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Frontiers in Blockchain ; 4:9, 2021.
Article in English | Web of Science | ID: covidwho-1613544


As the (Covid-19) pandemic spreads, the creativity of the scientific community is thriving while trying to control the situation. They are trying to treat patients viably and work with the almost exhausted medical equipment and staff, while growing new, successful antibodies. Successful screening of SARS-CoV-2 empowers fast and proficient determination of COVID-19 and can relieve the weight on medical care frameworks. Numerous forecast models are being created to comprehend and prognosticate the spread of the pandemic and to stay away from the following wave. But in the coming time, we can be sure that the models would experience the ill effects of a few issues, security being one of them. All the models need to be built in such a way that the investigation task gets successfully conducted without compromising the privacy and security of the patients. To take care of this, we propose a blockchain framework for sharing patients' personal data or medical reports. A blockchain will take care of the integrity part, but we still need to worry about confidentiality. Therefore, combining a genetic approach with a blockchain seemed like a good idea. A twofold hybrid methodology is proposed in this paper to tackle the issue of confidentiality. The outcomes displayed high entropy accomplishment for the utilized dataset. The sensitivity of the plaintext and ciphertext is also checked and compared with existing approaches which thus demonstrates the security of the proposed approach in the given setting.

Journal of Association of Physicians of India ; 69(10):17-23, 2021.
Article in English | Scopus | ID: covidwho-1469268


Background: There is more than twofold rise in prevalence of mucormycosis cases in India during the COVID-19 pandemic which needs to be evaluated. Aims: The study aimed to document the spectrum of cases of mucormycosis seen at our Institute during COVID-19 times. Methods: The study is a retrospective observational study carried out at our Institute from May 2021 to mid-June 2021. All patients with biopsy-proven mucormycosis were enrolled in the study. The patients were subjected to complete history taking, ophthalmological examination, and imaging studies. The patients were treated with a multidisciplinary approach with antifungal therapy as well as surgical intervention when needed. Results: Ten patients (n=10) were seen, with a mean age of 50.3 years. The major risk factors included recent use of steroids, uncontrolled diabetes, and CKD. The most common presentation was swelling of unilateral eye and ptosis, followed by loss of vision. Inflammatory marker (CRP) and d-dimer were raised at presentation in all cases. Imaging showed the spread of infection from paranasal sinus to orbit and brain via cavernous sinus, which was a poor prognostic factor. Intravenous Amphotericin-B was given to all patients for at least 4 weeks. Two patients were discharged after completion of treatment and mortality was seen in three patients. Conclusion: We present an array of COVID-associated-mucormycosis (CAM) cases from Eastern India. CAM is presenting with rhino-orbito-cerebral involvement. There is poor outcome with cerebral involvement and high incidence of adverse effects with deoxycholate formulation of amphotericin-B. The causal association of COVID-19 with mucormycosis needs to be unearthed but possible preventive role of anticoagulation should be evaluated. © 2021 Journal of Association of Physicians of India. All rights reserved.

Current Biotechnology ; 10(1):3-6, 2021.
Article in English | EMBASE | ID: covidwho-1264277


The current SARS coronavirus-2 (SARS-CoV-2) pandemic has raised serious concerns regarding the inefficiency of available diagnostic methods for rapid and efficient detection of the disease. It is agreed widely that Real-time Polymerase Chain Reaction (RT-PCR) and antibody-based assays have several limitations that did not help much in preventing the exponential spread of the disease in a short span of period. Unarguably, the world needs “new-generation diagnostic intervention(s)” against rapidly spreading disease like SARS-CoV-2. We have presented an aptamer-based strategy as a possible point of care testing for the diagnosis of the disease. It has several advantages over current tools available and can be used for efficient combating by the mean of quick,cost-effective and much more accurate diagnostic against the enigmatic SARS-CoV-2 disease and similar pandemic which world may possibly encounter in the future.