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ERS Monograph ; 2021(94):1-13, 2021.
Article in English | EMBASE | ID: covidwho-2321584


The major morbidity and mortality from COVID-19 is due to acute viral pneumonitis that evolves to ARDS. Furthermore, COVID-19 patients may be affected by extrarespiratory involvement, including cardiac, renal, neurological and vascular complications. Different hospitals reorganised their logistical structures to optimise the care of COVID-19 patients and ensure infection control, and the public health scenario worldwide was characterised by the rapid spread of multidisciplinary units specifically dedicated to COVID-19 patients. This chapter describes the personal experience and clinical case of a previously healthy and active patient who suffered from severe COVID-19. Two other cases of patients hospitalised because of severe acute respiratory failure due to COVID-19 are also discussed.Copyright © ERS 2021.

ERS Monograph ; 2021(94):180-196, 2021.
Article in English | EMBASE | ID: covidwho-2314985
European Respiratory Journal Conference: European Respiratory Society International Congress, ERS ; 60(Supplement 66), 2022.
Article in English | EMBASE | ID: covidwho-2285029
European Respiratory Journal Conference: European Respiratory Society International Congress, ERS ; 60(Supplement 66), 2022.
Article in English | EMBASE | ID: covidwho-2279138
Journal of Heart & Lung Transplantation ; 42(4):S306-S307, 2023.
Article in English | Academic Search Complete | ID: covidwho-2272916
Research and Practice in Thrombosis and Haemostasis Conference ; 6(Supplement 1), 2022.
Article in English | EMBASE | ID: covidwho-2128125
Pulmonology ; 28(6): 419-420, 2022.
Article in English | MEDLINE | ID: covidwho-2126565

Vaccination , Humans
Sci Rep ; 12(1): 18792, 2022 Nov 05.
Article in English | MEDLINE | ID: covidwho-2106466


The gut is of importance in the pathology of COVID-19 both as a route of infection, and gut dysfunction influencing the severity of disease. Systemic changes caused by SARS-CoV-2 gut infection include alterations in circulating levels of metabolites, nutrients and microbial products which alter immune and inflammatory responses. Circulating plasma markers for gut inflammation and damage such as zonulin, lipopolysaccharide and ß-glycan increase in plasma along with severity of disease. However, Intestinal Fatty Acid Binding Protein / Fatty Acid Binding Protein 2 (I-FABP/FABP2), a widely used biomarker for gut cell death, has paradoxically been shown to be reduced in moderate to severe COVID-19. We also found this pattern in a pilot cohort of mild (n = 18) and moderately severe (n = 19) COVID-19 patients in Milan from March to June 2020. These patients were part of the first phase of COVID-19 in Europe and were therefore all unvaccinated. After exclusion of outliers, patients with more severe vs milder disease showed reduced FABP2 levels (median [IQR]) (124 [368] vs. 274 [558] pg/mL, P < 0.01). A reduction in NMR measured plasma relative lipid-CH3 levels approached significance (median [IQR]) (0.081 [0.011] vs. 0.073 [0.024], P = 0.06). Changes in circulating lipid levels are another feature commonly observed in severe COVID-19 and a weak positive correlation was observed in the more severe group between reduced FABP2 and reduced relative lipid-CH3 and lipid-CH2 levels. FABP2 is a key regulator of enterocyte lipid import, a process which is inhibited by gut SARS-CoV-2 infection. We propose that the reduced circulating FABP2 in moderate to severe COVID-19 is a marker of infected enterocyte functional change rather than gut damage, which could also contribute to the development of hypolipidemia in patients with more severe disease.

COVID-19 , Humans , Enterocytes/metabolism , SARS-CoV-2 , Fatty Acid-Binding Proteins/metabolism , Biomarkers , Cell Death , Lipids
Journal of Heart and Lung Transplantation ; 41(4):S525-S526, 2022.
Article in English | Web of Science | ID: covidwho-1849015
Journal of Heart and Lung Transplantation ; 41(4):S424-S425, 2022.
Article in English | EMBASE | ID: covidwho-1796808
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation ; 41(4):S524-S524, 2022.
Article in English | EuropePMC | ID: covidwho-1782094