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J. Shanghai Jiaotong Univ. Med. Sci. ; 4(40): 417-421, 20200428.
Article in Chinese | WHO COVID, ELSEVIER | ID: covidwho-621324


Since December 2019, the coronavirus disease 2019 (COVID-19) has become one of the most significant infectious diseases in the world. The epidemic in China has been basically controlled through a series of prevention and control measures. But the number of confirmed cases and deaths in other countries and regions is still rapidly rising. In response to this major epidemic, the hospital's emergency management system is facing a great challenge, especially the department of emergency, which takes the responsibilities of the screening and diagnosis of fe-ver patients as well as the emergency treatment of ordinary patients. Through two months of practice and exploration, our hospital has summa-rized some experiences in improving the emergency management system, establishing a peace and war integration mechanism, reorganizing medical resources, guaranteeing the deployment of supplies and optimizing information system, and has achieved the "zero infection" of medical staff, "zero misdiagnosis" and "zero cross-infection" of patients with COVID-19.

Chronic Dis Transl Med ; 6(2): 106-114, 2020 Jun.
Article in English | MEDLINE | ID: covidwho-379972


Coronavirus disease (COVID-19) was first diagnosed in Wuhan in December 2019. The World Health Organization defined the subsequent outbreak of COVID-19 worldwide as a public health emergency of international concern. Epidemiological data indicate that at least 20% of COVID-19 patients have severe disease. In addition to impairment of the respiratory system, acute kidney injury (AKI) is a major complication. Immune damage mediated by cytokine storms and concomitant AKI is a key factor for poor prognosis. Based on previous experience of blood purification for patients with severe acute respiratory syndrome and Middle East respiratory syndrome combined with clinical front-line practice, we developed a blood purification protocol for patients with severe COVID-19. This protocol is divided into four major steps. The first step is to assess whether patients with severe COVID-19 require blood purification. The second step is to prescribe a blood purification treatment for patients with COVID-19. The third step is to monitor and adjust parameters of blood purification. The fourth step is to evaluate the timing of discontinuation of blood purification. It is expected that blood purification will play a key role in effectively reducing the mortality of patients with severe COVID-19 through the standardized implementation of the present protocol.