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1.
Revista Espanola de Quimioterapia ; 13:13, 2022.
Article in English | MEDLINE | ID: covidwho-2164727

ABSTRACT

Predictions for a near end of the pandemic by the World Health Organization should be interpreted with caution. Current evidence indicates that the efficacy of a fourth dose of classical mRNA vaccines (BT162b2 or mRNA-1273) is low and short-lived in preventing SARS-CoV-2 infection in its predominant variant (Omicron). However, its efficacy is high against severe symptomatic infection, hospitalization and death. The new vaccines being introduced are bivalent and active against the Omicron variants. Potential new vaccines to be introduced in the coming year include a vaccine based on a recombinant protein that emulates the receptor binding domain of the Spike protein under development by the Spanish company Hipra, as well as vaccines for nasal or oral administration. Available information suggests that vaccines against COVID-19 can be administered in association with influenza vaccination without particular complications. New drugs against COVID-19, both antiviral and anti-inflammatory, are under investigation, but this does not seem to be the case with monoclonal antibodies. The indication to use masks in some circumstances will be maintained next year in view of the accumulation of scientific data on their efficacy. Finally, the long COVID or Post-COVID syndrome may continue to affect a very high proportion of patients who have had the disease, requiring combined diagnostic and therapeutic resources.

2.
European Psychiatry ; 65(Supplement 1):S875-S876, 2022.
Article in English | EMBASE | ID: covidwho-2154176

ABSTRACT

Introduction: In Ecuador, the first case of covid19 was reported on February 29th of 2020, forcing people to remain in lockdown, which increased gender violence;post-traumatic stress disorder (PTSD) and depression. Objective(s): Determine the cases during the lockdown caused by the covid-19 pandemic we found victims of some type of gender-based violence, depression, and PTSD. Method(s): An observational, cross-sectional descriptive study was carried out based on surveys conducted online, the study was conducted on January 29th of 2021, in the province of Guayas- Ecuador. Performed with google forms platform, data on affiliation, the situation of intimate partner violence and the Davidson trauma test (PTSD) and the Beck test (depression) were collected. Result(s): A total of 411 samples were obtained, classified according to age, sex, number of children, education, occupation, intimate partner relationship, whether they had suffered gender violence and types of violence. 88 (21.41%) people reported having suffered some type of violence, of which 25 (28.42%) were men and 62 (70.45%) were women. The most common was psychological with 53 (60.23%) people. 82 respondents tested positive to Davidson test for PTSD, equivalent to 20% of the total sample. 51 people (12%) reported suffering from mild depression, 53 (13%) reported suffering from moderate depression and 38 people (9%) reported major depression with Beck test. Conclusion(s): In this study we evidenced that although the interviewers claimed they had never suffered gender violence , it was observed that the results were incongruent, so it is important to highlight that talking about gender violence is still considered a stigma in our society.

3.
Proceedings of the 7th Brazilian Technology Symposium (Btsym 21): Emerging Trends in Human Smart and Sustainable Future of Cities, Vol 1 ; 207:584-591, 2023.
Article in English | Web of Science | ID: covidwho-2122174

ABSTRACT

With the arrival of the COVID-19 pandemic, health systems were forced to adapt their intra- and extra-hospital processes through mechanisms of articulation, integration, and coordination between the organic units of public and private institutions, configuring a single national health system. In this sense, the objective of this study was to determine whether there is a relationship between clinical management for the hospitalization of patients with COVID-19 and resolution capacity functionality in a Health Network. A hypothetical deductive method was used with a descriptive-correlational analysis with a cross-sectional design. The sample consisted of 150 health care workers (100%). The selection was conducted in 3 level I-4 facilities of the Contumaza-Cajamarca Health Network, Peru, 2021. The dependent variable was resolution capacity functionality, and the independent variable was clinical management for the hospitalization of patients with COVID-19. The results suggest an average level both in clinical management and in resolution capacity functionality and the transport dimension in 45.3%, extending a significant relationship (p < 0.05) with Rho = 0.755 and Rho = 0.251, respectively.

4.
Jimenez, S.; Miro, O.; Alquezar-Arbe, A.; Pinera, P.; Jacob, J.; Llorens, P.; Garcia-Lamberechts, E. J.; Martin-Sanchez, F. J.; Del Castillo, J. G.; Burillo-Putze, G.; Martin, A.; Grima, M. L. L.; Gomez, M. A. J.; Millan, J.; Lazaro, L. S.; Espinosa, B.; Paya, A. B.; Noceda, J.; Cano, M. J. C.; Serra, R. S.; Bayarri, M. J. F.; Suarez, F. J. S.; Tejera, M. G.; Porrino, J. M. M.; Maestre, M. R.; Melendez, N.; Albero, P. B.; Escolano, E. R.; Manrique, K. J. A.; Del Rio, R.; Mestre, A. M.; Garcia, C. P.; Amador, P. S.; Aznar, J. V. B.; Lopez, J. L. R.; Ponce, M. C.; Belda, M. B. R.; Fernandez, E. D.; Valero, C. C.; Gimenez, L. M.; Gomez, A. P.; Bellver, E. G.; Rizzi, M.; Suarez, C. C.; Cardozo, C.; Llopis-Roca, F.; Roset-Rigat, A.; Boter, N. R.; Rovira, M. A.; Tost, J.; Tejedo, A. A.; Lorenzo, I. C.; Palau-Vendrell, A.; Tur, R. G.; Munoz, M. A.; Ferrer, E. S.; Garcia, L. L.; Mojarro, E. M.; Jimenez, B. S. A.; Huerta, A.; Fragiel, M.; Quiros, A. M.; Del Val, E. M.; Del Arco Galan, C.; Jimenez, G. F.; Garate, R. T.; Borrego, B. V.; Arias, A. S.; Cabezas, V. P.; Aviles, R. M.; Gonzalez, S. R.; Ramos, M. E. B.; Alonso, M. A.; Martin-Borregon Bendito, P.; Aguado, A. C.; Martin, S. G.; Somohano, F. V.; Lopez-Laguna, N.; Panadero, R. P.; De Frutos, M. F.; Robledo, F. D.; Madrigal, A. A.; Castaneda, A. B.; Diez, M. P. L.; Izquierdo, R. L.; Ruperez, I. G.; Chaib, F. B.; Abdelkader, I. S. M.; Rafael, I. R.; Tornero, A. P.; Soriano, J. J. C.; Perez, E. M.; Urbano, C. A.; Soto, A. B. G.; Garcia, J. P.; De Simon Almela, A. F.; Lopez, R. C.; Diaz, J. J. L.; Vera, M. T. M.; Calveiro, R. R.; Lucas-Imbernon, F. J.; Moreno, M. R.; Martinez, F. G.; Olmeda, D. M.; Juarez, R.; Hernandez, P. E.; Rodriguez, M. E.; Monzo, J. P.; Gonzalez, N. C.; Herrera, D. M. V.; Bautista, B. M. M.; Alvarez, L. A.; Hevia, M. D. R. C.; Motto, E. Q.; Garcia, N. T.; Diaz, N. M.; Mercader, M. P. O.; De Lobera, N. R.; Amez, J. M. F.; Entrala, B. A..
Emergencias ; 34(5):369-376, 2022.
Article in Spanish | EMBASE | ID: covidwho-2111934

ABSTRACT

Objectives. To define quality of care indicators and care process standards for treating patients with COVID-19 in hospital emergency departments (EDs), to determine the level of adherence to standards during the first wave in 2020, and to detect factors associated with different levels of adherence. Methods. We selected care indicators and standards by applying the Delphi method. We then analyzed the level of adherence in the SIESTA cohort (registered by the Spanish Investigators in Emergency Situations Team). This cohort was comprised of patients with COVID-19 treated in 62 Spanish hospitals in March and April 2020. Adherence was compared according to pandemic-related ED caseload pressure, time periods during the wave (earlier and later), and age groups. Results. Fourteen quality indicators were identified. Three were adhered to in less than 50% of the patients. Polymerase chain reaction testing for SARS-CoV-2 infection was the indicator most often disregarded, in 29% of patients when the caseload was high vs 40% at other times (P <.001) and in 30% of patients in the later period vs 37% in the earlier period (P =.04). Adherence to the following indicators was better in the later part of the wave: Monitoring of oxygen saturation (100% vs 99%, P =.035), electrocardiogram monitoring in patients treated with hydroxychloroquine (87% vs 65%, P <.001), and avoiding of lopinavir/ritonavir treatment in patients with diarrhea (79% vs 53%, P <.001). No differences related to age groups were found. Conclusions. Adherence to certain quality indicators deteriorated during ED treatment of patients with COVID-19 during the first wave of the pandemic. Pressure from high caseloads may have exacerbated this deterioration. A learning effect led to improvement. No differences related to patient age were detected. Copyright © 2022, Saned. All rights reserved.

5.
Emergencias ; 34(6):428-436, 2022.
Article in Spanish | EMBASE | ID: covidwho-2111909

ABSTRACT

Objective. To describe the sociodemographic characteristics, comorbidity, and baseline functional status of patients aged 65 or older who came to hospital emergency departments (EDs) during the first wave of the COVID-19 pandemic, and to compare them with the findings for an earlier period to analyze factors of the index episode that were related to mortality. Methods. We studied data from the EDEN-COVID cohort (Emergency Department and Elder Needs During COVID-19) of patients aged 65 years or older treated in 40 Spanish EDs on 7 consecutive days. Nine sociodemographic variables, 18 comorbidities, and 7 function variables were registered and compared with the findings for the EDEN cohort of patients included with the same criteria and treated a year earlier in the same EDs . In-hospital mortality was calculated in the 2 cohorts and a multivariable logistic regression model was used to explore associated factors. Results. The EDEN-COVID cohort included 6806 patients with a median age of 78 years;49% were women. The pandemic cohort had a higher proportion of men, patients covered by the national health care system, patients brought from residential facilities, and patients who arrived in an ambulance equipped for advanced life support. Pandemic-cohort patients more often had diabetes mellitus, chronic kidney disease, and dementia;they less often had connective tissue and thromboembolic diseases. The Barthel and Charlson indices were worse in this period, and cognitive decline was more common. Fewer patients had a history of depression or falls. Eight hundred ninety these patients (13.1%) died, 122 of them in the ED (1.8%);these percentages were lower in the earlier EDEN cohort, at 3.1% and 0.5%, respectively. Independent sociodemographic factors associated with higher mortality were transport by ambulance, older age, male sex, and living in a residential facility. Mortalityassociated comorbidities were neoplasms, chronic kidney disease, and heart failure. The only function variable associated with mortality was the inability to walk independently. A history of falls in the past 6 months was a protective factor. Conclusions. The sociodemographic characteristics, comorbidity, and functional status of patients aged 65 years or older who were treated in hospital EDs during the pandemic differed in many ways from those usually seen in this older-age population. Mortality was higher than in the prepandemic period. Certain sociodemographic, comorbidity, and function variables were associated with in-hospital mortality. Copyright © 2022, Saned. All rights reserved.

6.
International Conference on Production and Operations Management, POMS 2021 ; 391:513-531, 2022.
Article in English | Scopus | ID: covidwho-2094334

ABSTRACT

In Peru, the traditional channel dominates with a 70% of market share;however, the modern channel and other organized retail chains (e.g., convenience stores) have been growing in recent years in the retail landscape. Moreover, the COVID-19 pandemic represented a new challenge for retailers due to the mobilization restrictions that affected consumption. Thus, the present work aims to describe the main characteristics of two nanostores from Ica, Peru, and capture the activities that compose their supply chain strategy. The applied methodology was adapted to the retail environment from a widely known procedure. We also supplemented it by adding a semi-structured interview based on qualitative semi-open questions to characterize processes, context and performance metrics. Finally, we added a 26-item questionnaire to score good business practices of the studied nanostores. This information allows us to visualize how these nanostores have adapted their business practices and operations after the pandemic and understand how nanostore owners manage their business. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

7.
20th LACCEI International Multi-Conference for Engineering, Education Caribbean Conference for Engineering and Technology, LACCEI 2022 ; 2022-July, 2022.
Article in Spanish | Scopus | ID: covidwho-2091202

ABSTRACT

The objective of the research was to design a logistics management model for the competitiveness of an SME in the balanced food industry to the year2021. The methodology used has a mixed, applied and prospective approach. Validated instruments were applied according to experts, identifying nine root causes demonstrating inadequate logistical management and low competitiveness. A logistics management model was developed by means of eight strategies to improve the processes: supply, storage, inventory and distribution. Diagrams were restructured increasing 6% the total activitiesand 16% the automated activitiesby means of information technologies, annual savings of S/16 920 have been estimated in salaries and 80% in merchandise acquisition costs, likewise, the numberof operatorswasreduced by 50% anda recovery of 5% of merchandise is achieved. Implementation costs were estimated at S/61 103 and finally;the environmental impact was determined using the 3 R's, being a precedent for companiesin the same industry that want to increase their competitiveness. © 2022 Latin American and Caribbean Consortium of Engineering Institutions. All rights reserved.

8.
Pixel-Bit, Revista de Medios y Educacion ; - (65):237-273, 2022.
Article in English, Spanish | Scopus | ID: covidwho-2090915

ABSTRACT

This article arises as a result of the great uncertainty that currently exists in the educational context as a consequence of the implementation of an emergency model of distance education in times of COVID-19 throughout the world. The work provides the perspective of 2063 students from diverse contexts in the Mexican Southeast, who answered an instrument that evaluates four domains of the distance learning process: assignments and strategies, course design, communication and interaction, content and attitude. There were notable differences in the perceptions of urban and rural students in all the domains evaluated. Communication and interaction obtained the highest scores for students in rural and urban contexts, in contrast, the lowest scores recorded for both contexts were: Design of assignments and strategies for urban contexts and the Attitude domain for rural contexts. One of the conclusions of this study shows the disadvantages of students belonging to rural communities and the possible increase in inequality gaps in access to knowledge during confinement. © 2022 Universidad de Sevilla. All rights reserved.

9.
European psychiatry : the journal of the Association of European Psychiatrists ; 65(Suppl 1):S875-S876, 2022.
Article in English | EuropePMC | ID: covidwho-2072885

ABSTRACT

Introduction In Ecuador, the first case of covid19 was reported on February 29th of 2020, forcing people to remain in lockdown, which increased gender violence;post-traumatic stress disorder (PTSD) and depression. Objectives Determine the cases during the lockdown caused by the covid-19 pandemic we found victims of some type of gender-based violence, depression, and PTSD. Methods An observational, cross-sectional descriptive study was carried out based on surveys conducted online, the study was conducted on January 29th of 2021, in the province of Guayas-Ecuador. Performed with “google forms” platform, data on affiliation, the situation of intimate partner violence and the Davidson trauma test (PTSD) and the Beck test (depression) were collected. Results A total of 411 samples were obtained, classified according to age, sex, number of children, education, occupation, intimate partner relationship, whether they had suffered gender violence and types of violence. 88 (21.41%) people reported having suffered some type of violence, of which 25 (28.42%) were men and 62 (70.45%) were women. The most common was psychological with 53 (60.23%) people. 82 respondents tested positive to Davidson test for PTSD, equivalent to 20% of the total sample. 51 people (12%) reported suffering from mild depression, 53 (13%) reported suffering from moderate depression and 38 people (9%) reported major depression with Beck test. Conclusions In this study we evidenced that although the interviewers claimed they had never suffered gender violence , it was observed that the results were incongruent, so it is important to highlight that talking about gender violence is still considered a stigma in our society. Disclosure No significant relationships.

10.
Human Reproduction ; 37:I468-I468, 2022.
Article in English | Web of Science | ID: covidwho-2067879
11.
ASAIO Journal ; 68:21, 2022.
Article in English | EMBASE | ID: covidwho-2032178

ABSTRACT

Background: SARS-CoV-2 pandemic brought new attention to blood substitutes as a potential remedy for treatment of COVID-19 associated hypoxemia and more importantly to provide relief for sagging blood banks. In fact the American Red Cross declared a national blood crisis, the worst in decades. Although commercialization attempts of 1st generation blood substitutes have been unsuccessful due to toxicity and/or poor efficacy problems, the artificial oxygen carriers' field is rapidly expanding again creating more innovative products. To attenuate the adverse effects of blood substitutes caused by intrinsic toxicity of Hb we implemented a novel concept of 'pharmacologic cross-linking' and formulated a safe and effective blood substitute - HemoTech. Methods: HemoTech consists of pure bovine Hb cross-linked intramolecularly with o-ATP and intermolecularly with oadenosine and conjugated with reduced glutathione (GSH). HemoTech cGMP manufacturing includes a novel, validated orthogonal technology platform for effective clearance of endotoxin, prions and non-enveloped and enveloped viruses. Regulatory mandated requirements have been met including CMC and GLP non-clinical pharmacology, toxicology, genotoxicity and efficacy studies. HemoTech's clinical 'proof-of-concept' was performed in children with sickle cell anemia. Results: HemoTech is formulated as a 6.5 g/dL modified Hb solution in oxy- or carbon monoxy-form, enriched with electrolytes and mannitol. The 'pharmacologic cross-linking' does not interfere with Hb respiratory function, but eradicates Hb's intrinsic toxicity and provides Hb molecules with new medicinal properties of ATP, adenosine and GSH. The results of preclinical and clinical studies indicate that HemoTech is non-toxic and works as a physiological oxygen carrier with prolonged intravascular persistence, is vasodilatory and can reduce vasoconstriction that follows hemorrhage, has antioxidant and anti-inflammatory activities, and erythropoietic properties. Conclusion: HemoTech promises to be an effective blood substitute for various clinical indications.

12.
Asia Pacific Journal of Health Management ; 16(4):83-88, 2021.
Article in English | Web of Science | ID: covidwho-2011069

ABSTRACT

This study aims to provide an understanding of how certain factors lead to the formation of clusters of areas of COVID-19 dispersion to guide policy decisions and government actions. It utilized an ecological study design that analyzes data at the population or group level. The units of observation are the barangays in Cebu City. These barangays are the nodes in the network and the edge considered is the presence of areas of convergence. In order to identify the nodes for this study, data mining was done to get the number of reported COVID-19 cases in Cebu City from the Cebu City Health Office as of May23, 2020. Only thirty-nine (39) barangays with COVID-19 cases were included in the study. Results revealed that although public and private transportation is controlled during the implementation of Enhanced Community Quarantine, it is assumed that the spread started prior to the implementation of strict prohibitions which led to the rise of cases later on. Even at the time of the strict community quarantine restrictions, economic activities related to basic necessities were still allowed. For instance, public markets were open with prohibitions related to schedules only. This implies that people are still mobile at certain times despite the presence of restrictions. People still converge in areas where economic activities are present.

13.
European heart journal. Cardiovascular Imaging ; 23(Suppl 1), 2022.
Article in English | EuropePMC | ID: covidwho-1999134

ABSTRACT

Funding Acknowledgements Type of funding sources: None. Introduction Myocardial damage has been widely described in patients with COVID-19. Right ventriculoarterial coupling (RVAC) is a marker of subclinical myocardial damage. The association with mortality in COVID-19 patients has been recently investigated. Objectives To determine if there is a difference in patients with abnormal vs normal RVAC, in clinical, laboratory and echocardiographic variables. Analyze if there is an association between the presence of abnormal RVAC and one-year mortality. Investigate the cutoff value of the RVAC to predict mortality. Methods. A single-center, prospective, analytical study. Patients with a diagnosis of COVID-19 were included. Patients who were on mechanical ventilation during the study, a history of ischemic heart disease, valvular heart disease, and chronic obstructive pulmonary disease were excluded. The patients were included during the period from May to August 2020, the 1-year follow-up was carried out through the electronic medical record and telephone calls. The echocardiograms were performed with the Phillips IE-33, the strain determination was obtained with the Qlab 13.0 software. The quantitative variables were compared with the Student"s T test or the U Mann-Whitney test, according to the normality of the variables;qualitative variables were contrasted with the x2 test. One-year survival was determined with the Kaplan-Meier curves, and the association with one-year mortality was investigated with Cox regression. The cut-off value for predicting mortality was determined with ROC curves. The RVAC was determined with the right ventricular free wall longitudinal strain / pulmonary systolic artery pressure ratio.  Abnormal right ventriculoarterial coupling was determined with a value less than 0.8. Results 81 patients were included, of whom 45 had an abnormal RVAC. Patients with abnormal RVAC had higher mortality and a higher requirement for mechanical ventilation;they had higher levels of biomarkers. Among the echocardiographic variables, they had lower the right ventricular fractional area change, the tricuspid annular plane systolic excursion, the left ventricular longitudinal strain, the left atrial reservoir strain, the right ventricular free wall longitudinal strain, the RVAC;while they also presented higher the pulmonary systolic artery pressure and the tricuspid regurgitation velocity. The one-year survival of patients with abnormal RVAC was 53% vs 91%, the association with 1-year mortality was HR: 7.0 (CI95 2.1-23;p = 0.0001). The cutoff value of the RVAC to predict mortality was <0.48 (Sensitivity 71%, Specificity 90%, AUC: 0.836;p = <0.0001). Conclusion The patients with COVID-19 and an abnormal RVAC had a higher requirement for mechanical ventilation and mortality;presented higher levels of biomarkers. Half of the patients with abnormal RVAC died, presenting an association to predict mortality. The cut-off value of <0.48 was the best associated with mortality. Table 1   Figure 1

14.
Human reproduction (Oxford, England) ; 37(Suppl 1), 2022.
Article in English | EuropePMC | ID: covidwho-1998460

ABSTRACT

Study question What is the effect of mRNA SARS-CoV-2 vaccines on oocyte donors regarding oocyte quality, embryo development and clinical outcomes? Summary answer Oocyte quality, fertilization, blastocyst formation, embryo quality and pregnancy rates were similar following donors' mRNA SARS-CoV-2 vaccination compared to previous oocyte donation cycles. What is known already The severe acute respiratory syndrome Coronavirus 2 (SARS–CoV-2) infection, urged scientists to develop safe and effective vaccines. During the ongoing pandemic, the scientific community has promoted vaccination programs to reduce morbidity and mortality. While it has been suggested that SARS–CoV-2 infection might impact fertility, limited evidence shows that vaccination has no influence on sperm parameters, follicular steroidogenesis, or oocyte quality and only one study reported no effects on fertilization or top-quality embryos rate in vaccinated patients undergoing IVF. There is a paucity of evidence with regards to younger population undergoing ovarian stimulation. Study design, size, duration This prospective, multicentre cohort study evaluated 32 oocyte donors with two controlled and similar ovarian stimulation, before and after complete SARS-CoV-2 vaccination, between November 2020 and January 2022. A total of 64 oocyte recipient cycles were analysed equally separately into these two groups. Severe male factor was excluded. Participants/materials, setting, methods Complete SARS-CoV-2 vaccination of the oocyte donor made the difference between the two groups of recipients analysed. The time frame between the previous ovarian stimulation and the vaccination was lower than 8 months. We evaluated and compared the rates of matured eggs (metaphase II, MII), the fertilization and blastocyst formation rates, blastocyst quality (A/B ASEBIR categories), positive pregnancy test and clinical pregnancy rates in both groups of recipients. The statistical analysis was performed using SPSS. Main results and the role of chance The average number of MII collected were similar before and following vaccination (12.23 vs 12.91, p = 0.198, respectively). In recipients, the outcomes with regards to fertilization rate (81.4% vs 77.3% p = 0.210), blastocyst formation rate (60.2% vs 61.5%, p = 0.771) and high-quality blastocysts (quality A: 31.1% vs 36.4% and quality B: 29.0% vs 25.1%, p = 0.430) did not differ statistically between the control group (n = 32, pre-vaccination) and the study group (n = 32, post-vaccination), respectively. Furthermore, regarding clinical outcomes, there were not statistically differences in pregnancy rates (64.0% vs 77.4%, p = 0.269) or clinical pregnancy rates (60.0% vs 64.5%, p = 0.729) before and after vaccination respectively. Limitations, reasons for caution Our encouraging results should be interpreted with caution due to the small sample size and the short period of follow-up. Larger controlled trials are needed to corroborate our findings as the countries continue making forward with the vaccination campaign. Wider implications of the findings The present study suggests no influence of mRNA SARS-CoV2 vaccines on donor oocyte cycles, reflecting no detrimental effects on the assisted reproduction outcomes. The safety of SARS-CoV-2 vaccination concerning IVF cycles is encouraging for the medical community and the health of our patients. Trial registration number Not Applicable

15.
Telos-Revista Interdisciplinaria En Ciencias Sociales ; 24(2):370-383, 2022.
Article in English | Web of Science | ID: covidwho-1998184

ABSTRACT

Engagement and burnout have been defined as extremes of a continuum to represent the health and well-being of people at work, whether as a work result or other life circumstances. On the other hand, it must be recognized that the pandemic times have considerably affected all areas of human life, and the organizational one has not escaped this. In this context, this research aims to review scientific articles that deal with Engagement and Burnout to know the contributions made by researchers in this relevant organizational field, focusing the analysis on the times we live in as a result of the Covid-19 pandemic. To achieve the objectives, a database of 315 articles published in Web of Science (WOS) indexed journals during the period 2020-2022 was analyzed. Following the guidelines of Toulmin's argumentative model (Rodriguez-Bello, 2004), the following causal assertion was defined: "The engagement and burnout of workers during the COVID-19 pandemic is influenced by the governance of organizations". The reviewed articles were established as evidence and the database as collateral. The main results show that social and organizational governance influences the health and well-being of workers, which impacts their performance and thus the outcomes of their respective organizations.

17.
7th Brazilian Technology Symposium, BTSym 2021 ; 207 SIST:584-591, 2023.
Article in English | Scopus | ID: covidwho-1971374

ABSTRACT

With the arrival of the COVID-19 pandemic, health systems were forced to adapt their intra- and extra-hospital processes through mechanisms of articulation, integration, and coordination between the organic units of public and private institutions, configuring a single national health system. In this sense, the objective of this study was to determine whether there is a relationship between clinical management for the hospitalization of patients with COVID-19 and resolution capacity functionality in a Health Network. A hypothetical deductive method was used with a descriptive-correlational analysis with a cross-sectional design. The sample consisted of 150 health care workers (100%). The selection was conducted in 3 level I-4 facilities of the Contumazá-Cajamarca Health Network, Peru, 2021. The dependent variable was resolution capacity functionality, and the independent variable was clinical management for the hospitalization of patients with COVID-19. The results suggest an average level both in clinical management and in resolution capacity functionality and the transport dimension in 45.3%, extending a significant relationship (p < 0.05) with Rho = 0.755 and Rho = 0.251, respectively. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

18.
Rev Esp Quimioter ; 35(4): 357-361, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1935025

ABSTRACT

Paxlovid (nirmatrelvir plus ritonavir) is a new oral antiviral therapeutic for the treatment and post-exposure prophylaxis of COVID-19. Nirmatrelvir is an inhibitor of SARS-CoV-2 main protease, while ritonavir is used as a CYP3A inhibitor in low doses to slow the metabolism of nirmatrelvir, thus enhancing their therapeutic effect. The isoenzyme CYP3A4 is responsible for at least part of the oxidative metabolism of approximately 60% of available medications and ritonavir is therefore a significant source of drug interactions. We describe here the drugs that are contraindicated or should be used with or without precautions when Paxlovid (nirmaltrevir plus ritonavir) should be administered according to each fact sheet in force at the Spanish Agency for Medicines and Health Products.


Subject(s)
COVID-19 , Ritonavir , Antiviral Agents/therapeutic use , COVID-19/drug therapy , Drug Combinations , Humans , Lactams , Leucine , Nitriles , Proline , Ritonavir/therapeutic use , SARS-CoV-2
19.
American Journal of Respiratory and Critical Care Medicine ; 205(1), 2022.
Article in English | EMBASE | ID: covidwho-1927800

ABSTRACT

Rationale Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterised by an IL-6 driven cytokinemia, associated with a rapidly developing acute respiratory distress syndrome (ARDS). A blunted AAT response to IL-6 in SARS-CoV-2 has been associated with increased morbidity and mortality. One of the main functions of IL-6 is regulation of acute-phase proteins such as alpha-1 antitrypsin (AAT), a key lung anti-protease. We investigated the proteaseanti- protease balance in the circulation and pulmonary compartments in SARS-CoV-2 acute respiratory distress syndrome (ARDS). In addition, we investigated the effect of anti-IL-6 therapy on anti-protease defence. Methods Levels and activity of AAT and neutrophil elastase (NE) were measured in plasma (n=20), airway tissue (n=8) and tracheal secretions (n=13) of people with severe SARS-CoV-2 infection. AAT and IL-6 levels were also evaluated over time in people with moderate SARS-CoV-2 infection who received standard of care +/- tocilizumab (n=30). Results AAT plasma levels doubled in severe SARS-CoV-2 ARDS patients (329g/L +/- 08 g/L as compared to baseline levels 174g/L +/- 011 g/L, P<0001). In lung parenchyma AAT levels were increased. Despite no increase in neutrophils, an increased percentage of neutrophils involved in NET formation were observed in the alveoli. A protease-anti-protease imbalance was detected in tracheal aspirates (TA). NE was active and AAT inactivated, reflecting cleavage and complexation with NE. The major airway anti-protease, secretory leukoprotease inhibitor (SLPI) was decreased in SARS-CoV-2-infected lungs and cleaved in TAs. Induction of AAT in SARS-CoV-2 infection occurred mainly through IL-6 signalling. Tocilizumab (IL-6 receptor antagonist) down-regulated AAT during infection (13g/L+/-0225 from 2469 g/L+/-0197, P<00001) while IL-6 remained elevated (NS=0.0998) as reflected by the IL-6/AAT ratio (P=0046). Conclusion This study shows that the AAT response to SARS-CoV-2 infection is compartmentalized with an appropriate increase in plasma and alveoli but an inadequate response in airways. This underlines a significant, but potentially treatable, protease-antiprotease imbalance in SARS-CoV-2 ARDS as well as highlighting IL-6's importance in SARS-CoV-2 pathology not only as a pro-inflammatory cytokine but as an anti-inflammatory regulator. In conclusion there is unopposed NE activity in the airways of people with SARS-CoV-2 ARDS which could be amenable to AAT therapy. Our data suggest caution in the use of IL-6 blocking therapies in SARS-CoV-2-infected individuals.

20.
Rev Esp Quimioter ; 35(5): 444-454, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-1912745

ABSTRACT

A "Pandemic/Disaster Law" is needed to condense and organize the current dispersed and multiple legislation. The State must exercise a single power and command appropriate to each situation, with national validity. The production of plans for the use of land and real estate as potential centers for health care, shelter or refuge is recommended. There should be specific disaster plans at least for Primary Health Care, Hospitals and Socio-sanitary Centers. The guarantee of the maintenance of communication and supply routes is essential, as well as the guarantee of the autochthonous production of basic goods. The pandemic has highlighted the need to redefine the training plans for physicians who, in their different specialties, have to undertake reforms that allow a more versatile and transversal training. National research must have plans to be able to respond quickly to questions posed by the various crises, using all the nation's resources and in particular, all the data and capabilities of the health sector. Contingency plans must consider ethical aspects, and meet the needs of patients and families with a humanized approach. In circumstances of catastrophe, conflicts increase and require a bioethical response that allows the best decisions to be made, with the utmost respect for people's values. Rapid, efficient and truthful communication systems must be contained in a special project for this sector in critic circumstances. Finally, we believe that the creation of National Coordination Centers for major disasters and Public Health can contribute to better face the crises of the future.


Subject(s)
COVID-19 , Disasters , Forecasting , Humans , Pandemics , Public Health
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