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1.
European journal of public health ; 32(Suppl 3), 2022.
Article in English | EuropePMC | ID: covidwho-2101820

ABSTRACT

Background Personal protection equipment (PPE) use in hospitals has consistently increased due to the Sars-Cov-2 outbreak, in wards repurposed for Covid-19 patients and wards that kept their usual activity. This increase influenced an environmental emergency in terms of health waste (HW) disposal. This study aims to assess the economic and environmental impact of the increase in HW generated before and during the pandemic in an Italian Hospital. Methods Data from 2016 to 2019 and 2020 to 2021 was retrieved from Risk Management department. Per capita and per days-of-stay waste quantity were calculated for the hospital inpatient wards and medical service areas (anatomical pathology, laboratories, radiology, nuclear medicine). Linear regression models assessed the epidemiological impact of COVID, and LOESS analysis modeled the relationship between infectious HW generation and the percentage of COVID-related inpatient days. Average weight of HW per patient was used to estimate the monetary value of CO2 produced. Results Preliminary results show that the inpatient days related to COVID nonlinearly influenced the infectious HW generated by wards. PPE usage increased in every context, and the proportion of COVID-related bed-days ranged from 2% to 12% in low-incidence months to 17% to 31% during acute phases. Pre-COVID CO2 production weighted 487 kg per patient and cost 1705€ per-capita, whereas during the pandemic it amounted to 768 kg per patient and cost 2688€ per capita which resulted in a significant increase of 983€ per patient. Conclusions In light of the results, HW disposal is an urgent issue that should be addressed by policy makers when implementing new monitoring systems for hospitals. A more adequate disposal of HW could substantially contribute in reducing air pollution and concurrently reduce the economic impact health systems due to the coronavirus pandemic. Key messages The COVID-19 pandemic has brought an increase in hospital waste generation. The improvement of HW disposal monitoring system should be considered to avoid reaching critical levels in the near future.

2.
Managing Sport and Leisure ; 27(1/2):166-174, 2022.
Article in English | CAB Abstracts | ID: covidwho-1769076

ABSTRACT

The COVID-19 pandemic has changed the conditions for competitive football around the globe dramatically. Several competitions and leagues have been cancelled or postponed. Players have firstly been forced to training in solitude. In a second stage, players start training in small groups with strict contact restriction and return to competitive play might occur after only few weeks of normal team training preparation. These special circumstances are likely to impact football performance and injury risk in the upcoming competitions. Thus, clubs, coaching and medical staff, as well as players are challenged on the prioritization of fitness and performance, which easily can create several "catch-22-dilemmas". The present article presents views on fitness training, physical preparation and recovery during these uncommon conditions, and how elite football players can return to the competitive field well-prepared for post-crisis football endeavours around the world. Due to the multifaceted physiological demands in elite football, the long recovery requirements after match-play and an upcoming reality with many games within a short period, elite football players, managers and clubs may face extraordinary challenges associated with return to play under the current circumstances.

3.
Embase;
Preprint in English | EMBASE | ID: ppcovidwho-326792

ABSTRACT

The devastation caused by SARS-CoV-2 has made clear the importance of pandemic preparedness. To address future zoonotic outbreaks due to related viruses in the sarbecovirus subgenus, we identified a human monoclonal antibody, 10-40, that neutralized or bound all sarbecoviruses tested in vitro and protected against SARS-CoV-2 and SARS-CoV in vivo. Comparative studies with other receptor-binding domain (RBD)-directed antibodies showed 10-40 to have the greatest breadth against sarbecoviruses and thus its promise as an agent for pandemic preparedness. Moreover, structural analyses on 10-40 and similar antibodies not only defined an epitope cluster in the inner face of the RBD that is well conserved among sarbecoviruses, but also uncovered a new antibody class with a common CDRH3 motif. Our analyses also suggested that elicitation of this class of antibodies may not be overly difficult, an observation that bodes well for the development of a pan-sarbecovirus vaccine.

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