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1.
14th Mexican Conference on Pattern Recognition, MCPR 2022 ; 13264 LNCS:225-234, 2022.
Article in English | Scopus | ID: covidwho-1919714

ABSTRACT

Public health surveillance via social media can be a useful tool to identify and track potential cases of a disease. The aim of this research was to design a method for identifying tweets describing potential Covid-19 cases. The proposed method uses a Wide & Deep (W&D) architecture, which combines two learning branches fed from different features to improve classification effectiveness. The deep branch uses a BERT-type model, while the wide branch considers two different lexical-based features. It was evaluated on the data from Task 5 of the Social Media Mining For Health (#SMM4H) 2021 competition. Results show that the proposed W&D method performed better than the wide-only and deep-only models, achieving an F1-score of 0.79 which matches the results of the 1st place ensemble-model. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

2.
Revista Espanola de Salud Publica ; 96(e202203029), 2022.
Article in Spanish | GIM | ID: covidwho-1870920

ABSTRACT

Background: The increase in the demand for healthcare caused by COVID-19 implies a lower availability of health resources and influences the appropriateness of their use. Due to the variability of demand during the pandemic, the study aimed to compare the appropriateness of hospital admissions between the 2nd and 5th phases of the pandemic according to the criteria of the Hospital Emergency Service (CiHRyC). These results were compared with those obtained according to the Pneumonity Severity Index (FINE) and the Appropriateness Evaluation Protocol (AEP). As a secondary objective, the clinical and sociodemographic characteristics of the patients studied were described.

3.
Revista Espanola de Salud Publica ; 96:11, 2022.
Article in Spanish | MEDLINE | ID: covidwho-1738130

ABSTRACT

OBJECTIVE: The increase in the demand for healthcare caused by COVID-19 implies a lower availability of health resources and influences the appropriateness of their use. Due to the variability of demand during the pandemic, the study aimed to compare the appropriateness of hospital admissions between the 2nd and 5th phases of the pandemic according to the criteria of the Hospital Emergency Service (CiHRyC). These results were compared with those obtained according to the Pneumonity Severity Index (FINE) and the Appropriateness Evaluation Protocol (AEP). As a secondary objective, the clinical and sociodemographic characteristics of the patients studied were described. METHODS: 80 patients hospitalized from the Emergency Department were randomly selected in two study periods (2nd and 5th pandemic phase) obtained from the registry of hospitalizations of the Preventive Medicine service of Hospital Ramon y Cajal. Prevalences of inappropriateness were estimated according to the CiHRyC, FINE and AEP and an analysis was performed using univariate logistic regression between epidemiological variables of both periods collected through the electronical medical records. RESULTS: Inappropriateness of admissions were 35% and 45% in the 2nd and 5th phase of the pandemic according with CiHRyC, 25% and 5/% according with FINE and 0% and 5% according with AEP. Median age was 71.4 and 50.0 years in 2nd and 5th phase (p=0.02). 72.5% and 17.5% of the patients in the 2nd and 5th phases had at least one risk factor for COVID-19 severe illness (p<0.01). CONCLUSIONS: The measurement tools used identified more inappropriately cases in the 5th phase of the pandemic than in the 2nd one. CiHRyC coincided with FINE and AEP in the result of their evaluation.

4.
Embase;
Preprint in English | EMBASE | ID: ppcovidwho-326792

ABSTRACT

The devastation caused by SARS-CoV-2 has made clear the importance of pandemic preparedness. To address future zoonotic outbreaks due to related viruses in the sarbecovirus subgenus, we identified a human monoclonal antibody, 10-40, that neutralized or bound all sarbecoviruses tested in vitro and protected against SARS-CoV-2 and SARS-CoV in vivo. Comparative studies with other receptor-binding domain (RBD)-directed antibodies showed 10-40 to have the greatest breadth against sarbecoviruses and thus its promise as an agent for pandemic preparedness. Moreover, structural analyses on 10-40 and similar antibodies not only defined an epitope cluster in the inner face of the RBD that is well conserved among sarbecoviruses, but also uncovered a new antibody class with a common CDRH3 motif. Our analyses also suggested that elicitation of this class of antibodies may not be overly difficult, an observation that bodes well for the development of a pan-sarbecovirus vaccine.

5.
Gastroenterology ; 160(6):S-260-S-261, 2021.
Article in English | EMBASE | ID: covidwho-1598666

ABSTRACT

Background: The medical and psychological impacts of the COVID-19 pandemic on individuals affected by eosinophilic esophagitis (EoE) remain largely unknown. We seek to describe the current perceptions of COVID-19 in the EoE population of the United States (US). Methods: For this cross-sectional study, we anonymously surveyed individuals aged 18 years or older who self-identified as having EoE or as being a caregiver for someone with EoE. This survey was sent via an invitation and link to email subscribers of the American Partnership for Eosinophilic Disorders in November 2020. Our primary aim was to describe patients’ and caregivers’ perceptions of COVID-19. We collected patient demographics and asked five multiple-choice questions that assessed the responder’s anxiety related to the pandemic, belief on whether patients with EoE are at higher risk of acquiring COVID-19, willingness to take an approved vaccine, experiences with access to medical care during the pandemic, and use of social media to learn about the impact of COVID-19 on EoE. Our secondary exploratory aim was to identify patient characteristics associated with a positive response to each question. All variables were treated as categorical variables (with age dichotomized into age <48 and >48). Variables were analyzed with proportions and compared using chi-square tests. Results: The majority of responders were female (84.7%) and white (91.9%) (Table 1). The responses to COVID-19 questions are shown in Figure 1. Notably, majority (53%) of responders are anxious about the pandemic, 20% believe that patients with EoE are at higher risk of acquiring COVID-19, 41% are agreeable to taking an approved vaccine, 44% report interruptions in EoE-related care (either missed upper endoscopy or clinic visit) for themself or the person they care for, and only 24% have found social media to be useful to learn about the impact of COVID-19 on the EoE population. Caregivers are more concerned than patients that EoE patients are at higher risk of acquiring COVID-19 (OR 3.65, 95% CI 1.25-12.02). The older age group is less likely to use social media to learn about COVID-19 in the context of EoE (OR 0.35, 95% CI 0.13-0.90). There is a trend toward females being more likely to have interruptions in EoE-related care compared to males (OR 2.95, 95% CI 0.83-12.15). Conclusion: Our pilot data suggests that COVID-19 has led to anxiety and interruptions in care in the EoE population of the US. EoE care providers should take measures to address anxiety and create care plans that decrease pandemic-related delays. Further efforts should be made to study the risk of COVID-19 in EoE patients and to disperse such research on social media for easy accessibility. If and when a safe and efficacious vaccination is approved, providers will be critical in educating the EoE population on risks and benefits of vaccination. (Table presented) Baseline characteristics of all survey responders (Figure presented) Percentage of participants who responded “Yes” to each COVID-19 related question

8.
Medisur-Revista De Ciencias Medicas De Cienfuegos ; 19(5):895-897, 2021.
Article in Spanish | Web of Science | ID: covidwho-1515884

ABSTRACT

The COVID-19 pandemic has undoubtedly left deep marks on individual and collective mental health. Although SARS-Cov2 is certainly a disease that does not discriminate age, sex, social status, economic class, etc., it has been shown that certain social determinants highly influence their risk of mortality. Therefore, these deaths will not be seen in the same way by all people, but will depend on the social context in which they exist. Managing the normal grieving process after a loss is never easy, much less if the current health emergency and the psychosocial problems that it entails are involved.

9.
Journal of Virology ; 95(14):16, 2021.
Article in English | Web of Science | ID: covidwho-1486522

ABSTRACT

We describe a mammalian cell-based assay to identify coronavirus 3CL protease (3CLpro) inhibitors. This assay is based on rescuing protease-mediated cytotoxicity and does not require live virus. By enabling the facile testing of compounds across a range of 15 distantly related coronavirus 3CLpro enzymes, we identified compounds with broad 3CLpro-inhibitory activity. We also adapted the assay for use in compound screening and in doing so uncovered additional severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3CLpro inhibitors. We observed strong concordance between data emerging from this assay and those obtained from live virus testing. The reported approach democratizes the testing of 3CLpro inhibitors by developing a simplified method for identifying coronavirus 3CLpro inhibitors that can be used by the majority of laboratories, rather than the few with extensive biosafety infrastructure. We identified two lead compounds, GC376 and compound 4, with broad activity against all 3CL proteases tested, including 3CLpro enzymes from understudied zoonotic coronaviruses. IMPORTANCE Multiple coronavirus pandemics have occurred over the last 2 decades. This has highlighted a need to be proactive in the development of therapeutics that can be readily deployed in the case of future coronavirus pandemics. We developed and validated a simplified cell-based assay for the identification of chemical inhibitors of 3CL proteases encoded by a wide range of coronaviruses. This assay is reporter free, does not require specialized biocontainment, and is optimized for performance in high-throughput screening. By testing reported 3CL protease inhibitors against a large collection of 3CL proteases with variable sequence similarity, we identified compounds with broad activity against 3CL proteases and uncovered structural insights into features that contribute to their broad activity. Furthermore, we demonstrated that this assay is suitable for identifying chemical inhibitors of pro teases from families other than 3CL proteases.

10.
Revista Ecuatoriana de Neurologia ; 30(2):16-17, 2021.
Article in Spanish | Scopus | ID: covidwho-1485810
11.
Neurology ; 96(15 SUPPL 1), 2021.
Article in English | EMBASE | ID: covidwho-1407846

ABSTRACT

Objective: To describe the autonomic and SNC manifestations of patients with coronavirus disease 2019 (COVID-19) and happy hypoxemia. Background: Happy hypoxemia is the absence of dyspnea despite low oxygen saturation. Several hypotheses for its occurrence include potential viral neuroinvasion, autonomic dysfunction, and cortical ischemic damage. Design/Methods: We studied prospectively nine patients with COVID-19 who arrived at the ER with very low oxygen saturation (50-79%) and no dyspnea complaints. Patients were invited to participate and underwent a full clinical history, brain MRI with gadolinium, and 24H-Holter with spectroscopy while hospitalized and bed-ridden. We used Pearson's coefficient correlation for the correlation analysis. Results: Two patients were excluded from the study because they no longer wished to participate and one because he had FA. we analyzed six patients (66% women) with a mean age of 59 years old (47-83). Two patients had high blood pressure, one patient had a history of tuberculosis, and one had Down Syndrome. Upon arrival at the ER, the mean oxygen saturation was 67% and PaO2 59.3 (47-83). One patient (14%) complain of headache and none of anosmia or ageusia. Four patients underwent a brain MRI that showed gadolinium enhancement of the olfactory bulbs and white matter lesions. One patient also had a left insular lesion. Three patients had abnormal SDNN<100 (83ms, 30-146), and one had RMSSD <15. Vagally mediated changes reflected in HRv were significantly lower in patients with lower blood O2 saturation (SDDN p=0.002, r=.95, HF p=0.009, r=.92, LF/HF ns, -0.42). Conclusions: Patients with happy hypoxemia had decreased heart rate variability that correlated with the degree of hypoxemia, suggesting altered modulation of vagal tone and autonomic dysregulation. All the patients had olfactory bulb enhancement. In our patients, hyposmia /anosmia did not correlate with olfactory bulb hyperintensities or happy hypoxemia.

12.
Gastroenterology ; 160(6):S260-S261, 2021.
Article in English | Web of Science | ID: covidwho-1250782
13.
Clinical & Experimental Rheumatology ; 05:05, 2021.
Article in English | MEDLINE | ID: covidwho-1231708

ABSTRACT

Systemic autoimmune diseases (SAD) are a heterogeneous group of diseases with a common aetiopathogenic basis affecting all ages characterised by a systemic phenotypic expression with a wide range of severity and outcomes that often require immunosuppressive therapies, leaving patients at high risk of infection. Knowledge of the impact of COVID-19 in patients with SAD is limited because most are included in studies carried out in patients with autoimmune and rheumatic diseases (mainly inflammatory arthritis). Most studies supported an increased risk of SARS-Cov-2 infection in patients with AD and SAD. Although case-control studies reported no significant differences in the rate of poor outcomes between patients with and without AD, large population-based studies analysing baseline risk factors reported a 2-3 times higher rate of poor outcomes in patients with AD, especially in those with SAD. Individual risk factors associated with poor outcomes included gender male, older age, and underlying comorbidities and therapies (glucocorticoids, sulfasalazine, immunosuppressants and rituximab). Patients with SAD had less favourable COVID-19 outcomes than those with inflammatory arthritis, possibly due to a differentiated underlying therapeutic approach (glucocorticoids, immunosuppressants and B-cell depleting agents for most SAD, anti-cytokine therapies and JAK inhibitors for inflammatory arthritis). Despite the limited evidence, most studies suggest that patients with SAD have an increased risk of a worse evolution of SARS-CoV-2 infection, including a greater risk of hospitalisation/ICU admission and worse survival rates and, therefore, should be considered a high-risk group for COVID-19.

14.
Journal of the American Geriatrics Society ; 69(SUPPL 1):S246-S247, 2021.
Article in English | EMBASE | ID: covidwho-1214820

ABSTRACT

The Garrison Geriatric Care and Education Center was established in 2005 as a teaching nursing home at Texas Tech University, (TTU), focused on memory care. Pre-health profession students run a volunteer group and have created a progressive learning platform to perform dementia caregiving tasks, including emotional support, managing behavioral symptoms, feeding, and structured activities. Our objectives were to provide experiential learning for pre-health students in a memory care unit, and to provide supportive care for dementia patients without increasing financial burden. Students are given opportunities for innovation, interprofessional collaboration, and leadership experience. Experiential learning of future health care professionals in this setting may produce healthcare teams that are more empathetic, anticipatory of patient needs, and who value an integrated health care system. Additionally, pre-health students receive volunteer hours in a healthcare setting which improve their professional school applications. Unpaid caregivers provided 18.6 billion hours of care to patients with age-related dementias in 2019.1 Despite this, the lifetime cost to a patient diagnosed with dementia for skilled care, medical attention, and housing is $357,297.1 Over the past four years through spring 2020, TTU volunteers contributed ∼1700 hours of unpaid care. We estimated the value of this care to be ∼$5,355 per year. The COVID-19 Pandemic has provided an opportunity to implement and evaluate innovative and collaborative education models in long-term care. The TTU Clinical Council has recently developed a work group, reporting to the Office of the President, based upon the success and passions of our student-run group. Undergraduate pre-health students are an untapped resource that could decrease the financial burden on families and the healthcare system, and serve as a powerful driver for change in the care of memory patients.

15.
Journal of Allergy and Clinical Immunology ; 147(2):AB102-AB102, 2021.
Article in English | Web of Science | ID: covidwho-1148694
16.
Educacion Medica ; 2021.
Article in English, Spanish | Scopus | ID: covidwho-1131255

ABSTRACT

The COVID-19 pandemic hit the current university educational model without warning, and the health sciences were no exception. Adapting to the new times is essential. With the rise and almost universal access of new communication technologies, it is unjustifiable not to implement new forms of teaching with professionals in training. Although traditionally medical education has required real practice for the development of skills, it is necessary to complement this education with digital materials and methods available to students and teachers. Disease will change forever the health education and therefore also our way of acquiring the necessary knowledge to sustain it. © 2021 Elsevier España, S.L.U.

17.
Journal of the American Society of Nephrology ; 31:807, 2020.
Article in English | EMBASE | ID: covidwho-984422

ABSTRACT

Background: Although severe acute respiratory syndrome coronavirus (SARSCoV- 2) infection is primarily a respiratory disease, other organs are also affected. Several pathological studies confirm that SARS-CoV-2 invades kidney tissue causing endothelial damage, glomerular and vascular changes, extensive acute tubular injury and podocyte viral infection. AKI in COVID-19 appears to be frequent, with an AKI incidence of up to 46%, and a 20% requirement for renal replacement therapy (RRT). Patients with AKI show a trend towards worse outcomes and increased mortality. Information on Latin- American population is scarce. Methods: We created a cohort to describe the incidence, risk factors, and outcomes associated with AKI in hospitalized patients with COVID-19 in Mexico City, excluding patients with a known chronic kidney disease. AKI was defined and classified according to KDIGO guidelines. Results: We included 127 patients. 11 patients (8.66%) met the criteria for severe COVID-19, and were more likely to have AKI (81.82% vs. 54.31%, p=0.078). Of the 72 (56.69%) patients that had AKI, 48% were diagnosed at the time of admission. Patients with AKI were more likely to be men (61.7% vs. 42.42%, p=0.043) and older (55.68 years vs. 48.89 years, 0.018). With regards disease severity, 72% of them had a grade 1 AKI. 7 patients (9.72%) had grade 3 AKI, 4 of which needed renal replacement therapy. Overall length of stay was longer in patients with AKI (12 days vs. 7 days, p=0.003). A nonsignificant trend towards stay in critical care units was observed. 3 out of 127 patients died, all 3 had AKI. Conclusions: Amongst our studied population, AKI was associated with a longer length of stay and with a trend towards a more use of critical care services. The lack of association of AKI with mortality could be due to the low overall in-hospital mortality of COVID-19 patients (2.40%).

18.
Family Practice Management ; 27(3):1, 2020.
Article in English | Scopus | ID: covidwho-958712
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