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Eur J Clin Microbiol Infect Dis ; 40(9): 1963-1974, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1217443


It has been demonstrated that obesity is an independent risk factor for worse outcomes in patients with COVID-19. Our objectives were to investigate which classes of obesity are associated with higher in-hospital mortality and to assess the association between obesity and systemic inflammation. This was a retrospective study which included consecutive hospitalized patients with COVID-19 in a tertiary center. Three thousand five hundred thirty patients were included in this analysis (female sex: 1579, median age: 65 years). The median body mass index (BMI) was 28.8 kg/m2. In the overall cohort, a J-shaped association between BMI and in-hospital mortality was depicted. In the subgroup of men, BMI 35-39.9 kg/m2 and BMI ≥40 kg/m2 were found to have significant association with higher in-hospital mortality, while only BMI ≥40 kg/m2 was found significant in the subgroup of women. No significant association between BMI and IL-6 was noted. Obesity classes II and III in men and obesity class III in women were independently associated with higher in-hospital mortality in patients with COVID-19. The male population with severe obesity was the one that mainly drove this association. No significant association between BMI and IL-6 was noted.

COVID-19/therapy , Obesity, Morbid/therapy , Aged , Aged, 80 and over , Body Mass Index , COVID-19/complications , COVID-19/epidemiology , COVID-19/mortality , Female , Hospital Mortality , Hospitalization , Humans , Male , Middle Aged , New York City/epidemiology , Obesity, Morbid/complications , Obesity, Morbid/epidemiology , Obesity, Morbid/mortality , Retrospective Studies , Sex Factors , Treatment Outcome