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1.
Journal of Hydrology ; : 127613, 2022.
Article in English | ScienceDirect | ID: covidwho-1693270

ABSTRACT

Lake eutrophication has become a critical environmental issue due to the global effects of anthropogenic activities and climate change, and has been comprehensively studied for many years. A series of models and indicators have been proposed to assess the trophic state of lakes. The trophic state index (TSI) is a synthetic index that integrates chlorophyll-a, water clarity, and total phosphorus and is widely used to evaluate the trophic state of aquatic environments. In this study, we collected in situ lake samples (N=431) from typical lakes to match Sentinel-2 MultiSpectral Instrument (MSI) imagery data using the Case 2 Regional Coast Color processor. Then we developed a new empirical model, TSI = –34.04 × (band 4/band 5) – 1.114 × (band 1/band 4) + 97.376). This model is valid for all of China, with good performance and few errors (RMSE=7.36;MAE=6.25) for the validation dataset. Recognizing that over 94% of the Chinese population located along eastern watersheds and large lakes have competing water uses, and given the TSI model on the seasonal scales, we further estimated the mean TSI and trophic state in eastern Chinese lakes (> 100 km2) from 2019 to 2020. The results revealed that more lakes were eutrophic in autumn (94.28%) than in spring (> 77.14%), indicating a serious eutrophication of eastern lakes. Although the eastern lakes have been studied in more detail, this study found that eutrophication still has markedly negative impacts on lake ecosystems. In addition, no significant improvement was observed in spring, most likely due to the months of curfew/lockdown from January 2020 onwards due to COVID-19. This may be due to the enrichment of nutrients deposited in sediment or watershed soil, which can be characterized as “autochthonous sources” of lake eutrophication, over decades with high rates of economic development. This study demonstrates the applicability of Sentinel-2 MSI data to monitor lake eutrophication as well as the feasibility of blue/red and red/red edge combinations. The framework and TSI model used bands available on MSI sensors to develop a novel approach for generating historical eutrophication data for large-scale evaluation of and decision-making related aquatic environmental changes, even in poorly studied areas.

2.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-324813

ABSTRACT

Background: The outbreak of Coronavirus Disease 2019 (COVID-19) has caused serious threats to people’s health and lives. The police officers are bravely fighting on the front lines of the epidemic. Our study is the first survey of psychological response in the police officers of China during the tumultuous time of the COVID − 19 outbreak. Methods A cross-sectional online questionnaire was conducted to the police officers from 5 districts (Yijiang, Sanshan, Jiujiang, jinghu and Jingkai) and 4 counties (Wuhu, Nanling,Fanchang and Wuwei) of Wuhu City through Wechat, and the data were collected between 10 and 26 March 2020. A total of 3561 questionnaires were received in the study, of which 3517 were considered valid. The questionnaires included the demographic information and psychological survey. The depression scale of the patient health questionnaire (PHQ-9) and generalized anxiety disorder 7-item scale (GAD-7) were employed to assess depression and anxiety, respectively. Results The mean depression score of the participants was 4.10 ± 4.87 (0 ~ 27). 12.17% of the police officers had moderate to severe depression. The mean anxiety score of the participants was 3.59 ± 4.228 (0 ~ 21). 8.79% the police officers had moderate to severe anxiety. The participants of senior high school or below and academy had lower depression and anxiety scores than these of bachelor or above, respectively. The police officers Unmarried had lower anxiety scores than married. The different location and police classification were associated with the different degree of depression and anxiety. The participants who did not take sleeping pills had lower depression and anxiety scores than those who took sleeping pills. The depression scores of the police officers were strongly correlated with their anxiety scores of the police officers. Conclusion The police officers have different levels of anxiety and depression during the COVID-19 epidemic in Wuhu. We should call for attention to the psychological response of police officers during the epidemic, and provide them with corresponding help and follow-up.

4.
Front Immunol ; 12: 690742, 2021.
Article in English | MEDLINE | ID: covidwho-1389184

ABSTRACT

Since December 2019, the SARS-CoV-2 has erupted on a large scale worldwide and spread rapidly. Passive immunization of antibody-related molecules provides opportunities for prevention and treatment of high-risk patients and children. Nanobodies (Nbs) have many strong physical and chemical properties. They can be atomized, administered by inhalation, and can be directly applied to the infected site, with fast onset, high local drug concentration/high bioavailability, and high patient compliance (no needles). It has very attractive potential in the treatment of respiratory viruses. Rapid and low-cost development of Nbs targeting SARS-CoV-2 can quickly be achieved. Nbs against SARS-CoV-2 mutant strains also can be utilized quickly to prevent the virus from escaping. It provides important technical supports for the treatment of the SARS-CoV-2 and has the potential to become an essential medicine in the toolbox against the SARS-CoV-2.


Subject(s)
Antibodies, Neutralizing/immunology , Antibodies, Viral/immunology , COVID-19/immunology , COVID-19/virology , SARS-CoV-2/immunology , Single-Domain Antibodies/immunology , Animals , Antibody Affinity/immunology , Binding Sites , Epitopes/immunology , Humans , Neutralization Tests , Peptide Library , Protein Binding
5.
Transl Psychiatry ; 11(1): 342, 2021 06 03.
Article in English | MEDLINE | ID: covidwho-1258580

ABSTRACT

This study aims to explore the psychosocial and behavioral problems of children and adolescents in the early stage of reopening schools. In this national cross-sectional study, a total of 11072 students from China were naturally divided into two groups based on their schooling status: reopened schools (RS) and home schooling (HS) group. The psychosocial and behavioral functioning were measured by Achenbach Child Behaviour Checklist (CBCL) and compared in these two groups. Multivariable logistic regression analyses were conducted to explore the independent predictors associated with the psychosocial and behavioral problems. Our results showed that the students in the RS group had more adverse behaviors than that of HS group. The RS group had the higher rates of parent-offspring conflict, prolonged homework time, increased sedentary time and sleep problems (all p < 0.001). When separate analyses were conducted in boys and girls, the RS group had the higher scores for (1) overall behavioral problems (p = 0.02 and p = 0.01), internalizing (p = 0.02 and p = 0.02) and externalizing (p = 0.02 and p = 0.004) behaviors in the 6-11 age group; (2) externalizing (p = 0.049 and p = 0.006) behaviors in the 12-16 age group. Multivariable regression showed parent-offspring conflict and increased sedentary time were the most common risk factors, while physical activity and number of close friends were protective factors for behavior problems in RS students (p < 0.01 or 0.05). The present study revealed that students' psychosocial and behavioral problems increased in the early stage of schools reopened unexpectedly. These findings suggest that close attention must be paid and holistic strategies employed in the school reopening process of post-COVID-19 period.


Subject(s)
COVID-19 , Problem Behavior , Adolescent , Child , China/epidemiology , Cross-Sectional Studies , Female , Humans , Male , Pandemics , SARS-CoV-2 , Schools
6.
Risk Manag Healthc Policy ; 13: 2689-2697, 2020.
Article in English | MEDLINE | ID: covidwho-948006

ABSTRACT

BACKGROUND: The outbreak of coronavirus disease 2019 (COVID-19) has presented serious threats to people's health and lives. Police officers are bravely fighting on the front lines of the epidemic. The main purpose of this study was to assess the prevalence and severity of psychological responses among police officers during the COVID-19 pandemic and find influencing factors in depression and anxiety. METHODS: A cross-sectional online questionnaire was administered to police officers in Wuhu through WeChat, and data were collected between March 10 and 26, 2020. A total of 3,561 questionnaires were received, of which 3,517 were considered valid. The questionnaires included demographic information and a psychological survey. The depression scale of the Patient Health QuestionnaireQ9) and Generalized Anxiety Disorder scale were utilized to assess depression and anxiety, respectively. RESULTS: The mean depression score of participants was 4.10±4.87 (0-27), and 12.17%had moderate-severe depression. The mean anxiety score of participants was 3.59±4.228 (0-21), and 8.79% had moderate-severe anxiety. Older and married police officers were at higher risk of anxiety. Those with a bachelor's degree or above, living near the city center, and taking sleeping pills were at greater risk of depression and anxiety. Auxiliary police had lower depression and anxiety scores. Depression scores were strongly correlated withanxiety scores (r=0.863, p<0.001). CONCLUSION: Our findings identify factors associated with higher levels of depression and anxiety that can be utilized to develop psychological interventions to improve the mental health of vulnerable populations during the COVID-19 pandemic.

7.
J Crit Care ; 60: 32-37, 2020 12.
Article in English | MEDLINE | ID: covidwho-635117

ABSTRACT

PURPOSE: To clarify the epidemiological, clinical, and therapeutic features of patients with severe COVID-19. METHODS: In this study, we enrolled 681 patients with confirmed cases of severe COVID-19. The epidemiological, demographic, clinical, laboratory, treatment, and outcome data were collected. RESULTS: The median age of the study participants was 65 years, 53.2% were male, and 104 (15.3%) died. Age, Neutrophil-To-Lymphocyte Ratio (NLR), acute myocardial injury, and levels of C-reactive protein (CRP), lactate dehydrogenase (LDH), and CD3 T cells counts were independently associated with death, while arbidol and ribavirin were protective from death. The combination of NLR and acute myocardial injury on admission (AUC = 0.914) predicted mortality better than NLR, CRP, LDH, and acute myocardial injury. There were 312 (45.8%) patients with cardiovascular disease, of whom 23.4% died. ß-blockers, ACEI/ARB, arbidol, and ribavirin might have a beneficial effect for severe COVID-19 patients with cardiovascular disease. CONCLUSION: The combination of NLR and acute myocardial injury on admission was highly predictive of mortality and survival. Clinicians should adopt more aggressive strategies for patients with a high NLR (>6.66) combined with myocardial injury. ß-blockers and ACEI/ARB, as well as arbidol and ribavirin, were effective in COVID-19 patients with cardiovascular disease.


Subject(s)
Angiotensin Receptor Antagonists/therapeutic use , Angiotensin-Converting Enzyme Inhibitors/therapeutic use , COVID-19/drug therapy , Adult , Aged , Area Under Curve , C-Reactive Protein/metabolism , CD3 Complex/metabolism , China , Female , Humans , Indoles/therapeutic use , L-Lactate Dehydrogenase/metabolism , Lymphocyte Count , Lymphocytes/cytology , Male , Middle Aged , Multivariate Analysis , Neutrophils/cytology , ROC Curve , Retrospective Studies , Ribavirin/therapeutic use , Young Adult
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