Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 44
Filter
1.
Frontiers in Public Health ; 10, 2022.
Article in English | Web of Science | ID: covidwho-2022967

ABSTRACT

IntroductionDigital eye strain, which is often ignored by the public, has emerged as a "Shadow Pandemic" in the era of the COVID-19 pandemic. AimThe current paper is aimed at discussing the ill effect of digital screens on eyes in the wake of the COVID-19 pandemic. MethodologyA literature search was done using "PubMed," "Google scholar", and "Scopus" using key terms like "Digital Eye Strain," "Eyestrain," or "Computer Vision Syndrome." Relevant articles were identified and included to support the argument for this narrative review. ResultsStudies conducted in the UK reported that 68% of children extensively use computers, while 54% undertake online activities after the age of 3. Similar studies estimated 4 h and 45 min per day of screen exposure time among adults in the UK. Indian studies reveal that the prevalence of DES is 69% in adults and 50% in children respectively. Indian ophthalmologists found that computer-using and specialized ophthalmologists were more informed of symptoms and diagnostic signs but were misinformed about treatment modalities. The use of social media and multitasking is particularly prominent among younger adults, with 87% of individuals aged 20-29 years reporting the use of two or more digital devices simultaneously. It has been observed that the use of computer glasses corrects refractive errors and helps in the reduction of symptoms, while precision spectral filters help in reducing symptoms of micro-fluctuation of accommodation. ConclusionWe concluded that DES is emerging globally as a "Shadow Pandemic" and it is high time to respond. Community ophthalmologists, public health authorities, and educational sectors especially should be involved to prevent this.

2.
The Egyptian Heart Journal ; 74(1):66, 2022.
Article in English | MEDLINE | ID: covidwho-2021363

ABSTRACT

BACKGROUND: The Coronavirus disease 2019 (COVID-19) was declared a worldwide pandemic in 2020 by the World Health Organization (WHO). Certain individuals are at higher risk, (age > 65 years, pre-existing lung or heart conditions, diabetes and obesity) especially those requiring cardiac surgery, including Coronary Artery Bypass Grafting (CABG). Here we present a case series of 11 patients, operated between April 2020 and April 2022, all of whom had recently recovered from COVID-19, who presented with unstable angina, and therefore required urgent Coronary Artery Bypass Grafting (CABG). Similar cases reported in the past, have had a high morbidity and mortality rate. CASE PRESENTATION: The study included 11 males, and their age varied between 53 and 68 years (median of 65 years). They were either partially or fully vaccinated. All of them had a history of recent mild COVID-19 infection. The European system for cardiac operative risk evaluation, EuroSCORE II in-hospital mortality risk at admission, varied between 1.48% and 5.12%. Six out of 11 patients (54.55%) had a recent Acute Coronary Syndrome (ACS) which is associated with a higher risk and poor prognosis. All of them underwent urgent CABG (10 of them, 90.91% cases, using the off-pump technique and one patient had to be converted to the on-pump beating heart surgery technique during surgery). Ten of the 11 patients were operated using the off-pump technique, and there was one death (9.09%). All surviving patients made an uneventful recovery and have been followed up with a median follow-up period of 12 months. CONCLUSIONS: Previous studies on a similar group of patients have resulted in high morbidity and mortality. A conscious effort was made to perform all surgeries off-pump, thereby eliminating the inflammatory effects and other hazards of cardiopulmonary bypass in this case series, with only one out of 11 (9.09%) being converted to the on-pump beating heart technique due to the hemodynamic instability faced during surgery. Our findings show a mortality rate of 9.09%, with the surviving patients doing well at a median follow-up period of 12 months, suggesting that it is a safe procedure in this patient subset.

3.
Cytotherapy ; 24(5):S99, 2022.
Article in English | EMBASE | ID: covidwho-1996722

ABSTRACT

Background & Aim: Background: Traditionally, ‘fresh’ Hematopoietic progenitors cell (HPC) infusions have been preferred over cryopreserved HPC in Allo-HCT because cryopreservation and thawing leads to cell loss, besides DMSO-related adverse reactions in patients. Emergence of COVID-19 pandemic has severely affected fresh HPC infusions and most professional bodies recommend cryopreservation of HPC products before initiating conditioning chemotherapy. Although some western studies suggest no significant impact of graft manipulation on patient outcome, there is no available data from the developing world.Aim: We compare neutrophil and platelet engraftment in patients undergoing Allo-HCT with fresh and cryopreserved HPC products. Methods, Results & Conclusion: Material and Method: Allo-HCT data from October 2018 to October 2021 were analyzed. Cryopreservation was performed by controlled-rate freezing using 10% DMSO, plasmalyte- A and human albumin ( 1:2:1) as cryoprotectant. Cryopreserved products were stored in vapour-phase of Liquid nitrogen tank. CD34+ enumeration and viablity( by 7-AAD) was done on Flow-cytometry on fresh and post-thaw HPC samples. Neutrophil engraftment was defined as absolute neutrophil count >0.5 ×109/L for 3 days. Platelet engraftment was defined as independence from platelet transfusion for at least 7 days with a platelet count >20 × 109/L. Statistical analysis using Wilcoxon Rank Sum test. Results: Ninety-six patients underwent allo-HCT (46 received fresh and 50 received cryopreserved HPC products) (Table 1). There was no significant difference in neutrophil engraftment with fresh and cryopreserved grafts (p>0.05) in different types of transplants( Matched related/unrelated and haploidentical). 22% (11/50) of cryopreserved graft infusions were associated with Grade-1 DMSO-related adverse reactions, which were managed with symptomatic treatment. Cryopreservation increased the cost of related allogeneic transplants by USD1100. No cryopreserved HPC product was culture positive on microbiological assessment. Conclusion: In our experience, the engraftment kinetics were similar with fresh and cryopreserved HPC products as CD34+cell dose administered was almost the same. Cryopreserved grafts had a median 7% CD34+cell loss, associated with mild DMSO-related adverse reactions and cost increment. Even though, graft cryopreservation is a feasible alternative during the pandemic, it is crucial to ensure graft quality and promptly manage DMSO-related adverse reactions.(Table Presented) Table 1 Comparison of Fresh and cryopreserved HPC products in Allo-HCT

4.
International Journal of Early Childhood Special Education ; 14(4):2642-2654, 2022.
Article in English | Web of Science | ID: covidwho-1979675

ABSTRACT

This research paper looks into how the crude oil prices impact the bond yields issued by the central government of the top ten oil-importing nations before and after the outbreak of Coronavirus and analyze and compare the correlation the bond yields have with crude oil. All the top ten importers are classified into clusters based on their products to identify similarities between them and understand the correlation with oil prices before and after the coronavirus pandemic. The paper has looked into the Central bank's interest rates of these nations to explain the difference in properties that the clusters exhibited during the two periods (I.e., before and after the Coronavirus outbreak of Coronavirus).The control of these policy interest rates plays a vital role in shielding the bond yields from the shocks of oil prices. Nations that we're able to revitalize confidence in investors through their actions by adjusting their interest rates were having a better position than nations that could not change their interest rates.

5.
Gastroenterology ; 162(7):S-593, 2022.
Article in English | EMBASE | ID: covidwho-1967335

ABSTRACT

Background: Several SARS-CoV-2 vaccines are highly effective in preventing most infections, serious disease, hospitalization, and death from COVID-19 in the general population, but data regarding their use and efficacy in patients with inflammatory bowel disease (IBD) are limited. In this study we assessed the use patterns and efficacy of SARS-CoV-2 vaccines in patients with IBD. Methods: We established a multicenter matched case-control cohort of patients with IBD [Crohn's disease (CD), ulcerative colitis (UC)] and COVID-19 between February 2020 and December 2020 for the Surveillance of COVID-19 Impact on Long- Term Outcomes in IBD (SCOUT IBD) study. Cases were defined by the presence of COVID- 19-related symptoms and confirmatory SARS-CoV-2 PCR or IgG testing and non-COVID controls were defined as absence of symptoms and both a negative PCR and IgG in 2020. Cases were matched 1:1 to controls based on age, sex and IBD type. Data were collected on vaccine administration in 2021 and incidence of interval COVID-19 (defined as above) between January and September 2021. Results: The total cohort included 502 patients with IBD [UC (n=222, 44%), CD (n=278, 55%), IBD-undefined (n=2, 1%)] of whom 251 had a history of COVID-19 in 2020. The overall vaccination rate was 61% (n=306) with 189 (62%) patients receiving Pfizer-BioNTech, 101 (33%) Moderna, and 12 (4%) Johnson & Johnson. Vaccinated patients were more likely to be older (P=0.02), female (P=0.07), have a co-morbidity (cardiovascular, respiratory, renal) (P=0.04), or currently be on a biologic (P=0.01), and less likely to have had prior COVID-19 (P<0.001) than patients who did not get vaccinated (Table 1). The overall incidence of interval COVID-19 was 1.6% (N=8), with an infection rate of 0.3% (1/311) in vaccinated patients vs. 3.7% (7/184) in unvaccinated patients (P<0.01). Of infections occurring in unvaccinated patients, 1/7 (14.2%) was severe and required hospitalization requiring ICU admission, and the breakthrough infection in the vaccinated patient was mild and self-limited. COVID-19 reinfection occurred in one patient (0.4%) with prior COVID-19 who was unvaccinated. Under multivariable logistic regression, COVID-19 vaccination (aOR 0.05, 95% CI 0.01-0.41) and prior COVID-19 infection (OR 0.07, 95% CI 0.01-0.63) were highly protective against interval COVID-19. Conclusion: COVID-19 vaccines are effective in patients with IBD and markedly reduce the incidence of COVID-19. Prior COVID-19 is also protective against subsequent infection, although re-infections may occur at a very low rate. These results reaffirm the importance of COVID-19 vaccination in patients with IBD.(Table Presented)(Table Presented)

6.
Gastroenterology ; 162(7):S-592-S-593, 2022.
Article in English | EMBASE | ID: covidwho-1967334

ABSTRACT

Background: Inflammatory bowel disease (IBD) and IBD-related biologic therapies are not associated with worse outcomes of Coronavirus Disease 2019 (COVID-19), however, data are lacking regarding the long-term impact of COVID-19 and its inflammatory sequelae on the disease course of IBD. We aimed to investigate the long-term outcomes of patients with IBD and COVID-19. Methods: We performed a multicenter matched case-control study of patients with IBD [Crohn's disease (CD), ulcerative colitis (UC)] and COVID-19 between February 2020 and December 2020 at 5 large health systems. Cases were defined by the presence of COVID-19-related symptoms and confirmatory SARS-CoV-2 PCR or IgG testing. Non-COVID controls were defined as absence of symptoms and both a negative PCR and IgG during the study entry period. Cases were matched 1:1 to controls based on age, sex and IBD type. The primary composite outcome was IBD-related hospitalization or surgery, and outcomes were sub-stratified by COVID-19 severity. Results: We identified 251 cases with IBD [UC (n=111, 44%), CD (n=139, 55%)] and confirmed COVID-19, matched with 251 non-COVID-19 IBD controls, with a median follow-up of 394 days. COVID-19 patients had higher rates of prior IBD-related hospitalizations (36% vs. 27%;P=0.03), corticosteroid use (75% vs. 65%;P=0.06), and biologic exposure (73% vs. 64%;P=0.04) than controls. There were no differences in UC extent or CD phenotype between groups. In COVID-19 positive patients, the most common symptoms were fever (61%), cough (48%), fatigue (30%) and diarrhea (28%). Severe COVID-19 (defined as hospitalization, ICU requirement or mechanical ventilation) occurred in 16% (n=39) of cases. The primary composite outcome of IBD-related hospitalization or surgery occurred in 12% (n=38) of cases vs. 15% (n=29) of controls (P=0.24;Table 1). When further stratified by COVID-19 severity, the incidence of the primary composite outcome was highest in patients with severe COVID-19, followed by controls and non-severe COVID-19 (Figure 1). Under multivariate Cox regression, severe COVID-19 remained a predictor of worse IBD outcomes (aHR 2.09, 95% CI 0.91-4.86) whereas non-severe COVID-19 was associated with decreased risk (aHR 0.52, 95% CI 0.28- 0.99). Prior IBD-related hospitalization or surgery (aHR 3.10, 95% CI 1.70-6.57) and current steroid use (aHR 2.17, 95% CI 0.95-4.94) were also predictive of worse IBD outcomes. Conclusion: In this matched case-control study, a history of any COVID-19 infection did not appear to exacerbate the course of IBD, however, severe COVID-19 was associated with worse IBD outcomes. These data suggest that the inflammatory sequelae of COVID-19 may adversely impact the subsequent disease course of IBD. Further studies are required to confirm these associations, which underscore the importance of COVID-19 mitigation measures.(Table Presented) (Figure Presented)

7.
Journal of Clinical and Diagnostic Research ; 16(6):DC06-DC08, 2022.
Article in English | EMBASE | ID: covidwho-1928869

ABSTRACT

Introduction: Coronavirus Disease-2019 (COVID-19) causes respiratory tract infections in human beings ranging from mild illnesses like common cold to severe disease like pneumonia. Currently, nucleic acid amplification tests Reverse Transcriptase Polymerase Chain Reaction (RT-PCR), Cartridge Based Nucleic Acid Amplification Test (CBNAAT) and Truenat) and rapid antigen detection tests are approved for diagnostic purpose by Indian Council of Medical Research (ICMR). Medical Interns, the primary contact health-care personnel, need to be sensitised regarding proper utilisation of CBNAAT, so that rapid and accurate diagnosis of Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) can be made in comparison to the more commonly used RT-PCR technique. Aim: To evaluate the Knowledge, Attitude and Practices (KAP) of Bachelor of Medicine and a Bachelor of Surgery (MBBS) interns towards accessibility of CBNAAT in SARS-CoV-2 infection in a tertiary care hospital. Materials and Methods: A cross-sectional study was performed through questionnaire shared via online platform amongst 102 Medical interns working at College of Medicine and Sagore Dutta Hospital from 22nd August 2021 to 21st September 2021. Based on their response, KAP was assessed by using a three-point Likert Scale. The collected data was entered in Microsoft excel, and reported as frequencies and percentages. Results: Among 102 internees, 84 interns responded. Among 84 medical interns 31% had good, 50% had average whereas 19% had poor level of knowledge. About 58 (69%) agreed that CBNAAT can be used as a method for rapid diagnosis of SARS-CoV-2. About 75 (89.3%) answered that they are sending samples for COVID-19 testing. Only 56 (66.7%) agreed that CBNAAT should be recommended. Conclusion: This study revealed that majority of the MBBS interns had positive attitude towards different aspects of CBNAAT utility but most of them had gaps in their KAP. This demands extra efforts to sensitise and train them adequately.

8.
American Journal of Respiratory and Critical Care Medicine ; 205(1), 2022.
Article in English | EMBASE | ID: covidwho-1927801

ABSTRACT

The correlates of COVID-19 illness severity following infection with SARS-Coronavirus 2 (SCoV2) are poorly understood. While several demographic and underlying clinical variables increase risk for severe outcomes, at the onset of symptoms, it is challenging to identify those who will progress to requiring intensive care support. We conducted a pilot study to understand peripheral blood gene expression correlates of COVID19 illness across the spectrum of disease severity. We assessed gene expression in 53 confirmed SCoV2-infected adult participants during acute illness (within 28 days of onset). We found global gene expression patterns in participants with mild and moderate illness were highly similar, but significantly different from participants with severe illness. When comparing gene expression in those with severe as compared to non-severe illness, we identified >4000 genes significantly differentially expressed (FDR<0.05). Biological pathways represented by genes significantly increased in severe COVID19 were associated with platelet activation and coagulation, while those significantly decreased in severe COVID19 were associated with T cell signaling and differentiation (Figure 1). We used statistical modeling with crossvalidation to identify an 18-gene signature which classified severe illness (ROC AUC=0.98) in our training cohort, and strongly predicted hospitalization in an independent test cohort (ROC AUC=0.85). A weighted gene expression risk score (WGERS) provided 100% sensitivity and 85% specificity for classifying severe illness in our training cohort, and only mis-classified (5/19) participants with moderate illness. Importantly, the WGERS demonstrated 84% sensitivity and 74% specificity for predicting hospitalization in the test cohort. These data indicate that gene expression classifiers may provide clinical utility for identifying participants likely to require intensive care following SCoV2 infection.

9.
Coatings ; 12(6):18, 2022.
Article in English | Web of Science | ID: covidwho-1917322

ABSTRACT

Edible coatings and films appear to be a very promising strategy for delivering bioactive compounds and probiotics in food systems when direct incorporation/inoculation is not an option. The production of dairy products has undergone radical modifications thanks to nanotechnology. Despite being a relatively new occurrence in the dairy sector, nanotechnology has quickly become a popular means of increasing the bioavailability and favorable health effects of a variety of bioactive components. The present review describes, in detail, the various processes being practiced worldwide for yoghurt preparation, microencapsulation, and nanotechnology-based approaches for preserving and/or enriching yoghurt with biologically, and its effect on health and in treating various diseases. In the case of yoghurt, as a perfect medium for functional ingredients supplementation, different gums (e.g., alginate, xanthan gum, and gum arabic), alone or in combination with maltodextrin, seem to be excellent coatings materials to encapsulate functional ingredients. Edible coatings and films are ideal carriers of bioactive compounds, such as antioxidants, antimicrobials, flavors, and probiotics, to improve the quality of dairy food products. Yoghurt is regarded as a functional superfood with a variety of health benefits, especially with a high importance for women's health, as a probiotic. Consumption of yoghurt with certain types of probiotic strains which contain gamma-linolenic acid or PUFA can help solve healthy problems or alleviate different symptoms, and this review will be shed light on the latest studies that have focused on the impact of functional yoghurt on women's health. Recently, it has been discovered that fermented milk products effectively prevent influenza and COVID-19 viruses. Bioactive molecules from yoghurt are quite effective in treating various inflammations, including so-called "cytokine storms" (hypercytokinaemia) caused by COVID-19.

10.
American Journal of Respiratory and Critical Care Medicine ; 205:1, 2022.
Article in English | English Web of Science | ID: covidwho-1880589
11.
American Journal of Respiratory and Critical Care Medicine ; 205:2, 2022.
Article in English | English Web of Science | ID: covidwho-1880006
12.
American Journal of Respiratory and Critical Care Medicine ; 205:2, 2022.
Article in English | English Web of Science | ID: covidwho-1880005
13.
Journal of Clinical and Diagnostic Research ; 16(4):OC28-OC31, 2022.
Article in English | Web of Science | ID: covidwho-1856272

ABSTRACT

Introduction: In view of the present Coronavirus Disease 2019 (COVID-19) pandemic it is of utmost importance to look out for the 'trojan horse' that is the asymptomatic population who are potential for spreading the disease. Healthcare Workers (HCWs) are the most vulnerable group. The possibility of having the infection does not always correlate well with the symptoms. It urges the need for development of certain special plans beyond continuous surveillance and symptom monitoring. Aim: To explore asymptomatic COVID-19 infection among HCWs as a potential source of transmission. Materials and Methods: This hospital-based cross-sectional study was conducted at Medical College and Hospital, Kolkata, West Bengal, India, from June 2020 to September 2020. The data were collected from 714 HCWs over a period of three months of study period, with the help of a standard questionnaire and blood sample was analysed by serological assessment of Immunoglobulin G (IgG) for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by EUROIMMUN Kit, Enzyme-Linked Immunosorbent Assay (ELISA). Epi info software 7, available from the World Health Organization (WHO) site was used to manage and analyse the data. Results: The mean age was 35.30 +/- 11.79 years. Out of 714 people, 54.8% (391/714) were male and 45.2% (323/714) were female. In this survey, 9.16% of HCWs in COVID-19 designated duties were IgG positive;whereas 21.89% of HCWs designated in other parts of area were detected to be IgG positive. Seroprevalence was least amongst nursing staffs with 5.41% (8/148);among doctor's it was 9.62% (41/426). Most interestingly among ward boys and cleaners this prevalence was found to be 29.90% (29/97) being the highest. Overall seroprevalence for IgG against SARS-CoV-2 was found to be 12.75% (91/714). Conclusion: This serosurvey at this tertiary COVID-19 care facility is a unique venture to look for the possible sources of super-spread. The high rate of sero-positivity among ward boys and cleaners might be due to their lack of knowledge and training regarding steps to prevent a droplet borne pandemic. This study also points out that if adequate precautions are taken, infectivity is not to an alarming extent, even in a full-fledged COVID-19 care hospital.

14.
Journal of Communicable Diseases ; 2022:9-14, 2022.
Article in English | Scopus | ID: covidwho-1848037

ABSTRACT

Introduction: During the COVID-19 pandemic, online classes in India as in other parts of the world, became a prioritised source for learning. The researchers in the present study attempted to assess the perception of online classes including their impact and challenges amongst the students. Methodology: A quantitative approach using descriptive sample survey research design was incorporated to conduct the study. Subjects were students chosen from school and university. A structured questionnaire as Google Form was used to collect primary data. Descriptive statistics was employed to analyse the data. Results: 97% of students spent 2 to 7 hours daily for online classes. Online classes give the right theoretical and practical experience as expressed by 55.4% and 21% respectively. 62% of students perceive that online grading system is less effective than offline grading system. Half of the subjects prefer face to face learning and one fourth preferred hybrid mode. 67.5% of students opined that online classes do not allow adequate interaction with the teachers. Among health impacts, 68%, 38%, 43% and 59% of the students reported eye, ear, and sleep and socialisation problems respectively. 74% of them reported drastic change in eating habits, while 76% of the subjects reported weight gain;posture problems were reported to be faced by 98 (62%) students;57 (64.3%) reported pain in the back of the neck, 52 (58.2%) reported low back pain, 42 (42.9%) reported pain during forward bending of shoulders, and 26 (26.5%) complained of stiff shoulders. Conclusion: Online classes at the present time are not considered a preferred mode of learning by students. The students identified various restrictions of online classes towards the understanding of subjects, limiting interaction with teachers and students asserted many negative impacts of prolonged online classes on their health. Copyright (c) 2022: Author(s).

15.
PubMed; 2020.
Preprint in English | PubMed | ID: ppcovidwho-333646

ABSTRACT

OBJECTIVES: The COVID-19 pandemic has highlighted the importance of rapid dissemination of scientific and medical discovery. Social media (SoMe) has become an invaluable platform in science and medicine. This study analyzed activity of SoMe (Twitter), preprints, and publications related to COVID-19 and gastroenterology (GI) during the COVID-19 pandemic. METHODS: Data from Twitter, preprint servers and PubMed was collected and analyzed from December 2019 through May 2020. Global and regional geographic and gastrointestinal organ specific social media trends were compared to preprint and publication activity;any associations were identified. RESULTS: Over the 6-month period, there were 73,079 tweets from 44,609 users, 7,164 publications, and 4,702 preprints. Twitter activity peaked during March while preprints and publications peaked in April 2020. Strong correlations were identified between Twitter and both preprints and publications activity (p<0.001 for both). While COVID-19 data across the 3 platforms concentrated on pulmonology/critical care, the majority of GI tweets pertained to pancreatology, most publications focused on hepatology, and most preprints covered hepatology and luminal GI (LGI). There were significant associations between Twitter activity and research for all GI subfields (p=0.009 for LGI, p=0.006 for hepatology and IBD, p=0.007 for endoscopy), except pancreatology (p=0.2). Twitter activity was highest in the US (7,331 tweets) whereas PubMed activity was highest in China (1,768 publications). CONCLUSIONS: The COVID-19 pandemic has highlighted the utility of SoMe as a vehicle for disseminating scientific information during a public health crisis. Scientists and clinicians should consider the use of SoMe in augmenting public awareness of their scholarly pursuits.

16.
Embase; 2021.
Preprint in English | EMBASE | ID: ppcovidwho-331173

ABSTRACT

Due to the restrictions imposed to contain the coronavirus disease 2019 (COVID-19) pandemic, different population groups have adapted to varying screen time levels, which may have profound implications on their physical and mental wellbeing. Several empirical studies included in this review reported a sudden upward change in screen time across different population groups. A higher number of people with increased screen time compared to their pre-pandemic state and prolonged duration of total screen time substantiates such assertions. The available evidence suggests that screen time is associated with obesity, hypertension, type 2 diabetes, myopia, depression, sleep disorders, and several non-communicable diseases. This elevated burden of diseases is more prevalent among individuals who have sedentary lifestyles and other unhealthy behaviors that are likely to increase during quarantine or isolation due to COVID-19. Hence, it is critical to assess the adverse health outcomes that may appear as long-term consequences of such behavior. Researchers and practitioners need to revisit the available guidelines and incorporate evidence-based interventions for preventing unhealthy screen time among the affected individuals. Such interventions may address harmful behaviors associated with screen time and promote active lifestyles that may improve health across populations during and after this pandemic.

17.
J Hosp Infect ; 122: 173-179, 2022 Apr.
Article in English | MEDLINE | ID: covidwho-1729910

ABSTRACT

BACKGROUND: An unprecedented rise in the number of COVID-19-associated mucormycosis (CAM) cases has been reported in India. Myriad hypotheses are proposed for the outbreak. We recently reported uncontrolled diabetes and inappropriate steroid therapy as significant risk factors for the outbreak. However, Mucorales contamination of hospital environment was not studied. AIM: To perform a multi-centre study across India to determine possible Mucorales contamination of hospital environment during the outbreak. METHODS: Eleven hospitals from four zones of India representing high to low incidence for mucormycosis cases were included in the study. Samples from a variety of equipment used by the patients and ambient air were collected during May 19th, 2021 through August 25th, 2021. FINDINGS: None of the hospital equipment sampled was contaminated with Mucorales. However, Mucorales were isolated from 11.1% air-conditioning vents and 1.7% of patients' used masks. Other fungi were isolated from 18% of hospital equipment and surfaces, and 8.1% of used masks. Mucorales grew from 21.7% indoor and 53.8% outdoor air samples. Spore counts of Mucorales in air were significantly higher in the hospitals of North and South zones compared to West and East zones (P < 0.0001). Among Mucorales isolated from the environment, Rhizopus spp. were the most frequent genus. CONCLUSION: Contamination of air-conditioning vents and hospital air by Mucorales was found. Presence of Mucorales in these areas demands regular surveillance and improvement of hospital environment, as contamination may contribute to healthcare-associated mucormycosis outbreaks, especially among immunocompromised patients.


Subject(s)
COVID-19 , Mucorales , Mucormycosis , Disease Outbreaks , Hospitals , Humans , India/epidemiology , Mucormycosis/epidemiology
18.
Journal of Association of Physicians of India ; 70(2):83, 2022.
Article in English | Scopus | ID: covidwho-1728250
19.
National Journal of Physiology, Pharmacy and Pharmacology ; 12(1):55-59, 2022.
Article in English | EMBASE | ID: covidwho-1677748

ABSTRACT

Background: Most of the patients of Coronavirus Disease-19 (COVID-19) presented with mild symptoms and recovered, but a considerable number of cases deteriorated and succumbed to death. They often present with hemostatic abnormalities mimicking disseminated intravascular coagulation with increased risk of thrombosis rather than bleeding. Hence, early prediction of disease severity by some easily available hematological parameters might be helpful to reduce mortality in COVID-19 cases. Aim and Objectives: The aim of the study was to determine whether values of Prothrombin Time (PT), International Normalized Ratio (INR), Activated Partial Thromboplastin Time (APTT) and D-Dimer (DD) correlate with disease severity in COVID-19 and also to find out cutoff value of these parameters to predict disease severity. Materials and Methods: This observational cross-sectional study was done on total 400 hospitalized COVID-19 adult patients where patients were categorized into moderate and severe cases as per guideline of Government of India. Patients with pre-existing coagulation disorder or receiving anticoagulant drugs were excluded from the study. PT, INR, APTT, and DD values of these two groups were evaluated and compared statistically to determine their significance and the cutoff value to predict severity. Results: Among the measured blood parameters means of PT (P < 0.001), INR (P < 0.001) and DD (P < 0.001) found to be significantly higher in the severe group of patients compared to moderate ones and DD value ≥1.365 mg/L indicates severe disease. APTT showed no statistically significant association with severity. Conclusion: PT and INR can be used as severity marker in COVID-19 patients;however, DD is the most reliable marker correlating with disease severity.

20.
Journal of Communicable Diseases ; 53(3):232-235, 2021.
Article in English | Scopus | ID: covidwho-1591754

ABSTRACT

The inability to identify the source of origin of SARS-CoV-2 even after more than twenty months of its emergence is intriguing and challenges the scientists and the public health personnel alike. Apprehension has been raised in certain quarters that some sort of human interference has taken place in the already dynamic gene pool of coronaviruses, which is a matter of concern. The need to have a scientific audit is paramount to unearth the real narrative about its origin as the precipitous assumption based on reports of human case incidences of infectious respiratory viral diseases having pandemic potential from a specific region is scientifically premature and it does not conclusively confirm the region to be the place of origin of the viral pathogen. Delineation of the source of origin of SARS-CoV-2 is vital for formulating strategies for the prevention of future outbreaks of viral zoonotic diseases if any, development of effective candidate vaccines, and designing target specific drugs. Further, this will put to rest the controversy about the origin and emergence of SARS-CoV-2 and create an ambience for cooperative functioning among the global stakeholders. It is pertinent to have comprehensive scrutiny of the laboratories conducting experimental research on coronaviruses particularly bat and other suspected mammalian beta-coronaviruses to avert such calamitous situations in future. Mitigation of the disastrous effects of the COVID-19 pandemic is a global responsibility and necessitates joint efforts from all stakeholders across the globe. Copyright (c) 2021: Author(s). Published by Advanced Research Publications

SELECTION OF CITATIONS
SEARCH DETAIL