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International Journal of Academic Medicine and Pharmacy ; 4(3):70-73, 2022.
Article in English | EMBASE | ID: covidwho-1998208

ABSTRACT

Background: In India, laboratory diagnosis of SARS - CoV-2 infection has been mostly based on real-time reverse transcriptase-polymerase chain reaction (RT-PCR). Studies have shown that IgG antibodies may be detected usually 10-18 days after the onset of covid-19 infection, persist after 4 weeks till few months but may decline later. In the neutralization of SARS-CoV-2, B-cell response and the production of IgG antibodies play an important role. The aim of the present study is to describe the antibody kinetics in relation to treatment in health care workers with RT-qPCR-confirmed COVID-19, and analyse antibody response by using IgG antibody Merilisa kit. Materials and Methods: The present study enrolled 120 health care workers who were working in COVID wards (aged between 20-60 years) with laboratory confirmed COVID-19, from whom sera were analyzed on 10th day and 3 months after COVID-19 diagnosis. Result: Out of the study population which included 120 health care workers, only 46.6% remained positive for IgG antibodies after 3 months post infection of COVID-19. This study showed that presence of IgG antibodies against SARS-CoV-2 was higher among HCWs who were only on Antibiotics (60%) followed by those only on Antivirals (53.3%) as treatment modality. Conclusion: Compared to the IgG detected during treatment or hospitalization, the difference in IgG positivity after 3months was significant. It also shows that administration of steroids results in early weaning of antibodies suggesting re-infection could be more in such cases. Our findings may be of significance in interpreting anti-SARS-CoV-2 antibody test results and in understanding humoral immune response patterns for SARS-CoV-2 infection with respect to treatment strategies in current and potential future COVID-19 outbreak scenarios.

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