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1.
J Virol ; : e0077422, 2022 Aug 16.
Article in English | MEDLINE | ID: covidwho-1992940

ABSTRACT

XIAP-associated factor 1 (XAF1) is an interferon (IFN)-stimulated gene (ISG) that enhances IFN-induced apoptosis. However, it is unexplored whether XAF1 is essential for the host fighting against invaded viruses. Here, we find that XAF1 is significantly upregulated in the host cells infected with emerging RNA viruses, including influenza, Zika virus (ZIKV), and SARS-CoV-2. IFN regulatory factor 1 (IRF1), a key transcription factor in immune cells, determines the induction of XAF1 during antiviral immunity. Ectopic expression of XAF1 protects host cells against various RNA viruses independent of apoptosis. Knockout of XAF1 attenuates host antiviral innate immunity in vitro and in vivo, which leads to more severe lung injuries and higher mortality in the influenza infection mouse model. XAF1 stabilizes IRF1 protein by antagonizing the CHIP-mediated degradation of IRF1, thus inducing more antiviral IRF1 target genes, including DDX58, DDX60, MX1, and OAS2. Our study has described a protective role of XAF1 in the host antiviral innate immunity against RNA viruses. We have also elucidated the molecular mechanism that IRF1 and XAF1 form a positive feedback loop to induce rapid and robust antiviral immunity. IMPORTANCE Rapid and robust induction of antiviral genes is essential for the host to clear the invaded viruses. In addition to the IRF3/7-IFN-I-STAT1 signaling axis, the XAF1-IRF1 positive feedback loop synergistically or independently drives the transcription of antiviral genes. Moreover, XAF1 is a sensitive and reliable gene that positively correlates with the viral infection, suggesting that XAF1 is a potential diagnostic marker for viral infectious diseases. In addition to the antitumor role, our study has shown that XAF1 is essential for antiviral immunity. XAF1 is not only a proapoptotic ISG, but it also stabilizes the master transcription factor IRF1 to induce antiviral genes. IRF1 directly binds to the IRF-Es of its target gene promoters and drives their transcriptions, which suggests a unique role of the XAF1-IRF1 loop in antiviral innate immunity, particularly in the host defect of IFN-I signaling such as invertebrates.

2.
Frontiers in psychology ; 13, 2022.
Article in English | EuropePMC | ID: covidwho-1939987

ABSTRACT

Objectives Wuhan is the city where coronavirus disease (COVID-19) was first reported and developed into a pandemic. However, the impact of the prolonged COVID-19 pandemic on medical staff burnout remains limited. We aimed to identify the prevalence and major determinants of burnout among medical staff 1 year after the beginning of the COVID-19 pandemic in Wuhan, China. Materials and Methods A total of 1,602 medical staff from three hospitals in Wuhan, China, were included from November 1–28, 2021. Chi-square tests were conducted to compare the prevalence of burnout across groups based on sociodemographic and professional characteristics. A multivariate analysis was performed using a forward stepwise logistic regression model. Results Approximately 37.39% of the medical staff experienced burnout 1 year after COVID-19 pandemic. Emotional exhaustion (EE) was the most common symptom of burnout, with 1,422 (88.76%) participants reporting a severe EE. Burnout was associated with insufficient social support and “neutral” or “dissatisfied” patient-physician relationships. Respondents who participated in the care of COVID-19 patients had a higher risk of burnout symptoms than those who did not participate. In particular, mental resilience was negatively associated with burnout among the medical staff. Conclusion Nearly two-fifths of the participants had symptoms of burnout, with reduced personal accomplishment being the predominant symptom 1 year after COVID-19. Healthcare organizations should regularly measure and monitor burnout among the medical staff. In addition, creating positive work environments and improving the mental resilience of medical staff may be effective ways to reduce burnout.

3.
PLoS One ; 17(7): e0270902, 2022.
Article in English | MEDLINE | ID: covidwho-1933371

ABSTRACT

INTRODUCTION: As the frequency of infectious diseases rises, it's more important than ever to pay attention to the competency level of front-line nurses as the primary force in front-line rescue, which has an impact on the quality of anti-epidemic response. This paper aims to construct the competency evaluation index system for front-line nurses during the outbreak of major infectious diseases. MATERIALS AND METHODS: This study combined literature review, critical incident technique interviews, and semi-structured in-depth interviews, as well as two rounds of Delphi expert correspondence, to construct a competence evaluation index system for front-line nurses during the outbreak of major infectious diseases. The study used purposive sampling to select 26 experts from 11 provinces and cities across China to conduct two rounds of Delphi expert consultation, and the indicators were selected based on the mean importance score > 3.5 and the coefficient of variation < 0.25, and the weights of the indicators were calculated by the Analytic Hierarchy Process. The effective recovery rates of the two rounds of correspondence questionnaires were 93.1% and 96%. RESULTS: The effective recovery rates of the two rounds of correspondence questionnaires were 93.1% and 96%, the authority coefficients of experts were 0.96 and 0.98, the Kendall's coordination coefficients of the first, second, and third level indexes were 0.281, 0.132, and 0.285 (P < 0.001), 0.259, 0.158, and 0.415 (P < 0.001). The final index system includes 4 primary indicators (Knowledge System of Infectious Diseases, Nursing Skills for Infectious Diseases, Related Professional Abilities for Infectious Diseases, and Comprehensive Quality), 10 secondary indicators, and 64 tertiary indicators. CONCLUSION: The competency evaluation index system of front-line nurses during the outbreak of major infectious diseases is scientific, reasonable, and practical, which can provide a scientific basis for nursing managers to accurately understand, describe, analyze, and evaluate the competence level of nursing staff and scientifically implement the allocation of human resources in the future, as well as serve as a content framework for subsequent training programs.


Subject(s)
Communicable Diseases , Disease Outbreaks , China/epidemiology , Communicable Diseases/epidemiology , Delphi Technique , Humans , Surveys and Questionnaires
4.
Violence Against Women ; 28(8): 1750-1772, 2022 06.
Article in English | MEDLINE | ID: covidwho-1808094

ABSTRACT

Although there is a growing volume of research on violence against women, violence against older women has received little attention to date. Little is known about the experience of elder abuse, discrimination, loneliness, and health among older women, in particular in the era of COVID-19 when our lives have been changed drastically. Using two waves of survey data (N = 1,498), this study compared the estimates of elder abuse and age discrimination before and during the COVID-19 pandemic, examined their associations with physical and mental health, and explored the mediating effects of loneliness on the associations in two independent samples of older women in Hong Kong. Reductions in some forms of abuse and discrimination against older women during the pandemic were observed. Findings from regression analyses show that elder abuse and age discrimination were associated with poorer health, and these associations were mediated by loneliness.


Subject(s)
COVID-19 , Elder Abuse , Aged , Elder Abuse/psychology , Female , Hong Kong/epidemiology , Humans , Pandemics , Risk Factors , Surveys and Questionnaires
5.
BMC Med Educ ; 22(1): 286, 2022 Apr 15.
Article in English | MEDLINE | ID: covidwho-1793953

ABSTRACT

BACKGROUND: Individual-centred career questionnaires are important for understanding the motivations of medical students. This study aimed to collect validity evidence of a questionnaire to measure the career choice of medical undergraduates. METHODS: A cross-sectional survey was sent to third-year undergraduate students at a Chinese university-affiliated hospital. The questionnaire was formed using items that were selected after a systematic literature review. Item reduction was conducted using Mokken scale analysis, followed by reliability and validity testing, which described the validity evidence of the content, response process and internal structure. RESULTS: The preliminary 20-item questionnaire was returned by 213 undergraduate students (response rate: 86.59%). To construct a monotone homogeneity model, 6 items were removed after testing for unidimensionality, local independence, and latent monotonicity according to the sequence. The final questionnaire included 14 items in two subscales: a 10-item 'career advantage' subscale and a 4-item 'career disadvantage' subscale. The questionnaire was judged to be acceptably reliable (Molenaar-Sijtsma method: 0.87 and 0.75, Cronbach's alpha: 0.87 and 0.74) and to have good construct validity (χ2/df: 1.748, normed fit index: > 0.9, comparative fit index: > 0.9, root mean square error of approximation: 0.05-0.08). Male and female undergraduates had different responses regarding their salary, subspecialty, career prospects, and ability to serve their relatives. Male undergraduates might be more willing to accept on-call positions and have subspecialties with greater likelihoods of patient-physician conflict. CONCLUSION: We used Mokken scale analysis to develop and collect evidence of the validity of a 14-item questionnaire regarding career preferences among Chinese medical undergraduate students. This short and simple questionnaire may provide a suitable tool for exploring insights regarding the motivations of Chinese medical students.


Subject(s)
Students, Medical , Cross-Sectional Studies , Female , Humans , Male , Psychometrics , Reproducibility of Results , Surveys and Questionnaires
6.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-309736

ABSTRACT

Introduction: Since initially detected in late December 2019, the novel coronavirus disease (COVID-19) outbreak rapidly swept the world. We aimed to evaluate the impact of COVID-19 pandemic on the pattern of hospital admissions and healthcare services for acute pancreatitis(AP). Methods: This single-center, retrospective observational study from a regional medical center in the northeast of China included all consecutively admitted patients with AP from January 23 to June 10, 2020 (during the COVID-19 outbreak in Harbin), compared with the equivalent period of the previous year, in terms of demographics, clinical characteristics, and in-hospital outcomes. Results: In the present article, we observed a reduction in AP admissions after the onset of COVID-19. With the prolonged time from symptom onset to hospitalization (32.0 [22.0–72.0] versus 18.0 [12.0–24.0] hours;P &lt;.001), a higher proportion of patients developed acute renal failure (39% versus 34%, P =.004) and acute necrotic collection (16.5% versus 11.2%;P =.038) in the COVID-19 era. The percentage of alcohol etiology significantly reduced after the implementation of social restriction measures (11.5% versus 22.4%;P &lt;.001), whereas biliary etiology was numerically more common amidst the COVID-19 era (41.6% versus 32.6%;P = .014). No significant differences were found in the rates of intensive care unit admission and mortality between the two groups. Conclusions: The current study preliminarily demonstrated the descending trend and delay in hospital presentations for AP during the pandemic. The COVID-19 pandemic requires the modification of medical centers to optimize the management of AP and the containment of nosocomial viral transmission. Trial Registration: ClincialTrials.gov number, ChiCTR2100043350. Funding: None to declare Declaration of Interest: None to declare Ethical Approval: Ethical approval was obtained from the Ethics Committee of 1st HMU.<br>

7.
Innovation in Aging ; 5(Supplement_1):529-529, 2021.
Article in English | PMC | ID: covidwho-1584505

ABSTRACT

Increasing attention has been paid to the potential role of care planning in buffering future eldercare challenges. However, little is known about the characteristics of care planning among Chinese ageing families. It is also of interest to reflect how recent events such as COVID-19 pandemic may affect their views of the future care planning. From a family systems perspective, this study explored the extent, processes, and contents of intergenerational care planning of Chinese ageing families in Hong Kong. Dyadic interviews were conducted with 60 adult child-older parent pairs, and individual interviews were conducted with another 33 adult children. Intergenerational discrepancies in extent and processes of care planning, intergenerational congruence of care expectations and struggles, facilitating role of family capital and hindering role of cultural capital in care planning were primary themes. Although both generations demonstrated strong awareness of future eldercare needs, they were found engaged in different levels and processes of care planning. Adult children’s level of engagement in planning activities may influence parents’ extent and contents of care planning. Intergenerational transmission of eldercare values contributed to intergenerational congruence of care expectations but also led to similar struggles and ambivalent attitudes toward future care. Moreover, family capital was found to facilitate family care planning while Chinese cultural values that emphasize family care may hinder both generations’ efforts in care planning. The findings will deepen our understanding on characteristics of intergenerational care planning in Asian Chinese communities and inform services to improve adult children and ageing parents’ preparation for future eldercare.

8.
Journal of International Technology and Information Management ; 30(3):76-107, 2021.
Article in English | ProQuest Central | ID: covidwho-1513613

ABSTRACT

A large number of institutions of higher learning at all levels transitioned hurriedly to remote and online learning in response to the novel coronavirus (COVID-19) pandemic. However, recent studies have concluded that university-level students prefer learning in face-to-face settings. This study seeks to understand the factors that are driving students ' rejection of remote and online learning options and to provide insight into future efforts to implement strategies and tools to mitigate these adverse factors. The results show factors that contribute the most to students' perceived satisfaction in the remote instructional setting are less interaction during live lectures, more distractions, less engagement in virtual classrooms, less effectiveness in understanding lectures, delayed responses and inability to get immediate assistance. A theoretical framework was developed to classify the contributing factors into three desirable learning related dimensions.

9.
Chinese Journal of Virology ; 36(4):578-580, 2020.
Article in Chinese | CAB Abstracts | ID: covidwho-1407615

ABSTRACT

Since December 2019, an outbreak of pneumonia (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-Z) has been widespread in the world. Investigation of Virus spread is a constant research focus. At present, SARS-CoV-Z has not been detected in livestock, poultry, or fur animals. This study focused on the traceability of SARS-CoV-Z in rare and endangered migratory birds. A total of 383 samples (throat swabs, anal swabs and fecal samples) were collected from 10 types of rare or endangered migratory bird, including mallard, white duck, pheasant, swan goose and white swan, in Jilin Province, China, between September 2019 and April 2020. Real-time RT-PCR, as recommended by the World Health Organization, was used to detect SARS-CoV-Z in these samples. SARS-CoV-Z was not detected in any of the samples.

10.
Chinese Journal of Virology ; 36(4):692-693, 2020.
Article in Chinese | CAB Abstracts | ID: covidwho-1407612

ABSTRACT

In December 2019, an outbreak of a respiratory illness took place in Wuhan, Hubei Province, China, and spread throughout China and other countries. A beta genus coronavirus, SARS-CoV-2 was isolated and identified as a cause of the outbreak. Currently, the main infectious sources(host)of SARS-CoV-2 have not been identified. It has been reported that SARS-CoV-2 was possibly originated from wild animals, for example, bats. However, there are no reports on the traceability of SARS-CoV-2 to fur animals, such as minks, foxes and raccoon dogs, which are widely farmed in Northern China. Therefore, it is necessary to investigate the epidemiology of SARS-CoV-2 in fur animals. In this study, we detected SARS-CoV-2 in 625 tissue specimens collected from farmed minks, foxes and raccoon dogs of unknown death cases in 14 regions of China from 2016 to 2019 and 150 fecal samples collected from farmed minks, foxes and raccoon dogs in Jilin Province, China from August to December in 2019 using the Real-time RT-PCR method recommended by WHO. The results showed that SARS-CoV-2 was not detected in all the 775 samples.

11.
Drug Des Devel Ther ; 15: 2059-2089, 2021.
Article in English | MEDLINE | ID: covidwho-1231276

ABSTRACT

PURPOSE: One of the most common types of male infertility is recognized as oligoasthenozoospermia (OA), characterized by low sperm count and quality in males. As a traditional Chinese medicine (TCM), Cuscutae Semen-Mori Fructus coupled-herbs (CSMFCH) has been known to act a curative effect on OA for thousands of years. Nevertheless, the substantial basis and molecular mechanism of CSMFCH in treating OA remain elusive. METHODS: Herein, an integrated approach, including network pharmacology, molecular docking, and experiment validation, was utilized to reveal the new candidate active component and mechanism of CSMFCH in treating OA. RESULTS: The results show that kaempferol is the most significant bioactive component of CSMFCH on OA. The mechanism and targets of CSMFCH against OA are relevant to hormone regulation, oxidant stress, and reproductive promotion. In order to validate network pharmacology results, molecular docking and experiment validation were conducted. In detail, molecular docking was employed to verify the strong binding interactions between kaempferol and the core targets. UHPLC-Q-Orbitrap-MS was used to identify kaempferol in the CSMFCH extract. In vitro and in vivo experiments further proved CSMFCH and kaempferol could enhance the mouse Leydig (TM3) and mouse Sertoli (TM4) cell viability, improve the male reproductive organ weights, sperm quality, and decrease testis tissue damage in the OA mouse model induced by CP. CONCLUSION: Our results not only identify the new candidate active component of CSMFCH in treating OA but also provide new insights into the mechanisms of CSMFCH against OA.


Subject(s)
Asthenozoospermia/drug therapy , Drugs, Chinese Herbal/therapeutic use , Molecular Docking Simulation , Plant Extracts/therapeutic use , Animals , Cell Proliferation/drug effects , Cells, Cultured , Chromatography, High Pressure Liquid , Disease Models, Animal , Drugs, Chinese Herbal/chemistry , Drugs, Chinese Herbal/isolation & purification , Fruit/chemistry , Male , Mass Spectrometry , Medicine, Chinese Traditional , Mice , Mice, Inbred Strains , Plant Extracts/chemistry , Plant Extracts/isolation & purification
12.
Front Psychol ; 12: 646368, 2021.
Article in English | MEDLINE | ID: covidwho-1220257

ABSTRACT

The COVID-19 pandemic has dramatically changed the patterns of lifestyle and posed psychological stress on pregnant women. However, the association of sleep duration and screen time with anxiety among pregnant women under the backdrop of the COVID-19 pandemic scenario has been poorly addressed. We conducted one large-scale, multicenter cross-sectional study which recruited 1794 pregnant women across middle and west China. Self-reported demographic characteristics, lifestyle, and mental health status were collected from 6th February to 8th May 2020. We investigated the association of sleep duration and screen time with the risk of anxiety by multivariable logistic regression analysis and linear regression analysis after adjusting potential confounders. The dose-response relationship of sleep duration and screen time with anxiety was visualized using a cubic spline plot. Our data revealed that almost 35% of pregnant women suffered from anxiety during the COVID-19 pandemic. Sleep duration was dose-dependently associated with a lower risk of anxiety among pregnant women (OR = 0.41, 95% CI: 0.27-0.63), while screen time exhibited a conversed effect (OR = 2.01, 95% CI:1.00-4.39). Notably, sleep duration (≥8 h/day) synergistically combined with screen time (3-7 h/day) to diminish the risk of anxiety (OR = 0.70, 95% CI: 0.50-0.99). Taken together, sleep duration and screen time were independently and jointly associated with anxiety (P < 0.05). Therefore, promoting a more active lifestyle and maintaining higher sleep quality could improve the mental health of pregnant women, especially under public health emergency.

13.
Front Med (Lausanne) ; 8: 607059, 2021.
Article in English | MEDLINE | ID: covidwho-1110301

ABSTRACT

Background: Coronavirus disease-2019 (COVID-19) epidemic is spreading globally. Sex differences in the severity and mortality of COVID-19 emerged. This study aims to describe the impact of sex on outcomes in COVOD-19 with a special focus on the effect of estrogen. Methods: We performed a retrospective cohort study which included 413 patients (230 males and 183 females) with COVID-19 from three designated hospitals in China with a follow up time from January 31, 2020, to April 17, 2020. Women over 55 were considered as postmenopausal patients according to the previous epidemiological data from China. The interaction between age and sex on in-hospital mortality was determined through Cox regression analysis. In addition, multivariate Cox regression models were performed to explore risk factors associated with in-hospital mortality of COVID-19. Results: Age and sex had significant interaction for the in-hospital mortality (P < 0.001). Multivariate Cox regression showed that age (HR 1.041, 95% CI 1.009-1.073, P = 0.012), male sex (HR 2.033, 95% CI 1.007-2.098, P = 0.010), the interaction between age and sex (HR 1.118, 95% CI 1.003-1.232, P = 0.018), and comorbidities (HR 9.845, 95% CI 2.280-42.520, P = 0.002) were independently associated with in-hospital mortality of COVID-19 patients. In this multicentre study, female experienced a lower fatality for COVID-19 than male (4.4 vs. 10.0%, P = 0.031). Interestingly, stratification by age group revealed no difference in-hospital mortality was noted in women under 55 compared with women over 55 (3.8 vs. 5.2%, P = 0.144), as well as in women under 55 compared with the same age men (3.8 vs. 4.0%, P = 0.918). However, there was significantly difference in women over 55 with men of the same age group (5.2 vs. 21.0%, P = 0.007). Compared with male patients, female patients had higher lymphocyte (P < 0.001) and high-density lipoprotein (P < 0.001), lower high sensitive c reaction protein level (P < 0.001), and lower incidence rate of acute cardiac injury (6.6 vs. 13.5%, P = 0.022). Conclusion: Male sex is an independent risk factor for COVID-19 in-hospital mortality. Although female mortality in COVID-19 is lower than male, it might not be directly related to the effect of estrogen. Further study is warranted to identify the sex difference in COVID-19 and mechanisms involved.

14.
SciFinder; 2020.
Preprint | SciFinder | ID: ppcovidwho-3512

ABSTRACT

This study collected 625 tissues and stool samples of dead minks, foxes and raccoons, and 150 stool samples of mink, foxes and raccoons with unexplained deaths in 14 regions of 5 provinces of Jilin, Heilongjiang, Liaoning, Hebei and Shandong from 2016 to 2019. We used the Real-time RT-PCR recommended by WHO detects SARS-CoV2 in the above tissues and stool samples. The results showed that all the above 775 samples were negetive of the SARS-CoV-2 nucleic acid.

15.
Journal of Third Military Medical University ; 42(18):1823-1829, 2020.
Article in Chinese | GIM | ID: covidwho-1005499

ABSTRACT

Objective: To analyze the characteristics of risk perception of military personnel in different areas during the early stage of COVID-19 outbreak.

16.
Journal of Third Military Medical University ; 42(16):1619-1624, 2020.
Article in Chinese | CAB Abstracts | ID: covidwho-976630

ABSTRACT

Objective: To investigate the risk perception of coronavirus disease 2019 (COVID-19) among young military personnel serving in high-altitude regions in the early stage of COVID-19 outbreak.

17.
J Transl Med ; 18(1): 461, 2020 12 07.
Article in English | MEDLINE | ID: covidwho-963340

ABSTRACT

BACKGROUND: Information regarding characteristics and risk factors of COVID-19 amongst middle-aged (40-59 years) patients without comorbidities is scarce. METHODS: We therefore conducted this multicentre retrospective study and collected data of middle-aged COVID-19 patients without comorbidities at admission from three designated hospitals in China. RESULTS: Among 119 middle-aged patients without comorbidities, 18 (15.1%) developed into severe illness and 5 (3.9%) died in hospital. ARDS (26, 21.8%) and elevated D-dimer (36, 31.3%) were the most common complications, while other organ complications were relatively rare. Multivariable regression showed increasing odds of severe illness associated with neutrophil to lymphocyte ratio (NLR, OR, 11.238; 95% CI 1.110-1.382; p < 0.001) and D-dimer greater than 1 µg/ml (OR, 16.079; 95% CI 3.162-81.775; p = 0.001) on admission. The AUCs for the NLR, D-dimer greater than 1 µg/ml and combined NLR and D-dimer index were 0.862 (95% CI, 0.751-0.973), 0.800 (95% CI 0.684-0.915) and 0.916 (95% CI, 0.855-0.977), respectively. SOFA yielded an AUC of 0.750 (95% CI 0.602-0.987). There was significant difference in the AUC between SOFA and combined index (z = 2.574, p = 0.010). CONCLUSIONS: More attention should be paid to the monitoring and early treatment of respiratory and coagulation abnormalities in middle-aged COVID-19 patients without comorbidities. In addition, the combined NLR and D-dimer higher than 1 µg/ml index might be a potential and reliable predictor for the incidence of severe illness in this specific patient with COVID-19, which could guide clinicians on early classification and management of patients, thereby relieving the shortage of medical resource. However, it is warranted to validate the reliability of the predictor in larger sample COVID-19 patients.


Subject(s)
COVID-19/epidemiology , Adult , COVID-19/complications , COVID-19/diagnostic imaging , Cause of Death , Comorbidity , Female , Fibrin Fibrinogen Degradation Products/metabolism , Humans , Incidence , Logistic Models , Lymphocytes/pathology , Male , Middle Aged , Neutrophils/pathology , Organ Dysfunction Scores , Patient Admission , ROC Curve , Retrospective Studies , Risk Factors , Treatment Outcome
18.
Ann Palliat Med ; 9(4): 1404-1412, 2020 Jul.
Article in English | MEDLINE | ID: covidwho-661201

ABSTRACT

BACKGROUND: The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has outbreak in the world. Little is known about the clinical characteristics of patients with SARS-CoV-2 infection in the high-altitude region of China. We reported the clinical characteristics of patients with coronavirus disease 2019 (COVID-19) in Gansu province, China. METHODS: In this retrospective study, patients with laboratory-confirmed SARS-CoV-2 infection were consecutively enrolled from January 21, 2020 to February 11, 2020. The information on the epidemiological, clinical characteristics, laboratory tests, radiological features on admission, treatment and outcome were obtained with the final follow-up of March 13, 2020. On the basis of the median length of hospital stay, patients were further analyzed in two groups (long- vs. short-hospital stay). RESULTS: Of the 86 patients of COVID-19 in 11 cities of Gansu Province, the median hospital stay was 14.0 days (interquartile rang, 11.0-19.0 days). In the overall cohort, the median age was 41.0 years (interquartile rang, 31.0-54.3 years), and 48 (55.8%) patients were female. Forty (46.5%) had a history of exposure to epidemic regions, but none exposed to the Huanan seafood market in Wuhan. Common symptoms included fever (41, 47.7%), and cough (37, 43.0%). On admission, 30 (34.9%) and 58 (67.4%) patients had leukopenia and lymphopenia. According to chest CT scans, 53 (66.3%) of 80 patients showed bilateral pneumonia, and 19 (23.8%) of 80 patients showed unilateral pneumonia. Of the 15 asymptomatic cases, 10 (66.6%) cases were found CT findings of pneumonia. Besides, there were 65 (75.6%) patients with mild and moderate type of COVID-19. All 86 patients received antiviral and traditional Chinese medicine therapy, 53 (61.6%) received antibacterial therapy, and 3 (3.5%) patients received invasive ventilator mechanical ventilation. The proportion of patients received antibiotic treatment in long-hospital stay group was significantly higher than that in the short-hospital stay group (P=0.045). As of March 13, 2020, 84 (97.7%) patients were discharged, and two (2.3%) cases died. CONCLUSIONS: In the Gansu province cohort of 86 patients of COVID-19, most patients were with mild or moderate type, and most asymptomatic cases showed CT imaging findings of SARS-CoV-2 related pneumonia.


Subject(s)
Coronavirus Infections/diagnosis , Coronavirus Infections/therapy , Pneumonia, Viral/diagnosis , Pneumonia, Viral/therapy , Adolescent , Adult , Aged , Aged, 80 and over , Betacoronavirus/isolation & purification , COVID-19 , Child , Child, Preschool , China/epidemiology , Coronavirus Infections/epidemiology , Female , Humans , Infant , Length of Stay/statistics & numerical data , Male , Middle Aged , Pandemics , Pneumonia, Viral/epidemiology , Retrospective Studies , SARS-CoV-2 , Treatment Outcome , Young Adult
19.
Pol Arch Intern Med ; 130(5): 390-399, 2020 05 29.
Article in English | MEDLINE | ID: covidwho-627704

ABSTRACT

INTRODUCTION: Coronavirus disease 2019 (COVID­19) caused by severe acute respiratory syndrome coronavirus 2 (SARS­CoV­2) infection spread worldwide. OBJECTIVES: The aim of the study was to identify the clinical characteristics and risk factors associated with severe incidence of SARS ­CoV­2 infection. PATIENTS AND METHODS: All adult patients (median [IQR] age, 52 [37-58] years) consecutively admitted to the Dabieshan Medical Center from January 30, 2020 to February 11, 2020 were collected and reviewed. Only patients diagnosed with COVID­19  according to the World Health Organization interim guidance were included in this retrospective cohort study. RESULTS: A total of 108 patients with COVID­19 were retrospectively analyzed. Twenty­five patients (23.1%) developed severe disease, and of those 12 patients (48%) died. Advanced age, comorbidities (most commonly hypertension), higher blood leukocyte count, neutrophil count, higher C­reactive protein level, D­dimer level, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, and Sequential Organ Failure Assessment (SOFA) score were associated with greater risk of COVID­19, and so were lower lymphocyte count and albumin level. Multivariable regress ion showed increasing odds of severe COVID­19 associated with higher SOFA score (odds ratio [OR], 2.45; 95% CI, 1.302-4.608; P = 0.005), and lymphocyte count less than 0.8 × 109/l (OR, 9.017; 95% CI, 2.808-28.857; P <0.001) on admission. Higher SOFA score (OR, 2.402; 95% CI, 1.313-4.395; P = 0.004) on admission was identified as risk factor for in­hospital death. CONCLUSIONS: Lymphocytopenia and a higher SOFA score on admission could help clinicians to identify patients at high risk for developing severe COVID­19. More related studies are needed in the future.


Subject(s)
Betacoronavirus , Coronavirus Infections/diagnosis , Multiple Organ Failure/diagnosis , Pneumonia, Viral/diagnosis , Severity of Illness Index , Adult , COVID-19 , Female , Humans , Male , Middle Aged , Multiple Organ Failure/etiology , Pandemics , Prognosis , Retrospective Studies , Risk Factors , SARS-CoV-2 , Sepsis/diagnosis
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