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Nanoparticle Therapeutics: Production Technologies, Types of Nanoparticles, and Regulatory Aspects ; : 563-579, 2022.
Article in English | Scopus | ID: covidwho-2048736

ABSTRACT

A narrative intended for science interns and scientists to overview regulatory pathways and federal perspectives pertinent to the complexity of nanoparticle systems and chaos precipitated by the COVID-19 pandemic. It elaborates on fundamental aspects of US FDA guidance on nanotechnology. It juxtaposes guidance on nanotechnology with the COVID-19 guidance documents to get a deeper understanding of “good practices” in the context of professional response in chaotic, complex, complicated, and simple systems. The narrative spirals in on practical consideration for experiential learning to be self-assured. © 2022 Elsevier Inc. All rights reserved.

2.
African Journal of Accounting Auditing and Finance ; 7(4):326-345, 2021.
Article in English | Web of Science | ID: covidwho-1557626

ABSTRACT

It is crucial to conjecture the consequences of the COVID-19 for an economy, to plan its policy and guidelines at present, and to prepare itself for the future. In the finance world it is suggested by health experts to use more and more digital financial services (DFSs). Thus in this paper, we will try to understand the impact of COVID-19 on DFS and digital financial inclusion in India. This research suggests that the impact of COVID-19 is negative on financial inclusion, whereas some DFS were impacted positively. While some DFS have faced the negative as well as neutral impact during this pandemic. Overall it is concluded that the impact on DFS is neutral to date, but with time and with the opening up of an economy, the status of DFS is expected to improve, which in turn will improve the status of digital financial inclusion in India in the future.

3.
United European Gastroenterology Journal ; 9(SUPPL 8):892, 2021.
Article in English | EMBASE | ID: covidwho-1490999

ABSTRACT

Introduction: Following the first Covid-19 outbreak in March 2020, national BSG guidance1 called for high quality triage of endoscopy referrals in order to balance the individual need for endoscopy against the limited service capacity. Accordingly, we developed specific vetting criteria, organized a consultant-led triage system and assessed its performance in the higher urgency 2-week-wait (2WW) referrals. Aims & Methods: Five consultants developed a triage algorithm which would provide coloured urgency (Green, Yellow and Red in order of decreasing urgency) and a respective time window (2-4, 4-8 and 8-12 weeks, respectively) to endoscopy referrals. Vetting criteria were based on national guidance and criteria (BSG and NICE) and were supplemented by European guidance2 where applicable. Results: A total of 401 2WW referrals (53.6% females, mean age 62.3 years) were received over a 3.5-month study period. The commonest indication was upper gastrointestinal symptoms (39%), followed by anemia (18.2%), lower GI symptoms (16.7%) and rectal bleeding (14.5%). In total, 20 cases of neoplasia were identified among 391 2WW endoscopies, leading to a diagnostic yield of 5.1%. Our triage system reduced the number of high-urgency referrals by 65.6%. The new high-urgency group (Green code) led to a diagnostic yield for neoplasia of 10.9%, i.e. more than double compared to that of the 2WW pathway. Expanding our high-urgency group to include the Yellow code referrals would identify all cases of neoplasia and would defer almost 50% of the 2WW referrals with no missed diagnoses of cancer. FIT (fecal immunochemical testing) values ≥ 100 μg/g (Green code) and 4 to 99.9 μg/g (Yellow code) led to a neoplasia diagnosis in 25% and 3.5%, respectively. No case of lower GI neoplasia had normal FIT value. Conclusion: Our triage algorithm was particularly effective and safe to use during the Covid-19 outbreak. It reduced significantly the number of high urgency endoscopy referrals, increased the diagnostic yield for neoplasia and deferred safely all referrals in the lower urgency, Red code priority group. Specific vetting criteria, such as the FIT value and Edinburgh Dysphagia Score have high negative predictive value and their use should be generalized given the pressure imposed on the diagnostic services and the weaknesses of the existing triage systems and criteria.

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