Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add filters

Database
Language
Document Type
Year range
1.
Nat Commun ; 12(1): 4864, 2021 08 11.
Article in English | MEDLINE | ID: covidwho-1354101

ABSTRACT

Successful therapeutics and vaccines for coronavirus disease 2019 (COVID-19) have harnessed the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Evidence that SARS-CoV-2 exists as locally evolving variants suggests that immunological differences may impact the effectiveness of antibody-based treatments such as convalescent plasma and vaccines. Considering that near-sourced convalescent plasma likely reflects the antigenic composition of local viral strains, we hypothesize that convalescent plasma has a higher efficacy, as defined by death within 30 days of transfusion, when the convalescent plasma donor and treated patient were in close geographic proximity. Results of a series of modeling techniques applied to approximately 28,000 patients from the Expanded Access to Convalescent Plasma program (ClinicalTrials.gov number: NCT04338360) support this hypothesis. This work has implications for the interpretation of clinical studies, the ability to develop effective COVID-19 treatments, and, potentially, for the effectiveness of COVID-19 vaccines as additional locally-evolving variants continue to emerge.


Subject(s)
COVID-19/therapy , Plasma/immunology , Adolescent , Adult , Aged , Antibodies, Viral/immunology , Antibody Specificity , Antigenic Variation , Blood Donors , COVID-19/mortality , Female , Humans , Immunization, Passive/mortality , Male , Middle Aged , SARS-CoV-2/genetics , SARS-CoV-2/immunology , Treatment Outcome , United States/epidemiology , Young Adult
SELECTION OF CITATIONS
SEARCH DETAIL