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1.
Anatolian Journal of Cardiology ; 26(Supplement 1):S90-S91, 2022.
Article in English | EMBASE | ID: covidwho-2202575

ABSTRACT

Background and Aim: Troponin and some inflammation biomarkers were associated with Covid-19 severity and intensive care unit (ICU) admissions related with cardiac injury. But cardiac magnetic resonance imaging (CMRI) remains to be the gold standard for revealing myocardial involvement. In this study, we aim to investigate whether admission troponin levels were associated with both clinical severity and cardiac injury shown using CMRI. Method(s): The study sample consisted of 51 recovered patients who had needed in-hospital follow-up, either in COVID-19 ICU (Group 1, n=16) and COVID-19 clinics (Group 2, n=35). Hs-cTnT, CRP, PCT, NLR, D-dimer, ferritin levels and SII and were measured at admission to hospital. All of these participants were referred to electrocardiography (ECG), transthoracic echocardiography (TTE) and CMRI simultaneously on an average of 4-6 weeks after discharge. Study groups were compared according to these findings. Result(s): Among study population, 25 patients (49%) had SARS-CoV-2 variants, including the Alpha variant [n=16, (31%)], the Beta [n=5, (10%)] and the Delta variant [n=4, (8%)]. Respiratory distress as initial symptom was higher in group 1 compared to group 2. Group 1 had higher respiratory rate, lower SpO2 levels and higher supplemental oxygen requirement compared with group 2, which would explain respiratory distress. Hs-cTnT levels and inflammatory biomarkers were significantly higher in ICU patients (p<0.05). ROC curve revealed significant correlation between Hs-cTnT, NLR, D-dimer, ferritin, CRP, SII levels and ICU admission (p<0.05) (Figure 1). ECG and TTE features of groups were similar. Functional parameters were also similar for both groups in CMRI findings. But, a total of 32 patients had any kind of injury on CMRI, including at least one of the following: myocardial oedema (n=7), pericardial effusion (n=13) and right ventricular failure (n=12), ischemic (n=8) or non-ischemic fibrosis (n=27) on late gadolinium enhancement imaging. CMRI images of various myocardial injury patterns were shown in Figure 2. There was a significant difference between patients who followed up in Group 1 vs. Group 2 for non-ischemic fibrosis [n=12 (75%) vs. n=15 (43%);p=0.03]. ICU patients had more common non-ischemic fibrosis on CMRI (p=0.03). ROC curve exposed a significant correlation between Hs-cTnT and SII levels with any injury shown on CMRI (p<0.05) (Figure 3). Conclusion(s): Admission troponin and SII levels were associated with disease severity and cardiac injury shown by CMRI even if echocardiographic evaluation is normal. Both of them could be used to have an idea about both the need of ICU and serious cardiac involvement. (Figure Presented).

2.
Turkish Archives of Otorhinolaryngology ; 60(3):128-133, 2022.
Article in English | Web of Science | ID: covidwho-2144348

ABSTRACT

Objective: The severe acute respiratory syndrome-coronavirus-2 pandemic is one of the largest of the recent times and can cause many symptoms including smell and taste disorders. In the literature, smell disorders caused by coronavirus disease-2019 (COVID-19) have been reported within a wide range from 3.2% to 98.3%. A small number of these studies demonstrated smell and taste disorders through objective tests. Our aim in this study was to determine the prevalence of smell and taste disorders in hospitalized patients due to COVID-19 infection.Methods: The study was carried out with 100 patients who were positive for real-time polymerase chain reaction and treated at the Kayseri City Hospital, and 100 healthcare worker relatives. We used the Connecticut Chemosensory Clinical Research Center test to evaluate the sense of smell. Sense of taste was evaluated using four different standardized bottles of preparations, and the results were scored according to the patients' statements.Results: Patient (Group 1) and control (Group 2) groups were compared for age, gender, smell and taste disorders. There were 39 women and 61 men in the patient group, and 40 women and 60 men in the control group. Mean age was 50.2 +/- 1.37 (range 21-70) years in Group 1 and 47.6 +/- 1.25 (range 18-70) years in Group 2, and there was no significant difference between the two groups. While the rate of smell disorder was 80% in Group 1, we found this rate as 35% in Group 2. Taste disturbance was identified in 38 patients, of whom 16 had mild hypogeusia, 17 had moderate hypogeusia, four had severe hypogeusia, and one patient had ageusia. We found that taste disorder was 38% in Group 1 and 3% in Group 2.Conclusion: Smell and taste dysfunctions are very common symptoms in COVID-19 patients. The results obtained using objective test methods are higher than the rates obtained from patient statements.

3.
Pediatric Nephrology ; 37(11):2867-2867, 2022.
Article in English | Web of Science | ID: covidwho-2068141
4.
Mediterranean Journal of Infection Microbes and Antimicrobials ; 11:6, 2022.
Article in English | Web of Science | ID: covidwho-1988246

ABSTRACT

Introduction: The Coronavirus disease-2019 (COVID-19) pandemic that started over two years ago has led to high mortality and morbidity. Vaccine studies have been initiated worldwide to end the pandemic, and the CoronaVac (R) vaccine was first administered to healthcare workers at high risk of COVID-19 in Turkey. In our study, we aimed to investigate serum antibody levels after vaccination. Materials and Methods: Volunteer healthcare workers without COVID-19 disease who received two doses of CoronaVac (R) vaccine 28 days apart and were at least 14 days after the last dose of vaccine were included in this study. Assessment of antibodies against Severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2) in blood samples from participants was performed using the Elecsys (R) anti-SARS-CoV-2 electrochemiluminescence immunoassay. Samples with a cut-off index (COI) (COI;signal sample/cut-off) <1.0 were considered negative;whereas samples with COI >= 1.0 were deemed positive. Results: A total of 269 healthcare workers, 168 women (62.5%), were included in our study. The mean age of the participants was 37.7 +/- 8.6 (minimum-maximum: 21-62). Antibody levels were positive in 188 (69.9%) of the participants. The median antibody level was 9.2 COI (interquartile ranges=3-34.7). In terms of mean age, the mean age of participants with negative antibodies was higher with a statistically significant difference (p=0.001). The antibody positivity rate of women was higher than that of men (p<0.001). No statistically significant association was found between the time elapsed after vaccination, presence of comorbidities, development of post-vaccine side effects, and antibody levels. It was found that one or more side effects developed in 45.7% of the participants after vaccination. Conclusion: Our study showed that seropositivity developed significantly in healthcare workers after the CoronaVac (R) vaccine. It emphasizes the importance of maintaining infection prevention and control measures and administering the SARS-CoV-2 vaccine for healthcare workers at high risk.

5.
Philippine Journal of Science ; 150(5):925-937, 2021.
Article in English | CAB Abstracts | ID: covidwho-1871666

ABSTRACT

Herbal plants are often used as alternative medicine because they contain active compounds for the treatment of diseases and disorders with minimal side effects, and are easily obtained from the surrounding environment. Some of them have antiviral activity. This study aimed to analyze the potential of phytochemical compounds in the leaf of "pangi" (Pangium edule Reinw) as anti-SARS-CoV-2 using molecular docking study. The drug- and lead-likeness properties of the selected compounds were obtained from the Swiss ADME and admetSAR online server tools. Molecular dynamics (MD) simulation of the selected ligand was carried out to validate the stability of the interaction. The results suggested that pangi leaves contain three compounds with remarkable binding affinities with Mpro (main protease) and RBD (receptor binding domain) were (5.beta.)pregnane-3,20.beta.-diol, 14.alpha.,18.alpha.-[4-methyl-3-oxo-(1-oxa-4-azabutane-1,4-diyl)]-, diacetate (PD), ethyl cholate (EC), and bis(3,5,5-trimethylhexyl) phthalate. Because EC will be metabolized in the body into cholic acid (Cho), this compound was then docked and validated using MD simulation. The compound has the best free binding energy (G) with SARS-CoV-2 (-7.1 kcal/mol with Mpro and -6.0 kcal/mol with RBD). Moreover, the compound is bound strongly to the active cavity of Mpro on Thr24, Thr26, His41, and Cys145 residues. The MM-GBSA calculation showed that the interaction of Cho with Mpro was higher than with RBD. According to the RMSD (root mean square deviation), RMSF (root mean square fluctuation), the radius of gyration (Rg), and intermolecular hydrogen bond (H-bond) analysis obtained from 50 ns MD simulations, Cho formed stable interactions with Mpro and RBD. The finding of this study indicated that Cho showed good anti-SARS-CoV-2 activity. The potential of the compound to inhibit the virus can serve as a starting point in the process of developing COVID-19 therapeutic natural medicine.

6.
Information and Learning Science ; 2022.
Article in English | Scopus | ID: covidwho-1784456

ABSTRACT

Purpose: This study aims to explore Twitter posts of Turkish government agencies and the public under a specific hashtag, #NotHolidayButDistanceEducation, specifically related to online distance education during the Covid-19 pandemic. Design/methodology/approach: This study used a thematic analysis on 22,547 original tweets posted by 6,970 users during the first month of online distance education in Turkish K-12 schools. Based on like and retweet counts, the study further explored the extent of stakeholders’ engagement with the observed themes. Findings: The findings showed that government agencies and citizens used Twitter to provide technical and psychological support, appreciate and motivate stakeholders, demonstrate sample distance education activities, share information and offer suggestions about the ongoing online distance education. It was also observed that the hashtag has been used for expressing negative views about online distance education and for political purposes. A positive relationship was found between social media engagement and providing technical support or sharing information for online distance education. Practical implications: This study highlights the role of social media in providing practical and emotional support to education stakeholders in times of crisis. Thus, governments can use social media to provide evidence-based psychological and physical health support to their citizens during a pandemic. Social media can serve to improve education practices in schools through the interactions between the public and policymakers. Originality/value: To the best of the authors’ knowledge, this study can be considered unique because it demonstrates the civic use of social media for educational crisis management. This study highlights the influence of social media in educational policy and practice development in the contemporary era. © 2022, Ismail Celik, Muhterem Dindar and Hanni Muukkonen.

7.
Turkish Online Journal of Distance Education ; 23(1):19-42, 2022.
Article in English | Web of Science | ID: covidwho-1619320

ABSTRACT

The aim of the study is to examine the different effects of the COVID-19 pandemic on Audiology students in Turkey in terms of e-learning, tele-Audiology education, psychological-social situations and personal development. The study was carried out using an online survey created on Google Forms. The survey included 4 demographic questions, and 29 questions about the effects of COVID-19 on Audiology students. Study sample: A total of 518 undergraduate and graduate Audiology students participated in the study. The majority of the participants indicated that the pandemic had a negative effect on the practical knowledge and professional competence acquired through the online education system implemented due to the restrictions. A great majority of the participants indicated that their theoretical and practical knowledge about teleaudiology was "too insufficient". During this period, the level of anxiety in students and damage to their social relationships were obtained as "too much". In addition, a negative effect was observed in the personal development of the students. The study concluded that strategies and approaches should be developed for the current pandemic period and similar situations that may occur in the future.

8.
Allergy: European Journal of Allergy and Clinical Immunology ; 76(SUPPL 110):450-453, 2021.
Article in English | EMBASE | ID: covidwho-1570401

ABSTRACT

Background: There are a limited number of studies about the clinical findings of coronavirus infection in pediatric patients with asthma. We aimed to evaluate the clinical and laboratory characteristics of pediatric patients with asthma and healthy children without chronic disease who were infected with SARS-CoV-2. Method: This is a retrospective, case-control study comparing the children diagnosed with asthma and healthy children who were diagnosed with COVID-19 in our hospital between March,11 and November,10 2020. Results: During the study period, 6205 children were diagnosed with COVID-19 in our hospital. Only 54 (0.87%) patients had a diagnosis of asthma. The mean of the age was 10.7 years and 53.7% (n:29) of the patients with asthma were male. Cough, shortness of breath, emesis and diarrhea were found to be significantly higher in asthma group than in the control group (respectively p = 0.002,0.000, 0.002, 0.019, 0.015). Patients who were given SABA were significantly higher in asthma diagnosed patients (p = 0.000). There was no significant difference between the two groups in terms of oxygen treatment and hospitalization requirement. There was no significant difference in laboratory findings between groups. Conclusion: This study revealed that pediatric patients diagnosed with asthma were in mild clinic state and the clinic of COVID-19 was not different between the groups. According to these findings, asthma may not be a risk factor for the development of COVID-19 and may not affect the course of the disease in children. (Table Presented).

10.
Ankara Medical Journal ; 21(2):227-237, 2021.
Article in English | Scopus | ID: covidwho-1310185

ABSTRACT

Objectives: This study aimed to evaluate the test results of patients whose RT-PCR test result was negative, but thorax CT findings were compatible with COVID-19 and their infectiousness in terms of contacts. Materials and Methods: The study was designed as cross-sectional, descriptive research. In the first group, thorax CT revealed findings compatible with COVID-19 pneumonia, and the RT-PCR test result was negative. In the second group, thorax CT revealed findings compatible with COVID-19 pneumonia, and the RT-PCR test result was positive. Data collected were assessed with SPSS 21.0 software program. The significance level was accepted as 5%. Results: Of the participants, 54.41% were male, and 45.59% were female. There was no significant difference between the two groups in terms of contact environment and status of being a healthcare worker and exitus. There was no difference between the first and second groups in terms of the number of contacts. The rate of sample collection was higher in the second group. The number of people who had contact with the patients and positive RT-PCR test results was higher in the first group. Conclusion: Even if patients have negative RT-PCR test results for COVID-19, they are still infectious. © 2021 Ankara Yildirim Beyazit University. All rights reserved.

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