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1.
European journal of public health ; 32(Suppl 3), 2022.
Article in English | EuropePMC | ID: covidwho-2102747

ABSTRACT

Background COVID-19 usually cause a mild infection among children with a low fatality rate. On the other hand, increasing evidence suggests that children may have prolonged symptoms related to COVID-19. This study aims to describe the persistence of COVID-19 symptoms up to 12 or more weeks among children and to investigate associated factors including perceived socioeconomic status and parents’ education level. Methods The study group consisted of 759 cases aged <18 years detected as SARS-CoV-2 RT-PCR positive in DEU Hospital between March 2020, and May 2021. Interviews were conducted at 1st 3rd and 6th month of diagnosis. The ongoing self-reported symptoms 12 or more weeks after infection was the dependent variable. Multivariate logistic regression models were used to evaluate associated factors with long COVID, and robust clustering using links algorithm was used to assess long COVID symptoms clusters. Results Among 759 COVID-19 cases, 22 children were hospitalized, and 4 died. 9.6% of the children had at least one symptom related to COVID-19 after 12 weeks of the diagnosis, Symptom duration was minimum 84 days, maximum 344 days (mean±SD: 160±68 days). The most frequent symptoms were fatigue, muscle-joint pain, headache, and loss of smell and/or taste. In multivariate analysis, female gender (OR:2,3 95%CI:1.1-3.6) and symptomatic onset (OR:2,7 95%CI:1.7-20.9) were related to increased risk of long COVID. Age, long-term health conditions, socioeconomic status and mother's education level did not predict the risk of long COVID. No cluster of symptoms was found. Conclusions About 10% of children suffer from symptoms related to COVID-19 for up to six months. Female gender and symptomatic onset of disease increased the risk of prolonged symptoms. Socioeconomic status and mother's education level was not associated with the risk of long COVID, but the evidence of the effect of social determinants of health on the outcomes of COVID-19 among children is still needed. Key messages • One out of ten children may suffer from long COVID represents symptoms such as fatigue, headache, and muscle and joint pain. Girls and children with symptomatic onset have a higher risk of long COVID. • The effects of social determinants on the susceptibility and outcomes of COVID-19, including death, were well studied among the adult population. There is a need for sound evidence for children.

2.
Cocuk Enfeksiyon Dergisi ; 15(4):236-239, 2021.
Article in Turkish | EMBASE | ID: covidwho-1650975

ABSTRACT

Objective: With the rapid spread of SARS-CoV-2, a new coronavirus, around the world, a pandemic was declared by World Health Organization on March 2020. The first cases were reported in March 2020 from Turkey. In our hospital, the first pediatric case was detected on April 2, 2020. However, there is no data on whether this virus had been present in our region or not before this date. The aim of our study was to de-termine the first entry of SARS-CoV-2 virus to our region for pediatric patients. Material and Methods: SARS-CoV-2 positivity was investigated retro-spectively with the RT-qPCR method in the pediatric respiratory tract specimens taken between the October 1, 2019 and March 31, 2020. In the specimens, SARS-CoV-2 RNA was studied using real-time PCR based “COVID-19 RT-qPCR Detection Kit”. Results: 886 samples were included in the study. Of the respiratory tract specimens, 97.1% were nasopharyngeal swabs, 2.8% were bronchoal-veolar lavage. Most frequently, rhinovirus (28.6%), influenza A subtype H1N1 (pandemic H1N1) (18.5%) and influenza B (16%) were detected. Rhinovirus and enterovirus were the most frequent double agents seen together. No SARS-CoV-2 positivity was detected in the respiratory tract specimens studied. Conclusion: SARS-CoV-2 PCR test was conducted in a limited number of centers at the beginning of the pandemics may have affected the detection of the first case in Turkey. Multicenter studies of archived samples would enable more realistic results in tracking SARS-CoV-2 in our country.

4.
European Journal of Public Health ; 31, 2021.
Article in English | ProQuest Central | ID: covidwho-1514738

ABSTRACT

Background There is limited research on children infected with Covid-19 after initial diagnosis. The aim of this study was to describe changes in symptoms in children infected by Covid-19 after 1st and 3rd months of diagnosis. Methods Covid-19 patients age under 18 admitted to the Dokuz Eylul University Hospital, Izmir, Turkey during December 2020 (n = 144) and completed three months follow-up (n = 123) were included in this prospective cohort study. Data on age, sex, parents' educational status, perceived economic status, presence of Covid-19 patient at household, chronic diseases history, initial and existing symptoms and perception of recovery were collected via telephone interviews. Persistent symptom was defined as any symptom reported within a week of the interview. Chi-square and Mann-Whitney U Test were used for univariate analyses. Results Out of 124 patients, 89.3% reported a symptom at time of diagnosis, 21.0% at 1st month and 11.4% at the 3rd-month follow-up. Median number of symptoms was 2 at diagnosis, 0 at 1st and the 3rd month. The most common initial symptoms were fever (52.4%), weakness (40.3%), flu like symptoms (25.8%) and cough (24.4%). The most common persistent symptoms by the 1st month were fatigue (5.7%), cough (4.1%) and gastrointestinal symptoms (4.1%), and by the 3rd month were fatigue (2.4%), weakness (2.4%), respiratory symptoms and chest pain (2.4%). 10.6% of the patients were not fully recovered by the 3rd month. Persistent symptoms at the end of 1st month were more common in children with chronic diseases (36.6% vs 13.3%, p = 0.003) and who were not recovered fully (63.6% vs 15.5%, p = 0.001). Parents' education level, perceived economic status, and presence of Covid-19 patients at household were not associated with persisting symptoms. Conclusions COVID-19 symptoms may persist by three months of infection, especially in children with chronic conditions. Health care providers should consider following up those children with special care. Key messages COVID-19 symptoms may persist by three months of infection, especially in children with chronic conditions. Health care providers should consider following up those children with special care.

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