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1.
Ptitsevodstvo ; 12:49-52, 2020.
Article in Russian | CAB Abstracts | ID: covidwho-1876531

ABSTRACT

The results of the study of the antigenic properties are presented for an experimental sample of emulsified inactivated vaccine against Newcastle disease (ND) and avian infectious bronchitis (IB) supplemented with acrylic acid copolymer (CoAA) as an additional stimulator of the immunogenesis (ND + IB+ CoAA / AB-M4). Experiments with vaccinated chicks evidenced that the experimental inactivated vaccine induces a higher level of immune response compared to the emulsified inactivated vaccine against ND and IB (ND + IB / AB-M4) manufactured according to the standard method.

2.
Ptitsevodstvo ; 12:64-68, 2021.
Article in Russian | CAB Abstracts | ID: covidwho-1841843

ABSTRACT

The antigenicity of three inactivated emulsified associated vaccines against viruses of chicken infectious bronchitis (IB), Newcastle disease (ND), and egg drop syndrome-76 (EDS-76) based on the oil adjuvant ISA-15 (O/W) was comparatively studied: (1) reference vaccine (IB+ND+EDS-76/ISA-15);(2) experimental vaccine (IB+NB+EDS-76/ISA-15-Nano) with a nanoscale-dispersed oil phase obtained by the use of a high-pressure homogenizer;(3) similar nano-scale vaccine (IB+NB+EDS-76+CoAA/ ISA-15-Nano) additionally supplemented with a copolymer of acrylic acid (CoAA). The in vivo tests of the vaccines on the chicks evidenced that both nano-scale vaccines enhanced the immune response in vaccinated chicks as compared to the reference vaccine and that supplementation with CoAA resulted in the highest postvaccinal antibody titers.

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