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1.
Lwt-Food Science and Technology ; 167, 2022.
Article in English | Web of Science | ID: covidwho-2069457

ABSTRACT

Campylobacter is one of the most common foodborne pathogens worldwide. A new smartphone-assisted high-throughput integrated color-sensing platform, called the HICS platform, was developed for the rapid detection of Campylobacter coli. This platform was based on the visual loop-mediated isothermal amplification method. Using this system, as many as 64 samples could be assessed in less than an hour after enrichment. 60 meat samples were tested to compare the performance of the HICS platform and other methods. Having the consistent detection result with TaqMan qPCR (Quantitative Real-time Polymerase Chain Reaction), the HICS platform was able to reliably detect C. coli in meat samples, and its limit of detection is 550 CFU/mL and 120 copies/mu L, which was 10-fold higher than that of the PCR (Polymerase Chain Reaction) method. To conclude, considering that our platform showed robust performance and does not require any expensive equipment, it can also be reliably applied for the high-throughput detection of other pathogens.

2.
Investigative Ophthalmology and Visual Science ; 63(7):2799-A0129, 2022.
Article in English | EMBASE | ID: covidwho-2057653

ABSTRACT

Purpose : To evaluate the impact of the COVID-19 pandemic on diabetic retinopathy screening (DRS) to uninsured, predominantly Latino patients at the UC San Diego Student-Run Free Clinic Project (SRFCP). Methods : A retrospective analysis of the electronic medical records of all diabetic patients seen in the years 2019, 2020, and 2021 (N = 196, 183, and 178 respectively) at the SRFCP was performed. Ophthalmology specialty clinic metrics from before, during, and after the COVID-19 pandemic-related lockdowns were compared to assess the impact of the COVID-19 pandemic lockdowns on DRS rates. All statistical analyses were performed in Microsoft Excel. Results : In patients with available demographic data (N=164), 92.1% were Latino, 69.5% female, with a mean age of 58.7 years (SD=10.6). A chi-squared test for goodness of fit showed that the distribution of patients seen (p<0.001), referred (p=0.012), or scheduled (p<0.001) in 2020 and 2021 differed significantly when compared to 2019. In 2019, 99 (50.5%) of 196 patients requiring DRS were referred, of which 97 (49.5%) were scheduled, and 89 (45.4%) were seen by the ophthalmology clinic (Figure 1). In 2020, a similar percentage of patients were referred (76/183 patients, or 41.5%), but the number of patients scheduled and seen dropped to 37 (20.2%) and 21 (11.4%), respectively. In 2021, clinic performance recovered with 113 (63.5%) of 178 patients eligible for DRS referred, 100 (56.2%) scheduled, and 82 (46.1%) seen. No-shows and cancellations constituted 12 (12.4%) and 6 (6.2%) of the 97 encounters in 2019. Conversely, of the 37 encounters scheduled in 2020, the no-show (10.8%) and cancellation (40.5%) rates were notably higher. Conclusions : The COVID-19 pandemic significantly diminished the delivery of eye care to patients at the SRFCP. 2020 saw a meaningful decline from 2019 in all clinic performance metrics which was reversed in 2021. These results show the current need for annual DRS surpassed the ability of the ophthalmology specialty clinic to schedule and deliver care to these patients in all years evaluated, especially in 2020 due to COVID-19 restrictions. SRFCP patients may benefit from telemedicine-based DRS programs such as remote imaging during primary care visits to further improve screening capacity. (Figure Presented).

3.
Chinese Journal of Emergency Medicine ; 31(8):1110-1115, 2022.
Article in Chinese | Scopus | ID: covidwho-2055473

ABSTRACT

Objective To introduce how to quickly set up a doctor team to achieve efficient treatment of batchs COVID-19 patients in Changchun GongTi shelter hospital. Methods A cross-sectional study was conducted to analyze the basic situation of the doctors who supported the Changchun Gongti shelter hospital. The workload is the total number of patients from April 3 to 28, 2022. At the beginning of the task, the first week and the third week of the task, the five point scoring method was used to reflect the doctor's physical and mental state, stress state and rescue achievement. The time phased scheduling and disease grading management were fully implemented after 10 days of operation in the shelter. The doctors' ward round efficiency and self scoring changes before and after the implementation of the plan were compared, and the rescue results were summarized. Results Total of 56 doctors (the Sichuan medical assistance team to Changchun), who undertook the work of Changchun Gongti shelter Hospital, came from 12 professional departments of 14 hospitals. By internal and external linkage-time phased scheduling and information-based patient zoning and grading management, the admission time of batch patients was shortened from (14.64±10.09) min to (6.80±5.10) min per person(P<0.05), the number of patients that each doctor can view per hour ranges from (28.50±12.26) to (68.43±19.95) (P<0.01). A total of 1 293 patients were treated. There were no deaths, no accidents and no mild illness to severe illness in shelter hospital. 35 doctors completed a continuous survey. Before and after the implementation of those measures, the average physical state scores and the psychological state scores of doctors improved (P=0.03), the self-score of stress feeling decreased (P<0.01), and the self-score of professional achievement increased (P<0.01). Conclusions To adapt to the characteristics of emergency treatment for batch COVID-19 patients, the internal and external linkage-time phased scheduling and information-based patient zoning and grading management could help the temporarily convened doctors deal with a large number of patients efficiently, reduce work stress and exposure risk in shelter hospital. © 2022 Chinese Medical Association. All rights reserved.

4.
2022 IEEE International Conference on Consumer Electronics - Taiwan, ICCE-Taiwan 2022 ; : 23-24, 2022.
Article in English | Scopus | ID: covidwho-2051990

ABSTRACT

Hand hygiene has become even more im-portant in light of the COVID-19 pandemic, where hands are one of the high-risk transmission routes. Existing hand-hygiene education is focused on one-time training and does not ensure that correct handwashing procedures are undertaken. Our study, therefore, proposes a hand-hygiene education and facilitation system. Compared to previous systems, through an external RGB camera with our proposed image preprocessing and use the 3-D convo-lution and convolutional long short-term memory (Con-vLSTM) models to detect correctness of handwashing postures, which also facilitates children's ability to wash their hands properly through an on-screen tutorial. It also encourages children to develop good handwashing habits through a positive competition and reward system, and helps teachers to understand children's learning pro-gresses. The experimental results showed that the model was able to identify handwashing postures in real-time with 95.12% accuracy in a realistic and variable environ-ment. © 2022 IEEE.

5.
Transplantation ; 106(8):143-144, 2022.
Article in English | EMBASE | ID: covidwho-2040900

ABSTRACT

Background: With the highly effective direct-acting antiviral (DAA) therapy, the number of liver transplants for hepatitis C virus (HCV) has decreased worldwide. However, similar to the phenomenon occurring in COVID-19 infection, the residual virus reservoirs in target organ is warranted to be explored due to the potential replication and disease recurrence. Hence, we aim to investigate the significance of hepatic HCV RNA identification as well as the discrepancy between HCV RNA and HCV core antigen (HCV Ag) in native liver of chronic hepatitis C recipients undergoing living donor liver transplantation (LDLT). Methods: Between Feb 2016 to Aug 2019, we prospectively enrolled 80 serum anti-HCV positive recipients who underwent LDLT. HCV RNA extracted from the native liver tissues was subjected to one-step reverse transcribed qPCR, using the TopScript One Step qRT PCR Probe Kit with HCV qPCR probe assay and human GAPDH qPCR probe assay on ViiA 7 Real Time PCR System. Hepatic HCV Ag was identified from the native liver tissues by employing the qualitative enzyme immunoassay technique. All experimental steps were based on the protocol provided by Human HCV Ag ELISA Kit (Cat. No. MBS167758). Results: Among 80 recipients, 85% (68/80) positive HCV-RNA was significantly higher in the native liver tissues than in the serum before (29/80, 36.3%;p = 0.000) and after LDLT (3/80, 4.4%;p = 0.000). In contrast, hepatic HCV Ag was 100% negative identified in all 80 explanted native liver. Conclusions: Significant positive HCV-RNA identification in the native liver suggested that pre-LDLT serum HCV RNA should be underestimated in the real status of HCV activity. HCV Ag assay may have lack of sensitivity and negative predictive value in liver tissues. In contrast to serum HCV RNA and HCV Ag, a great discrepancy might be described between hepatic HCV RNA and HCV Ag in the liver tissue. (Figure Presented).

6.
Journal of Ecology and Rural Environment ; 38(5):578-586, 2022.
Article in Chinese | Scopus | ID: covidwho-2026019

ABSTRACT

Coordination is an important part of the new development philosophy. Promoting the coordinated development is the main goal of deepening the reform and development in state-owned forest region. Aiming to provide scientific basis and theoretical supports for promoting the continuous deepening of reform of state-owned forest region and realizing comprehensive and high-quality coordinated development, the key state-owned forest region in Daxing'anling, Heilongjiang Province was chosen as the research object. A compound system covering ecological conservation, industrial development, enterprise management, well-being of the people and support capability was constructed. The coupling coordination model was used to quantitatively evaluate the coupling coordination status of the compound system from 2000 to 2020. The Grey Markov model was used to predict the trend of coupling coordination development in this compound system from 2021 to 2022. Results show that, after 21-year of transformation and development, the development index of each subsystem of state-owned forest region in Daxing'anling, Heilongjiang Province has been changed, however, the process were different among subsystems. The growth rates of the subsystems of well-being of the people and resource conservation have been high, while the subsystems of enterprise management and the support capability have been lagged dramatically behind. The development stage of coupling coordination of the compound system has changed from misalignment to coordination, nevertheless, the coordinated development level was regressive in recent years due to certain factors such as policy, COVID-19, etc. It is predicted that by 2022, the development stage of coupling coordination of compound system will be recovered to the benign coordinated development type, however, there is still a big gap before it reaches the high-quality coordinated development type. It is suggested that the existing support policies and inputs should be kept stable, moreover, the enterprise management and support capability should be strengthened, in order to promote the stable and high-quality coupling coordinated development in the key state-owned forest regions in Daxing'anling, Heilongjiang Province. © 2022, China Environmental Science Press. All rights reserved.

7.
IEEE Access ; 10:85571-85581, 2022.
Article in English | Scopus | ID: covidwho-2018604

ABSTRACT

Chest X-ray is one of the most common radiological examinations for screening thoracic diseases. Despite the existing methods based on convolution neural network that have achieved remarkable progress in thoracic disease classification from chest X-ray images, the scale variation of the pathological abnormalities in different thoracic diseases is still challenging in chest X-ray image classification. Based on the above problems, this paper proposes a residual network model based on a pyramidal convolution module and shuffle attention module (PCSANet). Specifically, the pyramid convolution is used to extract more discriminative features of pathological abnormality compared with the standard $3\times 3$ convolution;the shuffle attention enables the PCSANet model to focus on more pathological abnormality features. The extensive experiment on the ChestX-ray14 and COVIDx datasets demonstrate that the PCSANet model achieves superior performance compared with the other state-of-the-art methods. The ablation study further proves that pyramidal convolution and shuffle attention can effectively improve thoracic disease classification performance. © 2022 IEEE.

8.
25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 ; : 835-836, 2021.
Article in English | Scopus | ID: covidwho-2011687

ABSTRACT

The COVID-19 outbreak spreads around world, accumulated to more than 27 million confirmed cases and 800k deaths. Polymerase Chain Reaction (PCR), a gold-standard diagnostic method, were labor intensive, time-consuming and costly, which restricted its application to widespread screening. Herein, this study purposes a one-pot and non-washing method to rapidly detect virus by dual-clamped surface-enhanced Raman scattering (SERS) mechanism. COVID Antigens were captured by SERS nanoparticles and novel SERS substrate simultaneously to achieve 6 order enhancements within 20 minutes. The dual-SERS sensors have reached a detection limit of 1 ng/ml in clinical samples for recognizing nucleocapsid & Spike proteins of COVID-19, which is comparable with PCR results. © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

9.
HemaSphere ; 6(Suppl), 2022.
Article in English | EuropePMC | ID: covidwho-2011671
10.
Female Pelvic Medicine and Reconstructive Surgery ; 28(6):S36-S37, 2022.
Article in English | EMBASE | ID: covidwho-2008717

ABSTRACT

Introduction: Several urogynecology conditions can be managed through telehealth visits as this is a combined surgical and medical specialty. However, geriatric patients may experience difficulty using such a modality due to the inherent ageism within the medical system. This manifests in portal developers and providers presuming the elderly's obligatory conformance to what is provided and a limited interest in this population's constraints, thus disregarding their needs when designing the interface as well as forgoing conversations on patient portals with their patients. With the COVID-19 pandemic catalyzing the digitalization of medicine, excluding the needs of this patient population risks impacting their care. Online health portal use must be optimized accordingly to improve access to geriatric urogynecology patients. Objective: To identify facilitators, concerns, technical or personal issues encountered, and the desired features of the online patient portals among geriatric urogynecology patients. Methods: This is a cross-sectional study of patients (> = 65 years of age) at an academic medical center in Northwest Ohio, where telehealth practices had been well established since early 2020. The data collection occurred between June 1-30, 2021. Two focus groups were conducted with the identified themes used to devise the anonymous survey. The questions addressed comfort with telehealth visits for urogynecology-specific conditions and the practicality of patient portals for physician visits. The promoters and deterrents were compared using the Pearson's Chi-squared test between those comfortable and uncomfortable having telehealth visits for preoperative, postoperative, and medical management. Results: A total of 205 patients completed the study (91% response rate, 225 surveys distributed). Mean age was 68.9 (SD 4.9) with 81% of participants being Caucasian and 10% being African American. Promoters of patient portal use identified included provider encouragement, enrollment on-site with concurrent education, and clarification of relevance of the telehealth to one's care (Table 1). Patients who were uncomfortable with telehealth use reported anxiety and technical issues as deterrents for using such technology. This included difficulty using the hardware, accessing the portal, and significant input needed to log on. More than half of the patients were comfortable having online visits for preoperative (51.7%), postoperative (66.3%), and medical management (73.7%) (Table 2). Up to 60.5% of the patients believed that telehealth visits were equally stressful as in-person visits, while 24.4% believed that the logistics of in-person visits were the cause of stress. Most of the patients who considered in-person visits stressful reported provider encouragement, enrollment by the hospital, and clarification of benefits as major promoters for portal use. Specific design features such as additional drop-down lists, colors, and icons in addition to an intuitive design were desired. Patients who preferred in-person visits were deterred primarily by technical and privacy concerns, anxiety, and cost of use (Figure 1). Conclusions: To improve access to care, augment the utilization of online patient portals, and combat ageism, enhancing the geriatric urogynecologic patient portal experience is vital. Investment in this population's needs includes education of patients, active enrollment, engagement by healthcare systems, and addressing technical concerns (Table Presented).

11.
Journal of General Internal Medicine ; 37:S578, 2022.
Article in English | EMBASE | ID: covidwho-1995836

ABSTRACT

STATEMENT OF PROBLEM/QUESTION: In the spring of 2020 during the initial outbreak of COVID-19, the Rocky Mountain Regional VA (RMR) was tasked with ensuring the health of infected veterans. The RMR COVID-19 Telehealth Clinic was developed to support veterans in the community diagnosed with COVID-19, identify those with clinical deterioration requiring a higher level of care, and encourage appropriate isolation protocols. DESCRIPTION OF PROGRAM/INTERVENTION: Patients were stratified by risk factors (obesity, CHF, DM, cancer, CAD, HTN, age > 64) and clinical status into 3 tiers, with high-risk (Tier 3) receiving daily telehealth, moderate-risk (Tier 2) telehealth every other day, and low-risk (Tier 1) telehealth every three or more days. Providing care seven days a week, Tier 1 veterans were contacted by nurses and advanced practitioners, while Tier 2 and 3 veterans were managed predominantly by resident physicians and attendings, who provided clinical care for exacerbations of chronic disease as well as comprehensive care of COVID-19 infection. Hypoxic patients were provided oxygen and closely monitored with pulse oximeters. MEASURES OF SUCCESS: Between April 13 to October 5, 2020, 351 veterans testing positive for COVID-19 were followed. Thirty-eight were excluded (26 were outside study dates, 7 covid negative, 5 never received care). Charts for the remaining 313 patients were retrospectively evaluated for demographic data, comorbid conditions, duration of follow-up, and interventions provided, including prescribing and managing medications, referrals for emergency services, and escalating tiers. FINDINGS TO DATE: Of the cohort, 88% were male, 43% obese, 34% over age 64, 40% HTN, and 27% DM. Veterans were followed for 10.4 days on average. Approximately 54% were assigned to Tier 1, 29% to Tier 2, and 16% to Tier 3. Medications were prescribed for 45% and 27% of Tier 3 and Tier 2 patients respectively, and emergency care was advised for 22% and 20% of Tier 3 and Tier 2 veterans. Of Tier 1 patients, medications were ordered on 5%, emergency care recommended for 3%, and only 7% were escalated to Tier 2. Of the five deaths that occurred, two were directly attributed to COVID-19. KEY LESSONS FOR DISSEMINATION: A dedicated telehealth clinic for veterans with Covid-19 appropriately identified patients into low, moderate, and high-risk categories based on risk factor assessment. Low-risk patients were safely followed with intermittent telehealth emphasizing self-care and isolation, avoiding unnecessary Emergency Department visits. More frequent monitoring of symptoms and pulse oximetry in moderate to high-risk patients facilitated identification of patients with clinical deterioration requiring emergency evaluation and avoiding admissions for at-risk clinically stable patients. Tiered management resulted in judicious utilization of health care resources during a critical time marked by scarcity of hospital beds and personal protective equipment.

12.
Journal of General Internal Medicine ; 37:S139-S140, 2022.
Article in English | EMBASE | ID: covidwho-1995621

ABSTRACT

BACKGROUND: Telehealth services may improve access to care by removing certain barriers to care. But, health systems and payors may be hesitant to provide or cover telehealth at the same rate as in-person services in part due to concerns around potential to increase overall healthcare utilization. During the coronavirus disease pandemic, many regulatory restrictions on telehealth were paused, allowing more widespread usage of telehealth. We sought to investigate whether patients engaged in telehealth had increased primary care (PC) utilization relative to those not engaged in telehealth. METHODS: We conducted an observational study of electronic health record data for patients with PC visits from July 1, 2020 to June 30, 2021 at 23 adult PC clinics at New York City Health + Hospitals, the nation's largest public healthcare system. This period represents when local COVID cases were past initial peak and telehealth visits were available to patients electively instead of preferentially. The primary outcome was the average number of annual completed PC visits per patient. We collected patient age, sex, race/ethnicity, language, insurance, and number of Elixhauser comorbidities and compared them between groups using χ2 tests. Then, we stratified patients by quintiles of comorbidity count and compared the average number of completed PC visits per patient between telehealth users and non-users using two-sided Welch's ttests. RESULTS: There were 569,724 visits by 225,147 patients. Of these patients, 133,830 (59.4%) were telehealth users. Compared to telehealth non-users, telehealth users were more likely to be older, female, Asian, Medicare beneficiaries, and have more comorbidities and less likely to be Black, commercially insured, or uninsured (p<0.001). The average (SD) number of PC visits were 2.9 (1.7) for telehealth users and 1.9 (1.3) for non-users. Compared to telehealth non-users, telehealth users had 1more PC visit per patient regardless of comorbidity count (Table;p<0.001). Among telehealth users, the average proportion of visits that were conducted via telehealth was 0.68 (0.28). CONCLUSIONS: Availability of telehealth may increase PC utilization in safety-net clinics. Differences in utilization may relate to decreases in barriers to care, lower efficacy of telehealth, or differences in propensity to engage in care not accounted for by comorbidity count. More research on outcomes, costs of care, patient and clinician experiences is essential to better inform policymakers' and payors' decisions around coverage of telehealth services.

13.
Frontiers in Veterinary Science ; 9:10, 2022.
Article in English | Web of Science | ID: covidwho-1979080

ABSTRACT

African swine fever virus (ASFV) is a leading cause of worldwide agricultural loss. ASFV is a highly contagious and lethal disease for both domestic and wild pigs, which has brought enormous economic losses to a number of countries. Conventional methods, such as general polymerase chain reaction and isothermal amplification, are time-consuming, instrument-dependent, and unsatisfactorily accurate. Therefore, rapid, sensitive, and field-deployable detection of ASFV is important for disease surveillance and control. Herein, we created a one-pot visual detection system for ASFV with CRISPR/Cas12a technology combined with LAMP or RPA. A mineral oil sealing strategy was adopted to mitigate sample cross-contamination between parallel vials during high-throughput testing. Furthermore, the blue fluorescence signal produced by ssDNA reporter could be observed by the naked eye without any dedicated instrument. For CRISPR-RPA system, detection could be completed within 40 min with advantageous sensitivity. While CRISPR-LAMP system could complete it within 60 min with a high sensitivity of 5.8 x 10(2) copies/mu l. Furthermore, we verified such detection platforms display no cross-reactivity with other porcine DNA or RNA viruses. Both CRISPR-RPA and CRISPR-LAMP systems permit highly rapid, sensitive, specific, and low-cost Cas12a-mediated visual diagnostic of ASFV for point-of-care testing (POCT) applications.

14.
BJU International ; 129:113, 2022.
Article in English | EMBASE | ID: covidwho-1956723

ABSTRACT

Introduction & Objectives: The COVID pandemic has rapidly catapulted scientific conferences into a virtual or hybrid format. The format of traditional scientific communication has abruptly changed from physical presentations at conferences, to virtual pre-recorded contributions and participations. We assessed the quality of presentation skills at a major urology conference, the European Association of Urology Annual Meeting (#EAU21), to identify areas for improvement. Methods: Using the EAU Urosource Resource Centre, we reviewed ondemand sessions posted from the #EAU21 virtual meeting, focusing on Plenary, Industry, Poster, Semi-live and Specialty sessions. Using a predefined matrix based on industry experts, a panel of reviewers rated presentations using quality criteria including camera angle, audio quality, virtual content optimised for virtual viewers which was assessed on both laptop and iphone to replicate typical viewer experiences. Levels of quality were defined from Level I (minimum standard), to Level 3 (excellent). Results: We reviewed 138 on-demand sessions (7 plenary, 44 poster, 11 industry, 9 semi-live, 67 specialty) posted from #EAU21. Of 2068 virtual appearances assessed, 1710 (82.7%) failed to meet the minimum defined quality standard of Level 1, with camera violations being the most common offence (91.7% of time). Of those who attained level 1 standards, 39/358 (10.8%) reached Level 2, out of which only 4 (10.3%) presentations met level 3 standards. Deficiencies in audio and content presentation domains were equally common (55.9% and 55.1%, respectively) in those with level 1 standards who did not reach level 2, while video elements were less common (51.5%). There was high inter-observer agreement in the scoring (87-91.3%). Even after excluding professional studio recordings provided by EAU, there was a consistent trend of chairpersons and moderators outperforming presenters in terms of level 1 standards (31.6% vs 13.7%, p<0.001). The only exception was seen in the industry sessions where more presenters met level 1 standards (48.1% vs 30.8%, p = 0.29). Qualitative analyses revealed a wide range of styles used including the interesting use of automated voiceover narrations seen only in poster sessions (1.2%) which could overcome language barriers. In the presentations that met level 3 standards, the use of professional video and audio editing tools was evident and helped optimised the delivery of the scientific content for viewers. Conclusions: A high proportion of virtual presentations did not achieve a reasonable minimum standard for scientific communication during the virtual #EAU21 meeting. Simple technical measures can significantly improve the quality of virtual presentations and ensure a better viewer experience. Further training will help the scientific community communicate more effectively in the virtual and hybrid meeting era.

15.
Annals of Oncology ; 33:S288, 2022.
Article in English | EMBASE | ID: covidwho-1936043

ABSTRACT

Background: The ongoing COVID-19 pandemic has disrupted worldwide cancer care delivery, leading to a decline in cancer screening, delayed diagnostic tests, and treatment modifications. Little has been reported on the care delivery impact of COVID-19 on patients (pts) with rare tumours, such as squamous cell carcinoma of the anus (SCCA). Our study aimed to evaluate the impact of the pandemic on care delivery of SCCA pts in two comprehensive cancer centres. Methods: We performed a retrospective study of two consecutive cohorts of adult pts diagnosed with SCCA at AC Camargo Cancer Center (AC) and Princess Margaret Cancer Center (PM) from the peri-COVID-19 period (1 February 2020- 31 January 2021) to the same period in the year prior (1 February 2019- 31 January 2020), utilizing electronic medical records to collect data on pts demographics and patterns of care in the six months following their first consultation. Comparisons of patterns of care between the peri- and pre-COVID-19 (control) cohorts were conducted using two-sided t-tests, Wilcoxon rank-sum tests, χ2 tests, or Fisher’s exact tests, as appropriate;p < 0.05 were deemed significant. Results: Overall, 73 pts were included: peri-COVID-19: n = 35 and pre-COVID-19: n = 38;both cohorts had similar demographic compositions in terms of age and sex [control: median age = 61.4 (IQR: 41.8 – 92.1), 55% female;peri-COVID-19: median age = 66.9 (IQR: 41-91.1), 63% female]. Pts from both institutions presented similar characteristics in both peri- and pre-COVID-19 periods. At AC, the number of pts diagnosed with SCCA during the peri-COVID-19 period was half of that prior to the pandemic. In the peri-COVID-19 period, the proportion of pts who received radiation therapy decreased in both institutions, when compared with the pre-pandemic period, however, the decrease was not found to be significant: 100% vs 83% at AC (p=0.32) and 84% vs 76% at PM (p=0.52). A similar proportion of pts received chemotherapy in the peri- and pre-COVID-19 periods, respectively: 80% vs 82%. Disease stage III at diagnosis was the most common (pre-COVID: 46%, peri-COVID: 46%). The proportion of pts who were operated on was similar between both cohorts (peri-COVID-19: 23%;control: 21%). Conclusions: Our multicenter study shows that during the peri-COVID-19 pandemic, the number of pts who received radiotherapy therapy to treat SCCA was numerically inferior, albeit not statistically significant. In one of the cancer centers, the number of new SCCA cases dropped by 50%. Longer follow-up is needed to understand the impact of the treatment modifications on SCCA clinical outcomes. Legal entity responsible for the study: The author. Funding: The study was funded by a grant from the Global Oncology Program at Princess Margaret Cancer Centre. Disclosures: All authors have declared no conflicts of interest.

17.
Aslib Journal of Information Management ; : 22, 2022.
Article in English | Web of Science | ID: covidwho-1886539

ABSTRACT

Purpose The present study aims to clarify the following two research objectives: (1) the user behavior of government websites during the coronavirus disease (COVID-19) period and (2) how the government improved government's website design during the COVID-19 period. Design/methodology/approach The authors used website analytics to examine usage patterns and behaviors of the government website via personal computer (PC) and mobile devices during the COVID-19 pandemic. In-depth interviews were conducted to understand the user experience of government website users and to gather users' opinions about how government websites should be redesigned. Findings With the rising of the COIVID-19 pandemic, most studies expect that the use of government websites through a mobile device will grow astonishingly. The authors uncovered that the COVID-19 pandemic did not increase the use of government websites. Instead, severe declines in website usage were observed for all device users with the declines being more pronounced in mobile device users than in PC users. This is an admonitory caveat that reveals public health and pandemic prevention information announced on government websites cannot be effectively transmitted to the general public through official online platforms. Originality/value The study highlights the gap in information behavior and usage patterns between PC and mobile device users when visiting government websites. Although mobile devices brought many new visitors, mobile devices are ineffective in retaining visitors and continuous long-term use. The results of localize experience is helpful in the improvement of government website evaluation worldwide.

18.
Journal of Urology ; 207(SUPPL 5):e721-e722, 2022.
Article in English | EMBASE | ID: covidwho-1886526

ABSTRACT

INTRODUCTION AND OBJECTIVE: The COVID pandemic has rapidly catapulted scientific conferences into a virtual or hybrid format. The format of traditional scientific communication has abruptly changed from physical presentations at conferences, to virtual pre-recorded contributions and participation. We assessed the quality of presentation skills at a major urology conference, the European Association of Urology Annual Meeting (#EAU21), to identify areas for improvement. METHODS: Using the EAU Urosource Resource Centre, we reviewed on-demand sessions posted from the #EAU21 virtual meeting, focusing on Plenary, Industry, Poster, Semi-live and Specialty sessions. Using a pre-defined matrix based on industry experts, a panel of reviewers rated presentations using quality criteria including camera angle, audio quality, virtual content optimised for virtual viewers which was assessed on both laptop and iphone to replicate typical viewer experiences. Levels of quality were defined from Level I (minimum standard), to Level 3 (excellent). RESULTS: We reviewed 138 on-demand sessions (7 plenary, 44 poster, 11 industry, 9 semi-live, 67 specialty) posted from #EAU21. Of 2068 virtual appearances assessed, 1710 (82.7%) failed to meet the minimum defined quality standard of Level 1, with poor camera angle being the most common offence (91.7% of cases). Of those who attained level 1 standards, 39/358 (10.8%) reached Level 2, out of which only 4 (10.3%) presentations met level 3 standards. Deficiencies in audio and content presentation domains were equally common (55.9% and 55.1%, respectively) in those with level 1 standards who did not reach level 2, while video elements were less common (51.5%). There was high inter-observer agreement in the scoring (87-91.3%). Even after excluding professional studio recordings provided by EAU, there was a consistent trend of chairpersons and moderators outperforming presenters in terms of level 1 standards (31.6% vs 13.7%, p <0.001). The only exception was seen in the industry sessions where more presenters met level 1 standards (48.1% vs 30.8%, p=0.29). Qualitative analyses revealed a wide range of styles used including the interesting use of automated voice-over narrations seen only in poster sessions (1.2%) which could overcome language barriers. In the presentations that met level 3 standards, the use of professional video and audio editing tools was evident and helped optimised the delivery of the scientific content for viewers. CONCLUSIONS: A high proportion of virtual presentations did not achieve a reasonable minimum standard for scientific communication during the virtual #EAU21 meeting. Simple technical measures can significantly improve the quality of virtual presentations and ensure a better viewer experience. Further training will help the scientific community communicate more effectively in the virtual and hybrid meeting era.

19.
Topics in Antiviral Medicine ; 30(1 SUPPL):40-41, 2022.
Article in English | EMBASE | ID: covidwho-1880656

ABSTRACT

Background:A previous report showed that a single 1200 mg subcutaneous (SC) dose of casirivimab and imdevimab (cas/imd) prevented symptomatic COVID-19 by 81.4% and reduced all SARS-CoV-2 infections (symptomatic and asymptomatic) by 66.4% in household contacts living with recently infected individuals over a 28-day period. While highly effective vaccines now exist for the prevention of COVID-19, a significant unmet need remains in patients who are unable to mount or maintain an adequate immune response to vaccination. Here we present additional results from 7-month follow-up period of the aforementioned study. Methods: In this randomized, double-blind, placebo-controlled Phase III trial, asymptomatic participants exposed to a SARS-CoV-2-infected household member were randomized 1:1 to a single SC dose of placebo or 1200 mg cas/imd (600 mg of each monoclonal antibody). Efficacy analyses include participants who were RT-qPCR negative for SARS-CoV-2 (no current infection) and seronegative for SARS-CoV-2 (no prior infection) at baseline. The trial consisted of a primary efficacy assessment period of 28 days (Month 1) and a 7-month follow-up period (Months 2-8). Results: Results from 842 placebo and 841 cas/imd RT-qPCR negative/seronegative enrolled participants (data through 04Oct2021, prior to emergence of Omicron) are presented. During the entirety of the 8-month study, cas/imd reduced the risk of symptomatic SARS-CoV-2 infections by 81.2% versus placebo (nominal P<0.0001;Table) and all SARS-CoV-2 infections (symptomatic and asymptomatic) by 68.2% versus placebo (nominal P<0.0001;Table). During Months 2-5, the risk of symptomatic and all infections were reduced by 100% and 89.5%, respectively (nominal P<0.0001). During Months 6-8 there was a resumption of symptomatic and all SARS-CoV-2 infections in the cas/imd group (19.9%;nominal P=0.6411 and 30.7%;nominal P=0.3967 risk reduction, respectively). Fewer cas/imd participants had a medically-attended visit versus placebo during the 8-months (1/841 [0.1%] vs 16/842 [1.9%], respectively). No new safety signals were identified for cas/imd during the follow-up period. Conclusion: During the 8-month study period, a 1200 mg SC dose of cas/imd prevented SARS-CoV-2 infections, with maximal protection through Month 5. The prolonged protection supports the use of cas/imd for the long-term prevention of COVID-19 against susceptible variants, offering a pre-exposure prophylaxis strategy for individuals who are unlikely to respond or be protected by vaccination.

20.
Fordham Law Review ; 90(6):2839-2868, 2022.
Article in English | Scopus | ID: covidwho-1870741

ABSTRACT

During the COVID-19 pandemic, industries around the world were forced to adapt to a new way of life dictated by rising public health concerns. The pandemic’s rapid spread left parties struggling to determine whether contractual performance would be excused or reinterpreted. Issues of prevailing industry standards arose and brought into question the point at which parties and courts should define these standards. While some parties argued that industry standards at the time of contract formation are determinative of performance, others claimed that their agreement referenced industry standards that had changed and that, therefore, their performance obligations had changed as well. By looking at contract disputes brought about by the COVID-19 pandemic, this Note examines potential issues of contract interpretation that arise when industry standards referenced by the parties change within the life of a contract. This Note addresses these issues in the context of different types of contracts and examines the use of specific language that references industry standards in the agreements. Ultimately, this Note proposes a general application of an ex ante interpretation of industry standards that would avoid issues of uncertainty even beyond the context of the COVID-19 pandemic. © 2022 Fordham University School of Law. All rights reserved.

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