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1.
Resources Policy ; : 103094, 2022.
Article in English | ScienceDirect | ID: covidwho-2095958

ABSTRACT

We examine the dynamic relationship between clean energy stock markets and energy commodity markets in China from a time-frequency perspective. The daily dataset spans from March 27th, 2018, to July 29th, 2022, and is utilized in this study. We find that the clean stock markets are the main contributors and recipients in this dynamic system in the short run, while the solid net contributor role of commodities is detected in the long run. In addition, in most cases, short-term spillovers can dominate the long-run ones. However, during the COVID-19 pandemic, long-term spillovers can dominate short-run spillovers. In particular, it can be seen that in the short run, energy commodities can be easily influenced by clean energy stocks. In the long run, traditional energy assets are less affected. Finally, we show that COVID-19 can increase the hedging effectiveness of the portfolio design. We conclude with policy implications for energy and resources policymakers.

2.
Lancet Microbe ; 3(7): e512-e520, 2022 07.
Article in English | MEDLINE | ID: covidwho-2050135

ABSTRACT

BACKGROUND: Chlamydia psittaci can infect a wide range of avian species, occasionally causing psittacosis (also known as parrot fever) in humans. Most human psittacosis cases are associated with close contact with pet birds or poultry. In December, 2020, an outbreak of severe community-acquired pneumonia of unknown aetiology was reported in a hospital in Shandong province, China, and some of the patients' close contacts had respiratory symptoms. Our aims were to determine the causative agent of this epidemic and whether there had been human-to-human transmission. METHODS: For this epidemiological and aetiological investigation study, we enrolled patients who had community-acquired pneumonia confirmed by chest CT at two local hospitals in Shandong Province in China. We collected sputum, bronchoalveolar lavage fluid, and nasopharyngeal swab samples from participants and detected pathogens by surveying for 22 target respiratory microbes using a commercial assay, followed by metagenomic next-generation sequencing, specific nested PCR, and qPCR tests. We excluded individuals who were C psittaci-negative on both tests. We recruited close contacts of the C psittaci-positive patients, and tested nasopharyngeal swabs from the close contacts and samples from ducks from the processing plant where these patients worked. We then integrated the epidemiological, clinical, and laboratory data to reveal the potential chain of transmission of C psittaci that characterised this outbreak. FINDINGS: Between Dec 4 and 29, 2020, we used metagenomic next-generation sequencing and different PCR-based approaches to test 12 inpatients with community-acquired pneumonia, of whom six (50%) were workers at a duck-meat processing plant and two (17%) were unemployed people, who were positive for C psittaci and enrolled in this study. We contacted 61 close contacts of the six patients who worked at the duck-meat processing plant, of whom 61 (100%) were enrolled and tested, and we determined that the community-acquired pneumonia outbreak was caused by C psittaci. Within the outbreak cluster, 17 (77%) of 22 participants had confirmed C psittaci infections and five (23%) of 22 participants were asymptomatic C psittaci carriers. The outbreak had begun with avian-to-human transmission, and was followed by secondary and tertiary human-to-human transmission, which included transmission by several asymptomatic carriers and by health-care workers. In addition, some of the participants with confirmed C psittaci infection had no identified source of infection, which suggested cryptic bacterial transmission. INTERPRETATION: Our study data might represent the first documented report of human-to-human transmission of C psittaci in China. Therefore, C psittaci has the potential to evolve human-to-human transmission via various routes, should be considered an elevated biosecurity and emergent risk, and be included as part of the routine diagnosis globally, especially for high-risk populations. FUNDING: Academic Promotion Programme of Shandong First Medical University, National Science and Technology Major Project, ARC Australian Laureate Fellowship.


Subject(s)
Chlamydophila psittaci , Community-Acquired Infections , Pneumonia , Psittacosis , Animals , Australia , Birds , China/epidemiology , Chlamydophila psittaci/genetics , Community-Acquired Infections/diagnosis , Humans , Pneumonia/diagnosis , Psittacosis/diagnosis
3.
Exp Hematol Oncol ; 11(1): 48, 2022 Sep 01.
Article in English | MEDLINE | ID: covidwho-2038943

ABSTRACT

BACKGROUND: Primary immune thrombocytopenia (ITP) is an autoimmune disease. Some ITP patients are associated with pathogen infection undetected with conventional technologies. Investigating the changes of T cells and potential metabolic mechanism are important for better understanding of ITP. METHODS: The study enrolled 75 newly diagnosed ITP patients. The pathogens of patients were detected by metagenomic next-generation sequencing (mNGS). Plasma lipids were measured by liquid chromatography-mass spectrometry (LC-MS). CD4 T cell and CD8 T cell were analyzed using flow cytometry. Mitochondrial reactive oxygen species (ROS) and mitochondrial membrane potential were measured by flow cytometry. Seahorse XF real-time ATP rate assay was used to investigate the change of cellular metabolism. RESULTS: Positive plasma pathogens were detected in seven ITP patients. Of them, 5 (71.4%) positive pathogen-ITP patients were no response (NR) after first-line treatment with corticosteroids. Regulatory T cells (Tregs) increased significantly in positive pathogen-ITP patients compared to negative pathogen-ITP patients and healthy controls (HC). Mitochondrial membrane potential of Th17 and Tregs were decreased in positive pathogen-ITP and negative pathogen-ITP patients, compared to HC (all p < 0.05). The overall metabolism flux of positive pathogen-ITP patients was decreased, as compared to HC (p = 0.004), of them a higher proportion of glycolysis-derived ATP and a smaller proportion of oxidative phosphorylation (OXPHOS)-derived ATP were found in Tregs. The ATP rate index of Tregs was decreased significantly in positive pathogen-ITP patients compared to negative pathogen-ITP patients and HC (p < 0.05). CONCLUSIONS: Impaired mitochondria function of Tregs in positive pathogen-ITP patients caused a decrease of OXPHOS-derived ATP and overall metabolism flux that might be the cause of steroid resistance in ITP patients.

4.
Chinese Journal of Nosocomiology ; 32(9):1435-1440, 2022.
Article in English, Chinese | GIM | ID: covidwho-2011916

ABSTRACT

After SARS-CoV-2 infects the body, it will trigger a series of pathophysiological processes. Humoral immunity is activated by antigen stimulation and T cell assistance to produce specific antibodies, which plays a vital role in clearing the virus. The detection of specific antibodies is an effective method for clinical screening and diagnosis and plays an important role in early diagnosis, assessment of infection stage, monitoring of treatment, follow-up and prediction of outcomes. However, the immune system is a 'double-edged sword'. COVID-19 humoral immunity may have antibody dependent enhancement (ADE) effect, resulting in immune injury and seriously affecting the outcomes and prognosis of patients. Since the epidemic, scientists around the world have carried out in-depth research on the interaction between SARS-CoV-2 and body immune system and have made great progress in development of antibody drugs and vaccines. However, the existence of ADE phenomenon poses many challenges for the research and development of drugs and vaccines. Therefore, it is necessary to further study the mechanisms of SARS-CoV-2 infection and the characteristics of COVID-19 humoral immunity so as to develop efficient and safe drugs and vaccines as early as possible and effectively control the epidemic.

5.
Chinese Journal of Nosocomiology ; 32(8):1271-1275, 2022.
Article in English, Chinese | CAB Abstracts | ID: covidwho-2011252

ABSTRACT

OBJECTIVE: COVID-19 continues to spread globally, which poses a significant threat to global public health security. Recently, the emergence of new variant strains of SARS-CoV-2 complicates the containment of COVID-19 due to its rapid transmission, high infectivity, high viral load, atypical symptoms and high number of severe cases. In order to further understand the transmission route, pathogenesis and pathological changes of COVID-19, and accelerate the research and development of antiviral drugs and vaccines, animal models of COVID-19 have played an important role in this process. The status of research on different animal models of COVID-19 was reviewed, the characteristics were compared among the models so as to provide theoretical basis for selecting appropriate animal models of COVID-19.

6.
Chinese Journal of Nosocomiology ; 32(10):1590-1595, 2022.
Article in English, Chinese | GIM | ID: covidwho-2011224

ABSTRACT

The major causes of death of patients with COVID-19 include metabolic acidosis, septic shock, pulmonary edema, multiple organ failure and deep venous thrombosis. These systemic manifestations are associated with severe pathological damages of vital organs like lung and kidney that are caused by inflammatory storms. The occurrence, development and deterioration of disease is closely associated with the immune imbalance mechanisms such as disorder of lymphocyte subsets and emergence of cytokine storm. The cellular immunity plays a vital role. The expression levels of some blood inflammatory factors of the severe COVID-19 patients are remarkably elevated, IL-6 is a typical proinflammatory factor that causes the cytokine storm, which can be used for prediction of prognosis. IL-6 blockade may be an effective method to block the cytokine storm.

7.
Psychology research and behavior management ; 15:2245-2258, 2022.
Article in English | EuropePMC | ID: covidwho-1998557

ABSTRACT

Objective The present study aims to analysis the mental health of high-risk health care workers (HHCWs) and low-risk HCWs (LHCWs) who were respectively exposed to COVID-19 wards and non-COVID-19 wards by following up on mental disorders in HCWs in China for 6 months. Methods A multi-psychological assessment questionnaire was used to follow up on the psychological status of HCWs in the Affiliated Hospital of Xuzhou Medical University in Xuzhou City (a non-core epidemic area) at 6 months after the first evaluation conducted during the COVID-19 epidemic. Based on the risk of exposure to COVID-19 patients, the HCWs were divided into two groups: high-risk HCWs, who worked in COVID-19 wards, and low-risk HCWs, who worked in non-COVID-19 wards. Results A total of 198 HCWs participated in the study, and 168 questionnaires were selected for evaluation. Among them, 93 (55.4%) were in the HHCW group and 75 (44.5%) were in the LHCW group. Significant differences were observed in salary, profession, and altruistic behavior between the two groups (P < 0.05). There were no significant differences in the anxiety, depression, insomnia, or posttraumatic stress disorder (PTSD) scores between the two groups. Logistic regression revealed that work stress was a major joint risk factor for mental disorders in HCWs. Among all the HCWs, a total of 58 voluntarily participated in psychotherapy;the analysis showed a significant decrease in anxiety, depression, PTSD, work stress, and work risk after attending psychotherapy. There were also significant differences in positive and negative coping styles before and after psychotherapy. Conclusion In the present follow-up, work stress was the major contributing factor to mental disorders in HCWs. Psychotherapy is helpful in terms of stress management and should be provided to first-line COVID-19 HCWs.

8.
Frontiers in psychology ; 13, 2022.
Article in English | EuropePMC | ID: covidwho-1989754

ABSTRACT

Loving-kindness meditation (LKM) was first practiced by Buddhists and then developed by clinical psychologist. Previous studies on LKM have mainly focused on the impact of real person-guided meditation on depression, anxiety, and other negative psychology. During the COVID-19 pandemic, this study explored the effect and mechanism of media-guided LKM on the improvement of social presence, mindfulness, spirituality, and subjective wellbeing (SWB). From the viewpoint of positive psychology, this study compared the different media effects of animated pedagogical agent (APA)-guided LKM and audio-guided LKM. A total of 82 flight attendants were recruited from airlines;then, they were randomly assigned to two groups: APA group (41 participants) and audio group (41 participants), which both underwent an 8-week LKM training intervention. The aforementioned four main variables were measured pre and post the meditation experiment. The results indicated that both APA-guided meditation and audio-guided meditation significantly improved subjects’ spirituality and SWB. Compared with audio-guided meditation, APA-guided meditation significantly improved the subjects’ spirituality, SWB, and social presence. Audio-guided meditation has no significant effect on social presence. This study highlights APA-guided meditation has a positive effect on spirituality, SWB, and social presence, which may provide individuals with a simple and easy method to improve their mental health.

9.
Technological Forecasting and Social Change ; 183:121933, 2022.
Article in English | ScienceDirect | ID: covidwho-1977859

ABSTRACT

We aim to document the impact of cryptocurrencies on China's carbon price variation using some quantile techniques during COVID-19 with the daily data spanning from August 7, 2015 to April 30, 2021. In this paper, we show that cryptocurrencies have a very strong explanation power for carbon market with the non-parametric causality-in-quantiles method. In addition, cryptocurrencies can work as a good hedging candidate for carbon market at different investment horizons with the quantile coherency approach. Using hedging effectiveness measure, we further show that COVID-19 can reverse the optimal hedging ratios in our portfolio specification in cryptocurrencies‑carbon emission trading pairs while this pandemic does not have effects on the trading effectiveness. Finally, the heterogeneity and asymmetry features in the dynamic quantile-on-quantile effects are detected and the effects on carbon efficient index show relatively strong fluctuation while on carbon emission trading market are relatively strong in magnitude. Our empirical results conclude with many potential applications for policymakers and investors.

10.
Preprint in English | medRxiv | ID: ppmedrxiv-22279047

ABSTRACT

ObjectiveConcerns have been raised about the widespread use of proton pump inhibitors (PPIs), and current findings linking the regular use of PPIs to respiratory infections remain inconsistent. Our study aims to evaluate whether PPI use increases the risk of pneumonia, influenza, and COVID-19. MethodThe presented study included 160,923 eligible participants from the UK Biobank (mean age 56.5 years, 53% women). Cox proportional hazards regression and propensity score-matching analyses were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs). Effect modifications by stratifications, including indications and CYP2C19 phenotypes were tested. ResultsThe regular use of PPIs was associated with increased risks of developing pneumonia (hazard ratio [HR] 1.42, 95% confidence interval [CI] 1.26-1.59) and influenza (HR 1.31, 95% CI 1.11-1.55). However, the risk of COVID-19 infection among regular PPI users was not significantly increased (HR 1.05, 95% CI 0.95-1.16). The burden was more notably observed in patients without indications of PPI use (HR 1.52, 95% CI 1.33-1.73 for pneumonia; HR 1.36, 95% CI 1.12-1.64 for influenza). The risk for pneumonia was higher among the CYP2C19 rapid and ultrarapid metabolizers (HR 1.45, 95% CI 1.22-1.73, P for interaction < 0.001). The propensity score-matching analyses yielded similar trends. ConclusionsThe regular use of PPIs is associated with increased susceptibility to pneumonia and influenza, but not COVID-19 infection. The risks are even higher among recipients without main indications. Our study highlights the appropriate use and de-prescribing of PPIs according to indications and CYP2C19 phenotypes for patients and clinical practitioners. What is already known on this topicO_LIProton pump inhibitors (PPIs) have been extensively used in clinical practice, while emerging studies suggest the adverse effects associated with their long-term use. C_LIO_LIThe linkage between PPIs and respiratory infections has been indicated, whereas controversy remains. C_LI What this study addsO_LIIn the large cohort involving 160,923 individuals, regular use of PPIs was associated with 42% and 31% increased risks of pneumonia and influenza, respectively, but not COVID-19 infection. C_LIO_LIThe burdens were more evident among PPI users without main indications, and CYP2C19 rapid and ultrarapid metabolizers. C_LI How this study might affect research, practice or policyO_LIConsidering the potential risk of respiratory infections, appropriate use following indications and metabolic phenotypes, as well as de-prescribing of PPIs are highlighted. C_LI

11.
Eur J Clin Microbiol Infect Dis ; 41(9): 1155-1163, 2022 Sep.
Article in English | MEDLINE | ID: covidwho-1971739

ABSTRACT

Coronavirus disease 2019 (COVID-19) is a global public health concern. The purpose of this study was to investigate the association between genetic variants and SARS-CoV-2 infection and the COVID-19 severity in Chinese population. A total of 256 individuals including 87 symptomatic patients (tested positive for SARS-CoV-2), 84 asymptomatic cases, and 85 close contacts of confirmed patients (tested negative for SARS-CoV-2) were recruited from February 2020 to May 2020. We carried out the whole exome genome sequencing between the individuals and conducted a genetic association study for SARS-CoV-2 infection and the COVID-19 severity. In total, we analyzed more than 100,000 single-nucleotide polymorphisms. The genome-wide association study suggested potential correlation between genetic variability in POLR2A, ANKRD27, MAN1A2, and ERAP1 genes and SARS-CoV-2 infection susceptibility. The most significant gene locus associated with SARS-CoV-2 infection was located in POLR2A (p = 5.71 × 10-6). Furthermore, genetic variants in PCNX2, CD200R1L, ZMAT3, PLCL2, NEIL3, and LINC00700 genes (p < 1 × 10-5) were closely associated with the COVID-19 severity in Chinese population. Our study confirmed that new genetic variant loci had significant association with SARS-CoV-2 infection and the COVID-19 severity in Chinese population, which provided new clues for the studies on the susceptibility of SARS-CoV-2 infection and the COVID-19 severity. These findings may give a better understanding on the molecular pathogenesis of COVID-19 and genetic basis of heterogeneous susceptibility, with potential impact on new therapeutic options.


Subject(s)
COVID-19 , Aminopeptidases , COVID-19/epidemiology , COVID-19/genetics , China/epidemiology , Genome-Wide Association Study , Humans , Intracellular Signaling Peptides and Proteins , Minor Histocompatibility Antigens , Polymorphism, Single Nucleotide , SARS-CoV-2/genetics
12.
Nat Commun ; 13(1): 4422, 2022 07 30.
Article in English | MEDLINE | ID: covidwho-1967602

ABSTRACT

Studies are needed to evaluate the safety and effectiveness of mRNA SARS-CoV-2 vaccination during pregnancy, and the levels of protection provided to their newborns through placental transfer of antibodies. Here, we evaluate the transplacental transfer of mRNA vaccine products and functional anti-SARS-CoV-2 antibodies during pregnancy and early infancy in a cohort of 20 individuals vaccinated during late pregnancy. We find no evidence of mRNA vaccine products in maternal blood, placenta tissue, or cord blood at delivery. However, we find time-dependent efficient transfer of IgG and neutralizing antibodies to the neonate that persists during early infancy. Additionally, using phage immunoprecipitation sequencing, we find a vaccine-specific signature of SARS-CoV-2 Spike protein epitope binding that is transplacentally transferred during pregnancy. Timing of vaccination during pregnancy is critical to ensure transplacental transfer of protective antibodies during early infancy.


Subject(s)
COVID-19 , Pregnancy Complications, Infectious , Antibodies, Neutralizing , Antibodies, Viral , COVID-19/prevention & control , COVID-19 Vaccines , Female , Humans , Immunoglobulin G , Infant, Newborn , Placenta , Pregnancy , RNA, Messenger , SARS-CoV-2/genetics , Spike Glycoprotein, Coronavirus , Vaccines, Synthetic , mRNA Vaccines
13.
Cell Discov ; 8(1): 70, 2022 Jul 25.
Article in English | MEDLINE | ID: covidwho-1960340

ABSTRACT

Little is known regarding why a subset of COVID-19 patients exhibited prolonged positivity of SARS-CoV-2 infection. Here, we found that patients with long viral RNA course (LC) exhibited prolonged high-level IgG antibodies and higher regulatory T (Treg) cell counts compared to those with short viral RNA course (SC) in terms of viral load. Longitudinal proteomics and metabolomics analyses of the patient sera uncovered that prolonged viral RNA shedding was associated with inhibition of the liver X receptor/retinoid X receptor (LXR/RXR) pathway, substantial suppression of diverse metabolites, activation of the complement system, suppressed cell migration, and enhanced viral replication. Furthermore, a ten-molecule learning model was established which could potentially predict viral RNA shedding period. In summary, this study uncovered enhanced inflammation and suppressed adaptive immunity in COVID-19 patients with prolonged viral RNA shedding, and proposed a multi-omic classifier for viral RNA shedding prediction.

14.
Ecotoxicol Environ Saf ; 242: 113908, 2022 Sep 01.
Article in English | MEDLINE | ID: covidwho-1955788

ABSTRACT

Disposable facemasks are a primary tool to prevent the transmission of SARS-COV-2 during the COVID-19 pandemic. However, plastic waste generated from their disposal represents a significant environmental problem that can be reduced by maximizing the service life of disposable masks. We evaluated the effect of repeated wearing on the fitted filtration efficiency (FFE) of N95, KF94, KN95, and procedure/surgical masks. The FFEs of masks were compared following extended wearing with and without washing. Results reveal that most disposable facemasks can retain a high level of their baseline FFE after extended wearing, even after 40 h of wearing. Laundering disposable masks degraded FFE in some instances. We conclude that the durability of disposable facemask performance is considerably longer than their intended single use indication, suggesting that reusing disposable masks is a safe means of reducing plastic waste in the environment.


Subject(s)
COVID-19 , Masks , COVID-19/prevention & control , Humans , Pandemics/prevention & control , Plastics , SARS-CoV-2
15.
Internet Research ; 32(4):1378-1400, 2022.
Article in English | ProQuest Central | ID: covidwho-1909120

ABSTRACT

Purpose>Social shopping platforms have flourished by using multiple social shopping features, yet little is known about how the combination of these features affects purchase intention, particularly in terms of the product itself. The purpose of the paper is to draw on the concept of social shopping feature richness, adopting a formative approach on the survey used, and endeavors to reveal the concept's impact on consumers' buying intention from a product perspective.Design/methodology/approach>Building on mental accounting and signaling theories, a theoretical model is proposed and empirically evaluated with 356 samples collected using a questionnaire survey.Findings>The results suggest that social shopping feature richness promotes consumers' consumption by providing information signals to satisfy acquisition utility and transaction utility. Specifically, social shopping feature richness enhances perceived product quality, while decreasing negative perceptions regarding price. Moreover, perceived product quality and perceived price significantly influence buying intention through the mechanism of perceived value.Originality/value>The authors' study highlights the role of the combination of functionally diverse social shopping features on product sales for social shopping platforms.

16.
Resour Policy ; 78: 102874, 2022 Sep.
Article in English | MEDLINE | ID: covidwho-1907728

ABSTRACT

We aim to investigate the static and dynamic time-frequency connectedness between energy and nonenergy commodity markets in China during COVID-19 based on Baruník and Krehlík (2018) method. First, in this paper, we find that the short-term connectedness dominates the long-term one, and the total connectedness increases after the COVID-19 outbreak. Second, the energy commodity is the receiver and is influenced much by the spillovers of non-energy commodity markets (e.g. chemical commodities and non-ferrous metals) in the short run. At the same time, the impact is less at the long-term investment horizons. In addition, chemical commodities and soft commodities are the primary transmitters in this system in the short run. In contrast, chemical commodities and coal steel iron commodities are the main long-run primary transmitters. Third, the spillover role varies with the time-frequency domain during COVID-19. To be more specific, the energy commodity shows a net receiver role in the short and long run before the COVID-19 pandemic, but after it, the role of the net transmitter can be seen in the long run with ease. Finally, we show that COVID can reduce the hedging effectiveness at different investment horizons. The mineral policymakers should note our dynamic empirical results between energy and nonenergy commodity.

17.
Chinese Journal of Dermatovenereology ; 36(5):550-552, 2022.
Article in Chinese | CAB Abstracts | ID: covidwho-1903930

ABSTRACT

Objective: To analyse the prevalence and characteristics about viral warts on the hands of Tibetan adolescents in Ganzi County.

18.
Sci China Life Sci ; 65(7): 1285-1324, 2022 07.
Article in English | MEDLINE | ID: covidwho-1899275

ABSTRACT

RNA structures are essential to support RNA functions and regulation in various biological processes. Recently, a range of novel technologies have been developed to decode genome-wide RNA structures and novel modes of functionality across a wide range of species. In this review, we summarize key strategies for probing the RNA structurome and discuss the pros and cons of representative technologies. In particular, these new technologies have been applied to dissect the structural landscape of the SARS-CoV-2 RNA genome. We also summarize the functionalities of RNA structures discovered in different regulatory layers-including RNA processing, transport, localization, and mRNA translation-across viruses, bacteria, animals, and plants. We review many versatile RNA structural elements in the context of different physiological and pathological processes (e.g., cell differentiation, stress response, and viral replication). Finally, we discuss future prospects for RNA structural studies to map the RNA structurome at higher resolution and at the single-molecule and single-cell level, and to decipher novel modes of RNA structures and functions for innovative applications.


Subject(s)
COVID-19 , RNA , Animals , Nucleic Acid Conformation , RNA/chemistry , RNA/genetics , RNA, Viral/genetics , SARS-CoV-2/genetics , Sequence Analysis, RNA
19.
J Clin Med ; 11(10)2022 May 12.
Article in English | MEDLINE | ID: covidwho-1855682

ABSTRACT

We investigated the storage lower urinary tract symptoms (LUTS) before and after the first dose of coronavirus disease 2019 (COVID-19) vaccine and the association between pre-vaccinated overactive bladder (OAB) and the worsening of storage LUTS following COVID-19 vaccination. This cross-sectional study in a third-level hospital in Taiwan used the validated pre- and post-vaccinated Overactive Bladder Symptom Score (OABSS). Diagnosis of OAB was made using pre-vaccinated OABSS. The deterioration of storage LUTS was assessed as the increased score of OABSS following vaccination. Of 889 subjects, up to 13.4% experienced worsened storage LUTS after vaccination. OAB was significantly associated with an increased risk of worsening urinary urgency (p = 0.030), frequency (p = 0.027), and seeking medical assistance due to urinary adverse events (p < 0.001) after vaccination. The OAB group faced significantly greater changes in OABSS-urgency (p = 0.003), OABSS-frequency (p = 0.025), and total OABSS (p = 0.014) after vaccination compared to those observed in the non-OAB group. Multivariate regression revealed that pre-vaccinated OAB (p = 0.003) was a risk for the deterioration of storage LUTS. In conclusion, storage LUTS may deteriorate after vaccination. OAB was significantly associated with higher risk and greater changes in worsening storage LUTS. Storage LUTS should be closely monitored after COVID-19 vaccination, especially in those OAB patients.

20.
Environ Int ; 165: 107299, 2022 07.
Article in English | MEDLINE | ID: covidwho-1851026

ABSTRACT

Melamine (MEL) and its derivatives are increasingly applied as nitrogenous flame retardants in consumer products. Nevertheless, limited information is available on their environmental occurrence and subsequent human exposure via multiple exposure pathways. In this study, we analysed MEL and its derivatives in dust (indication of the dust ingestion route) and hand wipe samples (indication of the hand-to-mouth route) collected in various microenvironments. The levels of ∑MELs in both dust (median: 24,100 ng/g) and participant hand samples (803 ng/m2) collected in e-waste dismantling workshops were significantly higher than those in samples collected in homes (15,600 ng/g and 196 ng/m2, respectively), dormitories (13,100 ng/g and 227 ng/m2, respectively) and hotel rooms (11,800 ng/g and 154 ng/m2, respectively). Generally, MEL dominated in dust samples collected in e-waste dismantling workshops, whereas cyanuric acid dominated in hand wipe samples. This may occur partly because the latter is an ingredient in disinfection products, which are more frequently employed in daily lives during the COVID-19 pandemic. Exposure assessment suggests that dust ingestion is an important exposure pathway among dismantling workers and the general population, whereas hand-to-mouth contact could not be overlooked in certain populations, such as children and dismantling workers not wear gloves at work.


Subject(s)
COVID-19 , Electronic Waste , Child , Dust/analysis , Eating , Electronic Waste/analysis , Humans , Mouth , Pandemics , Triazines
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