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Blood Purif ; 50(1): 102-109, 2021.
Article in English | MEDLINE | ID: covidwho-643726

ABSTRACT

BACKGROUND: There is no information on acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) among invasively ventilated coronavirus disease 2019 (COVID-19) patients in Western healthcare systems. OBJECTIVE: To study the prevalence, characteristics, risk factors and outcome of AKI and CRRT among invasively ventilated COVID-19 patients. METHODS: Observational study in a tertiary care hospital in Milan, Italy. RESULTS: Among 99 patients, 72 (75.0%) developed AKI and 17 (17.7%) received CRRT. Most of the patients developed stage 1 AKI (33 [45.8%]), while 15 (20.8%) developed stage 2 AKI and 24 (33.4%) a stage 3 AKI. Patients who developed AKI or needed CRRT at latest follow-up were older, and among CRRT treated patients a greater proportion had preexisting CKD. Hospital mortality was 38.9% for AKI and 52.9% for CRRT patients. CONCLUSIONS: Among invasively ventilated COVID-19 patients, AKI is very common and CRRT use is common. Both carry a high risk of in-hospital mortality.


Subject(s)
Acute Kidney Injury/etiology , Acute Kidney Injury/therapy , COVID-19/complications , COVID-19/therapy , Continuous Renal Replacement Therapy , Respiration, Artificial , Acute Kidney Injury/mortality , Aged , COVID-19/mortality , Cohort Studies , Female , Hospital Mortality , Humans , Male , Middle Aged , Prevalence , Risk Factors , SARS-CoV-2/isolation & purification , Treatment Outcome , Ventilators, Mechanical
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