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Respir Med ; 172: 106135, 2020 10.
Article in English | MEDLINE | ID: covidwho-773282

ABSTRACT

PURPOSE: Patients hospitalized for infection with SARS-CoV-2 typically present with pneumonia. The respiratory failure is frequently complicated by pulmonary embolism in segmental pulmonary arteries. The distribution of pulmonary embolism in regard to lung parenchymal opacifications has not been investigated yet. METHODS: All patients with COVID-19 treated at a medical intensive care unit between March 8th and April 15th, 2020 undergoing computed tomography pulmonary angiography (CTPA) were included. All CTPA were assessed by two radiologists independently in respect to parenchymal changes and pulmonary embolism on a lung segment basis. RESULTS: Out of 22 patients with severe COVID-19 treated within the observed time period, 16 (age 60.4 ± 10.2 years, 6 female SAPS2 score 49.2 ± 13.9) underwent CT. A total of 288 lung segment were analyzed. Thrombi were detectable in 9/16 (56.3%) patients, with 4.4 ± 2.9 segments occluded per patient and 40/288 (13.9%) segments affected in the whole cohort. Patients with thrombi had significantly worse segmental opacifications in CT (p < 0.05) and all thrombi were located in opacitated segments. There was no correlation between d-dimer level and number of occluded segmental arteries. CONCLUSIONS: Thrombi in segmental pulmonary arteries are common in COVID-19 and are located in opacitated lung segments. This might suggest local clot formation.


Subject(s)
Computed Tomography Angiography , Coronavirus Infections , Lung/diagnostic imaging , Pandemics , Pneumonia, Viral , Pulmonary Artery/diagnostic imaging , Pulmonary Embolism , Respiratory Distress Syndrome , Thrombosis , Betacoronavirus/isolation & purification , Blood Coagulation , COVID-19 , Computed Tomography Angiography/methods , Computed Tomography Angiography/statistics & numerical data , Coronavirus Infections/blood , Coronavirus Infections/physiopathology , Coronavirus Infections/therapy , Correlation of Data , Female , Humans , Male , Middle Aged , Pneumonia, Viral/blood , Pneumonia, Viral/diagnostic imaging , Pneumonia, Viral/etiology , Pneumonia, Viral/physiopathology , Pneumonia, Viral/therapy , Pulmonary Embolism/diagnosis , Pulmonary Embolism/etiology , Radiography, Thoracic/methods , Radiography, Thoracic/statistics & numerical data , Respiratory Distress Syndrome/diagnosis , Respiratory Distress Syndrome/virology , Retrospective Studies , SARS-CoV-2 , Thrombosis/diagnostic imaging , Thrombosis/etiology
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