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Investigacion Clinica ; 62(Suplemento 3):259-267, 2021.
Article in Spanish | CAB Abstracts | ID: covidwho-1929543

ABSTRACT

The global health emergency caused by SARS-CoV-2, has caused destabilization of health systems, deploying several proposals for platforms in order to obtain an accessible, effective and safe vaccine, thus having more than 250 potential candidates who are in the different stages of development but only 4 have managed to meet the standards of approval and marketing by the different Regulatory Agencies, these being Pfizer, Moderna, AstraZeneca and Johnson & Johnson, which reach an efficiency of 95%, 94.1%, 70% and 66% respectively. A systematic, up-to-date literature review of the latest published scientific articles was carried out;on the different vaccines qualified by the World Health Organization (WHO) against the threat of COVID-19, as well as their characteristics and implication in health. The review resulted in 30 scientific publications in specialized databases such as Medline, Cochrane, SCOPUS, PubMed, Scielo, SpringerLink, in search of scientific articles, meta-analyses, clinical practice guidelines and reports;published during the period of onset of the pandemic up to the latest covid-19 vaccination reports. The characteristics of each vaccine were described, giving a public knowledge of its advantages, limitations, safety and efficacy. The most significant conclusion was that vac-cines have been shown to be effective because they achieve a seroconversion greater than 90%, so countries should consider a strategic plan for vaccination against SARS-CoV-2 that includes the entire population.

2.
Neurology ; 98(18 SUPPL), 2022.
Article in English | EMBASE | ID: covidwho-1925439

ABSTRACT

Objective: To evaluate clinical, laboratory, and epidemiological features of acute neuroinflammatory disorders (ANIDs) that followed the 2016 Zika epidemic in Colombia. Background: The outbreak of Zika virus infection in Colombia in 2015-2016, produced an increased incidence of Guillain-Barré Syndrome (GBS) and other ANID cases. The Neuroviruses Emerging in the Americas Study (NEAS) network was established in 2016 as a multicenter-based observatory of ANIDs to investigate the role of emerging pathogens in neuroinflammatory diseases. Design/Methods: NEAS serves as a multi-center study based on 13 hospitals in 7 cities in Colombia which study all newly diagnosed patients who fulfill established criteria for GBS, encephalitis, myelitis, meningoencephalitis, or cranial nerve disorders as part of an observational cohort. We analyzed the clinical and epidemiological features of all cases evaluated between January 2016 and September 2021. Results: An observational cohort of 825 patients with ANIDs were recruited during the study period. 58.8% of cases were male with a median age of 43 (IQR 25-58) years. The most frequent ANIDs were GBS (46.1%) and facial nerve palsy (28.7%). The diagnosis of encephalitis (9.5%), myelitis (6.5%), and optic neuritis (5.9%) were less frequent. Patients with GBS were predominantly male (70.6%) and had a median age of 49 (IQR 32-60) years. Interestingly, there was an increase incidence of GBS in 2019. Conclusions: The outbreak of Zika in Colombia produced a marked increase in the incidence of GBS in 2016. Although cases of GBS and other ANIDs continued to emerge after the incidence of Zika infection decreased in July 2016, the recent SARS-CoV-2 pandemic has not produced any significant increase in the incidence of GBS in Colombia.

3.
Earth System Governance ; : 100074, 2020.
Article | ScienceDirect | ID: covidwho-778837

ABSTRACT

Many urban areas suffer from poor air quality as a consequence of high levels of car-based traffic. Even cities with well-developed multi-modal public transport networks and favourable conditions for alternative transportation, such as Barcelona, experience problems with air pollution. The restrictions imposed on movement in response to the COVID-19 pandemic offer insights into the collective social benefits of reduced traffic. This situation also provided much-needed evidence about teleworking that will indicate whether it could become a mainstream and institutionalised practice in certain professions. In Barcelona, the experience of a less polluted, quieter and more liveable city has inspired both the municipal government and the citizens to rethink the use of public spaces and look for ways to reduce car dependency. We argue that this unprecedented crisis is an opportunity to create a more sustainable future of work and mobility in cities in the post-pandemic world.

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