Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 27
Filter
1.
Chest ; 162(4):A287, 2022.
Article in English | EMBASE | ID: covidwho-2060551

ABSTRACT

SESSION TITLE: Cardiovascular Complications in Patients with COVID-19 SESSION TYPE: Rapid Fire Case Reports PRESENTED ON: 10/19/2022 12:45 pm - 1:45 pm INTRODUCTION: Cardiac manifestations of coronavirus disease 2019 (COVID-19) including bradyarrhythmias (BA) are well documented. Postulated mechanisms include direct myocardial injury through viral invasion, myocyte hypoxia, angiotensin-II receptor downregulation, hypercytokinemia and medication-related adverse events. Currently, there are no clear guidelines on the management of severe BA in the setting of COVID-19, including the threshold for permanent pacemaker (PPM) placement. We present a retrospective case series involving five COVID-19 patients with no prior history of cardiovascular disease, who developed severe BA of heart rate < 45 beats per minute. CASE PRESENTATION: Three females and two males were included in the series, with a median age of 50 years (IQR 36-61.5). Sinus bradycardia and high degree heart block were seen in two patients each. Most of the patients were noted to have sinus pauses. Inflammatory markers including D-dimer, LDH, and CRP were elevated. The median CRP in our patients was 106 mg/L (IQR 83.2-208.1) and median D-dimer was 5.63 ug/ml (IQR 1.8-13.2). All patients were treated with dexamethasone and remdesivir. However only one patient was on remdesivir on the day of onset of bradycardia. Four patients were critically ill, requiring ICU care with mechanical ventilation. Two patients required temporary transvenous pacing, one was supported on extracorporeal membrane oxygenation, and one was given atropine. No patient required PPM placement. Two deaths were observed but were not due to BA. DISCUSSION: In this single center, retrospective case series, 5 patients with COVID-19 infection developed severe BA prompting intervention. Laboratory findings demonstrated significantly elevated inflammatory markers in all our patients. The median CRP and D-Dimer in our patients was higher than the median inflammatory markers seen in a systematic review of patients with COVID-19 associated bradycardia showing that the patients in our series were suffering from severe inflammatory state. It was also observed that despite having no prior cardiac history, those more critically ill with COVID-19 infection developed severe BA requiring intervention. Conservative management and reversal of the underlying etiology prevented need for PPM implantation despite two patients developing high-grade atrioventricular-block, and one recurrent asystole. CONCLUSIONS: This preliminary data suggests that even severe BA that develops after COVID-19 infection may not require PPM placement. Further studies are required to elucidate implications, assess the reversibility, and clarify potential therapeutic targets including the indications for PPM in COVID-19 associated bradycardia. Reference #1: Nagamine, Todd et al. "Characteristics of bradyarrhythmia in patients with COVID-19: Systematic scoping review.” Pacing and clinical electrophysiology : PACE, 10.1111/pace.14466. 19 Feb. 2022, doi:10.1111/pace.14466 Reference #2: Chinitz, Jason S et al. "Bradyarrhythmias in patients with COVID-19: Marker of poor prognosis?.” Pacing and clinical electrophysiology : PACE vol. 43,10 (2020): 1199-1204. doi:10.1111/pace.14042 DISCLOSURES: No relevant relationships by Dipanjan Banerjee No relevant relationships by Monika Bernas No relevant relationships by Sandeep Randhawa No relevant relationships by Parthav Shah

2.
3rd International Conference on Emerging Technologies in Data Mining and Information Security, IEMIS 2022 ; 490:605-611, 2023.
Article in English | Scopus | ID: covidwho-2059760

ABSTRACT

The impact of COVID-19 over various sectors has continued to interest researchers. This work will investigate the impact of COVID-19 for economic uncertainty and gold price across various countries. This investigative research is done with the help of panel data concept programming packages associated with the R programming language, and therefore, we can call it longitudinal research. The current research deals with two important features related to COVID. These two are monthly COVID patient average and monthly COVID death average, and data is collected from countries such as India, China, Russia, USA, UK, Japan and Germany and apply panel data regression techniques to understand whether these two COVID-related factors significantly impact upon economic uncertainty and gold prices. The current work also observes that the monthly confirmed COVID patient average has more impact across the spectrum of countries on the economic policy uncertainty and the gold price in these countries compared to the other feature, i.e. monthly average COVID death tolls. The same conclusions have been made in the graphical as depicted below. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

3.
Studies in Big Data ; 114:13-31, 2022.
Article in English | Scopus | ID: covidwho-2048190

ABSTRACT

The outbreak of the deadly Covid-19 virus has snatched smiles from everyone’s face and now the entire world has been affected directly or indirectly by the effects of the virus, this virus keeps on mutating due to which there is no proper medicine or a final vaccine that assures it will curb the spread of the virus, major countries all over the world has lost more people than in a war and is still losing its people even after getting fully vaccinated. The horror is so much imbibed in each human it seems unrealistic to even think that the world will be normal ever again. This outbreak of the unknown virus is certainly a black-swan event that has annihilated people economically, emotionally, and socially and has made each individual realize the importance of one’s health and how to be a responsible person by taking care of whatever finances one has, as in unprecedented times savings are the only resort left with a person. It is a testing time and everyone is at war, we all are soldiers in this pandemic and our health care workers, administration, and government are trying their best to stop the spread of the disease as it has killed more than four lakh people in India only and in the world tally is more than forty lakhs with numbers increasing. In this appalling situation when everything has been shifted to online mode solutions must be looked at in more technologically driven methods, in today’s world due to rapid advancement in the IT and computer science sector there are ways to track the next rising hotspot of the virus and how it can be contained by taking swift actions if predicted within a particular time frame. Data collection, data analysis, and studying trends can help in assessing the upcoming threats, and in this manner, new job opportunities can also be created as it will involve people being prepared with limited medical knowledge to cure the people affected with the virus. In these times government and administration must adopt technologically backed solutions which will help the system to make accurate decisions based on real-time data-driven modeling capable of identifying the relevant information. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

4.
Indian Journal of Psychiatry ; 64, 2022.
Article in English | Web of Science | ID: covidwho-2003429
5.
6th International Conference on Computational Intelligence in Data Mining, ICCIDM 2021 ; 281:433-443, 2022.
Article in English | Scopus | ID: covidwho-1872355

ABSTRACT

COVID-19 has impacted the world unlike any other world event in our recent memory. Entire humanity has been afflicted by this pandemic. As a consequence of the pandemic, the governments around the world have decided to impose lockdowns restricting economic interactions and relationships in a scale and form which has not been witnessed by the modern man ever in his memory. The general assumption here is that growing COVID-19 patient and mortality counts give rise to a greater sense of uncertainty, and this greatly impacts the prices. It is imperative thus for both the researcher community to observe and investigate the influence of COVID-19 patient and mortality counts on geopolitical and economic index indicators as well as the influence of these COVID-19 indicators upon important economic indicators such as the gold price as well as stock market prices. For this specific purpose, this work investigates the influence of COVID-19 patient and monthly death counts on the economic indicators of gold and stock market prices. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

6.
PubMed; 2021.
Preprint in English | PubMed | ID: ppcovidwho-333736

ABSTRACT

BACKGROUND: DNA methylation patterns of the human genome can be modified by environmental stimuli and provide dense information on gene regulatory circuitries. We studied genome-wide DNA methylation in nasal samples from infants (<6 months) applying whole-genome bisulfite sequencing (WGBS) to characterize epigenome response to 10 different respiratory viral infections including SARS-CoV-2. RESULTS: We identified virus-specific differentially methylated regions (vDMR) with human metapneumovirus (hMPV) and SARS-CoV-2 followed by Influenza B (Flu B) causing the weakest vs. strongest epigenome response with 496 vs. 78541 and 14361 vDMR, respectively. We found a strong replication rate of FluB (52%) and SARS-CoV-2 (42%) vDMR in independent samples indicating robust epigenome perturbation upon infection. Among the FluB and SARS-CoV-2 vDMRs, around 70% were hypomethylated and significantly enriched among epithelial cell-specific regulatory elements whereas the hypermethylated vDMRs for these viruses mapped more frequently to immune cell regulatory elements, especially those of the myeloid lineage. The hypermethylated vDMRs were also enriched among genes and genetic loci in monocyte activation pathways and monocyte count. Finally, we perform single-cell RNA-sequencing characterization of nasal mucosa in response to these two viruses to functionally analyze the epigenome perturbations. Which supports the trends we identified in methylation data and highlights and important role for monocytes. CONCLUSIONS: All together, we find evidence indicating genetic predisposition to innate immune response upon a respiratory viral infection. Our genome-wide monitoring of infant viral response provides first catalogue of associated host regulatory elements. Assessing epigenetic variation in individual patients may reveal evidence for viral triggers of childhood disease.

7.
Kidney international reports ; 7(2):S425-S426, 2022.
Article in English | EuropePMC | ID: covidwho-1695166
8.
Kidney International Reports ; 7(2):S425-S426, 2022.
Article in English | PMC | ID: covidwho-1693511
9.
5th International Conference on Electronics, Materials Engineering and Nano-Technology, IEMENTech 2021 ; 2021.
Article in English | Scopus | ID: covidwho-1662212

ABSTRACT

With the emergence of Covid-19, as more people got affected by the fatal disease, the demand for a device to measure the oxygen content in our body has grown up. Due to unavailability of effective treatments, the outcome for critically ill Covid-19 patients depends on the availability of supportive medical care. In the current scenario of limited resources, it is important to identify patients who require close monitoring and serious care, including supplementary oxygen. The rapid spread of this virus as a global pandemic has brought in prodigious challenges to the healthcare system. Several oximeters are currently available on the market that can be utilized for this purpose. However, because they are powered by batteries, their performance degrades over time as the battery drains. In comparison to the widely utilized IR sensor in pulse oximeters, the MAX sensor employed in the suggested device is better. During the second wave of Covid-19, as more people got affected by this life-threatening illness, India witnessed a surge in the demand for oxygen supply. In light of this, apart from the oximeter, we have also suggested a methodology to construct a DIY oxygen generator that can be made using easily available materials in case of an emergency. Water has a chemical formula H2O which can be broken into its constitutional elements H2 and O2. Water is already rich in hydroxide ions but adding sodium bicarbonate as a catalyst raises the OH-concentration even more, allowing it to be utilized as an electrolyte. This paper aims to design a technique to develop both these devices cost-effectively and reliably. © 2021 IEEE.

10.
Comparative Studies of South Asia, Africa and the Middle East ; 41(3):312-317, 2021.
Article in English | Scopus | ID: covidwho-1643222

ABSTRACT

The steady rollout of Covid-19 vaccines comes attached with a series of difficult questions. Are vaccines a human right? Should patents be enforced in a way that puts people in the global South behind in a global queue? These questions are not new;the world struggled with these ethical dilemmas during the HIV-AIDS pandemic at the end of the twentieth century, when global South governments led by Nelson Mandela fought multinational pharmaceutical corporations for the right to essential life-saving drugs. Can the same strategies be mobilized to deal with inequalities in the distribution of the Covid-19 vaccine? This article demonstrates a technological and geopolitical shift in the last two decades that hinder global South solidarities actualized during the HIV-AIDS pandemic. Instead, Banerjee argues that in the present, multinational corporations and Euro-American governments are trying to reverse some of the key political visions and victories of HIV-AIDS internationalism, exploiting the urgency of the Covid-19 crisis to put in place a new vaccine apartheid. © 2021 by Duke University Press.

11.
International Psychogeriatrics ; 33:49-50, 2021.
Article in English | Web of Science | ID: covidwho-1548131
12.
International Psychogeriatrics ; 33:27-27, 2021.
Article in English | Web of Science | ID: covidwho-1548130
13.
Rhode Island Medicine ; 104(10):53-55, 2021.
Article in English | MEDLINE | ID: covidwho-1539511
14.
Journal of the American Society of Nephrology ; 32:66, 2021.
Article in English | EMBASE | ID: covidwho-1490028

ABSTRACT

Background: Global reports on the rates, risk factors and outcomes of acute kidney injury (AKI) with COVID-19 exhibit high variability. We evaluated all patients admitted with AKI to our centre where COVID-19 status was determined by PCR, and assessed risk factors for poor outcomes including death. Methods: Retrospective study of all patients admitted with AKI between 13/03/2020 and 13/05/2020. All variables including COVID-19 status, demographics, co-morbidities and laboratory parameters were collected from electronic patient records. We used competing risk-regression models to assess association with mortality by subdistribution hazards ratio (SHR). Results: Of 576 patients admitted with AKI, 257 (43.6%) were positive for COVID-19. Demographics and clinical characteristics of our cohort included: mean age 66.7 years, 58% male, 40.5% Caucasian, 56.3% hypertension, 33.1% diabetes. Overall 52.5% patients had AKI stage 1, 18.6% AKI stage 2, and 28.8% AKI stage 3. Patients with AKI stage 3 were 3.4 (95% CI 2.27-5.02) times more likely to be diagnosed with COVID-19 than those with AKI stage 1. Other factors associated with an increased likelihood of COVID-19 diagnosis adjusted for AKI stage were young age (p=0.004), non-Caucasian ethnicity (p=0.001), low lymphocyte count (p=0.002) and raised CRP, ferritin and D-dimer (p=0.001). Case fatality percentage of this cohort was 32.5% (10%, 19% and 35% mortality in COVID-19 negative patients with AKI stages 1, 2 and 3 respectively, compared with 33%, 52% and 71% in the COVID-19 positive counterparts). Patients with COVID-19 were 3.6 (95% CI 2.2-4.3) times more likely to die than those negative for COVID-19 (p<0.001). Furthermore, death in patients with COVID-19 and AKI stage 3 occurred rapidly, with 50% of patients dying within 10 days, 70% within 15 days and 95% within 21 days of admission. Those in the same group who survived had prolonged recovery, with 50% remaining inpatients in hospital for over 31 days. Conclusions: In patients with AKI, those who were positive for COVID-19 was associated with severe AKI, younger age, non-Caucasian ethnicity, raised inflammatory markers, and suffered from high case fatality. Severity of AKI in conjunction with COVID-19 was associated with high and rapid death rates, or prolonged hospital admission with increased morbidity.

15.
COVID-19 in International Media: Global Pandemic Perspectives ; : 129-138, 2021.
Article in English | Scopus | ID: covidwho-1411275
16.
Indian Journal of Gynecologic Oncology ; 19(3), 2021.
Article in English | EMBASE | ID: covidwho-1343075

ABSTRACT

Objective: Paucity of resources and trained professionals makes it difficult to implement a cervical cancer screening program in India. This study aims to evaluate the feasibility of self-sampling for detection of human papillomavirus (HPV) DNA in a communitybased cervical cancer screening project. Methods: Women (30-60 years) were assigned to do self-sampling or get their samples collected by healthcare workers in outreach clinics. The samples were brought to the institute and were tested by hybrid capture2 (HC2) test for 13 high-risk HPV types. HC2 positive women were brought to the institute where they underwent colposcopy, biopsy and treatment by Thermal ablation, Cryotherapy or Loop Electrosurgical Excision Procedure (LEEP). A focussed group discussion was done with health workers involved with this project in the form of a questionnaire. Results: From May 2017 and December 2020, 15,311 women were recruited. Amongst them, 4916 (32.1%) had self-sampling and 10,395 (67.9%) had health-worker collected sample. The HC2 positivity rates in both groups were 269 (5.5%) and 652 (6.3%), which was not significantly different statistically (P = 0.06). The colposcopy rates and Cervical Intraepithelial Neoplasia (CIN) 2 and 3 detection rates were also similar. All women were comfortable with self-sampling with no sample inadequacy or wastage of collection kits. The health workers rated both procedures as acceptable. The advantage of selfsampling was that no examining table or light source was required and the screened women were less ''shy'' while sample collection. Conclusion: Self-sampling for HPV may increase participation in cervical cancer screening programs, especially in the COVID19 era.

17.
American Journal of Respiratory and Critical Care Medicine ; 203(9), 2021.
Article in English | EMBASE | ID: covidwho-1277672

ABSTRACT

INTRODUCTION: Mucormycosis is a potentially fatal fungal infection that often infects patients who are immunocompromised. We present a case of pulmonary mucormycosis in a young patient admitted for a new diagnosis of diabetes in the form of diabetic ketoacidosis (DKA). CASE REPORT: A 21-year-old man with no medical history presented to the Emergency Department in February 2020, with fevers, dyspnea, cough and pleuritic chest pain. He was tachycardic, febrile and had left sided rales on lung auscultation. Labs were consistent with DKA with leukocytosis. Chest X-Ray, confirmed by computed tomography, showed a consolidative opacity in the left lower lobe. He was admitted and treated for DKA and community acquired pneumonia. He had persistent fevers and worsening consolidative opacities. Antibiotics were broadened and pulmonary and infectious disease services were consulted. Negative microbiological testing included a viral respiratory panel, blood cultures, and urine legionella antigen. Sputum culture grew 2+ mixed respiratory flora. Two sputum samples had negative acid-fast bacilli smear and tuberculosis polymerase chain reaction. HIV antibody, serum 1,3-beta-D glucan and galactomannan assays were negative. He was placed on airborne precautions and tested for SARS-CoV 2. Bronchoscopy was deferred pending this result. He developed erythema on his right flank and punch biopsy was performed on hospital day 10 which grew mold. A bronchoscopy showed markedly necrotic and devitalized endobronchial tissue (Figure). Washings and endobronchial biopsies were notable for non-septate fungal hyphae with irregular branching. The patient was started on IV liposomal amphotericin and underwent urgent left lower lobectomy. Pathology demonstrated multiple tan-white firm nodules, thrombus obstructing the main vessels and red hepatization of the entire lobe. Further staining revealed acute fungal bronchopneumonia with angioinvasion, vascular thrombi and associated parenchymal infarction. Fungal organisms morphologically consistent with Mucorales were identified. He subsequently had sharp debridement of the right flank lesion. The patient was discharged home on day 24 with intravenous amphotericin B to continue for at least 3 months. DISCUSSION: Mucormycosis should be considered in a patient with progressive pulmonary opacities despite broad spectrum antibiotic administration. Patterns of involvement include rhinocerebral, pulmonary, cutaneous, and disseminated infection. Risk factors include uncontrolled diabetes mellitus, immunosuppression, and deferoxamine therapy. No predisposing condition is identified in 18% of patients. Prophylaxis with voriconazole and echinocandins does not prevent mucormycosis infection. Beta-D glucan and galactomannan antigens are usually normal. Treatment involves antifungal drugs and aggressive resection of affected tissue.

19.
J. Phys. Conf. Ser. ; 1797, 2021.
Article in English | Scopus | ID: covidwho-1139946

ABSTRACT

Covid-19 forced all the schools, colleges and universities to suspend their physical classrooms and implemented the digital transformations into the entire education system worldwide. The structure of teaching-learning-assessment methodology becomes affected by this closure. Just a handful of universities, colleges and schools might follow teaching methods online, but private, government and low-income schools, on the other hand, have totally shut down because they do not have access to e-learning solutions. The higher education industry has been profoundly impacted by the pandemic. However, the biggest concern to everyone is how the illness impacts the pace of work. Recent graduates in India fear that the present situation will result in work offers being withdrawn from companies. To manage the crisis and develop a long-term, resilient Indian education system, a multi-stakeholder strategy is required. © 2021 Institute of Physics Publishing. All rights reserved.

20.
International Psychogeriatrics ; 32(SUPPL 1):130, 2020.
Article in English | EMBASE | ID: covidwho-1108870

ABSTRACT

Introduction: Older adults are at disproportionate risk of serious disease and mortality due to the novel coronavirus (COVID-19) pandemic. Further, the global response to the lockdown has rendered older adults particularly vulnerable to loneliness and social isolation due to the physical distancing and shelter in place mandate. We hypothesized that both these factors would lead to an increase in geriatric mental health problems during the COVID-19 pandemic. Material and Methods: We undertook a clinical audit of all geriatric patients (above 60 years of age) attending the psychiatry emergency services at a tertiary care hospital. This audit was conducted over a period of 52 days dating from the cessation of non-essential services at the hospital as part of the national response to the COVID-19 pandemic (lockdown). We used descriptive statistics to summarize the number, age, sex, presenting complaint and diagnoses of our patients. We further compared the average number of geriatric patients attending the psychiatry emergency services in the hospital during the lockdown to that of geriatric patients attending the same in the year before the lockdown. Results: A total of 112 geriatric patients attended the psychiatry emergency services during the lockdown period. Of these, 62 were male and 50 female. The average number of geriatric patients attending the emergency services daily during this period (μ1 2.15) was significantly higher (z 5.36, p ≤ 0.01) than the average number of patients attending the emergency services in the year preceding the lockdown (μ2 1.34). The most common presenting complaint was agitation in the preceding weeks. The most common diagnoses were late onset schizophrenia spectrum disorders followed by affective disorders and major neurocognitive disorders. Discussion: The COVID-19 pandemic and the global response to the same constitute life events for older adults. They may contribute to biological, psychological and social risk factors for mental health problems in older adults during this period. The increase in geriatric patients attending our emergency services, despite an increase in restrictions on mobility which act as barriers in the pathway to care, is worrying. Under stimulation in older adults during this period may contribute to an increase in agitation.

SELECTION OF CITATIONS
SEARCH DETAIL