Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 13 de 13
Filter
1.
15th International Conference on Information Technology and Applications, ICITA 2021 ; 350:183-194, 2022.
Article in English | Scopus | ID: covidwho-1844321

ABSTRACT

Several COVID19 statistical datasets are provided to support stakeholders for better planning and decision making in healthcare. However, the datasets are in heterogeneous proprietary formats that create data silos and compatibility issues and make data discovery and reuse difficult. Further, the data integration for analysis is difficult and is performed by the domain experts manually which is time consuming and error prone. Therefore, an explicit, flexible, and widely acceptable methodology is needed to represent, store, query, and visualize COVID19 statistical data in the datasets. In this paper, we have presented the design and development of OntoCOVID ontology for representing, organizing, sharing, and reusing COVID19 statistical data in the datasets. The OntoCOVID is a lightweight ontology providing definitions of classes, properties, and axioms to semantically represent and relate information in the COVID19 statistical datasets. The OntoCOVID is evaluated to demonstrate its completeness and information retrieval for different use-case scenarios. The results obtained are promising and advocate for the improved ontological design and applications of the OntoCOVID. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

2.
PubMed; 2021.
Preprint in English | PubMed | ID: ppcovidwho-334641

ABSTRACT

INTRODUCTION: The COVID-19 pandemic has resulted in social isolation and reports of insomnia. However, reports of changes in sleep duration and associated factors are few. METHODS: Data were from an online survey of adults recruited via social media that included a question asking whether the respondent slept less or more after the onset of the pandemic. Analyses determined the association between changes in sleep duration and self reported sociodemographic and occupational information;beliefs about COVID-19;changes in sleep patterns;and responses pertaining to loneliness, anxiety, and depression. RESULTS: There were 5,175 respondents;53.9% had a change in sleep duration. 17.1% slept less and 36.7% slept more. Sleeping more was related to greater education, being single/divorced/separated, unemployed or a student. Being retired, divorced/separated or a homemaker, and living in the Mountain or Central time zones were associated with less sleep. Beliefs that COVID-19 would result in personal adverse consequences was associated with both more and less sleep. However, the strongest associations with both more and less sleep were seen with depression, anxiety, and loneliness with adjusted odds ratios ranging from 1.92 ( 95% CI 1.67-2.21) for sleeping more and loneliness to 5.29 ( 95% CI 4.1-6.7) for sleeping less and anxiety. CONCLUSIONS: Changes in sleep duration since the start of the COVID-19 pandemic were highly prevalent among social media users and were associated with several sociodemographic factors and beliefs that COVID-19 would have adverse personal impacts. However, the strongest associations occurred with worse mental health suggesting that improvements may occur with better sleep.

3.
Journal of Research in Science Teaching ; : 31, 2022.
Article in English | Web of Science | ID: covidwho-1733949

ABSTRACT

Recent calls for reform in K-12 science education and the National Academy of Engineering's Grand Challenges for Engineering in the 21st Century emphasize improving science teaching, students' engagement, and learning. In this study, we designed and implemented a curriculum unit for sixth-grade students (i = 1305). The curriculum unit integrated science and engineering content and practices to teach ecology, water pollution, and engineering design. We investigated the designed integrated STEM unit's effectiveness in students' science learning outcomes on pre-, post-, and delayed post-assessments. We collected pre-and post-assessment data of students' science learning outcomes for both the baseline group (taught via existing district-adopted curriculum) and an intervention group (taught with integrated life science and engineering curriculum). We used a quasi-experimental research design and examined differences between baseline and intervention groups. We used ANCOVA to explore differences in students' learning in baseline and intervention groups. Furthermore, for students in the intervention group, we conducted repeated-measures ANOVA to investigate knowledge retention. Our analyses also accounted for students' gender and People of Color (POC) status. We conducted multiple regression analyses to explore the relationship between students' gender, POC status, and their learning outcomes. The results indicated that the intervention group students performed significantly better than the students in the baseline group. The repeated measures ANOVA showed that students in the intervention group retained science knowledge after 8 weeks of instruction. Finally, the regression analysis for the baseline group showed that gender and POC status were not significant predictors of their post-assessment scores. However, POC status was a significant predictor of post-assessment scores and knowledge retention for the intervention group. Overall, this study provides valuable findings on how an integrated STEM curriculum designed with engineering design and practices improves students' science learning outcomes.

4.
Springer Proceedings in Earth and Environmental Sciences ; : 65-75, 2021.
Article in English | Scopus | ID: covidwho-1718534

ABSTRACT

In present time countries all over the world are facing lockdown to slow down the transmission of COVID 19, an infectious respiratory disease with human to human transmission. The name COVID 19 represents the disease Corona Virus Disease 2019. The outbreak took place in December 2019 in Wuhan, Hubei province, China. Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) is known to be accountable for occurrence of this disease. As per the latest report of World Health Organization, a total of 3,588,773 cases has been reported worldwide. It is believed that the number of total cases will increase in coming days which will force countries worldwide to extend lockdown. Due to this throughout the world are following work from home culture, schools and colleges have been shut down. Malls, shopping complexes, amusement parks, multiplexes and all other places of social gatherings are facing closure;peoples worldwide are not allowed to come out of their homes. On road vehicular movements, flights, cruises are at halt. In this research paper an attempt has been made to compare the air quality index during lock down and prelock down period. © 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.

5.
Value in Health ; 25(1):S187-S188, 2022.
Article in English | EMBASE | ID: covidwho-1650301

ABSTRACT

Objectives: Conditional marketing authorisation (CMA) facilitates early approval for medicines intended for seriously debilitating or life-threatening diseases whose benefit of immediate availability outweighs the risk of less mature clinical data. While CMA has the potential to accelerate patient access, the perceived value at the regulatory level may not translate to value at the health technology assessment (HTA) level. This research explores whether CMA can accelerate time to patient access while maintaining optimal reimbursement outcomes. Methods: HTA outcomes of medicines with CMA from 2018-2020 were analysed, followed by 30-minute, qualitative, in-depth interviews with payer advisors from France and Germany to predict the evolution of HTA frameworks to accommodate future CMA candidates. Results: 22 medicines received CMA from the European Medicines Agency (EMA) from 2018-2020. Despite substantial unmet medical need across indications, CMA translated to poor HTA outcomes. Of 18 available HTAs in France, 8 medicines received a negative reimbursement recommendation of SMR ‘Insufficient’ (in primary indication or subgroup), while the remaining outcomes were split between ‘Important’, ‘Moderate’ and ‘Low’. Most of the reimbursed medicines demonstrated poor quality of evidence, and received ASMR V. Of 13 available HTAs in Germany, only one medicine achieved an added benefit rating, while most demonstrated ‘no’ or ‘non-quantifiable’ added benefit. Payers expect future CMA candidates will face similar reimbursement hurdles if market-specific HTA requirements are not met. Conclusions: While CMA accelerates regulatory approval, limited data packages create huge uncertainty in the appraisal of medicines. This leads to significant risk of unfavourable reimbursement outcomes and delays in patient access. While HTA frameworks continue to evolve over time, they are unlikely to reward immature data submissions particularly as payer bodies face ever-increasing funding constraints likely exacerbated by the COVID-19 pandemic. Manufacturers should ensure their drug development programs meet both regulatory and payer requirements to support accelerated patient access.

6.
JACCP Journal of the American College of Clinical Pharmacy ; 4(12):1729, 2021.
Article in English | EMBASE | ID: covidwho-1615993

ABSTRACT

Service or Program: Throughout COVID-19, complex therapeutics and medication protocols left clinicians overwhelmed by contradicting information leading to drug-related problems (DRPs) potentially leading to ineffective pharmacotherapy and drug-related morbidity and mortality. DRPs queries are time consuming, utilize different resources, and require skills and experience to provide accurate answers3. Quick answers are paramount in the Emergency Department (ED) especially during pandemic period. Clinical pharmacists (CP) can identify and resolve DRPs but are only available from 7AM-3PM in ED. We set up on-call CP service for ED DRPs calls during out-of-office hours.This study aimed to assess the capacity of the service to capture 100% of calls received and to measure the time taken to resolve DRP queries compared to international standard. Justification/Documentation: A dedicated ED CP on-call phone line until 10pm daily was arranged by Hamad General Hospital Pharmacy (Qatar).Data was documented on a logbook/Electronic Medical Records (EMR) and analysed using predefined parameters. Adaptability: Between March-September 2020, 133 DRPs calls were received and resolved by CP. 38% of these were related to drug interaction/safety, adverse drug reactions, dose-adjustments, drug-allergies, and drug in pregnancy.30% were related to medication administration, such as infusion rates, titration, and IV compatibility. Those questions were mostly received from nurses(Figure 1).Appropriate dose selection and appropriate indication represented 21% and 11% respectively (Figure 2). Caller's acceptance rate to responses provided by CP were 100%. Responses were documented in patients' EMR. The call duration extracted from phone-log showed an average time of 4.66 minutes/call which is below average standard of 15-30 minutes. Significance: Availability of clinical pharmacists to provide quick, acceptable responses to DRPs queries, is crucial given the complexity and diversity of ED patients. During COVID-19, on-call clinical pharmacy service has proven its capability to resolve DRPs and support clinical decision-making process in a relatively shorter time.

7.
United European Gastroenterology Journal ; 9(SUPPL 8):317-318, 2021.
Article in English | EMBASE | ID: covidwho-1490991

ABSTRACT

Introduction: UBT is the most accurate non-invasive test for H.pylori infection. The orally given urea, labelled with C13, is hydrolysed by the enzyme urease of H.pylori and C13O2 is measured expired in breath. UBT was our gold standard diagnostic test for H.pylori. This practice changed abruptly in March 2020, when our first wave of coronavirus -2 (SARS-CoV-2) started. UBT carries the risk of contamination by SARS-CoV-2 in the aerosol droplets generated by exhaled air. The British Society of Gastroenterology guideline at that time graded UBT as Aerosol Generating Procedure and therefore at high risk for transmission. Only emergency gastroenterology high risk procedures were recommended during restrictions which effectively terminated our standard UBT service. To maintain a non-invasive diagnostic option we developed a novel virtual test. C13 UBT At Home, is performed by patients at home with step by step instructions involving live video conference interaction between the patients and technicians. Aims & Methods: To determine the acceptability and the accuracy of the novel C13 UBT At Home service. Patients on a UBT waiting list were contacted and invited to undergo the alternative virtual breath test. Willing participants were pre assessed over phone to explain the process. Technical aspects (internet, smart phone or laptop requirements), navigation through the video call system attendanywhere and routine clinical parameters including PPI and antibiotic use were discussed. Suitable patients collected a Home UBT kit (Patient information sheet, test documentation, pre and post collection tubes, collection straw, urea tablet and feedback questionnaire) from a drop off point up to a week prior to their scheduled appointment. The test was performed as standard by the patient at home with live interaction for all active steps. The 20 minute rest between samples 1 and 2 collection was offline which allowed technicians to do concurrent cases. Patients were requested to fill in a feedback questionnaire after the test and to return it with the samples to the drop off point within 48 hours for analysis. The questionnaire included 6 questions covering pre procedure, procedure and post procedure domains. In addition to patient satisfaction, positivity rate, sample error rate and activity numbers were compared between UBT at home and a standard UBT cohort which was reinstated in 2021. Results: 300 patients were enrolled, mean age 41 years (range 7-85), 177 female (59%). Overall response rate was 96% (288), 96% (285) rated the entire UBT at home process as either excellent or good. All other parameters except connection to the hospital video call system, which was subject to external factors were also rated excellent/good by >90%. Accuracy between UBT tests was similar: positivity rate 23% (69/299) versus 22% (74/326), sample error rate 0.33% (1/300) versus 0.6% (2/326) for the UBT at home and standard tests respectively. Currently 3 of every 4 UBT's is now virtual despite reduced restrictions. Conclusion: UBT at home is possible and acceptable to patients with equivalent accuracy to standard UBT and should be continued to improve patient choice and satisfaction.

8.
Journal of Gastroenterology and Hepatology ; 36(SUPPL 3):168, 2021.
Article in English | EMBASE | ID: covidwho-1467577

ABSTRACT

Background and Aim: Post-marketing studies comparing low-volume polyethylene glycol (PEG)-based regimens are limited. The aim of this randomized controlled non-inferiority study was to compare the efficacy and tolerability of two commercially available low-volume PEG-based preparations: PLENVU (Norgine) macrogol 3350, sodium ascorbate, sodium sulfate, ascorbic acid, sodium chloride and potassium chloride and Prepkit-C (Fresenius Kabi) macrogol 3350, sodium chloride, potassium chloride and sodium sulfate, sodium picosulfate, magnesium oxide, citric acid and aspartame in an unselected adult colonoscopy outpatient population. Methods: Patients undergoing outpatient colonoscopy were randomized to receive either split-dose Prepkit-C or PLENVU. Patient compliance, satisfaction, and tolerability were captured using a standardized questionnaire on the day of the procedure. A blinded endoscopist assessed the quality of bowel preparation using the Boston Bowel Preparation Scale (BBPS) and Aronchick Scale during the colonoscopy. The procedure times, rates of cecal intubation, and polyp detection rates were also recorded. Results: The study was terminated at 19 months, as recruitment was halted due to the coronavirus disease 2019 pandemic, and an unplanned interim analysis was performed. A total of 164 patients were randomly assigned to either Prepkit-C (n = 82) or PLENVU (n = 82). In the PLENVU group, 89% of patients achieved satisfactory preparation (total BPPS score ≥6 and each subscore ≥2), compared with 85.4% in the Prepkit-C group, resulting in an estimated difference of 3.7% (95% CI, -6.6% to 13.9%;P = 0.48). The median BBPS score with PLENVU was significantly better in the right, middle, and left colonic subsegments with PLENVU (BBPS score, 3;IQR, 2-3) than with Prepkit-C (BBPS score, 2;IQR, 2-3) (P < 0.001). A significantly higher proportion of patients in the PLENVU group had a BBPS score of ≥7, compared with patients in the Prepkit-C group (80% vs 57%;P = 0.002). A significantly greater proportion of patients had good-excellent quality of bowel preparation in the PLENVU group compared with the Prepkit-C group (84% vs 57%;P < 0.001) (Fig. 1). More patients in the PLENVU group reported moderate to severe nausea compared with those in the Prepkit-C group (P = 0.028);however, there were no other differences in patient satisfaction or tolerability between the two groups. Conclusion: The quality of bowel preparation achieved with PLENVU is at least non-inferior to that with Prepkit-C in a real-world unselected group of colonoscopy outpatients, with equivalent tolerability outcomes. This is despite a lower volume of preparation (by 500 mL) that is required to be ingested with PLENVU. Further studies are required in patients at risk of suboptimal bowel preparation.

9.
Annals of the Rheumatic Diseases ; 80(SUPPL 1):1313-1314, 2021.
Article in English | EMBASE | ID: covidwho-1358787

ABSTRACT

Background: Real-world evidence on achieving treatment targets with apremilast (APR) in patients (pts) with PsA is limited. In the phase 3 PALACE trials, pts reached remission (REM)/low disease activity (LDA) targets at 52 wks most frequently when early APR treatment was initiated and pts were in moderate disease activity, as measured by Clinical Disease Activity Index for PsA (cDAPSA) score. In APPRAISE, we assessed APR effectiveness/tolerability in pts with PsA in routine clinical practice in Canada. Objectives: This interim efficacy analysis focused on the available data on APR effectiveness measuring rate of achieving cDAPSA REM or LDA at 12 mos and Pt Acceptable Symptom Status (PASS) results. Methods: The prospective, multicenter, observational APPRAISE study assessed APR effectiveness/tolerability in adults with active PsA in routine clinical care enrolled from July 2018-March 2020. Pts were followed from treatment initiation to 12 mos, with visits suggested every 4 mos. The primary effectiveness endpoint was the rate of achieving at least LDA (cDAPSA <14) at 12 mos. Pt-reported outcome measures were assessed. Data reported are as observed in pts continuing APR treatment. Results: In total, 101 pts were enrolled in APPRAISE. Mean age was 52 yrs;56% were women. Mean (SD) PsA duration at baseline (BL) was 6 (8) yrs. Oligoarticular disease (≤4 joint involvement) was most common (41%), followed by polyarticular (35%). Most pts (92%) received prior conventional DMARDs and 17% received prior biologic therapy;concomitant MTX was reported in 41% at BL. By 12 mos, 41/101 enrolled pts discontinued, 35 reached 12 mos follow-up (4 mos: n=92;8 mos: n=61), and 25 have yet to reach 12 mos. The majority (92%) of discontinuations due to lack/loss of effectiveness or AEs occurred within 4-8 mos. AEs were primarily GI related early in treatment. The proportion of pts with continued APR achieving cDAPSA REM/LDA treatment targets increased significantly over time (Figure 1). Significant reductions were seen over 12 mos in swollen/tender joint counts and plaque psoriasis, with reduced mean (SD) body surface area of -4% (9%) (Table 1). Prevalence of dactylitis/enthesitis at BL, 4, 8, and 12 mos was 17%/33%, 9%/24%, 5%/19%, and 0%/21%, respectively. Pain assessment (VAS) significantly improved over time. The proportion of pts achieving PASS with continued APR increased significantly over 12 mos (BL: 27%;12 mos: 65%) (Figure 1). COVID restrictions impacted in-office assessment visits, necessitating reliance on virtual visits. Conclusion: Pts with PsA receiving APR were assessed at regular intervals in routine clinical care in Canada. This interim analysis revealed a greater number of pts receiving APR (66%) who completed the 12-mo follow-up achieved REM or LDA, as measured by cDAPSA over 12 mos. A majority of pts (65%) reported satisfaction with their disease state, as measured by PASS. No new safety signals were observed.

10.
Bioscience Research ; 18(1):788-794, 2021.
Article in English | Web of Science | ID: covidwho-1250342

ABSTRACT

Indoor air environments contain a complex mixture of bioaerosols containing bacteria, protozoans, viruses possibly including SARS CoV-2 causing COVID-19, and their by-products as well such as endotoxins, mycotoxins, and volatile microbial organic compounds. Bioaerosols are forms of air particles, present mostly in the indoor air that humans inhale. Therefore, the indoor environment is crucial components causing various health-related problems. Almost 40% of individuals spent their quality time at home and the remaining 60 to 70% of individuals spent their day in the workplace. There is a lack of awareness about bioaerosols of the indoor environment and their contribution towards the spread of various infections. This review presents the trend of various elements of bioaerosols in indoor air and their association with pulmonary and other diseases due to indoor air pollution. Recently, the pandemic outbreak of COVID-19 has alerted us about the importance of bioaerosol research. Hence, the characterizations of bioaerosols including seasonal variation are necessary for its associated risk factor, prevention, and impact on human health.

11.
IEEE Transactions on Computational Social Systems ; 2021.
Article in English | Scopus | ID: covidwho-1132801

ABSTRACT

In December 2019, a pandemic named COVID-19 broke out in Wuhan, China, and in a few weeks, it spread to more than 200 countries worldwide. Every country infected with the disease started taking necessary measures to stop the spread and provide the best possible medical facilities to infected patients and take precautionary measures to control the spread. As the infection spread was exponential, there arose a need to model infection spread patterns to estimate the patient volume computationally. Such patients' estimation is the key to the necessary actions that local governments may take to counter the spread, control hospital load, and resource allocations. This article has used long short-term memory (LSTM) to predict the volume of COVID-19 patients in Pakistan. LSTM is a particular type of recurrent neural network (RNN) used for classification, prediction, and regression tasks. We have trained the RNN model on Covid-19 data (March 2020 to May 2020) of Pakistan and predict the Covid-19 Percentage of Positive Patients for June 2020. Finally, we have calculated the mean absolute percentage error (MAPE) to find the model's prediction effectiveness on different LSTM units, batch size, and epochs. Predicted patients are also compared with a prediction model for the same duration, and results revealed that the predicted patients' count of the proposed model is much closer to the actual patient count. IEEE

12.
2nd International Conference of Interdisciplinary Research on Green Environmental Approach for Sustainable Development, ICROEST 2020 ; 575, 2020.
Article in English | Scopus | ID: covidwho-947640

ABSTRACT

Hand soap is one of the products made from reu gongga bulbs, which is widely manufactured by the community. Hand soap, which is generally made from fat, has a high selling price caused by the price of fat, which is relatively expensive. These factors become the reason for the authors to propose alternative manufacture of hand soap at a fairly affordable price by using reu gongga bulbs as a raw material for making the hand soap. Processing reu gongga bulbs as raw material for hand soap can minimize the cost of raw materials, which will certainly affect the selling price of the hand soap and can create new ways of utilizing reu gongga bulbs, which are generally only used as cattle fodder. The aim and target of the results of the community service program activities are as an effort to help the community to maximize the production of processed hand soap based on reu gongga bulbs which can be used as an alternative effort in increasing community income. Hand soap made from reu gongga bulbs has a relatively low price compared to other hand soap without reducing the quality of the hand soap itself. Thus, it is expected to increase the productivity and income of the community. The development of increasingly sophisticated technology makes almost all manufacturers offer products in the online market. Thus, the authors are interested in participating in marketing products online. Online marketing, which is an alternative in the process of selling hand soap products, is social media in the form of Instagram, WhatsApp, Facebook, etc. © Published under licence by IOP Publishing Ltd.

13.
Asian Pacific Journal of Tropical Medicine ; 13(9):402-408, 2020.
Article in English | CAB Abstracts | ID: covidwho-826575

ABSTRACT

Objective: To assess healthcare workers' knowledge of novel coronavirus disease 2019 (COVID-19) in the early phase of the outbreak in Indonesia.

SELECTION OF CITATIONS
SEARCH DETAIL