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1.
Vaccines ; 8(4):611, 2020.
Article | WHO COVID | ID: covidwho-865150

ABSTRACT

Vaccines may induce positive non-specific immune responses to other pathogens This study aims to evaluate if influenza vaccination in the 2019–2020 season had any effect on the risk of SARS-CoV-2 confirmed infection in a cohort of health workers During the first SARS-CoV-2 epidemic wave in Spain, between March and May 2020, a cohort of 11,201 health workers was highly tested by RT-qPCR and/or rapid antibody test when the infection was suspected Later in June, 8665 of them were tested for total antibodies in serum A total of 890 (7 9%) health workers were laboratory-confirmed for SARS-CoV-2 infection by any type of test, while no case of influenza was detected The adjusted odds ratio between 2019–2020 influenza vaccination and SARS-CoV-2 confirmed infection was the same (1 07;95% CI, 0 92–1 24) in both comparisons of positive testers with all others (cohort design) and with negative testers (test-negative design) Among symptomatic patients tested by RT-qPCR, the comparison of positive cases and negative controls showed an adjusted odds ratio of 0 86 (95% CI, 0 68–1 08) These results suggest that influenza vaccination does not significantly modify the risk of SARS-CoV-2 infection The development of specific vaccines against SARS-CoV-2 is urgent

2.
Obesity (Silver Spring) ; 2020 Sep 04.
Article in English | MEDLINE | ID: covidwho-743688

ABSTRACT

OBJECTIVES: To analyze the association between morbid obesity and COVID-19 hospitalization and severe disease. METHODS: We evaluated the incidence of hospitalization for laboratory-confirmed COVID-19 in a prospective population-based cohort of 433,995 persons aged 25-79 years in Spain during March and April 2020. Persons with and without morbid obesity were compared using Poisson regression to estimate the adjusted relative risk (aRR) of morbid obesity for COVID-19 hospitalization and for severe disease (intensive care unit admission or death). Differences in the effect by age, sex and chronic conditions were evaluated. RESULTS: Individuals with morbid obesity had higher risk of hospitalization (aRR=2.20; 95% confidence interval (CI) 1.66-2.93) and severe COVID-19 (aRR=2.30; 95%CI 1.20-4.40). In people younger than 50 years, these effects were more pronounced (aRR=5.02, 95%CI 3.19-7.90; and aRR=13.80, 95%CI 3.11-61.17, respectively), while no significant effects were observed in those aged 65-79 years (aRR=1.22, 95%CI 0.70-2.12; and aRR=1.42, 95%CI 0.52-3.88, respectively). Sex and chronic conditions did not modify the effect of morbid in any of the outcomes. CONCLUSIONS: Morbid obesity is a relevant risk factor for COVID-19 hospitalization and severity in young adults, of a similar magnitude as aging. Tackling current obesity pandemic could alleviate impact of chronic and infectious diseases.

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