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1.
PLoS Global Public Health ; 2(6), 2022.
Article in English | CAB Abstracts | ID: covidwho-2021479

ABSTRACT

The prevalence of SARS-CoV-2 exposure in children during the global COVID-19 pandemic has been underestimated due to lack of testing and the relatively mild symptoms in adolescents. Understanding the exposure rates in the pediatric population is essential as children are the last to receive vaccines and can act as a source for SARS-CoV-2 mutants that may threaten vaccine escape. This cross-sectional study aims to quantify the prevalence of anti- SARS-CoV-2 serum antibodies in children in a major city in Me'xico in the Spring of 2021 and determine if there are any demographic or socioeconomic correlating factors. We obtained socioeconomic information and blood samples from 1,005 children from 50 neighborhood clusters in Me' rida, Yucata' n, Me' xico. We then tested the sera of these participants for anti-SARS-CoV-2 IgG and IgM antibodies using lateral flow immunochromatography. We found that 25.5% of children in our cohort were positive for anti-SARS-CoV-2 antibodies and there was no correlation between age and antibody prevalence. Children that lived with large families were statistically more likely to have antibodies against SARS-CoV-2. Spatial analyses identified two hotspots of high SARS-CoV-2 seroprevalence in the west of the city. These results indicate that a large urban population of unvaccinated children has been exposed to SARS-CoV-2 and that a major correlating factor was the number of people within the child's household with a minor correlation with particular geographical hotspots. There is also a larger population of children that may be susceptible to future infection upon easing of social distancing measures. These findings suggest that in future pandemic scenarios, limited public health resources can be best utilized on children living in large households in urban areas.

2.
Non-conventional in English | NTIS, Grey literature | ID: grc-754630

ABSTRACT

Presentation on the COVID-19 Exposures Assessment Tool (CEAT) and use with NASA centers.

3.
TANAFFOS Journal of Respiratory Disease, Thoracic Surgery, Intensive Care and Tuberculosis ; 20(3):232-239, 2021.
Article in English | GIM | ID: covidwho-1897795

ABSTRACT

Background: The purpose of this study was to investigate the prognostic factors in hospitalized COVID-19 pneumonia patients according to the baseline clinical, laboratory, and imaging manifestations. Materials and Methods: In this retrospective study on the SARS-CoV-2 laboratory-confirmed cases, clinical and laboratory data were collected from 156 hospitalized patients during August to October, 2020. Baseline chest CT was assessed, and the CT severity score was then calculated. Data were compared between the two groups of patients with moderate and severe/critical conditions.

4.
NASA-DOD Technical Interchange, Virtual , US. 2022-02-02. ; 2022.
Article in English | NTIS, Grey literature | ID: grc-754247

ABSTRACT

Presentation on the COVID-19 Exposures Assessment Tool (CEAT) and use with NASA centers.

5.
11th International Conference on Computer Engineering and Knowledge, ICCKE 2021 ; : 322-327, 2021.
Article in English | Scopus | ID: covidwho-1788699

ABSTRACT

In this paper, a novel hybrid method called DMHS-GMDH is presented to predict the time series of COVID-19 outbreaks. In this way, a new version of Harmony Search (HS) algorithm, named Double Memory HS (DMHS), is designed to optimize the structure of a Group Method of Data Handling (GMDH) type neural network. We conduct a series of experiments by applying proposed method on real COVID-19 dataset to forecast new cases and deaths of COVID-19. The statistical analysis indicates that the DMHS-GMDH algorithm on average provides better results than other competitors and the results demonstrate how our approach at least improves coefficient of determination and RMSE by 21% and 45%, respectively. © 2021 IEEE.

6.
Tanaffos ; 20(3):232-239, 2021.
Article in English | EMBASE | ID: covidwho-1766609

ABSTRACT

Background: The purpose of this study was to investigate the prognostic factors in hospitalized COVID-19 pneumonia patients according to the baseline clinical, laboratory, and imaging manifestations. Materials and Methods: In this retrospective study on the SARS-CoV-2 laboratory-confirmed cases, clinical and laboratory data were collected from 156 hospitalized patients during August to October, 2020. Baseline chest CT was assessed, and the CT severity score was then calculated. Data were compared between the two groups of patients with moderate and severe/critical conditions. Results: Of the 156 participants with the age range of 25-95 years (56.87±16.88), 70 and 86 patients were in the moderate and severe/critical groups, respectively. Most patients had typical imaging features on chest CT. Compared to the moderate group, the severe/critical group were older and were mainly suffering from underlying comorbidities. The rate of confusion on admission (P=0.008) and pulse rate≥100 (p=0.04) were significantly higher in the severe/critical group. According to the CT manifestations, consolidation, central and diffuse peripheral and central distribution, patchy/segmental morphology, crazy paving pattern, pleural effusion, aorta, and coronary artery calcification were more likely to emerge in the severe/critical group (p<0.05). In contrast, round/nodular morphology mainly appeared in the moderate group (p= 0.002). The chest CT severity scores were 10.24±7.91 and 6.13±4.42 in the severe/critical and moderate groups, respectively, indicating statistically significant values. Conclusion: The clinical, laboratory, and chest CT findings can be used for the prognosis of COVID-19 pneumonia. Predicting the outcomes for the patients on admission can play a critical role in decision making.

7.
Journal of Occupational Health and Epidemiology ; 10(3):183-192, 2021.
Article in English | Scopus | ID: covidwho-1597007

ABSTRACT

Background: The present study aims to assess the prevalence of musculoskeletal disorders and occupational stress among workers of a factory in Iran during the COVID-19 pandemic. Materials and Methods: This cross-sectional study was conducted on all workers of an engineering company (140 participants). The tools used in the present study included the Perceived Stress Scale (PSS-14) Questionnaire and the Body Map Questionnaire. The participants were asked to respond to the questions according to their physical and mental status after the onset of the COVID-19 pandemic. The data were analyzed using SPSS V25.0. Results: The most frequently reported musculoskeletal issues were related to the back (61.4%) and neck (53.6%) areas, while the lowest prevalence was related to elbows (17.9%). A significant correlation was found between the final scores obtained from the PSS-14 and Body Map Questionnaires for the neck (P = 0.026) and shoulder (P = 0.009) areas. Besides, a significant correlation was found between the participants' gender and pain in the neck (P = 0.005) and shoulder (P = 0.048) areas. Furthermore, a significant correlation was found between marital status and pain in the pelvis (P = 0.034) and leg (P = 0.007) areas as well as the thigh and knee (P = 0.017) areas. Conclusions: The COVID-19 pandemic has affected various aspects of mental and physical health in occupational environments and has contributed to an increase in musculoskeletal pain and occupational stress levels. Thus, the adoption of effective strategies and the use of a comprehensive stress management program are suggested to prevent musculoskeletal disorders in occupational environments. © The Author(s) 2021;All rights reserved.

8.
PubMed; 2021.
Preprint in English | PubMed | ID: ppcovidwho-296897

ABSTRACT

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus has infected over 115 million people and caused over 2.5 million deaths worldwide. Yet, the molecular mechanisms underlying the clinical manifestations of COVID-19, as well as what distinguishes them from common seasonal influenza virus and other lung injury states such as Acute Respiratory Distress Syndrome (ARDS), remains poorly understood. To address these challenges, we combined transcriptional profiling of 646 clinical nasopharyngeal swabs and 39 patient autopsy tissues, matched with spatial protein and expression profiling (GeoMx) across 357 tissue sections. These results define both body-wide and tissue-specific (heart, liver, lung, kidney, and lymph nodes) damage wrought by the SARS-CoV-2 infection, evident as a function of varying viral load (high vs. low) during the course of infection and specific, transcriptional dysregulation in splicing isoforms, T cell receptor expression, and cellular expression states. In particular, cardiac and lung tissues revealed the largest degree of splicing isoform switching and cell expression state loss. Overall, these findings reveal a systemic disruption of cellular and transcriptional pathways from COVID-19 across all tissues, which can inform subsequent studies to combat the mortality of COVID-19, as well to better understand the molecular dynamics of lethal SARS-CoV-2 infection and other viruses.

9.
Gastroenterology and Hepatology From Bed to Bench ; 13(4):410-414, 2020.
Article in English | GIM | ID: covidwho-1299946

ABSTRACT

As of December 2019, a new strain of coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was discovered in Wuhan, China, following an epidemic of a fast-spreading viral respiratory disease, later called Coronavirus Disease 2019 (COVID-19), which then lead to the present pandemic the world has come to know. Patients who tested positive for COVID-19 are mostly asymptomatic or present with mild self-limiting symptoms. While GI symptoms occur with less prevalence, they are increasingly being reported. A diagnosis of Covid-19 has increased dramatically in patients presenting with gastrointestinal symptoms suggesting that GI symptoms should be taken into serious consideration with patient diagnosis. Case 1: A 65-year-old man presented to the hospital emergency room with abdominal pain, Murphy's sign and chills without fever, subsequently diagnosed as acute acalculous cholecystitis with a positive COVID-19 rRT-PCR. Case 2: A 78-year-old woman presented to the hospital emergency room complaining of severe positional epigastric pain precipitated by lying supine, chills with no fever, being later diagnosed as acute pancreatitis and a positive COVID-19 rRT-PCR. It has become evident that the ACE2 receptor plays a significant role as the entry site into human cells for the virus. This receptor is generally expressed in respiratory cells, as well as the gastrointestinal tract, corresponding with extrapulmonary manifestations of COVID-19. Studies concluded that the origin of gastrointestinal symptoms could be caused by the interaction of the SARS-CoV-2 virus with cells through the ACE2 receptor. The findings of the present study support this theory, as both patients presented with symptoms regarding tissues with high ACE2 expression.

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