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Pathog Glob Health ; : 1-9, 2022 Nov 29.
Article in English | MEDLINE | ID: covidwho-2134535


The suppressor of the cytokine signaling-1 (SOCS1) gene is a short sequence located on chromosome 16 that functions to induce an appropriate immune response and is an essential physiological regulator of interferon (IFN) signaling. In addition to comparing the global DNA and SOCS1 gene promoter methylation status between our patients with coronavirus disease 2019 (COVID-19) and healthy controls, this study demonstrates the effect of the SOCS1 rs33989964 polymorphism on patients with COVID-19. The study group included 139 patients diagnosed with COVID-19 in our hospital's clinics between June and December 2020, and the control group included 78 healthy individuals. After comparing the initial gene polymorphisms of the patients with the healthy control group, three separate clinical subgroups were formed. The gene polymorphism distribution and the methylation status of SOCS1 were examined in these clinical subgroups. Hypomethylation of the SOCS1 gene was observed in the COVID-19 patient group compared to the healthy control group (p = 0.001). Between the patients divided into two separate clinical subgroups, those with severe and mild infections, the Del/Del genotype of the SOCS1 gene was more common in patients with severe infection than in patients with mild infection (p = 0.018). Patients with the CA/CA and CA/Del genotypes were 0.201 times more likely to have a severe infection (95% CI: 0.057-0.716, p = 0.007). Having a non-Del/Del genotype was a protective factor against severe infection. The effect of the SOCS1 rs33989964 polymorphism and methylation status of the SOCS1 gene throughout the COVID-19 pandemic could be significant contributions to the literature.

Exp Gerontol ; 167: 111907, 2022 10 01.
Article in English | MEDLINE | ID: covidwho-2031280


BACKGROUND: While there are substantial reports on the acute phase of Covid-19, the data on post-Covid phase are limited. AIM: To report the data on older post-Covid patients comparatively with the young adults. STUDY DESIGN: Retrospective, single-center study in post-Covid outpatient clinic. Clinical characteristics, laboratory examination, chest imagings were examined. RESULTS: 665 patients were included (median age, 46; 53 %, male; 10.5 %, aged ≥65). We assessed patients at 47th day (median) after recovery. 43.6 % were suffering from one or more ongoing symptomatology. The prevalence of symptoms or physical examination findings were not different between older and younger groups. Most prevalent ongoing symptom was dyspnea (14.3 % and 11.8 % older and younger group, respectively). Most common laboratory abnormality was high pro-BNP (12.2 %, in both age groups). Despite there was no differences regarding imaging findings at acute-phase, there were higher rates of control imaging abnormalities in older subgroup (35.7 % vs 19.4 %; p = 0.006). On admission 28.4 % younger patients had normal imaging, of whom 12.4 % developed some form of sequela; however, in older group, 40.0 % had normal imaging, of whom 25.0 % developed sequela. CONCLUSION: Complaints related to Covid-19 persisted in about half of the patients at about 1.5 months after Covid. More than 1/3 older post-Covid patients displayed pulmonary sequela in the post-acute period which was more prevalent than those in younger adults. Hence, compared to the younger counterparts, the clinicians should be alert in follow-up of older adults for subsequent pulmonary sequela, even among those that had normal imaging finding on initial presentation.

COVID-19 , Aged , Female , Humans , Lung/diagnostic imaging , Male , Retrospective Studies , SARS-CoV-2
Article in English | Academic Search Complete | ID: covidwho-1663005


Objective: In this study, we aimed to analyze the demographic characteristics, symptoms, and comorbidities of 504 patients hospitalized for COVID-19. We also sought to describe the relationship between these features and intensive care unit (ICU) admission and mortality. Materials and Methods: This study is a descriptive study involving 504 COVID-19 patients hospitalized between 16.03.2020 and 07.05.2020 at Istanbul Universitys’ Istanbul Faculty of Medicine Hospital. Information about the patients was obtained from the hospital automation system and evaluated retrospectively. Results: The average age of the 504 patients was 56±15.14, and 59.1% of them were male. The proportion of the patients admitted into ICU 11.9% and for 8.52% of them the disease resulted in death. Real time polymerase chain reaction (RT-PCR) test results were positive for 60.5% of the patients. The median time spent in the hospital was eight days. Fifty six percent of the patients had at least one accompanying comorbid disease, with hypertension (39.3%) and diabetes (20.8%) being the most common. Being 65 years old or older (p<0.001), days spent in the hospital (p<0.001), presence of at least one comorbidity (p=0.009), hypertension (p=0.003), coronary artery disease (p=0.004), congestive heart failure (p=0.005) and dyspnea (p<0.001) were all factors found in those admitted to ICU. Conclusion: COVID-19 infection leading to high morbidity-mortality rates and an increased requirement for ICU admission is mainly seen among older patients and those who have dyspnea. During the process of analyzing patients suspected of COVID-19 who are admitted to hospital, it is crucial to consider both the patient’s age and any respiratory symptoms. Such a clinical evaluation is crucial for a better understanding of the course of the disease. (English) [ FROM AUTHOR] Amaç: Bu araştırmada, COVID-19 nedeniyle tedavi almak üzere hastaneye yatırılan 504 hastanın demografik özellikleri, semptomları ve komorbiditeleri incelenerek;bu özelliklerin yoğun bakım ünitesine yatış ve mortalite ile ilişkisini ortaya koymak amaçlanmıştır. Gereç ve Yöntem: Bu araştırma, 16.03.2020-07.05.2020 tarihleri arasında COVID-19 tedavisi almak üzere Ístanbul Üniversitesi Ístanbul Tıp Fakültesi Hastanesi’ne yatırılan 504 hastanın dahil edildiği tanımlayıcı tipte bir araştırmadır. Hastalara ait bilgiler hastane otomasyon sisteminden alınarak retrospektif olarak değerlendirilmiştir. Bulgular: Beşyüz dört hastanın yaş ortalaması 56±15,14 yıl, hastaların %59,1’i erkekti. Yoğun bakım ünitesine yatışı olan hastaların oranı %11,9;ölen hastaların oranı %8,52 idi. Hastaların %60,5’inin test sonucu pozitifti. Hastanede kalınan sürenin ortancası sekiz gündü. Hastaların %56’sının en az bir komorbid hastalığı vardı;hipertansiyon (%39,3) ve diyabet (%20,8) en sık eşlik eden komorbiditelerdi. Altmış beş yaş ve üzeri olmak (p<0,001), hastanede kalınan gün sayısı (p<0,001), en az bir komorbidite varlığı (p=0,009), hipertansiyon (p=0,003), koroner arter hastalığı (p=0,004), konjestif kalp yetmezliği (p=0,005) ve dispne (p<0,001), yoğun bakıma yatış ile ilişkili bulunmuştur. Sonuç: Yüksek morbidite-mortalite oranlarına ve yoğun bakım ünitesine yatış ihtiyacının artmasına neden COVID-19, özellikle yaşlı hastalarda ve dispnesi olan hastalarda daha yüksek mortalite oranlarına neden olmaktadır. Hastaneye başvuran COVID-19 şüpheli hastalar değerlendirilirken özellikle hastanın yaşı ve solunum sistemi semptomları göz önünde bulundurularak klinik değerlendirilmesinin yapılması hastalığın seyri açısından önem taşımaktadır. (Turkish) [ FROM AUTHOR] Copyright of Istanbul Tip Fakültesi Dergisi is the property of Istanbul Tip Fakultesi Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)