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2.
Cogent Education ; 9(1), 2022.
Article in English | Web of Science | ID: covidwho-2097006

ABSTRACT

School leadership is a fast-paced job where stakeholder feedback is frequent, and decision-making requires quick thinking and strong organization. When school leaders transition from practitioner to scholar, they face a dramatic change in pace and responsibility. Unlike their peers who come from academia, practitioner-scholars experience a unique context and career shift that requires navigating unfamiliar organizational structures and translating existing skills into new contexts. This collaborative autoethnography explores the lived experiences of two junior faculty who recently transitioned from the campus principalship to the tenure track professoriate during the COVID-19 pandemic. Through a process of individual writing, group reflection, and shared analysis, common themes emerged from the data, including expectations, relationships, and identity. The research discusses processing unfamiliar experiences in academia, negotiating the reidentification of self, and developing new attachments during the shift from doing the work to supporting and advancing the field.

4.
American Journal of Transplantation ; 22(Supplement 3):637-638, 2022.
Article in English | EMBASE | ID: covidwho-2063471

ABSTRACT

Purpose: Solid organ transplant recipients (SOTRs) are at increased risk for severe COVID-19 and exhibit lower antibody responses to SARS-CoV-2 vaccines. This study aimed to determine if pre-vaccination cytokine levels are associated with antibody response to SARS-CoV-2 vaccination. Method(s): A cross-sectional study was performed among 58 SOTRs before and after two-dose mRNA vaccine series, 35 additional SOTRs before and after a third vaccine dose, with comparison to 16 healthy controls (HCs). Anti-spike antibody was assessed using the IgG Euroimmun ELISA. Electrochemiluminescence detectionbased multiplexed sandwich immunoassays were used to quantify plasma cytokine and chemokine concentrations (n=20 analytes). Concentrations between SOTRs and HCs, stratified by ultimate antibody response to the vaccine, were compared using Wilcoxon-rank-sum test with false discovery rates (FDR) computed to correct for multiple comparisons. Result(s): In the study population, 100% of HCs, 59% of SOTRs after two doses and 63% of SOTRs after three doses had a detectable antibody response. Multiple baseline cytokines were elevated in SOTRs versus HCs. There was no significant difference in cytokine levels between SOTRs with high vs low-titer antibodies after two doses of vaccine. However, as compared to poor antibody responders, SOTRs who went on to develop a high-titer antibody response to a third dose of vaccine had significantly higher pre-third dose levels of several innate immune cytokines including IL-17, IL-2Ra, IL-6, IP-10, MIP-1alpha, and TNF-alpha (FDR <0.05). Conclusion(s): A specific inflammatory profile or immune state may identify which SOTRs are likely to develop stronger sero-response and possible protection after a third dose of SARS-CoV-2 vaccine.

5.
American Journal of Transplantation ; 22(Supplement 3):770, 2022.
Article in English | EMBASE | ID: covidwho-2063470

ABSTRACT

Purpose: The impact of antigenic imprinting, when immune memory of one antigen influences the response to subsequent similar antigens, on the antibody response in solid organ transplant recipients (SOTRs) after SARS-CoV-2 vaccination is currently unknown. This study examines the relationship between seasonal coronaviruses (sCoV) and SARS-CoV-2 antibody levels pre- and post-vaccination in SOTRs. Method(s): Plasma from 52 SOTRs pre- and post-SARS-CoV-2 vaccination (2 doses, mRNA) was analyzed using the Meso Scale Diagnostic Coronavirus Panel 3 (an electrochemiluminescence detection-based multiplexed sandwich immunoassay) for IgG antibodies against alpha sCoVs (229E, NL63), beta sCoVs (HKU1, OC43), and SARS-CoV-2 spike proteins. Changes in IgG titers were determined by paired Wilcoxon rank-sum tests. Spearman correlation analysis was used to determine associations between pre-vaccination anti-sCoVs and post-vaccination anti-SARS-CoV-2 IgG. Result(s): Vaccination increased both anti-SARS-CoV-2 (fold change (FC) 1.9, p<0.001) and anti-beta sCoV (HKU1 [FC 0.05, p<0.001], OC43 [FC 0.8, p<0.001]) IgG titers in SOTRs, but did not increase anti-alpha sCoV IgG. Furthermore, prevaccination anti-beta sCoV (HKU1 [rho= -0.3, p=0.03], OC43 [rho= -0.3, p<0.03]) IgG titers were negatively correlated with post-vaccination anti-SARS-CoV-2 IgG. Conclusion(s): These exploratory findings suggest that prior exposure to seasonal betacoronaviruses may lead to antigenic imprinting in SOTRs that negatively impacts the antibody response to vaccination against the novel pandemic betacoronavirus, SARS-CoV-2.

6.
American Journal of Transplantation ; 22(Supplement 3):457, 2022.
Article in English | EMBASE | ID: covidwho-2063392

ABSTRACT

Purpose: While SARS-CoV-2 vaccination has dramatically reduced COVID-19 severity in the general population, fully vaccinated solid organ transplant recipients (SOTRs) demonstrate reduced seroconversion and increased breakthrough infection rates. Furthermore, a third vaccine dose only increases antibody and T cell responses in a proportion of SOTRs. We sought to investigate the underlying mechanisms resulting in varied humoral responses in SOTRs. Method(s): Within a longitudinal prospective cohort of SOTRs, anti-spike IgG, total and spike-specific B cells were evaluated in 44 SOTR participants before and after a third vaccine dose using high dimensional flow cytometry to assess immunologic and metabolic phenotypes. B cell phenotypes were compared to those of 10 healthy controls who received a standard two-dose mRNA series. Result(s): Notably, even in the absence anti-spike antibody after two doses, spikespecific B cells were detectable in most SOTRs (76%). While 15% of participants were seropositive before the third dose, 72% were seropositive afterward. B cells, however, were differentially skewed towards non-class switched B cells in SOTRs as compared to healthy control B cells. Expansion of spike-specific class-switched B cells in SOTRs following a third vaccine dose correlated with increased classswitched (IgG) antibody titers. Antibody response to a third vaccine dose was associated with expanded populations of germinal center-like (CD10+CD27+) B cells, as well as CD11c+ alternative lineage B cells with specific upregulation of CPT1a, the rate limiting enzyme of fatty acid oxidation and a preferred energy source of germinal center B cells. Conclusion(s): This analysis defines a distinct B cell phenotype in SOTRs who respond to a third SARS-CoV-2 vaccine dose, specifically identifying fatty acid oxidation as pathway that could be targeted to improve vaccine response such as through targeted immunosuppressive modulation. (Figure Presented).

7.
Chest ; 162(4):A346, 2022.
Article in English | EMBASE | ID: covidwho-2060570

ABSTRACT

SESSION TITLE: Long COVID: It Can Take Your Breath Away SESSION TYPE: Original Investigations PRESENTED ON: 10/16/2022 10:30 am - 11:30 am PURPOSE: Post-acute sequelae of COVID-19 (PASC) infection is an area of active research, and much remains unknown about the trajectory of respiratory system recovery. While chronic dyspnea is a commonly reported PASC symptom, it is unclear how objective lung function metrics change over time. In this study, we sought to in lung function in PASC by comparing serial pulmonary function tests (PFTs) after COVID-19 infection. METHODS: Patients with prior COVID-19 infection and at least two PFTs after acute infection were identified retrospectively from our COVID-19 recovery clinic at a tertiary care center in Chicago, Illinois. PFT data and other clinical information were ed from the electronic medical record. Using a matched paired t-test, the differences between forced expiratory volume at one second (FEV1), forced vital capacity (FVC), total lung capacity (TLC), and diffusion capacity of carbon monoxide (DLCO) were compared over time. RESULTS: There were 32 patients who underwent pulmonary function testing twice after COVID-19 illness from 2020-2022, with a mean age of 56 years. The majority of the cohort were female (59%) and white (56%). 16 patients (50%) had required hospitalization for their acute COVID-19 illness, and 7 (22%) had required ICU level of care. The mean time from illness onset to first PFT was 207 days, and the mean time between the first and second PFT was 204 days. There was a statistically significant increase in FVC (2.2%, p=0.01), TLC (2.2%, p=0.01), and DLCO (2.43 mL/min/mmHg), but not in FEV1. Rate of change was calculated for each patient by dividing the difference for each parameter by the time (in years) between PFTs. TLC improved most rapidly (median 10.9% per year, IQR 0-24), followed by DLCO (median 6.6% per year, IQR -1 – 19.4). FEV1 increased by 3.9% per year (IQR -12.5 – 22), and FVC increased by 5.1% per year (IQR -4.5 – 22.7). Rate of change was calculated for each patient by dividing the difference for each parameter by the time (in years) between PFTs. TLC improved most rapidly (median 10.9% per year, IQR 0-24), followed by DLCO (median 6.6% per year, IQR -1 – 19.4). FEV1 increased by 3.9% per year (IQR -12.5 – 22), and FVC increased by 5.1% per year (IQR -4.5 – 22.7). CONCLUSIONS: There was an improvement in lung function metrics in our PASC cohort. This data describes the rate of improvement for each parameter, which may be helpful in prognostication and counselling patients about expected recovery times. CLINICAL IMPLICATIONS: A large number of patients with PASC experience chronic dyspnea and have persistent radiographic changes and/or abnormal pulmonary function testing. Our data suggests that for patients with abnormal PFTs, there is gradual improvement over time. With the burden of COVID-19 illness worldwide, it is crucial that we can accurately risk stratify those at high risk for persistent symptoms as well as understand the trajectory of recovery. DISCLOSURES: no disclosure submitted for Joseph Bailey;No relevant relationships by Amy Ludwig No relevant relationships by Marc Sala

8.
Australian Journal of Primary Health ; 28(4):xxviii, 2022.
Article in English | EMBASE | ID: covidwho-2058085

ABSTRACT

Background: Since May 2020, the Australian Government has implemented e-prescription to provide convenience and choice to patients, improve efficiency of prescribing and dispensing medications, reduce errors, and minimise use of paper prescriptions. e-Prescriptions are digital prescriptions with a unique QR code which pharmacists could scan for the relevant information to provide patients with the prescribed medications. In the current COVID-19 pandemic environment, this initiative also provides an opportunity to protect community members and healthcare providers from exposure to infectious diseases by contributing to the telehealth services. However, there are mixed opinions amongst GPs and pharmacists about the switch to digital services. Anecdotally, there are also differences in the challenges in e-prescription faced by rural and metropolitan healthcare providers. Aims/Objective: Our study aims to explore the potential benefits, barriers and enablers of e-prescription to GPs and pharmacists in metropolitan Sydney by identifying challenges to and perceptions of its implementation. Findings will be compared with those of a similar study conducted in rural NSW. Method(s): This MBBS student research project is a qualitative study using semi-structured interviews with 10 GPs and 10 pharmacists, recruited via professional networks and social media, to explore their experiences and views about e-prescription. Their responses will be audio-recorded, transcribed and thematically analysed. More interviews will be conducted to reach data saturation if necessary. Findings will be compared with those of the study conducted by the Bathurst Rural Clinical School in 2021. Finding(s): Ethics approval for this project is pending. Data collection is planned to start in May for 2 months. Preliminary results will be presented at this conference. Implications: Findings may facilitate the implementation of e-prescription either through raised awareness of new technology or identification of areas for improvement. Further research to address any barriers that prevent providers from using e-prescription can improve patient care.

9.
HemaSphere ; 6:1985-1987, 2022.
Article in English | EMBASE | ID: covidwho-2032163

ABSTRACT

Background: Ibrutinib (IBR) is an oral covalent Bruton tyrosine kinase inhibitor (BTKi), licensed for treatment of relapsed or refractory mantle cell lymphoma (MCL). Under NHS interim Covid-19 agreements in England, IBR with or without rituximab (R) was approved for the frontline treatment for MCL patients (pts) as a safer alternative to conventional immunochemotherapy. Although recent phase 2 studies have reported high response rates in low-risk patients for this combination in the frontline setting, randomised phase 3 and real-world data are currently lacking. Aims: To describe the real-world response rates (overall response rate (ORR), complete response (CR) rate) and toxicity profile of IBR +/-R in adult patients with previously untreated MCL. Methods: Following institutional approval, adults commencing IBR +/-R for untreated MCL under interim Covid-19 arrangements were prospectively identified by contributing centres. Hospital records were interrogated for demographic, pathology, response, toxicity and survival data. ORR/CR were assessed per local investigator according to the Lugano criteria using CT and/or PET-CT. Results: Data were available for 66 pts (72.7% male, median age 71 years, range 41-89). Baseline demographic and clinical features are summarised in Table 1. 23/66 pts (34.8%) had high-risk disease (defined as presence of TP53 mutation/deletion, blastoid or pleomorphic variant MCL, or Ki67%/MiB-1 ≥30%). IBR starting dose was 560mg in 56/62 pts (90%) and was given with R in 22/64 pts (34%). At a median follow up of 8.7 months (m) (range 0-18.6), pts had received a median of 7 cycles of IBR. 19/60 pts (32%) required a dose reduction or delay in IBR treatment. New atrial fibrillation and grade ≥3 any-cause toxicity occurred in 3/59 pts (5.8%) and 8/57 (14.0%) respectively. For the whole population and high-risk pts only, ORR was 74.4% and 64.7% respectively (p=0.2379), with a median time to response of 3.8m, coinciding with the first response assessment scan. Seven pts (16.7%), of whom 2 had highrisk disease, attained CR at a median of 6.0m. ORR for pts receiving vs not receiving R were 84.2% and 66.7% respectively (p=0.1904). IBR was discontinued in 20/61 pts (32.8%) at a median time to discontinuation of 4.1m, due to progressive disease (PD, 19.7%), toxicity (4.9%), death (3.3%;1 pt each of Covid-19 and E. coli infection), pt choice (3.3%) and other unspecified reasons (1.6%). 15/66 pts (22.7%) overall and 7/23 (30.4%) with high-risk disease progressed on IBR at a median time to PD of 4.0m. No pts underwent autologous stem cell transplantation consolidation during the study period. 12/57 pts (21.1%) received second line treatment (R-chemotherapy n=7, Nordic MCL protocol n=2, VR-CAP n=2, pirtobrutinib n=1). Response to second line treatment was CR in 4/11 pts, PD in 7/11. Of the 2 Nordic-treated patients, 1 had CR after cycle 2 and 1 PD. Fourteen pts (21.2%) died during the follow up period, due to MCL (n=11), Covid-19 (n=2) and congestive cardiac failure (n=1). Overall survival was lower for patients with high-risk disease (HR 0.55, p=0.038). Image: Summary/Conclusion: In this real-world UK cohort of pts receiving first-line IBR +/-R for MCL, including older and high-risk pts, we report high ORR rates in a similar range to the phase II Geltamo IMCL-2015 study of combination IBR-R in an exclusively low-risk population. Documented CR rates were lower, possibly reflecting a low usage of rituximab in the Covid-19 pandemic as well as CT assessment of response. Treatment was generally well tolerated, with low rates of toxicityrelated treatment discontinuation. The study is ongoing.

10.
Journal of Clinical Oncology ; 40(16), 2022.
Article in English | EMBASE | ID: covidwho-2005728

ABSTRACT

Background: Cancer-related cognitive impairment (CRCI) can include persistent memory symptoms, and affects many cancer survivors. Memory and Attention Adaptation Training (MAAT) is an evidencebased cognitive behavioral therapy (CBT) that improves CRCI with demonstrated efficacy in telehealth delivery. MAAT consists of 8 weekly (45-minute) video visits. The aims of this study are to confirm MAAT telehealth efficacy in a phase III RCT (MAAT versus Supportive Therapy;ST) across large catchment areas of two comprehensive cancer centers. A secondary aim is to evaluate treatment-induced brain activation as assessed by functional MRI (fMRI) in a subset of participants. We present remote treatment and data capture methods of this open NCI-sponsored (R01CA244673) randomized clinical trial (NCT 04586530). These methods have high success in participant accrual despite COVID-19 pandemic conditions, and can be readily adopted to other clinical trials to enhance rural/underserved enrollment. Methods: We are enrolling 200 adult, stage I-III breast cancer survivors 1-5 years post-chemotherapy with cognitive complaints. Individuals with CNS disease, previous brain injury, dementia or psychiatric disorder are excluded. All study procedures are completed from the participant's home (except fMRI). Eligibility screening is a semi-structured phone interview followed by detailed informed consent online (Research Electronic Data Capture: REDCap) with staff phone guidance. Consented participants complete baseline brief phone-based neurocognitive assessment and validated patient-reported outcome measures (PROs) of cognition and quality of life via REDCap. Participants are randomized to MAAT or ST and assigned treating clinicians at respective cancer centers. All 8 visits are completed through secure telehealth platforms, followed by repeat phone/online assessment posttreatment and again at 6 months. Enrollment began in 3/2021. As of 1/2022 (9 months), 56 participants are enrolled (28% of the planned sample), 47 randomized (MAAT 24;ST 23), with 24 completing post-treatment assessments. If all assessments and treatment visits were in person, travel burden per participant is 968 miles/20.5 hours driven, and $542 (US 2021 Federal rate). Thus, study travel savings to date are $30,352. Participant feedback indicates telehealth makes participation possible, similar to previous MAAT research. The current RCT demonstrates utility, efficiency and cost-savings of telehealth and remote data capture technology in the conduct of cancer control research. Elements of methods described can also be adopted for cancer therapeutic trials. Comprehensive cancer centers, where most clinical trials are based, can enhance participation of remote and/or underserved populations that have higher rates of cancer, more disease burden and less opportunity for trial participation.

11.
Psychosomatic Medicine ; 84(5):A79, 2022.
Article in English | EMBASE | ID: covidwho-2003090

ABSTRACT

Introduction: Despite the ongoing roll-out of the vaccination programme in Wales, self-isolation remains a crucial strategy to reduce transmission of COVID-19, especially as cases remain high. Test, Trace, Protect (TTP) is Wales' contact tracing programme where people are asked to isolate and provided with information and resources. Public Health Wales ran a real-time text message survey of contacts of cases of COVID-19 to provide insight as people were starting a period of self-isolation after notification from NHS Wales Test Trace Protect (Adherence Confidence Text Survey (ACTS)). This research study was designed to investigate what those being asked to self-isolate felt was good about their experience with TTP and what do they feel could be done better based on their text responses. Method: Text responses between 15th November 2020 and 2nd May 2021 (N = 12,092) were analysed using an automated content analysis (ACA) and sentiment analysis using the software Leximancer. Next, we conducted a qualitative thematic analysis using the software NVivo to explore further the findings of the ACA, as well as to look more deeply into some of the reasons behind people's views of TTP at two time periods for comparison, T1: 15th November- 5th December 2020 (n=2956) and T2: 1st March - 31st 2021 (n = 515). Results: ACA revealed that there were substantially more (roughly ten times as many) instances of favorable (positive affective) (n=4,963) terms within the data than unfavorable (negative affective) (n=425). NVivo analysis were in keeping with this finding as the majority reported a positive experience with TTP (T1 N = 1717, 58%;T2 N = 355, 69%). One of the sources of confusion was the date of the end of required isolation (T1 N= 101, 3.4%;T2 N = 11, 2.1%) though clarity improved from T1 to T2. Another concern was the time it took to be contacted following a positive test (T1 N = 205, 6.9%, T2 N = 14, 2.7%) again improving with time. Less than 1% reported financial concerns at both time periods. Conclusions: The Welsh population responding to the text sent by PHW had a positive experience with TTP. Automated content analysis is a viable method to process large datasets of qualitative content such as text responses.

12.
American Journal of Respiratory and Critical Care Medicine ; 205(1), 2022.
Article in English | EMBASE | ID: covidwho-1927876

ABSTRACT

Rationale: The long-term consequences of SARS-CoV-2 infection on patients' health are increasingly recognized. It is unknown if these consequences are common to all severe viral infections or are specific to SARS-CoV-2. A syndrome of persistent exertional dyspnea has been described after influenza infection. Here, we describe patterns in healthcare expenditures for patients hospitalized for either influenza or COVID-19. Methods: We used an all-payer administrative dataset comprised of coding and billing data from over 600 healthcare entities in the United States that use a financial analytics platform by Strata Decision Technology, a private company. The de-identified analytic sample included patients aged 18 years or older who were admitted to a hospital between January 2018 and February 2021 with either an ICD-10 code for COVID-19 (COVID-19 hospitalizations) or for influenza (influenza hospitalizations). Linear regression models were used to evaluate the relationship between infection type (COVID-19 or influenza) and total post-acute healthcare expenditures (post-acute expenditures), defined as cumulative charges 1 month or more after hospitalization. The dependent variable was log-transformed post-acute expenditures and the independent variables included health system classification (academic, multi-site, single site community, and children's) and size (based on operating budget), pre-hospitalization charges, date of admission (spline), gender, and US census region. Analyses were stratified by age (18-44, 45-64, and 65+) and need for ventilation during acute hospitalization. Results: Of the 98222 patients included in our analysis, 83278 (84.8%) were COVID-19 hospitalizations and 14944 (15.2%) were influenza hospitalizations. This patient cohort was 52% female, and contained 36039 (36.7%) patients from the Midwest, 20102 (20.5%) from the Northeast, 32031 (32.6%) from the West, and 9514 (9.7%) from the South. Mean length of stay was 6.78 days. Patients with COVID-19 were more likely to receive mechanical ventilation during hospitalization (3.8%) than patients with influenza (1.8%). Compared to influenza, linear model results suggest that COVID-19 was associated with similar or lower postacute expenditures (see table 1). Results are presented separately by ventilation status to accommodate potentially differential relationships between infection severity, post-acute expenditures, and length of stay in the two patient populations. Conclusion: In previously hospitalized patients, post-acute expenditures are similar between COVID-19 (March 2020-February 2021) and influenza (January 2018- February 2021). Despite the high burden of healthcare utilization related to post-acute sequelae of COVID-19, these findings suggest that individual healthcare expenditures after acute COVID-19 infection are similar to severe influenza infection.

13.
Rheumatology (United Kingdom) ; 61(SUPPL 1):i105, 2022.
Article in English | EMBASE | ID: covidwho-1868413

ABSTRACT

Background/Aims The substantial personal and socioeconomic costs associated with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (SpA) make understanding their epidemiology crucial. The Clinical Practice Research Datalink (Aurum) is an electronic healthcare record (EHR) database, containing primary care records from ≥20% of English practices (>13 million patients currently registered). To determine RA/PsA/axial SpA epidemiology using EHR data, validated methods need to be applied to ascertain patients with these diagnoses. To address this, we updated and applied approaches validated in other primary care EHR databases in Aurum and described the annual incidence/point-prevalence of RA/PsA/axial SpA alongside patient characteristics (providing indirect evidence of coding accuracy). Methods Diagnosis and synthetic disease-modifying anti-rheumatic drug (DMARD) prescription code lists were constructed, and pre-defined approaches for ascertaining patients with RA/axial SpA/PsA applied. The annual incidence and point-prevalence of RA/PsA/axial SpA were calculated from 2004-2020. Samples were stratified by age/gender, and mean age and gender/ethnic-group relative frequencies described. The study was approved by the CPRD Independent Scientific Advisory Committee (reference 20-000244). Results From 2004-2019 the point-prevalence of RA/PsA increased annually, peaking in 2019 (RA 7.79/1,000;PsA 2.87/1,000) then falling slightly. From 2004-2020 the point-prevalence of axial SpA increased annually (except in 2018/2019), peaking in 2020 (1.13/1,000). Annual RA incidence was higher between 2013-2019 (when included in the Quality Outcomes Framework, ranging 0.491 to 0.521/1,000 personyears) than 2004-2012 (ranging 0.345 to 0.400/1,000 person-years). The annual incidence of PsA and axial SpA increased from 2006 (0.108 to a peak of 0.172/1,000 person-years) and 2010 (0.025 to a peak of 0.045/1,000 person-years), respectively. These years were when new disease classification criteria were introduced. Marked falls in the annual incidence of RA, PsA and axial SpA between 2019 and 2020 were seen, reducing by 40.1%, 67.4% and 38.1%, respectively, reflecting the impact of the COVID-19 pandemic on arthritis diagnoses. Stratifying incidence/prevalence by age/gender broadly showed expected patterns (although the incidence of axial SpA/PsA in women increased over time), and the mean age and gender proportions followed those previously reported. Conclusion The approaches we used to determine patients with RA, PsA, and axial SpA in Aurum led to incidence/prevalence estimates broadly consistent with published studies, and patient characteristics as would be expected. These data support the potential of the Aurum-updated ascertainment approaches for use in further studies of RA, PsA and axial SpA.

14.
13th Annual First Year Engineering Experience, FYEE 2020 ; 2021.
Article in English | Scopus | ID: covidwho-1716795
15.
J Med Internet Res ; 23(12): e28610, 2021 12 22.
Article in English | MEDLINE | ID: covidwho-1591657

ABSTRACT

BACKGROUND: Inequities in access to health services are a global concern and a concern for Canadian populations living in rural areas. Rural children hospitalized at tertiary children's hospitals have higher rates of medical complexity and experience more expensive hospitalizations and more frequent readmissions. The 2 tertiary pediatric hospitals in Alberta, Canada, have already been operating above capacity, but the pediatric beds at regional hospitals are underused. Such imbalance could lead to poor patient safety and increased readmission risk at tertiary pediatric hospitals and diminish the clinical exposure of regional pediatric health care providers, erode their confidence, and compel health systems to further reduce the capacity at regional sites. A Telemedicine Rounding and Consultation for Kids (TRaC-K) model was proposed to enable health care providers at Alberta Children's Hospital to partner with their counterparts at Medicine Hat Regional Hospital to provide inpatient clinical care for pediatric patients who would otherwise have to travel or be transferred to the tertiary site. OBJECTIVE: The aim of this study is to identify perceived barriers and enablers to implementing the TRaC-K model. METHODS: This study was guided by the Theoretical Domains Framework (TDF) and used qualitative methods. We collected qualitative data from 42 participants from tertiary and regional hospitals through 31 semistructured interviews and 2 focus groups. These data were thematically analyzed to identify major subthemes within each TDF domain. These subthemes were further aggregated and categorized into barriers or enablers to implementing the TRaC-K model and were tabulated separately. RESULTS: Our study identified 31 subthemes in 14 TDF domains, ranging from administrative issues to specific clinical conditions. We were able to merge these subthemes into larger themes and categorize them into 4 barriers and 4 enablers. Our findings showed that the barriers were lack of awareness of telemedicine, skills to provide virtual clinical care, unclear processes and resources to support TRaC-K, and concerns about clear roles and responsibilities. The enablers were health care providers' motivation to provide care closer to home, supporting system resource stewardship, site and practice compatibility, and motivation to strengthen tertiary-regional relationships. CONCLUSIONS: This systematic inquiry into the perceived barriers and enablers to the implementation of TRaC-K helped us to gain insights from various health care providers' and family members' perspectives. We will use these findings to design interventions to overcome the identified barriers and harness the enablers to encourage successful implementation of TRaC-K. These findings will inform the implementation of telemedicine-based interventions in pediatric settings in other parts of Canada and beyond. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.1186/s12913-018-3859-2.


Subject(s)
Telemedicine , Alberta , Child , Hospitals, Pediatric , Humans , Qualitative Research , Referral and Consultation
16.
British Journal of Surgery ; 108:1, 2021.
Article in English | Web of Science | ID: covidwho-1535696
19.
American Journal of Respiratory and Critical Care Medicine ; 203(9):1, 2021.
Article in English | Web of Science | ID: covidwho-1407019
20.
Parliamentary Affairs ; 74(3):597-616, 2021.
Article in English | Scopus | ID: covidwho-1367043

ABSTRACT

Coronavirus upended British politics in 2020 but where does it fit into the ideological map of party competition? Recent British elections have seen a shift from economic left-right competition between the major parties to competition on the cultural (liberal-authoritarian) dimension, most notably in terms of the issues of immigration and membership of the European Union. Using British Election Study data from June 2020, we find that coronavirus attitudes fall primarily onto the traditional economic left-right dimension, with left-wing voters more willing to make economic sacrifices of various types to reduce infections. However, more draconian coronavirus measures (such as fining or imprisoning those who violate the coronavirus rules) are most supported by voters who score high on authoritarianism. We show that the structure of coronavirus attitudes puts the Conservative government in a difficult position where many steps it takes to reduce infections risk alienating its core economic right-wing vote. © 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the Hansard Society;all rights reserved.

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