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Ann Neurol ; 89(5): 1041-1045, 2021 05.
Article in English | MEDLINE | ID: covidwho-1100843


Patients with coronavirus disease 2019 (COVID-19) can present with distinct neurological manifestations. This study shows that inflammatory neurological diseases were associated with increased levels of interleukin (IL)-2, IL-4, IL-6, IL-10, IL-12, chemokine (C-X-C motif) ligand 8 (CXCL8), and CXCL10 in the cerebrospinal fluid. Conversely, encephalopathy was associated with high serum levels of IL-6, CXCL8, and active tumor growth factor ß1. Inflammatory syndromes of the central nervous system in COVID-19 can appear early, as a parainfectious process without significant systemic involvement, or without direct evidence of severe acute respiratory syndrome coronavirus 2 neuroinvasion. At the same time, encephalopathy is mainly influenced by peripheral events, including inflammatory cytokines. ANN NEUROL 2021;89:1041-1045.

COVID-19/blood , COVID-19/cerebrospinal fluid , Inflammation Mediators/blood , Inflammation Mediators/cerebrospinal fluid , Nervous System Diseases/blood , Nervous System Diseases/cerebrospinal fluid , Biomarkers/blood , Biomarkers/cerebrospinal fluid , COVID-19/epidemiology , Cytokines/blood , Cytokines/cerebrospinal fluid , Humans , Nervous System Diseases/epidemiology
Am J Trop Med Hyg ; 103(3): 993-998, 2020 Sep.
Article in English | MEDLINE | ID: covidwho-657436


The COVID-19 pandemic has proved to be an enormous challenge to the health of the world population with tremendous consequences for the world economy. New knowledge about COVID-19 is being acquired continuously. Although the main manifestation of COVID-19 is SARS, dysfunction in other organs has been described in the last months. Neurological aspects of COVID-19 are still an underreported subject. However, a plethora of previous studies has shown that human CoVs might be neurotropic, neuroinvasive, and neurovirulent, highlighting the importance of this knowledge by physicians. Besides, several neurological manifestations had been described as complications of two other previous outbreaks of CoV diseases (SARS ad Middle East respiratory syndrome). Therefore, we should be watchful, searching for early evidence of neurological insults and promoting clinical protocols to investigate them. Our objectives are to review the potential neuropathogenesis of this new CoV and the neurological profile of COVID-19 patients described so far.

Betacoronavirus , Coronavirus Infections/complications , Nervous System Diseases/etiology , Pneumonia, Viral/complications , COVID-19 , Humans , Pandemics , SARS-CoV-2