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1.
Inorganic Chemistry Communications ; : 109133, 2021.
Article in English | ScienceDirect | ID: covidwho-1568767

ABSTRACT

Delivery of pharmaceutical compounds has been always an important issue to be solved by appropriate methodologies. In this regard, coronene surface was investigated in this work for possible delivery of favipiravir (FAV) as a well-known drug for medication of COVID-19 pandemic. To this aim, density functional theory (DFT) calculations were performed to explore surfaces of two representative carbon coronene (C) and boron nitride coronene (BN) models for adsorption of FAV drug. Consequently, complex formations of FAV@C and FAV@BN were examined using the computed molecular and atomic parameters. The results indicated that the FAV could interact with both of C and BN surfaces, but with better favorability of FAV@BN complex formation in comparison with FAV@C complex formation. Additionally, molecular orbitlas features indicated that the electronic behavior of FAV@BNC complex could be close to the original FAV in contrast with the results of FAV@CC complex. The evaluated diagrams of density of states (DOS) showed benefit of the employed models for sensor applications. The obtained features of quantum theory of atoms in molecule (QTAIM) affirmed formations interactions between substances and their strengths. Finally, FAV@BN complex was proposed as proper compound for further investigations of drug delivery processes.

3.
Pain ; 162(11): 2780, 2021 11 01.
Article in English | MEDLINE | ID: covidwho-1475891
4.
Preprint in English | EuropePMC | ID: ppcovidwho-291256

ABSTRACT

可以發現,中國版本的這篇文章: <a href="http://ssrn.com/abstract=3513705">http://ssrn.com/abstract=3513705</a>.It is recommended that everyone twice a day, half a cup of 100% ethanol is heated to a temperature of 40-50 degrees, with your mouth facing the tea cup, inhale the alcohol vapor from the tea cup 5 times. Or use a sprayer to spray 75% of the high-alcohol into your mouth, 4-5 times, and take a deep breath when spraying, once a day in the morning and evening. Prevents pneumonia from colds and new coronavirus infections. People who have been infected with the new coronavirus can do it once each morning, noon, and evening.It’s better to try it. It’s harmless anyway. Chinese people have a lot of alcohol, but this is inhaled into the lungs. After drinking, you can smell the gas. There are a large number of new coronaviruses in the human throat, mouth and trachea, which have been scientifically confirmed.In this article, the first case of pneumonia of unknown origin was discovered in Wuhan, Hubei, China in early December 2019.As of February 16, 2020,Reports from 31 provinces and the Xinjiang Construction Corps in China, there were 57416 confirmed cases, of which 11,272 were severe cases. A total of 1,665 deaths and 68,500 confirmed cases have been reported. There are 8228 suspected cases, and 529,418 close contacts have been tracked, and 158,764 close contacts are still in medical observation;among them, there are 49,030 confirmed cases in Hubei Province, China, of which 10,369 are severe cases. A total of 1569 deaths, 56249 confirmed cases, and 5234 suspected cases;there were 84 confirmed cases in Hong Kong, Macao and Taiwan and 1 died. There were 616 cases and 3 deaths in 24 countries overseas.Since January 22, 2020, in response to the national call, I stayed at home and watched CGTN and CCTV-related news reports about new coronaviruses daily. At the same time, I studied the team of Academician Zhong Nanshan, Academician Li Lanjuan, Researcher Shi Zhengli, etc. A total of 18 academic papers, as well as free papers related to downloading new coronaviruses from China Knowledge Network, combined with my university veterinary undergraduate expertise (1985-1989), and obtained a veterinary qualification in 1993, I would like to make a brief discussion on the treatment of the new coronavirus. How to make alcohol vapor into 70% alcohol liquid after entering the alveoli, Covering the surface of the respiratory membranes of the lungs, A theoretical feasibility study was carried out.

5.
Resour Policy ; 74: 102364, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1442544

ABSTRACT

This paper analyzes the time-frequency spillover effects between food and crude oil markets, two particularly important commodity markets, under the impact of the pandemic. Using the BK frequency domain spillover index and the rolling window method, we explore the spillover effects between the food and crude oil markets under the influence of COVID-19, and compare the changes of spillover effects in each market before and during the pandemic. Based the network connectedness method and the Bayesian structural time series method, we further reveal the changes of the pairwise spillover effects between markets on different time scales. Our study shows that the food-oil market system has the strongest spillover effect in the short term, and the spillovers during the pandemic are significantly weaker than that under the financial crisis. In addition, the pandemic has significantly increased the impact of corn on the crude oil market, but reduced its spillovers on soybeans and rice. Finally, during the COVID-19 period, the wheat market is likely to receive more spillovers from other markets, particularly corn and soybeans. These findings are of great significance for market participants with different horizons to understand the spillover effects of food and oil markets under the impact of the pandemic and to avoid the risk transmission across markets or assets.

6.
Asian Pacific Journal of Tropical Medicine ; 14(6):241-253, 2021.
Article in English | GIM | ID: covidwho-1310155

ABSTRACT

Background: Cardiopulmonary resuscitation (CPR) strategies in COVID-19 patients differ from those in patients suffering from cardiogenic cardiac arrest. During CPR, both healthcare and non-healthcare workers who provide resuscitation are at risk of infection. The Working Group for Expert Consensus on Prevention and Cardiopulmonary Resuscitation for Cardiac Arrest in COVID-19 has developed this Chinese Expert Consensus to guide clinical practice of CPR in COVID-19 patients. Main recommendations: (1) A medical team should be assigned to evaluate severe and critical COVID-19 for early monitoring of cardiac-arrest warning signs. (2) Psychological counseling and treatment are highly recommended, since sympathetic and vagal abnormalities induced by psychological stress from the COVID-19 pandemic can induce cardiac arrest. (3) Healthcare workers should wear personal protective equipment (PPE). (4) Mouth-to-mouth ventilation should be avoided on patients suspected of having or diagnosed with COVID-19. (5) Hands-only chest compression and mechanical chest compression are recommended. (6) Tracheal-intubation procedures should be optimized and tracheal-intubation strategies should be implemented early. (7) CPR should be provided for 20-30 min. (8) Various factors should be taken into consideration such as the interests of patients and family members, ethics, transmission risks, and laws and regulations governing infectious disease control. Changes in management: The following changes or modifications to CPR strategy in COVID-19 patients are proposed: (1) Healthcare workers should wear PPE. (2) Hands-only chest compression and mechanical chest compression can be implemented to reduce or avoid the spread of viruses by aerosols. (3) Both the benefits to patients and the risk of infection should be considered. (4) Hhealthcare workers should be fully aware of and trained in CPR strategies and procedures specifically for patients with COVID-19.

7.
Front Cell Dev Biol ; 9: 684874, 2021.
Article in English | MEDLINE | ID: covidwho-1305632

ABSTRACT

The whole world is suffering from the coronavirus disease 2019 (COVID-19) pandemic, induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through angiotensin-converting enzyme 2 (ACE2). Neurological manifestations in COVID-19 patients suggested the invasion of SARS-CoV-2 into the central nervous system. The present study mapped the expression level of ACE2 in 12 brain regions through immunohistochemistry and detected ACE2 in endothelial cells and non-vascular cells. The comparison among brain regions found that pons, visual cortex, and amygdala presented a relatively high level of ACE2. In addition, this study demonstrates that the protein level of ACE2 was downregulated in the basal nucleus, hippocampus and entorhinal cortex, middle frontal gyrus, visual cortex, and amygdala of the brain with Alzheimer's disease (AD) pathology. Collectively, our results suggested that ACE2 was expressed discriminatorily at different human brain regions, which was downregulated in the brain with AD pathology. This may contribute to a comprehensive understanding of the neurological symptoms caused by SARS-CoV-2 and provide clues for further research on the relationship between COVID-19 and AD.

8.
Case Studies in Thermal Engineering ; 26:101173, 2021.
Article in English | ScienceDirect | ID: covidwho-1275251

ABSTRACT

The importance of ventilation is highlighted through the recent COVID pandemic particularly in populated societies with crowded buildings. The application of single solar chimney ventilator with and without fin, at different tilt angles, is evaluated for Hong Kong climate using transient 3D validated numerical simulation in present research from energy and environmental viewpoints. The results show that the ventilation performance of the solar chimney ventilator is significantly enhanced by selecting an optimum value for the tilt angle of the chimney. Moreover, the maximum air mass flow rate increases from 0.06 to 0.14 kg/s by reducing the tilt angle from 80° to 20°. Energy saving performance of the solar chimney ventilator with tilt angle of 20° is around 144% higher than that of the solar chimney ventilator with the tilt angle of 80°. During the morning time (sunrise to noon), the highest performance is achieved under the tilt angle of 40°. From the environmental viewpoint, the solar chimney ventilator with the tilt angle of 20° and 40° can prevent 0.098 kg and 0.108 kg CO2 production through the morning. Prevention of the CO2 production through the afternoon is 0.209 kg and 0.151 kg for the mentioned tilt angles respectively.

9.
Renewable Energy ; 2021.
Article in English | ScienceDirect | ID: covidwho-1213493

ABSTRACT

The recent Covid-19 pandemic and its required hygiene protocols further revealed the importance of ventilation process in all buildings deal with human life. Solar Chimney Ventilator (SCV) is a type of renewable technology that is able to provide natural ventilation for the buildings. However, conventional SCV is not economical due to its low performance of ventilation. Thus, in the current study, an innovative tilted Solar Chimney Ventilator with Phase Change Material integrated with Photovoltaic technology (SCV-PV-PCM) is proposed and investigated under real unsteady transient weather condition (based on Hong Kong climate) via a validated three-dimensional numerical study. The characteristics of the SCV-PV-PCM is analyzed during the day (through different month i.e March, June, September, and December) and compared with conventional SCV-PV system. Based on the findings, the produced power and ventilation capacity of the SCV-PV-PCM is higher than those for the common SCV-PV system. Nonetheless, the system is not able to provide the appropriate ventilation power for the building through the winter due to lack of high ambient temperature and strong solar radiation. Moreover, it is concluded that using the SCV-PV-PCM in the building is most economically beneficial in the month of June by saving 2.88 $/month.

10.
Building and Environment ; : 107833, 2021.
Article in English | ScienceDirect | ID: covidwho-1157160

ABSTRACT

Ventilation process is a significant requirement of healthy life-style and its importance was further highlighted through the recent Covid-19 global outbreak. Solar chimney is a natural indoor air ventilator without the requirement of any electricity power consumption. Hybrid solar chimney, photovoltaic panel, and phase change material (SC-PV-PCM) is investigated in this study (see graphical abstract) as the most recent newly proposed technology which is able to provide simultaneous natural ventilation and electricity in an effective manner. The contribution of this research is to identify the most efficient characteristics of phase change material (PCM) for this unique application using a comprehensive 3D validated numerical simulation. It is note that, the desirable phase change material should be able to enhance the efficiency of the ventilation process and power generation simultaneously. Hence, in order to reach the aim of this research, the impact of many effective parameters of phase change material including conductivity, melting point, heat capacity, and its enthalpy on both ventilation features of the solar chimney and electrical efficiency of solar panel is investigated for the mentioned (SC-PV-PCM) hybrid technology. Besides, the economic characteristics of the above system is evaluated as well. The simulation is performed under transient real weather conditions of Hong Kong (solar radiation intensity, ambient temperature, sky temperature, and wind speed) through the month of June from sunrise until sunset.

11.
Preprint | SciFinder | ID: ppcovidwho-5299

ABSTRACT

A review. Cytokine storm is an excessive immune process when the body is stimulated. The disease progresses rapidly with a high mortality and complicated pathogenesis. In the outbreak of novel coronavirus pneumonia (NCP, COVID-19), the rapid deterioration of the condition of patient is closely related to the outbreak of cytokine storm in the body. The latest "NCP diagnosis and treatment plan" also provides a traditional Chinese medicine treatment plan. This paper reviewed the pharmacol. effects of traditional Chinese medicine in antigen clearance, immune modulation and tissue protection based on the source, process and harm of cytokine storm. Furthermore, traditional Chinese medicine is contributive in prevention and treatment of cytokine storm, which can provide valuable medication guidance for the treatment combining traditional Chinese and Western medicine in clinic.

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