever, dry cough, difficulty in breathing, and pain in muscles) to severe (acute respiratory distress syndrome [ARDS}, azotemia or acute renal failure, ventilation associated pneumonia [VAP], and shock from sepsis). In a multidisciplinary team, pharmacists play a strategic role as medical healthcare professionals in restricting the dissemination of SARS-CoV-2 and can serve as sentinels in their communities to control and counteract this epidemic domestically.

16.
La Revue de Médecine Interne ; 42:A444, 2021.
Article in French | ScienceDirect | ID: covidwho-1531749

ABSTRACT

Introduction Le personnel soignant est considéré parmi les populations les plus touchées par la pandémie Covid-19. Dans cette optique, nous avons mené une étude dont l’objectif était d’étudier l’impact de cette pandémie sur le comportement alimentaire des blouses blanches ainsi que sa relation avec leur profil anthropométrique. Matériels et méthodes Il s’agit d’une étude transversale incluant 40 résidents en médecine exerçant dans des centres hospitalo-universitaires à Tunis. Les données ont été collectées via un questionnaire renseignant sur les mesures anthropométriques et les conduites alimentaires des participants. Résultats L’âge moyen était de 28,5±1,8 ans. Une prédominance féminine était notée dans 77,5 % des cas. 80 % étaient sans antécédents. Une atopie, un diabète de type 2, une hypotension artérielle et des adénofibromes étaient retrouvés dans 10 %, 5 %, 2,5 % et 2,5 % des cas respectivement. 22,5 % étaient tabagiques et plus que le quart (27,5 %) étaient consommateurs réguliers d’alcool. L’activité physique était faible dans la moitié des cas, modérée dans 45 % des cas et intense dans 5 % des cas. Une infection SARS-COV 2 était retrouvée chez 44 % des participants. La forme légère était la forme prédominante (dans plus de 90 % des cas). Ils étaient tous vaccinés. L’IMC moyen était de 23,4±2,6 Kg/m2 avec une surcharge pondérale objectivée dans 20 % des cas (n=8). La consommation des compléments alimentaires était notée dans 62,5 % des cas (n=25). Plus que la moitié des résidents (60 %) présentaient des troubles du comportement alimentaire (TCA) à type de grignotage (56 %) (n=18), boulimie (6 %) (n=2), binge eating disorder (9 %) (n=3), night eating syndrome (9 %) (n=3), hyperphagie (16 %) (n=5) et compulsion alimentaire (26 %) (n=8). L’impact des régresseurs (sexe, tabagisme, IMC, consommation d’alcool, activité physique, consommation de compléments alimentaires, infection SARS-COV2) sur la présence de troubles des conduites alimentaires a été étudié par le modèle de régression logistique binaire. Seule la consommation d’alcool était considérée comme facteur de risque de développer un TCA avec p=0,05 (Odds ratio=19). Conclusion Notre étude a montré que les TCA sont bel et bien fréquents chez le personnel soignant pendant la pandémie du SARS-COV2. Outre la consommation d’alcool qui s’est avérée un facteur de risque de survenue des TCA, il faut mentionner que d’autres facteurs sont à rechercher et à évaluer dans d’autres études comme le stress qui s’est amplifié durant ces conditions particulières de l’exercice médical.

17.
IOP Conference Series. Earth and Environmental Science ; 910(1), 2021.
Article in English | ProQuest Central | ID: covidwho-1528145

ABSTRACT

Citrus (oranges, lemon, mandarin, limes and tangarines) has significant nutritional value in human foods. It is rich source of vitamin C, sugar, organic acids, amino acids, minerals like Ca, Mg and various other phytochemicals (flavonoids, hesperidin etc) compounds that are responsible for good health. Citrus is growing in more than one forty countries of the world including Pakistan, Brazil, China, Mexico, USA, Spain and India.Viral infection and inflammation triggers the production of oxygen free radicals and these radicals severely damage the cells, however hesperidin and vitamin C is reported to counteract these damages. Intake of plentiful citrus fruits is one of amongst the many possible approaches to prevent from COVID-19 role of nutrition. Citrus fruit are very rich in important substances with a potential beneficial for health such as modulating the immunity and in protecting cells from oxidative stress related with infection. Flavonoids and hesperidin two major key compound found in citrus have affinity to treat Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hesperidin has a low binding energy, both with the coronavirus “spike” protein, and with the fundamental protease that alters the primary proteins of the virus (pp1a and ppa1b) into the complex liable for viral replication hence these compounds could work as an antiviral function. Pakistan is amongst top ten citrus producers in the world. Citrus is one of the best commercial fruits of Pakistan cultivated on a large area, however, in Pakistan yield of citrus has been affected due to attack of insects and pathogens (nematode, fungal, bacterial and viral) which causes heavy losses both in quality and quantity. The purpose of this article is to focusing on the controlling the pathogens of citrus to boost citrus production in country as these beneficial plants are well known for its essential vitamin and flavonoid contents to control COVID-19.

18.
Applied Sciences ; 11(17):7772, 2021.
Article in English | MDPI | ID: covidwho-1374283

ABSTRACT

In this research, we applied deep learning to rank the effectiveness of candidate drug compounds in combating viral cells, in particular, SARS-Cov-2 viral cells. For this purpose, two different datasets from Recursion Pharmaceuticals, a siRNA image dataset (RxRx1), which were used to build and calibrate our model for feature extraction, and a SARS-CoV-2 dataset (RxRx19a) was used to train our model for ranking efficacy of candidate drug compounds. The SARS-CoV-2 dataset contained healthy, uninfected control or “mock” cells, as well as “active viral” cells (cells infected with COVID-19), which were the two cell types used to train our deep learning model. In addition, it contains viral cells treated with different drug compounds, which were the cells not used to train but test our model. We devised a new cascade transfer learning strategy to construct our model. We first trained a deep learning model, the DenseNet, with the siRNA set, a dataset with characteristics similar to the SARS-CoV-2 dataset, for feature extraction. We then added additional layers, including a SoftMax layer as an output layer, and retrained the model with active viral cells and mock cells from the SARS-CoV-2 dataset. In the test phase, the SoftMax layer outputs probability (equivalently, efficacy) scores which allows us to rank candidate compounds, and to study the performance of each candidate compound statistically. With this approach, we identified several compounds with high efficacy scores which are promising for the therapeutic treatment of COVID-19. The compounds showing the most promise were GS-441524 and then Remdesivir, which overlapped with these reported in the literature and with these drugs that are approved by FDA, or going through clinical trials and preclinical trials. This study shows the potential of deep learning in its ability to identify promising compounds to aid rapid responses to future pandemic outbreaks.

20.
New Microbes New Infect ; 43: 100926, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1336779

ABSTRACT

While many patients infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) eventually produce neutralising antibodies, the degree of susceptibility of previously infected individuals to reinfection by SARS-CoV-2 is currently unknown. To better understand the impact of the immunoglobulin (IgG) level on reinfection in recovered coronavirus disease 2019 (COVID-19) patients, anti-nucleocapsid IgG levels against SARS-CoV-2 were measured in 829 patients with a previously confirmed infection just after their recovery. Notably, 87 of these patients had no detectable IgG concentration. While there was just one case of asymptomatic reinfection 4.5 months after the initial recovery amongst patients with detectable anti-nucleocapsid IgG levels, 25 of the 87 patients negative for anti-nucleocapsid IgG were reinfected within one to three months after their first infection. Therefore, patients who recover from COVID-19 with no detectable anti-nucleocapsid IgG concentration appear to remain more susceptible to reinfection by SARS-CoV-2, with no apparent immunity. Also, although our results suggest the chance is lower, the possibility for recovered patients with positive anti-nucleocapsid IgG findings to be reinfected similarly exists.

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