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1.
Abu Dhabi International Petroleum Exhibition and Conference 2022, ADIPEC 2022 ; 2022.
Article in English | Scopus | ID: covidwho-2162740

ABSTRACT

Oil and Gas industry is seeking new ways to improve efficiencies, reducing operating costs and increasing revenues in the current volatile market conditions. Data Science and all the new emerging technologies enable the discovery of new opportunities and digitalization is a vital element for making business more effective and efficient. While COVID19 has disrupted the world, ADNOC Onshore has recognized the importance of reskilling and empowering the future workforce through strategic enterprise data science and analytics program to achieve 2030 smart growth strategy. This paper talks about successful approach and enablers for development of in-house capability for transformation that lead to generating significant business value The digital transition can pose both challenges and opportunities in this transformation. ADNOC ONSHORE has developed an integrated framework to encourage and accelerate data science capabilities. This framework promotes a vision with collaborative, sustainable mechanisms to develop talent. It is not just the formal learning and additional professional qualification that make it possible to build this in house capability. There are five major areas are enabled this framework such as data science & analytics skills competency model, sustainable on-line collaborative learning program, organizational culture change, democratizing AI through open platform & a digital business model for performing real business problems/use case PoCs. Each area has a detailed program and execution strategy with a collaborative effort from technical and non-technical stakeholders. ADNOC ONSHORE has successfully implemented this framework and able to certify 20 employees as part of this program. The Data Science Competency Model identified and defined the skills required to be successful within the enterprise with a clear learning path and mentorship. The leadership played a pivotal role to encourage data driven decision making and predictive capabilities in addition to executive awareness to lead the change with clear performance indicators. By democratizing AI platform across upstream user community, six real business cases have been successfully developed with clear business value in subsurface and production workflows according to the defined digital business model. The successful business cases have improved efficiency by 75% in performing cement & corrosion log interpretation & well portfolio optimization. Data driven analytics have been evaluated in subsurface workflows such as infill location optimization, gas-lift candidate identification and they have complemented the existing techniques. The framework has been successfully extended to other group companies in ADNOC. The rapid growth of AI in business in the last five years presents an opportunity for oil and gas professionals for enhancing the skills and transformation. This paper talks about an integrated framework, learning path, democratizing AI, engagement of leadership, digital business model for business case evaluation by applying agile way of working and sustainable value creation. Copyright © 2022, Society of Petroleum Engineers.

2.
Clinical Infectious Diseases ; 09:09, 2022.
Article in English | MEDLINE | ID: covidwho-2160990

ABSTRACT

BACKGROUND: Most studies of immunity to SARS-CoV-2 measure antibody or cellular responses in blood;however, the virus infects mucosal surfaces in the nose and conjunctivae and infectious virus is rarely if ever present in the blood.

3.
5th International Conference on Computational Intelligence and Communication Technologies, CCICT 2022 ; : 584-589, 2022.
Article in English | Scopus | ID: covidwho-2136140

ABSTRACT

Ransomware is a malware practice which cyber criminals usually inject through phishing practices to make money as their priority. With the high rise in the use of the internet amid the COVID phase, the cyber world is also reaching its peak as well. The attacker is also getting smarter with technology. We in this paper are taking blockchain technology as a weapon to fight against the terror of ransomware attacks, as this is the most notorious and devastating attack of all, and there is no doubt that it is going to be with us in the future too. Detection of ransomware attacks before they infect and decode the data is a complex thing. Several algorithms exist to detect attacks at their early stages, but the lack of information about the pre and post behavior similarities is proving to be an obstacle to accurately observing and detecting ransomware at its very first stage rather than making sense of paying the ransom and even not being sure of getting back the confidentialities. With the use of blockchain technology, we focus on making a record of the pre-encryption and post-encryption behaviour of ransomware attacks so that it is not going to be complex to track the nature, similarities, and behaviour of ransomware attacks. With inaccurate availability of data about pre and post behaviour of attacks and also weak design of detection models, both have a negative impact on selecting the features and similarities of the attack and thus developing a design model for the same. The paper is focusing on one of the most challenging variations of ransomware attacks, i.e., the crypto ransomware. Many researches before proposed solutions as performing regular backup of files but this measure has a significant overhead too as key backup schemes results in high computational cost as well. Thus, with the use of blockchain for gathering and maintaining records, we expect to be prepared for every unexpected attack. © 2022 IEEE.

4.
Journal of King Saud University - Science ; 35(1), 2023.
Article in English | Scopus | ID: covidwho-2131574

ABSTRACT

Masitinib is an orally acceptable tyrosine kinase inhibitor that is currently investigated under clinical trials against cancer, asthma, Alzheimer's disease, multiple sclerosis and amyotrophic lateral sclerosis. A recent study confirmed the anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) activity of masitinib through inhibition of the main protease (Mpro) enzyme, an important pharmacological drug target to block the replication of the coronavirus. However, due to the adverse effects and lower potency of the drug, there are opportunities to design better analogues of masitinib. Herein, we substituted the N-methylpiperazine group of Masitinib with different chemical moieties and evaluated their drug-likeness and toxicities. The filtered analogues were subjected to molecular docking studies which revealed that the analogues with substituents methylamine in M10 (CID10409602), morpholine in M23 (CID59789397) and 4-methylmorpholine in M32 (CID143003625) have a stronger affinity to the drug receptor compared to masitinib. The molecular dynamics (MD) simulation analysis reveals that the identified analogues alter the mobility, structural compactness, accessibility to solvent molecules, and the number of hydrogen bonds in the native target enzyme. These structural alterations can help explain the inhibitory mechanisms of these analogues against the target enzyme. Thus, our studies provide avenues for the design of new masitinib analogues as the SARS-CoV-2 Mpro inhibitors. © 2022 The Author(s)

5.
Immunogenetics: A Molecular and Clinical Overview A Molecular Approach to Immunogenetics ; : 1-392, 2021.
Article in English | Scopus | ID: covidwho-2075824

ABSTRACT

A Molecular Approach to Immunogenetics, Immunogenetics: A Molecular and Clinical Overview, Volume One provides readers with an exclusive, updated overview on the scientific knowledge, achievements and findings in the field of immunogenetics. The book presents readily available, updated information on the molecular and clinical aspects of immunogenetics, from origin and development to clinical applications and future prospects. The breadth of information goes from basics to developments, clinical applications and future prospects. The book's most attractive attribute is its academic and clinical amalgamation that covers both the theoretical and practical aspects of immunogenetics. An additional feature of the book is a special chapter on viral genetics that covers COVID-19. Above all, the book contains chapters that discuss immunogenetics in relation to pharmaco-genomics and immune-toxicology. © 2022 Elsevier Inc. All rights reserved.

6.
Open Access Macedonian Journal of Medical Sciences ; 10:1698-1705, 2022.
Article in English | EMBASE | ID: covidwho-2066674

ABSTRACT

BACKGROUND: The rapid worldwide spread of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) or COVID-19 pandemic from its epicenter;Wuhan was first reported in December 2019. Egypt reported its first COVID-19 case on February 14, 2020. Thereafter, Egypt scaled-up preventive measures, with a partial lockdown starting on March 25. Several therapeutic agents along with convalescent plasma transfusion (CPT) are under investigation and data from CPTs have been receiving a lot of attention, after Emergency approvals from the Food and Drug Administration suggesting that it may provide a clinical effect in the treatment of SARS-COV-2. IMPORTANCE: Early and effective treatment of COVID-19 is vital for control of SARS-CoV-2 infection. METHODS: Designs: An interventional, single-arm, and non-randomized clinical trial conducted in Egypt from April 15 to July 21, 2020. Settings: This was a multi-center study conducted in three hospitals in Egypt. Participants: A total of 94 COVID-19 laboratory-confirmed patients using quantitative real-time polymerase chain reaction were enrolled in the study. Intervention: All patients were administered with two plasma units (each unit is 200 cc). The volume of donated plasma was 800 cc. Main Outcome and measures: Primary measure was the degree of clinical improvement among the COVID-19 patients who received CPT within 7 days. RESULTS: A total of 94 patients were enrolled who received CPT either within 7 days or after 7 days of hospitalization. 82 were severely ill and 12 were critically ill. The average age remained 58 years (±standard deviation 15.1 years). Male were 69% and 49% patients got cured while 51% died with case fatality rate 51%. Seventy-five percent deaths were above 45 years of age. The symptoms were dyspnea (55%), fever (52%), cough (46%), and loss of taste and smell (21%), and cyanosis (15%). The most common co-morbidities among the <40 years remained diabetes mellitus (21%) and asthma (14%). Among 40–60 years hypertension (56%), diabetes mellitus (39%) and among >60 years age group hypertension (57%), and chronic heart disease (24%) were reported. CPT within 7 days remained significant as compared with the CPT after 7 days with the number of days to cure (p=0.007) and ICU stay (p = 0.008) among severely ill cured cases. CONCLUSIONS: Among patients with COVID-19 and severe or critical illness, the use of CPT along with routine standard therapy resulted in a statistically significant improvement when administered within seven days of hospital admission. However, plasma transfusion, irrespective of days to transfusion may not help treat critically ill patients. The overall mean time to cure in severely ill patients was 15 days if CPT provided within 7 days with 65% cure rate. TRIAL REGISTRATION: Clinical Intervention identifier: MOHP_COVID-19_Ver1.1 registered April 2020.

7.
5th International Symposium on New Metropolitan Perspectives, NMP 2022 ; 482 LNNS:1048-1058, 2022.
Article in English | Scopus | ID: covidwho-2048026

ABSTRACT

This research is concerned with understanding the context of influences the COVID-19 pandemic had/has on urban change in cities. It focuses on understanding the nexus of relations through which the pandemic impacted the urban space, urban place and public realm;specifically, the economic, environmental, social, human behavior, administrative and health factors. Using a mixed-methods approach and examples from around the world, an analysis was conducted to highlight the most important factors influencing urban change as a result of the pandemic. The research concluded that there are a multitude of direct and indirect connections between the factors that resulted in long-term and short-term impact on urban change and public realm. An understanding of this nexus of factors constitutes an important and essential step in creating more comprehensive and responsive urban planning/design policies. Thus, mitigating any undesirable urban change and better governing the public realm during similar situations and pandemics in the future. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

8.
129th ASEE Annual Conference and Exposition: Excellence Through Diversity, ASEE 2022 ; 2022.
Article in English | Scopus | ID: covidwho-2045460

ABSTRACT

Due to recent COVID-19 social distancing policies and procedures, there was no way to offer hands-on courses in an on-site format for many education institutions. The solution employed by many educators was to find new ways to implement web-based delivery tools and technologies in order to maintain course learning outcomes and help students successfully grasp course content. In this review paper, a number of innovative practices is highlighted used to deliver course content in several ways. Overall, the paper reports a number of available delivery mechanisms that could be implemented for several manufacturing courses and programs. © American Society for Engineering Education, 2022.

9.
Novel AI and Data Science Advancements for Sustainability in the Era of COVID-19 ; : 21-66, 2022.
Article in English | Scopus | ID: covidwho-2035527

ABSTRACT

This book chapter presents the review of COVID-19 and its status, as well as the scientific Analysis big data analytics with the help of machine learning. We provide in-depth literature review, and provide a summary of the current AI and machine learning methods, which have become increasingly important to provide accurate analyses. Various conceptual diagrams have been used to illustrate how different technologies can contribute to effective analyses for COVID-19. We demonstrate our work from both theoretical contributions and practical implementations. © 2022 Elsevier Inc. All rights reserved.

10.
Chemical and Biological Technologies in Agriculture ; 9(1), 2022.
Article in English | Web of Science | ID: covidwho-1997298

ABSTRACT

Background: Infectious laryngotracheitis (ILT) and infectious bronchitis (IB) are two common respiratory diseases of poultry that inflict great economic burden on the poultry industry. Developing an effective agent against both viruses is a crucial step to decrease the economic losses. Therefore, for the first time green synthesized silver nanoparticles using Cyperus rotundus L. aqueous extract was evaluated in vitro as a potential antiviral against both viruses. Results: Silver nanoparticles from Cyperus rotundus were characterized by the spherical shape, 11-19 nm size, and zeta potential of - 6.04 mV. The maximum nontoxic concentration (MNTC) was 50 mu g mL(-1 )for both viruses without harmful toxicity impact. The study suggested that some of the compounds in C. rotundus extract (gallic acid, chlorogenic acid, and naringenin) or its silver nanoparticles could interact with the external envelope proteins of both viruses, and inhibiting extracellular viruses. Conclusions: The results highlight that C. rotundus green synthesized silver nanoparticles could have antiviral activity against infectious laryngotracheitis virus (ILTV) and infectious bronchitis virus (IBV) in chickens.

11.
Journal of Applied Pharmaceutical Science ; 12(7):122-130, 2022.
Article in English | Scopus | ID: covidwho-1954735

ABSTRACT

The global pandemic caused by SARS-CoV-2 requires new lines of treatment to hinder viral entry and pathogenesis. Lucilia cuprina maggots’ excretion/secretion (E/S) contains proteases and antioxidants, among other active ingredients that contribute to its antibacterial, antifungal, and antiviral activity. This study aims to assess the potential effects of E/S on the entry and molecular pathogenesis of a SARS-CoV-2 isolate “NRC-03-nhCoV” in vitro for the first time. E/S was obtained from the collected maggots of L. cuprina that were maintained under controlled laboratory conditions. The E/S was used to treat VERO-E6 cells infected with SARS-CoV-2. The predicted antiviral activity of the E/S and the expression of the Notch pathway and viral pathogenesis-related genes were assessed at three time points. E/S showed potential antiviral activity against SARS-CoV-2 (IC50 = 0.324 µg/ml) with a high selectivity index value (SI = 572.997). Serine protease present in E/S was predicted to interact with transmembrane protease, serine 2 and cathepsin B. E/S was able to significantly downregulate Notch-related genes, SUMO1, and TDG in SARS-CoV-2-infected cells, shifting their expression toward levels of the control. Therefore, E/S of L. cuprina maggots is a potential strong inhibitor for SARS-CoV-2. © 2022. Mohammad R. K. Abdel-Samad et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).

12.
International Journal of Asian Business and Information Management ; 13(2):22, 2022.
Article in English | Web of Science | ID: covidwho-1917926

ABSTRACT

This exploratory study aims to assess and investigate Brunei Darussalam's readiness in developing and applying big data technologies for its public and private sectors, using the social, technological, environmental, and policy (STEP) framework. The results show that the population are digitally literate (social) and utilise smart devices as well as internet network connectivity that is widely offered by the local telecommunications company (technology). The government of Brunei Darussalam established multiple digital transformation initiatives including implementation of 5G connectivity as well as digital economy masterplan to digitally transformed in the near future (environment). Regardless of the absence of national digital data privacy policy (policy) in Brunei, the recent nation's successful big data application in public sector-BruHealth Application-to contain COVID-19 community spread was achieved. The existence of such policy in the near future will create opportunities for the local private sectors to capitalise on big data technologies to their business strategies.

13.
Egyptian Journal of Chemistry ; 65(9):467-476, 2022.
Article in English | Scopus | ID: covidwho-1876354

ABSTRACT

Various strategies, like those using vaccines and antibiotics, have been examined for the prevention and treatment of virus's diseases, but until this moment infection control is not at sufficient level. Exopolysaccharides, especially from probiotics, became one of the most innovative approaches for antiviral agents. This research tried to highlight the effect of a probiotic polysaccharide, such as levan, in COVID-19 prevention. Accordingly, 5 levans types previously obtained from bacterial honey isolates were tested against COVID-19. The most promising result was recorded with levans from Pseudomonas aeruginosa HI1 (levAE) and Bacillus subtilis 9A (lev9A). The lowest cytotoxicity was obtained from lev9A (CC50=5.567e+006 mg/ml) and the most promising IC50 was obtained by levAE (10.75 mg/ml) followed by lev13M (142.5 mg/ml) then lev9A (1299 mg/ml). The dialysis process of levAE greatly affected the virus inhibition activity (IC50 of levAE/D =7.773e+006 mg/ml). Pseudomonas aeruginosa HI1 and Bacillus subtilis 9A were highly tolerant to the acidic (pHs 2, 3) and alkaline conditions (pHs 9, 11). Moreover, when incubated with 0.3 bile salt for 24h, their surviving rates recorded 94% and 100% respectively. H2O2 tolerance showed 77% surviving of Pseudomonas aeruginosa HI1 and 100% surviving of Bacillus subtilis 9A. The blood hemolysis and the antibiotics sensitivity tests confirmed the isolate's safety. The hypothesis that the isolates adhere to the lung cells, could explain the ability of the isolates and their levans to inhibit covid-19 replication. © 2022 National Information and Documentation Center.

14.
International Conference on Decision Aid Sciences and Application (DASA) ; 2021.
Article in English | Web of Science | ID: covidwho-1819808

ABSTRACT

Foreign Direct Investment (FDI) plays an imperative role for the growth of the business sector and contributes to a significant level towards economic growth. It facilitates flow of funds towards poor and developing countries to establish business units, to raise their production capacity and to offer ample employment opportunities to unemployed youth, to raise labor skills by transfer of technology and managerial know-how, thereby FDI tries to assimilate domestic economy with the global economy. But because of COVID-19, there is a massive setback for various countries in attracting FDI, India is not an exception to it. The present study tries to critically analyze the impact of ongoing pandemic on FDI inflows in India. Thus, an attempt has been made in this study to ascertain the impact of COVID-19 on FDI in India and make recommendations to attract more FDI.

15.
Journal of Asian Finance Economics and Business ; 9(4):173-183, 2022.
Article in English | Web of Science | ID: covidwho-1798666

ABSTRACT

The objective of this research is to examine the influence of the COVID-19 pandemic on stock markets in a few developing and developed countries. This study uses daily data from January 2020 to May 2021 and obtained from World Health Organization and Thomson Reuters. The secondary data was evaluated through panel econometric methodology that includes different unit root tests, and to analyze the longrun relationship between variables, panel cointegration techniques were applied. The long-run causality among variables was examined through Panel Vector Error Correction Model. The overall findings of this study suggest a long-run association exists between several cases and death with the stock returns of the GCC and other stock markets. Furthermore, the VECM model also identified a long-run causality running from COVID cases and death towards the stock rerun of both sets of stock markets. However, a subsequent Wald test yielded mixed results, indicating no short-run causality between cases and deaths and stock returns in both groups;however, in the case of GCC, several COVID-19 cases are having a causal impact on stock markets, which is notable in light of the fact that the death rate in GCC is significantly lower than in many developed and developing countries.

16.
Biointerface Research in Applied Chemistry ; 13(1), 2023.
Article in English | Scopus | ID: covidwho-1789940

ABSTRACT

Phytochemical investigations of the methanolic extract of the whole plant of Micromelum minutum provided two coumarins, namely micromelin and murrangatin, and one sterol stigmast-4-en-3-one, the latter being reported for the first time from M. minutum. To evaluate bioactivities, different fractions of the crude methanol extracts of the plant obtained by partitioning were screened for antioxidant and cytotoxic activity by DPPH radical scavenging method and the brine shrimp lethality bioassay, respectively. Among the different fractions of M. minutum tested, pet ether and chloroform soluble fractions showed prominent antioxidant activities with IC50 values of 49.46 and 67.53 μg/mL compared to the standard butylated hydroxytoluene (IC50 31.02 μg/ml). The pet ether and chloroform fractions of M. minutum showed good brine shrimp larvicidal activity with LC50 values of 1.15 and 1.50 μg/ml, respectively, compared to vincristine sulfate (LC50 0.27 μg/ml). The results obtained from molecular docking, Stigmast-4-en-3-one exerts the highest negative binding affinity (-9.1 kcal/mol) for interaction with SARS-CoV-2 M protein and develops a strong network with eleven hydrophobic bonds established by ADMET profile studies and YASARA Dynamics program. © 2022 by the authors.

17.
2021 International Conference on Sustainable Islamic Business and Finance, SIBF 2021 ; : 154-158, 2021.
Article in English | Scopus | ID: covidwho-1741237

ABSTRACT

The Outbreak of Covid-19 pandemic has proved to be destructive at economic, social, and ecological ends across the globe. It has disrupted human life in an extremely adverse way. The pandemic aftermath is yet to be completely realised, yet the scale of economic, social, and ecological damage is unfathomable. The situation has elevated the responsibility on entrepreneurial ground to bring in solutions at the affected fronts and work towards sustainability. It is high time to realize the significance of sustainable entrepreneurship at the time when pandemic consequences are severe and still unfolding which will show in the times to come. Though the disruption caused by the pandemic is huge on everyone and everything, the study reveals that sustainable entrepreneurship has comparatively less effect of adversities of COVID-19 than the normal business. This study presents the need and significance of sustainable entrepreneurship to address the damages caused by COVID-19 pandemic. © 2021 IEEE.

18.
4th Symposium on Intelligent Manufacturing and Mechatronics, SIMM2021 ; 25:523-532, 2022.
Article in English | Scopus | ID: covidwho-1703424

ABSTRACT

The plastic industry is one of the biggest and essential industries, ranging from domestic to engineering products. Nowadays, plastic waste is one of the major issues human-faced worldwide. It is predicted to worsen due to the increment in online purchasing rising from the Covid-19 situations. On the other hand, the construction industry is the largest industry in different economies and the highest consumer of raw materials. Along with the growing demand for concrete aggregates, natural stone materials are overused and eventually deplete resources. Both severe problems can be mitigated by recycling these plastic wastes to serve as an alternative to aggregates in concrete. Despite accumulative efforts, the produced plastic waste aggregates (PWA) is still inferior in strengthening the concrete due to poor interaction between both particles. Therefore, steps to further improving their properties and compatibility with concrete through various approaches are crucial. This review briefly introduces the current situation of concrete industries and global plastic waste accumulation issues. The efforts in the utilization of plastic waste aggregates in concrete alongside their properties are also discussed. Lastly, the water-assisted melt compounding and advantages in the processing of thermoplastic composites are also presented to serve as the platform for a new processing approach to be utilized in PWA production. Therefore, a better insight into the potential of producing PWA with improved physical, mechanical properties corresponds to the enhancing concrete strength via water-assisted melt compounding is offered. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

19.
JPMA - Journal of the Pakistan Medical Association ; 71(Suppl 8)(12):S174-S178, 2021.
Article in English | MEDLINE | ID: covidwho-1668470

ABSTRACT

The clinical course of 26 cases from the time of hospital admission till discharge from Al Yarmouk teaching hospital, Baghdad from June to August 2020 was analysed. The results will reflect on the maternal and perinatal consequences of confirmed cases of Corona Virus Disease during pregnancy. The disease was scored as severe in 11.53% while one case was critical and ended with maternal and foetal death. Five (19.3%) cases delivered vaginally and 15(57.69%) delivered by Caesarean section, three of them were delivered preterm due to disease severity. The mean foetal weight was 2.4 kg, APGAR score at 5 min was 6.8, foetal growth restriction 2(7.69%) cases, intrauterine foetal death 3(11.53%), neonatal care unit admission 5(19.23%) and neonatal death in one of the preterm babies. The study showed significant rates of severe maternal and foetal complications which should be considered when managing such a disorder.

20.
Journal of the Pakistan Medical Association ; 71(12):S174-S178, 2021.
Article in English | Web of Science | ID: covidwho-1619230

ABSTRACT

The clinical course of 26 cases from the time of hospital admission till discharge from Al Yarmouk teaching hospital, Baghdad from June to August 2020 was analysed. The results will reflect on the maternal and perinatal consequences of confirmed cases of Corona Virus Disease during pregnancy. The disease was scored as severe in 11.53% while one case was critical and ended with maternal and foetal death. Five (19.3%) cases delivered vaginally and 15(57.69%) delivered by Caesarean section, three of them were delivered preterm due to disease severity. The mean foetal weight was 2.4 kg, APGAR score at 5 min was 6.8, foetal growth restriction 2(7.69%) cases, intrauterine foetal death 3(11.53%), neonatal care unit admission 5(19.23%) and neonatal death in one of the preterm babies. The study showed significant rates of severe maternal and foetal complications which should be considered when managing such a disorder.

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