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1.
Chembiochem ; 08:08, 2022.
Article in English | MEDLINE | ID: covidwho-2013397

ABSTRACT

Peptides are ideal candidates for the development of antiviral therapeutics due to their specificity, chemical diversity and potential for highly potent, safe, molecular interventions. By restricting conformational freedom and flexibility, cyclic peptides frequently increase peptide stability. Viral targets are often very challenging as their evasive strategies for infectivity can preclude standard therapies. In recent years, several peptides from natural sources mitigated an array of viral infections. In parallel, short peptides derived from key viral proteins, modified with chemical groups such as lipids and cell-penetrating sequences, led to highly effective antiviral inhibitor designs. These strategies have been further developed during the recent COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2. Several anti-SARS-CoV-2 peptides are gaining ground in pre-clinical development. Overall, peptides are strong contenders for lead compounds against many life-threatening viruses and may prove to be the key to future efforts revealing viral mechanisms of action and alleviating their effects.

2.
Biomedica ; 42, 2022.
Article in Spanish | Scopus | ID: covidwho-1994468

ABSTRACT

Introduction: The severe acute respiratory syndrome of the new coronavirus (SARS-CoV-2) is the causal agent of the health emergency due to the COVID-19 pandemic. Although humans are the main susceptible host, experimental studies and reported cases of natural infection have evidenced scenarios of SARS-CoV-2 reverse zoonosis in animals. Objective: To evaluate the natural infection of SARS-CoV-2 in cats and dogs of owners diagnosed with COVID-19 in the Aburrá Valley, Antioquia, Colombia. Materials and methods: The circulation of SARS-CoV-2 was evaluated by RT-qPCR and RT-PCR in samples of nasopharyngeal and oropharyngeal smears from cats and dogs whose owners had latency due to COVID-19 infection. The positive cases were verified by amplifying fragments of the RdRp, N and E genes;and the RdRp amplicon was sequenced and phylogenetically analyzed. Results: Six cats and three dogs were confirmed cases of natural infection for SARS-CoV-2 from 80 tested animals. The animals did not show clinical signs;and their owners, who suffered from the infection, reported only mild signs of the disease without clinical complications. In the analysis of one of the sequences, a single nucleotide polymorphism (SNP) was found with a change in position 647 substituting the amino acid serine (S) for an isoleucine (I). The cases occurred in the municipalities of Caldas, Medellín and Envigado. Conclusions: It is inferred that natural infection in cats and dogs is associated with direct contact with a COVID-19 patient. © 2022. Biomedica. All Rights Reserved.

3.
Biomedica ; 42(Suppl. 2), 2022.
Article in Spanish | CAB Abstracts | ID: covidwho-1957852

ABSTRACT

Introduction: The severe acute respiratory syndrome of the new coronavirus (SARS-CoV-2) is the causal agent of the health emergency due to the COVID-19 pandemic. Although humans are the main susceptible host, experimental studies and reported cases of natural infection have evidenced scenarios of SARS-CoV-2 reverse zoonosis in animals.

4.
Revista Lasallista de Investigacion ; 19(1):135-151, 2022.
Article in English | Scopus | ID: covidwho-1924876

ABSTRACT

Introduction: The SARS-CoV-2 is the denomination of the new betacoronavirus, which was discovered and isolated for the first time in Wuhan, China, at the end of December 2019, and it is the causal agent of the sanitary emergency of the COVID-19 pandemic. Experimental studies have shown susceptibility to infection in pets (dogs and cats). Objective: To present the current information available on SARS-CoV-2 in animals under the care of humans that have been officially reported in the sanitary registries of the World © 2022. Revista Lasallista de Investigacion. All Rights Reserved.

5.
Sci Rep ; 12(1): 10352, 2022 Jun 20.
Article in English | MEDLINE | ID: covidwho-1900656

ABSTRACT

The rapid spread of conspiracy ideas associated with the recent COVID-19 pandemic represents a major threat to the ongoing and coming vaccination programs. Yet, the cognitive factors underlying the pandemic-related conspiracy beliefs are not well described. We hypothesized that such cognitive style is driven by delusion proneness, a trait phenotype associated with formation of delusion-like beliefs that exists on a continuum in the normal population. To probe this hypothesis, we developed a COVID-19 conspiracy questionnaire (CCQ) and assessed 577 subjects online. Their responses clustered into three factors that included Conspiracy, Distrust and Fear/Action as identified using principal component analysis. We then showed that CCQ (in particular the Conspiracy and Distrust factors) related both to general delusion proneness assessed with Peter's Delusion Inventory (PDI) as well as resistance to belief update using a Bias Against Disconfirmatory Evidence (BADE) task. Further, linear regression and pathway analyses suggested a specific contribution of BADE to CCQ not directly explained by PDI. Importantly, the main results remained significant when using a truncated version of the PDI where questions on paranoia were removed (in order to avoid circular evidence), and when adjusting for ADHD- and autistic traits (that are known to be substantially related to delusion proneness). Altogether, our results strongly suggest that pandemic-related conspiracy ideation is associated with delusion proneness trait phenotype.


Subject(s)
COVID-19 , Delusions , Humans , Pandemics , Paranoid Disorders/epidemiology , Phenotype
6.
Journal of Clinical and Translational Science ; 2022.
Article in English | EMBASE | ID: covidwho-1895534

ABSTRACT

Introduction We created a COVID-19 Research Patient and Community Advisory Board (PCAB) to provide patient and community input into clinical and translational research studies. The purpose of this article is to describe the PCAB creation, implementation, and evaluation. Methods We identified PCAB members who had participated in previous stakeholder engaged activities at our institution and invited their participation. We created a systematic consultation process where researchers could submit plain language research summaries and questions for the PCAB. A facilitated one-hour virtual consultation was then held where PCAB members provided feedback. We assessed satisfaction of PCAB members and researchers who received consultations using surveys. We also reviewed video recordings of PCAB consultations and reflections from team meetings to identify key lessons learned. Results Twenty-seven PCAB members took part in 23 consultation sessions. Twenty-Two completed an evaluation survey (81% response rate). Most members agreed or strongly agreed their opinions were valued (86%), it was a productive use of time (86%) and were satisfied (86%). Nineteen researchers completed an evaluation survey (63% response rate). Researchers reported positive experiences of working with the PCAB. Additional insights include limited funding in COVID-19 research for equitable community engagement, deficiencies in researcher communication skills, and a lack of cultural humility incorporated into study activities. Conclusions PCAB members provided recommendations that maximized the patient-centeredness and health equity focus of COVID-19 research. The detailed description of the process of developing, implementing, and evaluating our PCAB can be used as a template for others wishing to replicate this engagement model.

7.
Revista Cubana de Medicina Militar ; 51(2), 2022.
Article in Spanish | Scopus | ID: covidwho-1888126

ABSTRACT

Introduction: COVID-19 has generated diverse reactions and social changes in different populations, which may influence mental health. Objective: To describe the characteristics and risk factors of post-traumatic stress by COVID-19 in the Peruvian population. Methods: A retrospective cohort was studied in 2276 people over 18 years of age. The diagnosis of post-traumatic stress disorder was obtained with the Short Post-traumatic Stress Disorder Rating Interview (SPRINT-E) scale (α = 0.92), which was crossed with important variables;association statistics were obtained. Results: The main risk factors for post-traumatic stress were being a woman (p < 0.001);having obesity or cardiovascular disease (p < 0.001);spending more hours per day being informed about the subject (p< 0.001);having a family member who had suffered from post-traumatic stress disorder (p < 0.001);having a relative who has suffered from COVID-19 (p = 0.045), having a relative or friend who has died from this disease (p = 0.020);having relatives with psychiatric diagnoses (p = 0.018);having a harmful habit (p < 0.001), suffering from depression, anxiety or stress (p < 0.001;for each of the three disorders). On the contrary, the older the age (p<0.001) and the higher the academic degree (p<0.001), the lower the risk of post-traumatic stress. Conclusion: The factors associated with post-traumatic stress due to COVID-19 in the Peruvian population are obesity or cardiovascular disease, possession of harmful habits, family psychiatric history, having family members infected or killed by COVID-19, and suffering from depression, anxiety or stress. © 2022, Editorial Ciencias Medicas. All rights reserved.

8.
Revista de la Asociacion Espanola de Especialistas en Medicina del Trabajo ; 31(1):9-18, 2022.
Article in Spanish | Scopus | ID: covidwho-1877309

ABSTRACT

Objectives: The present study makes it possible to establish the profile of the worker most susceptible to SARS-CoV-2 infection, describe seroprevalence and determine the presence of anosmia and / or dysgeusia. Material and Methods:A descriptive, cross-sectional, and retrospective epidemiological study was carried out for 263 days in an ICU of a tertiary hospital. One hundred forty-six workers from 11 different categories were included. The results of the diagnostic tests for infection were consulted, and a telephone interview was carried out. Results: Fifty-six workers were infected (39.4%).The risk of infection in healthcare workers was higher (OR 3.38). Nursing staff and shift workers had a higher infection rate (p = 0, 000). Anti SARS-CoV-2 (AntiN) IgG antibodies were detected for more than four months. 38.1% developed anosmia and/or dysgeusia with a recovery of 117.41 days on average. Conclusions: The data obtained may be of interest for assessing occupational risk against SARS-CoV-2 in the health field. © 2022, Accion Medica S.A.. All rights reserved.

9.
Biomedica ; 42(3):41, 2022.
Article in Spanish | Web of Science | ID: covidwho-1865874

ABSTRACT

Introduction: The severe acute respiratory syndrome of the new coronavirus (SARS-CoV-2) is the causal agent of the health emergency due to the COVID-19 pandemic. Although humans are the main susceptible host, experimental studies and reported cases of natural infection have evidenced scenarios of SARS-CoV-2 reverse zoonosis in animals. Objective: To evaluate the natural infection of SARS-CoV-2 in cats and dogs of owners diagnosed with COVID-19 in the Aburra Valley, Antioquia, Colombia. Materials and methods: The circulation of SARS-CoV-2 was evaluated by RT-qPCR and RT-PCR in samples of nasopharyngeal and oropharyngeal smears from cats and dogs whose owners had latency due to COVID-19 infection. The positive cases were verified by amplifying fragments of the RdRp, N and E genes;and the RdRp amplicon was sequenced and phylogenetically analyzed. Results: Six cats and three dogs were confirmed cases of natural infection for SARS-CoV-2 from 80 tested animals. The animals did not show clinical signs;and their owners, who suffered from the infection, reported only mild signs of the disease without clinical complications. In the analysis of one of the sequences, a single nucleotide polymorphism (SNP) was found with a change in position 647 substituting the amino acid serine (S) for an isoleucine (I). The cases occurred in the municipalities of Caldas, Medellin and Envigado. Conclusions: It is inferred that natural infection in cats and dogs is associated with direct contact with a COVID-19 patient.

10.
RISTI - Revista Iberica de Sistemas e Tecnologias de Informacao ; 2022(E47):352-362, 2022.
Article in Spanish | Scopus | ID: covidwho-1787089

ABSTRACT

Due to the crisis caused by the COVID-19 pandemic and the growing need for services and information, universities in Ecuador face the challenge of providing the necessary technological support for the development of their substantive activities: teaching, research, and linkage with society. Enterprise architecture and cloud computing can help universities achieve their goals in the short term through an architectural management scheme that allows them access to advanced IT infrastructure. This paper proposes a four-phase strategy for universities to manage the migration to the cloud, where the leadership of senior executives is considered fundamental for this type of strategy. In addition, the strategy mediated by architectural transformation methodologies will allow the definition of an operational model that ensures that this migration is manageable and committed to a disciplined transition strategy. © 2022, Associacao Iberica de Sistemas e Tecnologias de Informacao. All rights reserved.

11.
Revista Cubana de Investigaciones Biomedicas ; 40(3), 2021.
Article in Spanish | Scopus | ID: covidwho-1782251
13.
Revista Estudiantil 16 de Abril ; 60(281), 2021.
Article in English, Spanish | CAB Abstracts | ID: covidwho-1529230

ABSTRACT

Introduction: the speedy expansion of the illness and the exponential increase of cases confirmed with COVID-19, forced to the World Organization of the Health, declared as pandemic.

14.
Scopus; 2021.
Preprint in English | Scopus | ID: ppcovidwho-290754

ABSTRACT

Background: During the COVID-19 pandemic, it has been necessary to deliver mental health care using technologies (e-mental health). But there have been difficulties in its application. Quantitative systematic reviews such as meta-analysis doesn't allow us to fully identify and properly describe this subject. Thus, our study has two main objectives: a) "to determine what evidence is available for synchronous e-mental health implementation";and b) "to develop a framework informed by a realist analysis for the implementation of synchronous e-mental health". Methods: We will search MEDLINE, EBM Reviews, PsycINFO, EMBASE, SCOPUS, CINAHL Complete, and Web of Science databases from 1st January 2015 to September 2020, with no language restriction. A systematic review with a narrative description and a realist synthesis will be conducted. Primary studies relating to adults with common mental health problems using any type of mobile mental health intervention that includes a synchronic component and communication with a mental health professional will be included. For the analysis, we will make a realist synthesis of the systematic reviews, using a grounded theory approach with an emergent approach to synthesize the information, prioritizing the systematic reviews with a lower risk of bias in the AMSTAR-2 tool. The realist synthesis will be based on the interpretation, integration, and inference of the evaluated elements and the generation of hypotheses to better understand the implementation process of synchronous e-mental health. Finally, we will present the overall assessment in a Summary of Qualitative Findings table. Conclusion: Our results will allow a better understanding of the facilitator and limitations in implementing e-mental health. © 2021 Villarreal-Zegarra D et al.

15.
MEDLINE; 2020.
Preprint in English | MEDLINE | ID: ppcovidwho-290753

ABSTRACT

Background: During the COVID-19 pandemic, it has been necessary to incorporate technologies in the care of mental health problems. But there have been difficulties in the application of technology-based interventions in mental health. Some quantitative systematic reviews don't allow us to fully identify and properly describe this subject. In order to answer the question "how do electronic interventions apply in mental health and what makes the application of any of these interventions work", this study will carry out an overview of systematic reviews, which will make it possible to develop a theoretical framework on the implementation of electronic care in mental health problems.

16.
Sustainable Development of Mountain Territories ; 14(2), 2021.
Article in English | Scopus | ID: covidwho-1399812

ABSTRACT

Flipped learning and augmented reality have become two emerging didactic proposals today in the field of education. This study analyzes the effectiveness of flipped learning and augmented reality in various dimensions related to the learning process. A quasi-experimental design has been carried out in a sample of 116 students from Spain, of the third level of Secondary Education. A questionnaire has been used to collect the research data. The results show that there is a high appreciation by students of both educational experiences, although differences in various dimensions are present. Those who have received teaching based on flipped learning show significance in the dimensions teacher-student, autonomy, deepening and classtime. On the other hand, those who have developed the experience with augmented reality show significance in the dimensions of motivation, interrelation with content and students, and resolution. In conclusion, both the application of an emerging methodology based on flipped learning and the use of educational technology with augmented reality contributes positively to the optimization of learning processes in the Mathematics classroom. © 2021 North Caucasian Institute of Mining and Metallurgy, State Technological University. All rights reserved.

17.
HemaSphere ; 5(SUPPL 2):645, 2021.
Article in English | EMBASE | ID: covidwho-1393448

ABSTRACT

Background: Coagulopathy associated with COVID-19 is one of the main complications, especially in individuals with risk factors. Simultaneously, the use of low molecular weight heparin is the recommended strategy in hospitalized individuals, but the usefulness of other strategies such as DOACs in outpatients is still unknown. Aims: Describe the benefit of the use of rivaroxaban at discharge on the risk of thrombosis in patients discharged from COVID-19.Identify the behavior of Dimero-D at discharge and its modification with anticoagulant therapy. Methods: Randomized 1: 1 study (Rivaroxaban 10mg for 14 days versus observation) at discharge in individuals with COVID-19 who have not required mechanical ventilation. D-dimer was evaluated at 14 and 30 days after discharge in conjunction with a CT angiography at four weeks after hospital discharge. The protocol was developed in the Hospital Regional de Alta Especialidad de Ixtapaluca, authorized by the ethics committee with registration number NR-19-2020. The study is identified in ClinicalTrials.gov with the following registry NCT04508439 Results: Forty individuals were evaluated (20 in each arm) with follow- up greater than 100 days. Gender distribution was equitable in each arm, with a mean age of 50 years (21 to 74 years), 40% (n = 16) were older than 55 years, 27.5% (n = 11) had hypertension and 20% (n = 8) had diabetes. The mean length of hospital stay was 10.5 days (6 to 23 days) treated with oxygen and low molecular weight heparin. At discharge, treatment was started with rivaroxaban 10mg x 14d vs. observation;in the rivaroxaban group, four events were identified (3 hemorrhages / 1 thrombosis), this difference being significant (Log Rank 0.016). Only one thrombosis event (pulmonary embolism) was identified in the rivaroxaban group at eight treatment days. Compared to the diagnosis, DD levels were lower at both 14 and 30 days (p = 0.000, 95% CI, 440.8-1164.9) without finding a difference in those treated with rivaroxaban or observation (p = 0.721, 95% CI, -68.48 to 241.18). Summary/Conclusion: The use of DOACs at discharge does not benefit from an increased risk of hemorrhagic events;the anticoagulant strategy should be individualized, focused only on those patients at very high risk of thrombosis.

18.
European Journal of Hospital Pharmacy ; 28(SUPPL 1):A81, 2021.
Article in English | EMBASE | ID: covidwho-1186323

ABSTRACT

Background and importance Multiple sclerosis (MS) secondline disease modifying treatments (DMT) cause lymphocyte or B cell depletion, such as therapy with natalizumab, ocrelizumab, alemtuzumab or rituximab. They can present a varying degree of immunodeficiency that can translate into an increased risk of infections. The decision making process should balance the risks of stopping an active treatment and the risk of COVID- 19 infection. Aim and objectives To evaluate the management of MS patients with secondline DMT via infusion with natalizumab, ocrelizumab, rituximab and alemtuzumab during the COVID- 19 pandemic. Material and methods An observational retrospective study was conducted between January 2020 and October 2020 of MS patients on active treatment with natalizumab, ocrelizumab, rituximab or alemtuzumab who were expected to receive new dosages in this period. For data collection, the electronic clinic history system (Selene) and the programme Farmatools were used. Variables collected were: sex, age, expanded disability status scale (EDSS), COVID-19 diagnosis and type of MS. Treatment changes/delays due to COVID-19 were reviewed. In case of delay, the number of days was quantified. Results 40 patients (65% women) treated with different infusion therapies were evaluated with a median age of 47.3 (SD 13,3). The average EDSS was 3.8 (SD 2.1). 29 patients had relapsing-remitting MS (72,5%), 7 had primary progressive MS (17.5%) and 4 had secondary progressive MS (10%). Five (12.5%) COVID-19 cases were diagnosed. No delays were registered in 13 infusions of natalizumab;2 patients, due to a suboptimal response, were changed to ocrelizumab, reducing hospital visits, and one was transferred to another hospital. Three patients were expected to receive alemtuzumab. No one received alemtuzumab and two were changed to ocrelizumab due to the European Medicines Agency (EMA) alert that recommended restricting the use of alemtuzumab during the COVID-19 pandemic. Two patients received rituximab in time;one was changed to natalizumab due to infusion reactions and in one case the dosing interval was extended to 36 days. Eight patients began ocrelizumab treatment, eight received their dose without delay, one died and in five cases the dosing interval was extended to 39 days (SD 23.8). Conclusion and relevance According to the recommendations, a case-by-case analysis should be performed, but it seems that the COVID-19 pandemic has conditioned MS treatments as changes/delays were registered. Five (12.5%) COVID-19 cases were diagnosed, similar to the outcomes obtained in the seroprevalence study in the same region.

19.
Media and Jornalismo ; 20(37):185-204, 2020.
Article in Portuguese | Scopus | ID: covidwho-937741

ABSTRACT

2020 will be remembered globally as the year of the Covid-19 pandemic. Although this disease had emerged in China in the end of 2019, its global spread a few months later threatened the globalized society, causing serious social, political, and economic effects, not all yet understood. Journalism has been in crisis over the past few decades (Zelizer, 2004;2009;2017), but the coverage of this pandemic through diverse devices and screens (Deuze, 2019) brought a new vigor to the role of journalism. In Portugal, during a period of homely isolation, television played a role of social link (Wolton, 1994), demonstrating that it is still the dominant medium (ERC, 2016, 2019;OBERCOM, 2018;Statista, 2018). In this context, our tribute to Nelson Traquina has the aim of presenting, commenting, and discussing his contribution to the study of television journalism in Portugal by assessing the television coverage of this pandemic crisis. For this purpose, we have retrieved theoretical studies about the theories of news and empirical studies about HIV/AIDS done by Traquina (1993, 2002, 2004, 2010 and Traquina et al., 2001). We have empirically assessed both the lunchtime and evening television news services of the channels RTP1, SIC and TVI. We have built a database using a definition of assessment categories, which although was inspired by the work of Traquina about HIV/AIDS, was adapted to the specificities of this new disease. The results enable a discussion about the theories of news as “construction” (Traquina, 1993) and the role of routines in the production of news. © 2020 Universidade Nova de Lisboa - Center for Media Research and Journalism. All rights reserved.

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