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1.
Alzheimer's & Dementia ; 18 Suppl 9:e065137, 2022.
Article in English | MEDLINE | ID: covidwho-2172393

ABSTRACT

BACKGROUND: The COVID-19 pandemic and associated restrictions have greatly affected the delivery of treatment and access to in-person interventions for dementia, especially in low- and middle-income countries such as India. Technology use could potentially help bring the above-mentioned services to persons with dementia (PwD) and their caregivers in the safety of their homes. The aim of this study is to evaluate the dementia care services delivered by the Dementia Care in SCARF (DEMCARES) team in the densely populated city of Chennai in South India during the COVID-19 pandemic.

2.
Computational and Mathematical Biophysics ; 10(1):281-303, 2022.
Article in English | Scopus | ID: covidwho-2197311

ABSTRACT

In this study, we develop a mathematical model incorporating age-specific transmission dynamics of COVID-19 to evaluate the role of vaccination and treatment strategies in reducing the size of COVID-19 burden. Initially, we establish the positivity and boundedness of the solutions of the non controlled model and calculate the basic reproduction number and do the stability analysis. We then formulate an optimal control problem with vaccination and treatment as control variables and study the same. Pontryagin's Minimum Principle is used to obtain the optimal vaccination and treatment rates. Optimal vaccination and treatment policies are analysed for different values of the weight constant associated with the cost of vaccination and different efficacy levels of vaccine. Findings from these suggested that the combined strategies (vaccination and treatment) worked best in minimizing the infection and disease induced mortality. In order to reduce COVID-19 infection and COVID-19 induced deaths to maximum, it was observed that optimal control strategy should be prioritized to the population with age greater than 40 years. Varying the cost of vaccination it was found that sufficient implementation of vaccines (more than 77 %) reduces the size of COVID-19 infections and number of deaths. The infection curves varying the efficacies of the vaccines against infection were also analysed and it was found that higher efficacy of the vaccine resulted in lesser number of infections and COVID induced deaths. The findings would help policymakers to plan effective strategies to contain the size of the COVID-19 pandemic. © 2022 Bishal Chhetri et al., published by De Gruyter.

3.
Information Technology and Tourism ; 24(2):165-179, 2022.
Article in English | CAB Abstracts | ID: covidwho-2035475

ABSTRACT

This viewpoint article proposes an enabling framework that identifies the use of various blockchain technologies in tourism and their applications (digitalization, automation, disintermediation, and intelligent environment) across the different stages of travel (pre-trip, during the trip, and post-trip). As we know, the tourism sector contributes immensely to world GDP and job creation. However, the COVID-19 pandemic, even after two years since it first appeared, continues to adversely impact the tourism prospects of countries across the world due to nationwide lockdowns and travel restrictions. As the world tries to adapt to the "new normal," the tourism sector is forced to re-think its ways of doing business and bring about innovations to facilitate the new norms of contactless and safe transactions. Also, the sector, more than ever, need to effectively deal with its inherent challenges such as transparency and credibility of information, fraudulent practices, opportunistic behavior of intermediaries, and foreign currency risks. Blockchain technology can transform the tourism sector by offering innovative solutions that address its pressing issues. However, our current understanding of blockchain application in tourism is quite limited, with previous work being largely fragmented and narrow in terms of both scope and application. We foresee that the insights offered in this viewpoint, including the framework, will advance both theory and practice and facilitate the implementation of blockchain-enabled solutions across different travel stages.

4.
World Cancer Research Journal ; 9, 2022.
Article in English | Scopus | ID: covidwho-2026564

ABSTRACT

Objective: The objective of the study is to estimate the level of the COVID-19 related stress and perceived stress and the pattern of coping styles among Oncology Health Care Workers (OHCW) during the COVID-19 pandemic. Patients and Methods: The cross-sectional study was conducted in a tertiary cancer centre in the rural part of Kerala (India). The OHCW working in the centre during the COVID-19 pandemic were included, andstudents and observers were excluded from the study. The COVID-19 stress rat-ing scale, perceived stress scale and brief-COPE were used to collect the data. Results: Data were collected when the COVID-19 cases were in their first peak in Kerala. Two hundred and eighty two OHCW participated in the study.The COVID-19 stress of 5 or above was reported by 48.6% of OHCW. More than half (59.6%) of them reported moderate to severe perceived stress. On the Brief-COPE scale, the mean score of approach coping was 35.58 and of avoidance coping was 24.26. A significant positive correlation (r =0.347) was found between COVID-19 related stress and perceived stress. Significantly high stress was found among males, front office staff, those between 30 and 40 years, with a history of the COVID-19 contact and those with co-morbidity. Conclusions: Although half of the OHCW reported high COVID-19 related stress and perceived stress, they used an approach coping style to deal with the stress during this pandemic. © 2022, Verduci International. All rights reserved.

5.
Indian Pediatrics ; 59(5):427-428, 2022.
Article in English | EMBASE | ID: covidwho-1935887
6.
7.
Sens Int ; 3: 100169, 2022.
Article in English | MEDLINE | ID: covidwho-1712979

ABSTRACT

The coronavirus disease2019 (COVID-19) pandemic has highlighted the need for disposable biosensors that can detect viruses in infected patients quickly due to fast response and also at a low cost.The present review provides an overview of the applications of disposable biosensors based on metal nanoparticles in enzymatic and non-enzymatic sensors with special reference to glucose and H2O2, immunosensors as well as genosensors (DNA biosensors in which the recognized event consists of the hybridization reaction)for point-of-care diagnostics. The disposable biosensors for COVID19 have also been discussed.

8.
Indian Pediatrics ; 59(1):51-57, 2022.
Article in English | Web of Science | ID: covidwho-1694235

ABSTRACT

Justification Data generated after the first wave has revealed that some children with Coronavirus 19 (COVID-19) can become seriously ill. Multi-inflammatory syndrome in children (MIS-C) and long COVID cause significant morbidity in children. Prolonged school closures and quarantine have played havoc with the psychosocial health of children. Many countries in the world have issued emergency use authorisation (EUA) of selected COVID-19 vaccines for use in children. In India, a Subject Expert Committee (SEC) has recommended the use of Covaxin (Bharat Biotech) for children from the ages of 2-18 years. The recommendation has been given to the Drugs Controller General of India (DCGI) for final approval. Objective To provide an evidence-based document to guide the pediatricians on the recommendation to administer COVID vaccines to children, as and when they are available for use. Process Formulation of key questions was done by the committee, followed by review of literature on epidemiology and burden of COVID-19 in children, review of the studies on COVID vaccines in children, and the IAP stand on COVID-19 vaccination in children. The available data was discussed in the ACVIP focused WhatsApp group followed by an online meeting on 24 October, 2021, wherein the document was discussed in detail and finalized. Recommendations The IAP supports the Government of India's decision to extend the COVID-19 vaccination program to children between 2-18 years of age. Children with high-risk conditions may be immunized on a priority basis. The IAP and its members should be a partner with the Government of India, in the implementation of this program and the surveillance that is necessary following the roll-out.

9.
Biomedical Research and Therapy ; 8(10):4612-4613, 2021.
Article in English | Web of Science | ID: covidwho-1689724

ABSTRACT

The second wave of coronavirus disease 19 (COVID-19) has hit India badly with a rapid surge of cases. One of the greatest challenges in managing infections from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the incomplete knowledge regarding the disease course, hypersensitivity, and relative resistance in a number of individuals. Recently, it has been reported that besides the Angiotensin-converting enzyme 2 (ACE2), certain sialic acids present on the cell surface may also function as potential receptors for binding the spike protein of SARS-CoV-2. In this brief commentary we briefly discuss the role of sialic acids in SARS-CoV-2 infection and suggest more research investigations pertaining to this arena. This may pave the way for breakthrough solutions to combat the current pandemic more effectively by developing specific drug-targeted therapies.

10.
World Cancer Research Journal ; 9:8, 2022.
Article in English | Web of Science | ID: covidwho-1668562

ABSTRACT

Objective: The objective of the study is to estimate the level of the COVID-19 related stress and perceived stress and the pattern of coping styles among Oncology Health Care Workers (OHCW) during the COVID-19 pandemic. Patients and Methods: The cross-sectional study was conducted in a tertiary cancer centre in the rural part of Kerala (India). The OHCW working in the centre during the COVID-19 pandemic were included, andstudents and observers were excluded from the study. The COVID-19 stress rating scale, perceived stress scale and brief-COPE were used to collect the data. Results: Data were collected when the COVID-19 cases were in their first peak in Kerala. Two hundred and eighty two OHCW participated in the study. The COVID-19 stress of 5 or above was reported by 48.6% of OHCW. More than half (59.6%) of them reported moderate to severe perceived stress. On the Brief-COPE scale, the mean score of approach coping was 35.58 and of avoidance coping was 24.26. A significant positive correlation (r =0.347) was found between COVID-19 related stress and perceived stress. Significantly high stress was found among males, front office staff, those between 30 and 40 years, with a history of the COVID-19 contact and those with co-morbidity. Conclusions: Although half of the OHCW reported high COVID-19 related stress and perceived stress, they used an approach coping style to deal with the stress during this pandemic.

11.
Circulation ; 144(SUPPL 1), 2021.
Article in English | EMBASE | ID: covidwho-1630124

ABSTRACT

A previously healthy 27 years-old male presented with 2 weeks of substernal chest pain, progressive dyspnea, palpitations, dizziness, and(&) fever. On exam, he had tachypnea & tachycardia, was hypotensive with an elevated JVP & muffled heart sounds. Labs showed elevated WBC, CRP, lactate & high sensitive troponin. Negative for COVID-19, flu. EKG showed sinus tachycardia. CT showed large pericardial effusion with gas in the pericardial space. Echo (Figure 1) revealed large pericardial effusion with tamponade. Emergent pericardiocentesis was performed draining a liter of straw-colored thick fluid (fluid: serum LDH >3) (Figure 2). Cultures grew Strep. Anginosus & Propionibacterium acnes. Extensive infectious & immunological workup returned negative. He had initially improved on broad-spectrum antibiotics however declined clinically on day 5. Repeat CT (Figures 3 & 4) showed recurrent pericardial effusion & mediastinal abscess with trace extravasation of contrast from the esophagus to posterior mediastinum. We present a case of esophageal perforation leading to Pyopneumopericardium. Stephenson et al. reported a case series of 13 patients with esophagopericardial fistulas & pyopneumopericardium with a 100% mortality rate. Another case series showed survival rates of only 17% in 60 patients with pyopneumopericardium secondary to esophageal perforation. Erosion of esophageal ulcers, ingestion of foreign body, iatrogenic, trauma, malignancy, localized inflammation can lead to esophageal perforation. Streptococcus pneumoniae & Staphylococcus aureus are common pathogens involved. Constrictive pericarditis is a possible complication in up to 20 to 30%. Our patient underwent pericardial window & surgical debridement followed by EGD-guided gastro-jejunal tube placement. He did well after 4 weeks of IV antibiotics. Our case demonstrates that early recognition & intervention can favorably alter the course of this potentially fatal cardiac condition.

12.
Indian Pediatrics ; 17:17, 2021.
Article in English | MEDLINE | ID: covidwho-1589624

ABSTRACT

JUSTIFICATION: Data generated after the first wave has revealed that some children with coronavirus 19 (COVID-19) can become seriously ill. Multi-inflammatory syndrome in children (MIS-C) and long COVID cause significant morbidity in children. Prolonged school closures and quarantine have played havoc with the psychosocial health of children. Many countries in the world have issued emergency use authorisation (EUA) of selected COVID-19 vaccines for use in children. In India, a Subject Expert Committee (SEC) has recommended the use of Covaxin (Bharat Biotech) for children from the ages of 2-18 years. The recommendation has been given to the Drugs Controller General of India (DCGI) for final approval. OBJECTIVE: To provide an evidence-based document to guide the pediatricians on the recommendation to administer COVID vaccines to children, as and when they are available for use. PROCESS: Formulation of key questions was done by the committee, followed by review of literature on epidemiology and burden of Covid-19 in children, review of the studies on COVID vaccines in children, and the IAP stand on Covid-19 vaccination in children. The available data was discussed in the ACVIP focused WhatsApp group followed by an online meeting on 24 October, 2021, wherein the document was discussed in detail and finalized. RECOMMENDATIONS: The IAP supports the Govt. of India's decision to extend the COVID-19 vaccination program to children between 2-18 years of age. Children with high-risk conditions may be immunized on a priority basis. The IAP and its members should be a partner with the Government of India, in the implementation of this program and the surveillance that is necessary following the roll-out.

13.
Biomedical Research and Therapy ; 8(11):4679-4681, 2021.
Article in English | Web of Science | ID: covidwho-1579701

ABSTRACT

The current manuscript sheds light on the possible role of bioaerosols (from mouth breathing) that may serve as vectors for transmitting COVID-19 in asymptomatic carriers reporting to dental hospitals and, hence, may pose a great challenge for even a simple orthodontic diagnosis. Further, we would like to add a few preventive considerations for containment of this novel disease spread via bioaerosols emitted, particularly during mouth breathing.

14.
Computational and Mathematical Biophysics ; 9(1):146-174, 2021.
Article in English | Scopus | ID: covidwho-1496579

ABSTRACT

The dynamics of COVID-19 in India are captured using a set of delay differential equations by dividing a population into five compartments. The Positivity and Boundedness of the system is shown. The Existence and Uniqueness condition for the solution of system of equations is presented. The equilibrium points are calculated and stability analysis is performed. Sensitivity analysis is performed on the parameters of the model. Bifurcation analysis is performed and the critical delay is calculated. By formulating the spread parameter as a function of temperature, the impact of temperature on the population is studied. We concluded that with the decrease in temperature, the average infections in the population increases. In view of the coming winter season in India, there will be an increase in new infections. This model falls in line with the characteristics that increase in isolation delay increases average infections in the population. © 2021 D Bhanu Prakash et al.

15.
Indian Pediatrics ; 58(7):647-649, 2021.
Article in English | GIM | ID: covidwho-1491447

ABSTRACT

Justification: In India, till recently, breastfeeding women have been excluded from the coronavirus disease (COVID-19) vaccination program, rendering a significant population of the country, including frontline workers, ineligible to derive the benefits of the COVID-19 vaccine rollout.

17.
Lancet Rheumatol ; 3(9): e615-e616, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1321531
18.
American Journal of Human Genetics ; 108(7):1350-1355, 2021.
Article in English | Web of Science | ID: covidwho-1312879

ABSTRACT

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a respiratory illness that can result in hospitalization or death. We used exome sequence data to investigate associations between rare genetic variants and seven COVID-19 outcomes in 586,157 individuals, including 20,952 with COVID-19. After accounting for multiple testing, we did not identify any clear associations with rare variants either exome wide or when specifically focusing on (1) 13 interferon pathway genes in which rare deleterious variants have been reported in individuals with severe COVID-19, (2) 281 genes located in susceptibility loci identified by the COVID-19 Host Genetics Initiative, or (3) 32 additional genes of immunologic relevance and/or therapeutic potential. Our analyses indicate there are no significant associations with rare protein-coding variants with detectable effect sizes at our current sample sizes. Analyses will be updated as additional data become available, and results are publicly available through the Regeneron Genetics Center COVID-19 Results Browser.

19.
Journal of Clinical and Diagnostic Research ; 15(5):ZC32-ZC37, 2021.
Article in English | EMBASE | ID: covidwho-1261426

ABSTRACT

Introduction: Coronavirus Disease 2019 (COVID-19) has spread like wildfire across the globe affecting all the age-groups. Children usually present with mild symptoms or may even remain asymptomatic. Due to the asymptomatic presentation, they may act as silent carriers and aid in the spread of infection, hence prompting greater vigilance. Therefore, it becomes imperative to increase awareness among children and alter their habits in order to curb the pandemic. Aim: This study aimed to assess the level of awareness among children regarding coronavirus infection and the behavioural changes they wish to make post-COVID-19. Additionally, it also recorded the recommendations of children for their schools to curb the COVID-19 infection. Materials and Methods: This cross-sectional study was conducted among 246 private school going children across India in 9-15 years age group. Questionnaire was circulated via online platform which assessed the level of awareness regarding COVID-19, its influence on their behavioural patterns and recommendations of children for their schools. The mean knowledge scores were recorded for first part and chi-square test was employed to evaluate the changes in behaviour before and after COVID-19 for second part. For the third part, percentage for each response was determined. Data was compiled in MS Office Excel sheet (version 2019, Microsoft Redmond Campus, Redmond, Washington, United States). Statistical analysis was performed on Statistical Package for the Social Sciences version 16.0( SPSS) software. Results: The average knowledge score was 85.50%. This increased awareness among children was reflected in the statistically significant difference in their behavioural patterns before and after COVID-19 (p-value <0.05) and also in the recommendations given by children to their schools. Conclusion: To the best of our knowledge, this is a pioneer study assessing the awareness of COVID-19 in children and its impact on their behaviour pattern. Children showed good knowledge about COVID-19 with the average knowledge score of the entire sample being 85.50% and also wished to make changes in their behaviour post-COVID-19. Additionally, schools are also required to make numerous amendments in their functioning in order to provide a safe environment. This study will serve as a basis for future awareness programmes which could be directed towards children belonging to various socioeconomic status and educational backgrounds highlighting the aspects in which they lack knowledge.

20.
Indian Pediatrics ; 28:28, 2021.
Article in English | MEDLINE | ID: covidwho-1245155

ABSTRACT

JUSTIFICATION: In India, till recently, breastfeeding women have been excluded from the coronavirus disease (COVID-19) vaccination program, rendering a significant population of the country, including frontline workers, ineligible to derive the benefits of the COVID-19 vaccine rollout. OBJECTIVE: The objective of this recommendation is production of an evidence-based document to guide the pediatricians to give advice to breastfeeding mothers regarding the safety of COVID-19 vaccines in lactating women. PROCESS: Formulation of key question was done under the chairmanship of president of the IAP. It was followed by review of literature regarding efficacy and safety of COVID-19 vaccines in breastfeeding women. The recommendations of other international and national professional bodies were also deliberated in detail. The available data was discussed in the ACVIP focused WhatsApp group. Opinion of all members was taken and the final document was prepared after achieving consensus. RECOMMENDATIONS: The IAP/ACVIP recommends the administration of COVID-19 vaccines to all breastfeeding women. The IAP/ACVIP endorses the recent recommendation of the Government of India, to consider all breastfeeding women as eligible for COVID-19 vaccination.

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