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1.
Infection Control & Hospital Epidemiology ; : 1-12, 2022.
Article in English | MEDLINE | ID: covidwho-2016431

ABSTRACT

During the pandemic, the rate of healthcare facility-onset MRSA bacteremia was five times greater in patients admitted with COVID-19. Presence of central lines and mechanical ventilation are likely contributing factors for this increased rate. The number of central line-associated bacteremias may be underestimated in patients with COVID-19.

2.
Journal of Heart and Lung Transplantation ; 41(4):S278-S278, 2022.
Article in English | Web of Science | ID: covidwho-1849287
3.
Journal of Heart and Lung Transplantation ; 41(4):S392-S392, 2022.
Article in English | Web of Science | ID: covidwho-1848805
4.
Journal of Heart and Lung Transplantation ; 41(4):S324-S325, 2022.
Article in English | Web of Science | ID: covidwho-1848352
5.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation ; 41(4):S278-S278, 2022.
Article in English | EuropePMC | ID: covidwho-1782213

ABSTRACT

Purpose The goal of this study was to assess the frequency and common symptoms of post-acute COVID-19 syndrome (Long COVID-19) in heart transplant recipients (HTR). Methods After obtaining IRB approval, we conducted telephone surveys of HTR (n=30) who had tested positive for SARS-CoV-2 to evaluate their experience with acute COVID-19 illness and assess symptoms of Long COVID-19. Symptoms at onset and also beyond 6, 12, and 24 weeks of the initial diagnosis were recorded. Additionally, medical charts were reviewed for detailed information regarding transplant history, immunosuppression, COVID-19 management and hospitalization, and COVID-19 vaccination status. Results As noted in Table 1, among the 30 participants, 10 (33%) had symptoms consistent with Long COVID-19. Those with Long COVID-19 were more symptomatic during acute illness, with 40% of patients reporting cough, fevers or chills, and headaches, compared with 15%, 25%, and 20% respectively in those without Long COVID-19. Emergency department visits at initial illness (80% vs. 20%) and admission to the intensive care unit were more frequent (60% vs. 5%) in the Long COVID-19. Symptoms of Long COVID-19 lasted for a median of 9 weeks with 30% reporting ongoing symptoms at week 24. The most common persistent symptoms were depression, confusion, and difficulty concentrating. Conclusion This study is an early investigation of a complex syndrome of Long COVID-19 in transplant patients. Long COVID-19 is not well described in the transplant setting. HTR at our center with Long COVID-19 were sicker at their initial COVID-19 diagnosis and had more emergency room visits, hospital admissions, and longer hospital stays than those without subsequent Long COVID-19. Although, recall bias could affect participants’ ability to remember details and symptoms, this would have impacted both groups similarly as the time since COVID-19 diagnosis to study enrollment was similar between the two groups. These are preliminary findings and the study is currently ongoing.

6.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation ; 41(4):S399-S399, 2022.
Article in English | EuropePMC | ID: covidwho-1781950

ABSTRACT

Introduction Solid organ transplant recipients (SOTR) have lower SARS-CoV-2 spike seroconversion than healthy subjects (HS) following vaccination. A breakthrough (BT) infection is defined as the detection of SARS-CoV-2 in a respiratory specimen after a person is ≥14 days after completing the recommended doses for a vaccine. We report a case of SARS-CoV-2 BT infection in a SOTR who was immunologically followed longitudinally following vaccination. Case Report A 44-year-old man with a history of non-ischemic cardiomyopathy (NICM) and end stage renal disease had undergone heart and kidney transplantation in December 2017 with thymoglobulin induction. His NICM was secondary to radiation for non-Hodgkin's lymphoma treated with autologous bone marrow transplant in 2001. Maintenance immunosuppression consisted of sirolimus 2mg daily, tacrolimus 2mg twice daily (BID), and prednisone 5mg daily at his 1st Moderna vaccine in April 2021. In anticipation of surgery, sirolimus was stopped and mycophenolate mofetil (MMF) 500mg BID was started. He was on this regimen at the time of his 2nd Moderna vaccine. Sirolimus was restarted in July and increased to 1mg daily while continuing MMF 500mg BID, tacrolimus, and prednisone. At the end of July, the patient was exposed to several family members with COVID-19. He tested positive 89 days after his 2nd Moderna vaccine (cycle threshold of 33.5). He was asymptomatic at the time, but later developed fever, myalgias, headache, and loss of taste and smell and was treated with casirivimab and imdevimab monoclonal antibody (mAb) infusion. We assessed the patient's immunologic response 14 days post 2nd Moderna vaccination and at BT infection prior to mAb infusion and compared this to HS. The patient developed SARS-CoV-2 spike-specific CD4+ T cells at 14 days post 2nd mRNA vaccine at a frequency below the average frequency for HS. At BT infection, the patient did not have SARS-CoV-2 spike-specific CD4+ T cells, partly due to virus induced lymphopenia. The patient did not develop spike-specific CD8+ T cells, spike IgG or neutralizing antibodies at 14 days post 2nd Moderna vaccination or at BT infection. Summary The patient developed SARS-CoV-2-specific CD4+ T cells following vaccination. His uneventful recovery may be secondary to these SARS-CoV-2 specific CD4+ T cells post vaccination as well as receiving mAb therapy 8 days post infection.

7.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation ; 41(4):S324-S325, 2022.
Article in English | EuropePMC | ID: covidwho-1781797

ABSTRACT

Purpose Management of COVID-19 has evolved over the course of the pandemic, with new therapies contributing to a decline in mortality in the general population. Immunosuppressed heart transplant (HT) recipients are at high risk of infection, but questions remain regarding their optimal management as these patients were excluded from many clinical trials on COVID-19 therapeutics and vaccines. Methods Retrospective search of electronic health records identified 41 HT recipients who tested positive for SARS-CoV-2 from February 1, 2020-October 13, 2021. Results Among the 41 HT recipients infected with SARS-CoV-2, 15 (36%) were monitored as outpatient, and of these, 4 received casirivimab/imdevimab and 1 received oral steroid. No COVID-19 related deaths were observed in this group. The remaining 26 patients (64%) were admitted for pneumonia or hypoxia. Five required admission to the intensive care unit (ICU), of which 3 required intubation and pressor support and 2 died (7.7% in-hospital mortality, 4.9% overall mortality). Of those admitted, 15 were treated with remdesivir and 7 received steroids. After vaccines were available in January 2021, 10 patients developed breakthrough COVID-19 occurring 2 weeks after the second Pfizer dose (n=6) and second Moderna dose (n=4). 8 of these patients were admitted for pneumonia or hypoxia and treated with COVID-19 directed therapies (4 received remdesivir, 2 received dexamethasone, 3 received casirivimab/imdevimab). 2 patients were monitored as outpatient where they received casirivimab/imdevimab. There was no severe illness or deaths observed in vaccinated patients. Conclusion We present 41 HT recipients at UCSD infected with COVID-19. By using outpatient isolation, monoclonal antibody infusions, and admission for treatment of hypoxic patients with remdesivir and steroid, we have demonstrated a lower mortality from COVID-19 compared to other studies on HT recipients. No mortality was observed in the breakthrough cases.

8.
Journal of Heart & Lung Transplantation ; 41(4):S392-S392, 2022.
Article in English | Academic Search Complete | ID: covidwho-1783391

ABSTRACT

The characteristics and outcomes, including acute cellular rejection (ACR), of lung transplant recipients (LTR) post COVID-19 infection are incompletely studied. We sought to show whether or not COVID-19 infection in LTR is associated with ACR. This single center, retrospective study of LTR examined data among those who contracted COVID-19 between June 2020 and May 2021. Patient demographics, immunosuppression regimen, and hospital course related to COVID-19 infection were recorded. Subsequent spirometry, imaging, and biopsy results were documented. We identified 16 LTR who tested positive for COVID by PCR testing. Acute radiographic changes were detected in half (8) of the cohort, 3 patients eventually required ICU admission, 1 which required venovenous extracorporeal membrane oxygenation. The median drop in FEV1 and FVC after COVID-19 infection was -375 (-1140 to +120) and -260mL (-1790 to +410), respectively. ACR was diagnosed in 2 patients at 6 weeks post COVID-19 infection. Both of the patients who were diagnosed with ACR required hospitalization, and one required ICU admission. There was 1 death at >6 months after infection due to progressive chronic lung allograft dysfunction and renal failure. This analysis characterizes short and intermediate term outcomes of LTR after COVID-19 infection. Specifically, the association between such infection and both rates of ACR and allograft function is uniquely described. ACR was observed in 12.5% of patients 6 weeks post COVID-19 infection. There was a notable reduction in lung function, which was mostly accounted for by the 3 patients in our cohort who required ICU admission. This study has several limitations. The sample size is small and involves a single center. It is also retrospective in nature, and there were a large number of asymptomatic patients included. Further analyses, to further assess the incidence of ACR in LTR are warranted to determine the associated factors and optimize management in this at risk patient population. [ FROM AUTHOR] Copyright of Journal of Heart & Lung Transplantation is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

9.
Pakistan Armed Forces Medical Journal ; 71:S432-S436, 2021.
Article in English | Scopus | ID: covidwho-1732701

ABSTRACT

Objective: To comparison was made between standard (control group) nasopharyngeal sample collection technique for RT-PCR and modified technique and the outcome was compared in terms of the proportion of positive results of Rt-PCR tests. Study Design: Double blinded randomized clinical trial. Place and Duration of Study: Pakistan Naval Ship Shifa Hospital Karachi Pakistan, from June and July 2020. Methodology: This study was a newly developed modified technique for nasopharyngeal sampling for RT-PCR tests of COVID-19 suspects. Target population included all patients who developed COVID-19 related symptoms and/or also had history of recent travel or closed contact with Covid-19 patients. Total 1500 nasopharyngeal PCR tests were done by a team of trained technicians. Systemetic probability sampling technique was utilized. Subjects were divided into two groups by using even and odd serial numbers. Proportion of positive test results were compared between two groups by using chi square test. Results: Results were collected for 3000 nasopharyngeal swab sample for RT-PCR testing. Mean age was 31.68 ± 11.89 years. In study group with modified technique, 470 tests were found positive for a total of 1500 samples while only 297 out of 1500 samples were detected positive in control group with standard technique. Chi square test applied to assess the difference between this proportion and it proved that the difference was highly statistically significant (p-value <0.00). Conclusion: we interpret that modified samples collection technique is relatively safe for sample collector of Covid-19 PCR which has got potential benefits to get more genuine results of these samples. © 2021, Army Medical College. All rights reserved.

10.
Journal of Food Quality and Hazards Control ; 8(3):92-93, 2021.
Article in English | Scopus | ID: covidwho-1529058
11.
2021 IEEE International Conference on Educational Technology, ICET 2021 ; : 203-207, 2021.
Article in English | Scopus | ID: covidwho-1501297

ABSTRACT

The Covid-19 Pandemic forced the global closure of numerous activities along with education and shifted traditional education to an online version via two e-learning platforms, i.e., synchronous and asynchronous. This transition was unplanned for all educational institutions, due to which teachers and students had to face several teaching/learning challenges. Thereby a quantitative study was designed to investigate the learning satisfaction of students in both synchronous and asynchronous learning environments from public universities of Karachi, Pakistan. The participants of the study were selected through simple random sampling, and 108 students from different universities filled the complete questionnaires. The data were analyzed through various statistical tests, i.e., (mean, standard deviation and Pearson correlation, and T-test. The Findings identified that students showed significantly higher satisfaction in the synchronous learning environment. Thereby, the study mainly suggests that the learning process should be facilitated by synchronous e-learning mode by providing adequate institutional support to optimize their learning satisfaction by raising their digital competence. Besides, teachers should employ activity-based teaching Strategies for keeping students involved in the learning process. © 2021 IEEE.

12.
American Journal of Transplantation ; 21(SUPPL 4):617, 2021.
Article in English | EMBASE | ID: covidwho-1494539

ABSTRACT

Purpose: The optimal testing strategy for solid organ transplantation (SOT) donor and recipient evaluation, as well as treatment for COVID-19 is unknown. We assessed the management strategy of COVID-19 within the West Coast Transplant Infectious Disease group. Methods: A survey assessing strategies for COVID-19 management was sent to 11 Transplant Infectious Diseases providers from 8 centers. Results: For both living and deceased donor clearance, 81.8% (n=9) providers utilize one negative PCR within 72 hours of transplantation. However, when a living donor tests positive for SARS-COV-2, 36.4% (n=4) will require two negative PCR tests >24 hours apart for donor clearance, with 90.9% (n=10) requiring at least a 28-day wait period prior to retesting. Amongst providers caring for lung transplant recipients, 77.7% (7/9) utilized negative PCR from donor BAL as part of pre-transplant evaluation. For transplant candidates, all providers required both the absence of COVID-19 symptoms with only one negative PCR test. In candidates that tested positive for SARS-COV-2, 54.5% (n=6) required at least two negative PCRs prior to transplantation. For positive candidates, 63.6% (n=7) considered re-testing for PCR negativity at 20 days. When a transplant recipient tested positive for SARSCoV-2, all providers would reduce antimetabolites and utilized dexamethasone for patients requiring oxygen therapy. Remdesivir was prescribed by all providers with variability in the timing of administration. Conclusions: Management and treatment of COVID-19 for SOT donors, candidates, and recipients was heterogeneous. While all providers require at least one negative COVID-19 test as both donor and recipient evaluation prior to transplantation, the number of negative tests sent varied amongst providers, geographical region, and clinical scenario. The significant diversity of COVID-19 management strategies for immunocompromised adults seen in this study highlights the further need for studies defining the optimal management of COVID-19.

13.
American Journal of Transplantation ; 21(SUPPL 4):351, 2021.
Article in English | EMBASE | ID: covidwho-1494443

ABSTRACT

Purpose: US Solid organ transplantation rates significantly decreased during the initial wave of the COVID-19 pandemic. The concern for potential donor derived COVID-19 was one of many contributing factors. We describe the early experience of the Organ Procurement and Transplantation Network (OPTN) Disease Transmission Advisory Committee (DTAC) Coronavirus disease 2019 (COVID-19) investigations. Methods: COVID-19 cases reported to DTAC between January 2020 and October 2020 as potential donor-derived transmission events (PPDTE) were included. All of the events were investigated by the Centers for Disease Control and Prevention and adjudicated by the DTAC based on consensus definitions. Results: Eighteen PDTE COVID-19 events were reported during the study period. 12 PDTE reports have completed DTAC adjudication (Table 1). These included 12 donors with 44 recipients. Ten investigations were initiated by the transplant center due to recipient testing (36 total recipients). The median time to presentation in these index cases was 11 days (IQR 7-16). Nine donors in these events (35 recipients) had a prospective or retrospective pre-recovery negative SARS-CoV-2 PCR result. In all of these events, the index recipient had either a possible or confirmed community or hospital exposure. In one recipient index case (5 total recipients), the positive SARS-CoV-2 PCR result post-transplant was ultimately deemed a false positive and considered not a case by the committee. Two investigations were initiated by an OPO (8 recipients). In both events, the OPO performed SARS-CoV-2 PCR was negative, but a post-procurement nasopharyngeal SARS-CoV-2 PCR performed by the tissue collector was reported as positive and retrospectively deemed false positives. None of these recipients developed COVID-19;the events were adjudicated as not cases. Conclusions: The initial DTAC experience reflecting the early pandemic era emphasizes the need to implement hospital prevention measures to avoid nosocomial transmission, provide patient education to avoid community exposure and to recognize the possibility of post-procurement SARS-CoV-2 false positive testing. Vigilance for the possibility of a SARS-CoV-2 donor derived event remains important as the pandemic continues. (Table Presented) .

14.
Library Philosophy and Practice ; 2021, 2021.
Article in English | Scopus | ID: covidwho-1469151

ABSTRACT

The coronavirus disease (COVID-19) epidemic has wreaked havoc across the globe. In the realm of education, this pandemic has resulted in the widespread suspension of face-to-face operations at educational institutions in over 190 countries in order to limit the virus's spread and reduce its effects. According to the United Nations Educational, Scientific, and Cultural Organization (UNESCO), more than 1.2 billion students at all levels of education have quit attending face-to-face lectures by mid-May 2020. More than 1.5 billion students and learners have been affected by school and university closures caused by the COVID-19 pandemic. Therefore, different tools and techniques for online learning which can ensure the continuity of learning are highlighted. Some emerging approaches by the Ministry of Education across the country for online learning platforms are presented. It consists of all country-wise online learning platforms under UNESCO. The descriptive research method was used in the study and data was collected from different countries by visiting UNESCO websites. The results indicate that the global financial situation has boosted educational innovation. The study has seen innovative methods for guaranteeing education and training continuity, from radio and television to take-home packages. The significant learning experience of students, as well as governments' and other relevant stakeholders' long-term responsibilities to learners, and students' reactions to online education depend on their competency with online tools. © 2021. Library Philosophy and Practice. All Rights Reserved.

15.
Library Philosophy and Practice ; 2021:1-15, 2021.
Article in English | Scopus | ID: covidwho-1445015

ABSTRACT

This study assessed the partial as well as the collaborative impact of age and gender on academic staff preparedness to adopt Internet tools for research sharing in African universities during Covid-19. Although evidence abounds in the literature on gender and age as they affect relatively,scholars’ utilisation of digital tools for research communication, such studies did not examine scholars’ preparedness to adopt from a broad perspective of Africa. This study was conducted based on the argument that the preparedness of scholars may affect their future interest to utilize digital tools for research sharing. A quantitative method, based on the descriptive survey research design, was adopted to provide answers to four prevailing research questions. The examination focused on a populace of 8,591 staff in African universities, nonetheless, information was gathered from 1,977 of them, who deliberately took part from 24 African nations. A validated electronic rating scale, which was mailed/posted to targeted participants, was used as the instrument for data collection. Gender and age significantly affected academic staff preparedness to adopt Internet tools for research sharing partially and interactively in African Universities during Covid-19. Female staff were more prepared than males to adopt internet tools for research sharing during the pandemic. Older lecturers reported a higher rate of preparedness than their youngercolleagues to adopt Internet tools for research sharing during Covid-19. In light of these proofs, ramifications and proposals for future exploration are discussed © 2021, Library Philosophy and Practice. All Rights Reserved.

16.
Journal of Open Innovation: Technology, Market, and Complexity ; 7(3), 2021.
Article in English | Scopus | ID: covidwho-1344368

ABSTRACT

The prevailing pandemic (COVID-19) has increased socioeconomic problems and caused psychological distress due to work uncertainty, specifically in emerging economies. Small and medium enterprises (SMEs) in emerging economies have been severely affected. Particularly, work uncertainty is becoming a hindrance towards proactive work behaviour (PWB) that can be improved by an effective entrepreneurial leadership role and proactive personality attribute. Based on fortifying self-determination theory, this research answered the question to what extent proactive personality moderates the relationship between work uncertainty and PWB and strengthens the relationship between entrepreneurial leadership and PWB. To empirically examine the study’s underlying theoretical framework, respondents were selected from SMEs working in Pakistan from the high-tech industry. Multisource data were accumulated from 420 workers and their leaders utilizing a two-wave, time-lagged research design. Conclusions revealed that entrepreneurial leadership first reduced individuals’ work uncertainty, which in turn, led to enhanced proactive work behaviour of employees. Furthermore, the results revealed that work uncertainty mediates the relationship between entrepreneurial leadership and proactive work behaviour. Moreover, proactive personality moderates the link concerning work uncertainty and proactive work behaviour, such that this association is significant only when proactive personality is low. Additionally, the moderated mediation analysis indicated that less proactive people, compared with their extraordinarily proactive colleagues, trusted entrepreneurial leadership to be more proactive in the workplace. These findings have important implications to induce PWB among employees. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

17.
Pakistan Journal of Medical and Health Sciences ; 15(6):1266-1268, 2021.
Article in English | EMBASE | ID: covidwho-1326230

ABSTRACT

Background: The whole world is facing one of the biggest health related disasters of the century. As a novel disease, Covid-19 has so many parameters yet to explore. Aim: To explore varied pattern of clinical presentation of COVID-19 in obstetric population in tertiary care hospital. Study design: Cross-sectional study. Methodology: This study with enrolled pregnant females (n=36) was carried out after ethical review committee s (ERC) approval at Department of Gynecology & Obstetrics, Sir Ganga Ram Hospital, Lahore-Pakistan over a period of 3 months in 2020. Data was analyzed by SPSS software, version-20. Presenting symptoms of subjects were presented as frequency and percentage. Results: Total 36 patients were selected. Twenty four (66.66%) patients were symptomatic while the rest 12 (33.33%) patients were asymptomatic. Conclusion: We concluded that clinical presentation of COVID-19 pregnant patients is similar as in rest of the world and it is also same as in general population.

18.
Library Philosophy and Practice ; 2021:1-22, 2021.
Article in English | Scopus | ID: covidwho-1267103

ABSTRACT

With the rapid advancement of society, online learning has become more popular in the entire world due to Covid-19 pandemic. The pandemic offered almost a total paradigm shift to online teaching and learning across various educational platforms. This paper was aimed at reviewing the teaching and learning changes in higher education during COVID-19 Lockdown using empirical evidence from central universities in India. The study adopted a survey method utilizing an online questionnaire as the primary tool for data collection. The study covered 19 Central Universities in India that are offering Library and Information Science courses. Major findings showed, amongst others, that- most universities provided online classes during the lockdown period;Zoom application was the most utilized for online instructional during the COVID-19 Lockdown;the major difficulty faced by students during the online classes was the lack of internet facilities;the use of webinars in the field of LIS field was considered as an important source of education and learning. Based on these findings, key implications were discussed for the sustainability of LIS teaching and learning in higher education. © 2021. All Rights Reserved.

19.
Journal of Cataract & Refractive Surgery ; 12:12, 2021.
Article in English | MEDLINE | ID: covidwho-1209339
20.
Journal of Heart and Lung Transplantation ; 40(4):S20-S20, 2021.
Article in English | Web of Science | ID: covidwho-1187398
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