Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 16 de 16
Filter
1.
Entertainment Computing ; : 100511, 2022.
Article in English | ScienceDirect | ID: covidwho-1926426

ABSTRACT

Remote collaboration tools for conferencing and presentation are gaining significant popularity during the COVID-19 pandemic period. Most prior work has drawbacks, such as a) limited support for media types, b) lack of interactivity, for example, an efficient replay mechanism, c) large bandwidth consumption for screen sharing tools. In this paper, we propose a general-purpose multimedia collaboration platform-CWcollab. It supports collaboration on general multimedia by using simple messages to represent media controls with an object-prioritized synchronization approach. Thus, CWcollab can not only support fine-grained accurate collaboration, but also rich functionalities such as replay of these collaboration events. The evaluation shows hundreds of kilobytes can be enough to store the events in a collaboration session for accurate replays, compared with hundreds of megabytes of Google Meet.

2.
9th International Conference on Learning and Collaboration Technologies, LCT 2022 Held as Part of the 24th HCI International Conference, HCII 2022 ; 13329 LNCS:61-70, 2022.
Article in English | Scopus | ID: covidwho-1919642

ABSTRACT

In order to face the requirement of distant education after covid-19, this paper has presented a cyber-physical co-existence environment for practical distance learning events, we called it as a “Co-existing Practical Environment, CPE”. CPE includes: “Holographic Wearable Device, HWD” for behavior sensing and vision sharing mechanism, cloud “Digital Twin Model, DTM” database for expert correcting variables real time, and collaborative fabrication discussion interface. We built an immersive HoloLens interface to help distance learning participators, understanding the concept of structural mechanics form morphs with mix-reality sensing, communicating the augmented information of parts of models for collaborative fabrication, and sharing the views of operation process for lecturers to solve the technical problems instantly. Furthermore, users are able to make their own custom digital twin project in CPE and optimize their fabricating process by adding more realistic material factors, operation callbacks, or analyzing their practice results in parameters relationships. This paper revised an application of holographic technology with a practical distance learning workshop as example, and discover CPE as a new kind of co-creation, cross-field, and remotely prepared cooperation mechanism. While the epidemic is still ragging, we are looking further researchers of more immersive methods for distance education. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

3.
28th Asia-Pacific Software Engineering Conference (APSEC) ; : 285-295, 2021.
Article in English | Web of Science | ID: covidwho-1895885

ABSTRACT

The COVID-19 pandemic has birthed a wealth of information through many publicly accessible sources, such as news outlets and social media. However, gathering and understanding the content can be difficult due to inaccuracies or inconsistencies between the different sources. To alleviate this challenge in Australia, a team of 48 student volunteers developed an opensource COVID-19 information dashboard to provide accurate, reliable, and real-time COVID-19 information for Australians. The students developed this software while working under legislative restrictions that required social isolation. The goal of this study is to characterize the experiences of the students throughout the project. We conducted an online survey completed by 39 of the volunteering students contributing to the COVID-19 dashboard project. Our results indicate that playing a positive role in the COVID-19 crisis and learning new skills and technologies were the most cited motivating factors for the students to participate in the project. While working on the project, some students struggled to maintain a work-life balance due to working from home. However, the students generally did not express strong sentiment towards general project challenges. The students expressed more strongly that data collection was a significant challenge as it was difficult to collect reliable, accurate, and upto-date data from various government sources. The students have been able to mitigate these challenges by establishing a systematic data collection process in the team, leveraging frequent and clear communication through text, and appreciating and encouraging each other's efforts. By participating in the project, the students boosted their technical (e.g., front-end development) and nontechnical (e.g., task prioritization) skills. Our study discusses several implications for students, educators, and policymakers.

4.
Ccs Chemistry ; 3(1):1501-1528, 2021.
Article in English | Web of Science | ID: covidwho-1887435

ABSTRACT

Coronavirus disease 2019 (COVID-19) is caused by a novel strain of coronavirus, designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has caused a global pandemic rapidly sweeping across all countries, bringing social and economic hardship to millions. Most countries have implemented early warning measures to detect, isolate, and treat patients infected with SARS-CoV-2. This minireview summarizes some of those steps, in particular, testing methods and drug development in the context of chemical biology, and discusses the molecular basis of COVID-19's virulent transmissibility.

5.
PubMed; 2022.
Preprint in English | PubMed | ID: ppcovidwho-331088

ABSTRACT

The COVID-19 pandemic is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The betacoronvirus has a positive sense RNA genome which encodes for several RNA binding proteins. Here, we use enhanced crosslinking and immunoprecipitation to investigate SARS-CoV-2 protein interactions with viral and host RNAs in authentic virus-infected cells. SARS-CoV-2 proteins, NSP8, NSP12, and nucleocapsid display distinct preferences to specific regions in the RNA viral genome, providing evidence for their shared and separate roles in replication, transcription, and viral packaging. SARS-CoV-2 proteins expressed in human lung epithelial cells bind to 4773 unique host coding RNAs. Nine SARS-CoV-2 proteins upregulate target gene expression, including NSP12 and ORF9c, whose RNA substrates are associated with pathways in protein N-linked glycosylation ER processing and mitochondrial processes. Furthermore, siRNA knockdown of host genes targeted by viral proteins in human lung organoid cells identify potential antiviral host targets across different SARS-CoV-2 variants. Conversely, NSP9 inhibits host gene expression by blocking mRNA export and dampens cytokine productions, including interleukin-1α/β. Our viral protein-RNA interactome provides a catalog of potential therapeutic targets and offers insight into the etiology of COVID-19 as a safeguard against future pandemics.

6.
Journal of Virology ; 96(3):14, 2022.
Article in English | Web of Science | ID: covidwho-1755770

ABSTRACT

Human adenovirus serotype 26 (Ad26) is used as a gene-based vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and HIV-1. However, its primary receptor portfolio remains controversial, potentially including sialic acid, coxsackie and adenovirus receptor (CAR), integrins, and CD46. We and others have shown that Ad26 can use CD46, but these observations were questioned on the basis of the inability to cocrystallize Ad26 fiber with CD46. Recent work demonstrated that Ad26 binds CD46 with its hexon protein rather than its fiber. We examined the functional consequences of Ad26 for infection in vitro and in vivo. Ectopic expression of human CD46 on Chinese hamster ovary cells increased Ad26 infection significantly. Deletion of the complement control protein domain CCP1 or CCP2 or the serine-threonine-proline (STP) region of CD46 reduced infection. Comparing wild-type and sialic acid-deficient CHO cells, we show that the usage of CD46 is independent of its sialylation status. Ad26 transduction was increased in CD46 transgenic mice after intramuscular (i.m.) injection but not after intranasal (i.n.) administration. Ad26 transduction was 10-fold lower than Ad5 transduction after intratumoral (i.t.) injection of CD46expressing tumors. Ad26 transduction of liver was 1,000-fold lower than that ofAd5 after intravenous (i.v.) injection. These data demonstrate the use of CD46 by Ad26 in certain situations but also show that the receptor has little consequence by other routes of administration. Finally, i.v. injection of high doses of Ad26 into CD46 mice induced release of liver enzymes into the bloodstream and reduced white blood cell counts but did not induce thrombocytopenia. This suggests that Ad26 virions do not induce direct clotting side effects seen during coronavirus disease 2019 (COVID-19) vaccination with this serotype of adenovirus. IMPORTANCE The human species D Ad26 is being investigated as a low-seroprevalence vector for oncolytic virotherapy and gene-based vaccination against HIV-1 and SARS-CoV-2. However, there is debate in the literature about its tropism and receptor utilization, which directly influence its efficiency for certain applications. This work was aimed at determining which receptor(s) this virus uses for infection and its role in virus biology, vaccine efficacy, and, importantly, vaccine safety.

7.
European Journal of Immunology ; 51:255-255, 2021.
Article in English | Web of Science | ID: covidwho-1716902
8.
PubMed; 2022.
Preprint in English | PubMed | ID: ppcovidwho-329172

ABSTRACT

The COVID-19 pandemic is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The betacoronvirus has a positive sense RNA genome which encodes for several RNA binding proteins. Here, we use enhanced crosslinking and immunoprecipitation to investigate SARS-CoV-2 protein interactions with viral and host RNAs in authentic virus-infected cells. SARS-CoV-2 proteins, NSP8, NSP12, and nucleocapsid display distinct preferences to specific regions in the RNA viral genome, providing evidence for their shared and separate roles in replication, transcription, and viral packaging. SARS-CoV-2 proteins expressed in human lung epithelial cells bind to 4773 unique host coding RNAs. Nine SARS-CoV-2 proteins upregulate target gene expression, including NSP12 and ORF9c, whose RNA substrates are associated with pathways in protein N-linked glycosylation ER processing and mitochondrial processes. Furthermore, siRNA knockdown of host genes targeted by viral proteins in human lung organoid cells identify potential antiviral host targets across different SARS-CoV-2 variants. Conversely, NSP9 inhibits host gene expression by blocking mRNA export and dampens cytokine productions, including interleukin-1alpha/beta. Our viral protein-RNA interactome provides a catalog of potential therapeutic targets and offers insight into the etiology of COVID-19 as a safeguard against future pandemics.

9.
Safety and Health at Work ; 13:S186-S187, 2022.
Article in English | EMBASE | ID: covidwho-1677095

ABSTRACT

Introduction: The COVID-19 pandemic has changed the practices of occupational health in many aspects. Due to heavy caseloads, the traditional approach of contact tracing may not be implemented comprehensively, impeding the determination of causality of workplace exposure on COVID-19. The current study examines measures adopted by selected countries for recognizing work-related COVID-19. Material and Methods: Regulation and rules of recognition of work-related COVID-19 in various countries were obtained through a systematic review of published literature and official government websites. The US, France, Germany, South Korea, Taiwan were among the fifty countries included in the comparative analysis. Data on approved and total claims cases were obtained through open data of national Workers’ Compensation systems and analyzed by types of regulation. Results: Some countries stuck to the case-by-case investigation of causality, while others introduced unique measures, including the rebuttable presumption of compensability. In the latter cases, the work-relatedness of patients from certain high-risk occupations was automatically recognized unless the dominant evidence proved the contrary. As with traditional understandings, health care professionals and first responders were defined as high-risk in most presumption rules. However, in the context of substantial community transmission, occupations with frequent public contact, like aircrews, customs personnel, and store clerks, were also included in some countries. Conclusions: The presumption rules had an active role in facilitating the compensation of work-related COVID-19.

10.
13th EAI International Conference on Bio-inspired Information and Communications Technologies, BICT 2021 ; 403 LNICST:15-25, 2021.
Article in English | Scopus | ID: covidwho-1598807

ABSTRACT

The global COVID-19 pandemic leads people to intermittent quarantines and lockdowns. Many large and crowded gatherings were postponed or even cancelled to prevent social distance violation. The paper aims to tackle the placement problem of macro sites, microcells and picocells under a restricted network topology. The cell placement problem is defined based on linear programming. The algorithm named Cost Efficiency algorithm is proposed to construct a network with higher performance and lower cost. Simulation results showed that the proposed algorithm yields higher SINR value and more number of served users over construction cost compared with other planning algorithms. The result of this work is expected to help users have better network service quality when they are isolated in hospital or self-health monitoring at home. © 2021, ICST Institute for Computer Sciences, Social Informatics and Telecommunications Engineering.

11.
IEEE International Conference on Communications (ICC) ; 2021.
Article in English | Web of Science | ID: covidwho-1559481

ABSTRACT

Remote collaboration tools for conferencing and presentation are gaining significant popularity during the COVID-19 pandemic period. Most prior work has issues, such as a) limited support for media types, b) lack of interactivity, for example, an efficient replay mechanism, c) large bandwidth consumption for screen sharing tools. In this paper, we propose a general-purpose multimedia collaboration platform-CWcollab. It supports collaboration on general multimedia by using simple messages to represent media controls with an object-prioritized synchronization approach. Thus, CWcollab can not only support fine-grained accurate collaboration, but also rich functionalities such as replay of these collaboration events. The evaluation shows hundreds of kilobytes can be enough to store the events in a collaboration session for accurate replays, compared with hundreds of megabytes of Google Hangouts.

12.
45th Annual International IEEE-Computer-Society Computers, Software, and Applications Conference (COMPSAC) ; : 804-811, 2021.
Article in English | Web of Science | ID: covidwho-1511212

ABSTRACT

When high school students leave their homes for a college education, they often face enormous changes and challenges in life, such as meeting new people, more responsibilities in life, and being away from family and their comfort zones. These sudden changes often lead to an elevation of stress and anxiety, affecting a student's health and well-being. Situations can even get worse in the age of global pandemics, such as COVID-19, when regular life and social activities are significantly disrupted due to lockdown or stay-at-home orders. Therefore, predicting phone call patterns (a measure of social engagement) based on various factors and activities of a person can be helpful to foster social engagement and promote health and well-being during sudden lifestyle changes. In this work, we investigate a cohort of 370 on-campus college students over three consecutive semesters and breaks between them to find various geo-temporal factors and activities that affect students' phone call behaviors and develop models that can predict the next call duration with a correlation of up to 0.89 between the actual and predicted duration using individual-level generalized linear models. Findings from this work can further be extended to other populations, and thereby, our findings will enable the design and delivery of new smartphone-based health interventions (guided feedback) to help people to adapt and cope up with situations that affect their lifestyle and social activities.

13.
2021 IEEE International Conference on Communications, ICC 2021 ; 2021.
Article in English | Scopus | ID: covidwho-1447818

ABSTRACT

Remote collaboration tools for conferencing and presentation are gaining significant popularity during the COVID-19 pandemic period. Most prior work has issues, such as a) limited support for media types, b) lack of interactivity, for example, an efficient replay mechanism, c) large bandwidth consumption for screen sharing tools. In this paper, we propose a general-purpose multimedia collaboration platform-CWcollab. It supports collaboration on general multimedia by using simple messages to represent media controls with an object-prioritized synchronization approach. Thus, CWcollab can not only support fine-grained accurate collaboration, but also rich functionalities such as replay of these collaboration events. The evaluation shows hundreds of kilobytes can be enough to store the events in a collaboration session for accurate replays, compared with hundreds of megabytes of Google Hangouts. © 2021 IEEE.

14.
Journal of Behavioral Science ; 16(2):16-27, 2021.
Article in English | Web of Science | ID: covidwho-1271331

ABSTRACT

Sugar intake has increasingly been a threat because of its association with chronic diseases such as diabetes. During the ongoing Covid-19 pandemic, people have stayed indoors with minimal activities, leading to unhealthy eating habits and weight gain. However, through health-promotion education, these threats could be managed. This study focused on an online heath nutrition program for sugar reduction, with an aim of developing an online training program for reducing sugar intake. Data were collected from 100 participants belonging to a Facebook community in Taiwan. They performed activities guided by research's daily lesson plans for a maximum of 10 minutes per day for three weeks. Online questionnaires were used for the pretest and posttest. Findings revealed significant differences in health knowledge (t(99) = -8.27, p < .001), attitude (t(99) = -8.98, p < .001), self-efficacy (t(99) = -10.14, p < .001), and perceived healthy behavior (t(99) = -12.40, p < .001), with their posttest scores being higher than their pretest scores. These findings imply that online training on Facebook is an effective educational tool during the Covid-19 pandemic. Therefore, this study contributes to behavioral science knowledge by revealing Facebook as a facilitating and training platform for promoting healthy behavior, and access to information on reduction of sugar intake during pandemic. Furthermore, these findings could be used as empirical evidence of the possibility of implementing online nutrition programs for the teaching and training of online communities.

15.
2020 3rd International Conference on Big Data and Education ; : 21-25, 2020.
Article in English | Web of Science | ID: covidwho-1180979

ABSTRACT

Exposed in environment of big data, college students come easily into contact with massive data presentation. When crisis events occur, college students will be affected not only by crisis events but also by human psychological crisis. The greater psychological threat, faced by college students in the crisis environment, is the loss of sense of security. Through literature review, the hypotheses in crisis events are as followed: crisis events, government and media response, university coping measures, group coping behavior are the four main factors that affect college students' sense of security in crisis events. The outbreak of COVID-19 in Wuhan, Hubei affecting all the people, all colleges and universities across the country delayed the opening time. Among the affected universities, take the University of Electronic Science and Technology as an example, 600 samples were randomly selected to collect data. Through the exploratory factor analysis test, the influence hypotheses are verified. Through the structural equation model test, the four kinds of factors can explain the loss of college students' sense of security in the crisis, but show differences in explanatory power. Based on the elements of college students' sense of security, this paper puts forward an further explanation on the action path of the four factors on the public sense of security. According to the conclusion, we come to the conclusion that improving the coping ability of colleges and universities, enhancing the sense of crisis determination and the efficiency of control are the key to improve college students' sense of security and ensure the effectiveness of crisis management in colleges and universities.

16.
Resuscitation ; 155:S30, 2020.
Article in English | EMBASE | ID: covidwho-888898

ABSTRACT

Purpose: The impact of emerging infections disease pandemic such as COVID-19 on bystander CPR performance is not well known. Materials-and-methods: This was an observational database prospectively collected from National Registry for DACPR (dispatcher-assisted CPR), a continuous quality control for OHCA by audio records analyses of EMS calls. The performance of DACPR before and after the COVID-19 epidemic was compared among four individual EMS systems (three metropolitan and one suburban). The bystander chest compressions (BCC) rate prior to the call, successful delivery of BCC after dispatcher-assisted, and the continuity of CC until hand-over by the paramedics after arrival (HCC) as the categorical indicators, and the operational time interval corresponding to call-to-compression were evaluated and analyzed using Pearson's chi-squared test, Independent t-test, and Kruskal–Wallis test with SPSS Version 22. Results: In a total of 3263 eligible patients from four EMS systems, for patients already receiving BCC prior to the call, though showing a tendency of decrease, there were no significant differences after the epidemics (A: 3.6% vs. 5.7%, p = 0.13;B: 4.5% vs. 6.1%, p = 0.46;C: 6.0% vs. 6.6%, p = 0.71;D: 6.8% vs. 10.7%, p = 0.59;Total: 4.9% vs. 6.4%, p = 0.11). For dispatcher-assisted BCC delivery, a metropolitan (B) significantly decreased and the suburban (D) significantly increased (A: 55.0% vs. 56.1%, p = 0.72;B: 41.8% vs. 52.3%, p = 0.03;C: 60.6% vs. 56.5%, p = 0.19;D: 83.0% vs. 60.2%, p < 0.01;Total: 56.8% vs. 55.6%, p = 0.53). For continuity of HCC, a metropolitan(C) and the suburban (D) both significantly increased as well as the total cases (A: 43.9% vs. 46.4%, p = 0.43;B: 28.5% vs. 31.0%, p = 0.56;C: 54.0% vs. 40.0%, p < 0.01;D: 77.4% vs. 59.3%, p = 0.02;Total: 47.4%vs.41.3%, p < 0.01). For call-to-compression interval, all regions showed a tendency to be faster without significance (A: 185 vs. 189 s, p = 0.8;B: 141 vs. 156 s, p = 0.19;C: 173 vs. 182 s, p = 0.12;D: 156 vs. 171 s, p = 0.27;Total: 164 vs. 172 s, p = 0.19). Conclusions: The impacts of COVID-19 pandemic showed a tendency to decrease BCC prior to dispatcher-assisted, and were significantly varied for dispatcher-assisted BCC among different EMS systems, however the timely BCC would not be delayed. Continuity of BCC even significantly increased under the national continuous auditing.

SELECTION OF CITATIONS
SEARCH DETAIL