Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 3 de 3
Journal of Complementary Medicine Research ; 12(4):256-264, 2021.
Article in English | Web of Science | ID: covidwho-1667555


Introduction: Non-tested asymptomatic COVID-19 cases poses threat of transmitting the disease silently. The Siddha polyherbal formulation, hnology Kabasurakudineer, (KSK) was found to be effective in preventing viral replication of SARS-CoV-2 by in-silico studies. A pilot study was conducted to test the antiviral activity of KSK in asymptomatic individuals tested positive for COVID-19. Methods: A single centre, open labelled, randomized controlled study was carried out during June-August 2020, in Tertiary Medical College Hospital, after approval from the institutional ethics committee and registered in CTRI. RTPCR confirmed COVID-19 asymptomatic cases, aged 18-65 years, consented to participate were . included and those with co-morbidities like diabetes, hypertension, severe respiratory disease, malignancies, pregnant and lactating mothers were excluded. Hospitals of Semnan Uniiessi y 60 participants were randomly assigned to study and control group. Study group received KSK (60 ml) along with vitamin C in the morning and zinc in the night, while the control group (CZ) received vitamin C and zinc for 10 days. The primary outcome was the reduction in the SARS-CoV-2 load (ct value), prevention of progression to symptomatic state. Results: In the study group, there was faster reduction in the viral load in terms of ct value as all the 30 participants turned negative for SARS-Co-V2, while 4 remain positive in the control group on the 10th day. The inflammatory markers and serum cytokine findings were inconclusive. No one progressed to the symptomatic state and no adverse event was reported in either groups. Conclusion: This study demonstrated the potential of Kabasurakudineer in reducing the viral load. Further clinical studies are warranted with larger sample size.

Journal of Complementary Medicine Research ; 12(2):227-230, 2021.
Article in English | Web of Science | ID: covidwho-1538735


Many campaigns rolled out to enhance the awareness of people on COVID-19 prevention, control, and promotive measures. Siddha polyherbal formulations, namely Kabasura kudineer (KSK) and Nilavembu kudineer (NVK) were recommended by the Ministry of AYUSH, Govt of India as an advisory for AYUSH interventions for COVID-19. This study was conducted to estimate traditional siddha medicine practices and preventive measures against COVID 19 among the population accessing research clinic facility and the residents of containment zones of Chennai, the capital of Tamil Nadu State, India. We interviewed 569 participants, and most of the participants aware of adopting general preventive measures of COVID-19, 85% practiced hand wash and 95% wore mask. Siddha-specific measures such as drinking of KSK is reported in 77% (n=444, 77%) and NVK in 60% (n=360) in the containment zone areas for prevention and control of COVID-19. The population behavior documents belief in traditional medical system and to consider integrated medical approach for effective communication during public health emergencies.

J Assoc Physicians India ; 68(12): 21-27, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-946705


BACKGROUND AND OBJECTIVES: A virtual registry study evaluating real world evidence on physicians' use of prophylactic regimens for protection against SARS-CoV-2. This paper summarizes the interim results. METHODS: Asymptomatic physicians at risk of acquiring SARS-CoV-2 responded to online questions at baseline and 7 weeks post-baseline. Baseline data included demographics, prophylaxis regimen (including "no prophylaxis") and start date. Participants who provided complete week-7 data (information on type of health facility [COVID/Non-COVID], number of presumed/confirmed cases exposed to, PPE use, SARS-CoV-2 testing and symptoms, regimen adherence and intercurrent illness) comprised the Completer population. Limited data (regimen adherence, SARS-CoV-2 testing) was collected for participants who failed to provide complete week7 data. Those providing limited/complete information comprised the Evaluable population. RESULTS: Of 369 enrolled participants, 182 (mean age 42±11.05 years) comprised the Evaluable population. They showed a male preponderance (67.6%). Practitioners from Maharashtra (59.9%) and specialties of Pediatrics, Internal Medicine, Anesthesiology and Critical Care (63.2%) accounted for the majority. ICMR's HCQ prophylaxis regimen was initiated by 125 (68.7%) participants with 31 (17%) initiating 'No prophylaxis'. The highest adherence was for the ICMRregimen (87.2%). In the Completer population comprising 150 participants, 87 were exposed to presumed (81) and/or confirmed cases (60). Most exposures to confirmed cases (49, 81.7%) were high-risk. PPE use was generally high (75-100%). Most participants (94.7%) did not report an AE. The proportions with an AE was similar with ICMR regimen (5.9%) and no prophylaxis (6.5%). INTERPRETATION AND CONCLUSIONS: Physicians in India preferred ICMR's HCQ regimen. The regimen appears to be safe and associated with a high level of adherence.

Coronavirus Infections , Pandemics , Physicians , Pneumonia, Viral , Adult , Betacoronavirus , COVID-19 , COVID-19 Testing , Child , Clinical Laboratory Techniques , Coronavirus Infections/diagnosis , Coronavirus Infections/drug therapy , Humans , Hydroxychloroquine , India/epidemiology , Infection Control , Male , Middle Aged , Practice Patterns, Physicians' , SARS-CoV-2 , COVID-19 Drug Treatment