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1.
Am J Trop Med Hyg ; 2022 Jul 25.
Article in English | MEDLINE | ID: covidwho-1964289

ABSTRACT

China has basically controlled the COVID-19 epidemic as a result of widespread vaccination and other containment strategies, despite localized outbreaks, as of September 2021. This study investigates the knowledge, attitudes, and practices (KAP) of COVID-19 and COVID-19 vaccines among Chinese small-town residents to provide suggestions for public health policy. Residents who were vaccinated against COVID-19 were asked to complete a paper questionnaire on KAP in Xidian, Zhejiang. The knowledge questionnaire consisted of 12 questions regarding COVID-19 and 12 questions regarding COVID-19 vaccines. Attitude and practice evaluation included agreement on the eventual control of COVID-19 and having recently worn a mask outside. Of 405 survey responders, 52.3% were male, 71.4% had middle school education or less, and 59.0% engaged in physical labor as an occupation. The correct answer rates of the COVID-19 section and the vaccine section were 79.2% and 71.7%, respectively. Age groups of 18 to 29 years and > 50 years, occupations of physical labor and unemployment, and primary school education and less were associated with lower knowledge scores. The majority of participants (91.6%) believed that COVID-19 will eventually be controlled, whereas women, students, and patients with chronic held relatively negative attitudes toward epidemic control. Most participants (87.4%) wore masks outside recently. In conclusion, Chinese small-town residents have a medium level of knowledge regarding COVID-19 and vaccines, hold positive attitudes, and have appropriate practices. Health education should be provided to the target populations to enrich their knowledge of COVID-19 and vaccines, and to improve their attitudes toward epidemic control.

2.
Cell Mol Life Sci ; 79(6): 309, 2022 May 21.
Article in English | MEDLINE | ID: covidwho-1919755

ABSTRACT

Blood clot formation induced by dysfunctional coagulation is a frequent complication of coronavirus disease 2019 (COVID-19) and a high-risk factor for severe illness and death. Neutrophil extracellular traps (NETs) are implicated in COVID-19-induced immunothrombosis. Furthermore, human cathelicidin, a NET component, can perturb the interaction between the SARS-CoV-2 spike protein and its ACE2 receptor, which mediates viral entry into cells. At present, however, the levels of cathelicidin antimicrobial peptides after SARS-CoV-2 infection and their role in COVID-19 thrombosis formation remain unclear. In the current study, we analyzed coagulation function and found a decrease in thrombin time but an increase in fibrinogen level, prothrombin time, and activated partial thromboplastin time in COVID-19 patients. In addition, the cathelicidin antimicrobial peptide LL-37 was upregulated by the spike protein and significantly elevated in the plasma of patients. Furthermore, LL-37 levels were negatively correlated with thrombin time but positively correlated with fibrinogen level. In addition to platelet activation, cathelicidin peptides enhanced the activity of coagulation factors, such as factor Xa (FXa) and thrombin, which may induce hypercoagulation in diseases with high cathelicidin peptide levels. Injection of cathelicidin peptides promoted the formation of thrombosis, whereas deletion of cathelicidin inhibited thrombosis in vivo. These results suggest that cathelicidin antimicrobial peptide LL-37 is elevated during SARS-CoV-2 infection, which may induce hypercoagulation in COVID-19 patients by activating coagulation factors.


Subject(s)
Antimicrobial Cationic Peptides , COVID-19 , Thrombosis , Blood Coagulation Factors , COVID-19/complications , Fibrinogen , Humans , SARS-CoV-2 , Spike Glycoprotein, Coronavirus , Thrombosis/virology
3.
Sci Data ; 9(1): 294, 2022 06 13.
Article in English | MEDLINE | ID: covidwho-1890207

ABSTRACT

Since 2019, the novel coronavirus (SARS-COV-2) disease (COVID-19) has caused a worldwide epidemic. Anti-coronavirus peptides (ACovPs), a type of antimicrobial peptides (AMPs), have demonstrated excellent inhibitory effects on coronaviruses. However, state-of-the-art AMP databases contain only a small number of ACovPs. Additionally, the fields of these databases are not uniform, and the units or evaluation standards of the same field are inconsistent. Most of these databases have not included the target domains of ACovPs and description of in vitro and in vivo assays to measure the inhibitory effects of ACovPs. Here, we present a database focused on ACovPs (ACovPepDB), which contains comprehensive and precise ACovPs information of 518 entries with 214 unique ACovPs manually collected from public databases and published peer-reviewed articles. We believe that ACovPepDB is of great significance for facilitating the development of new peptides and improving treatment for coronavirus infection. The database will become a portal for ACovPs and guide and help researchers perform further studies. The ACovPepDB is available at http://i.uestc.edu.cn/ACovPepDB/ .


Subject(s)
Antiviral Agents , COVID-19 , SARS-CoV-2 , Antiviral Agents/chemistry , Antiviral Agents/pharmacology , Antiviral Agents/therapeutic use , COVID-19/drug therapy , Databases, Chemical , Humans , Peptides/chemistry , Peptides/pharmacology , Peptides/therapeutic use , SARS-CoV-2/drug effects
4.
Acta Neurol Scand ; 146(3): 225-236, 2022 Sep.
Article in English | MEDLINE | ID: covidwho-1886639

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is more than merely a respiratory disease, as it also presents with various neurological symptoms. SARS-CoV-2 may infect the central nervous system (CNS) and thus is neurotropic. However, the pathophysiological mechanism of coronavirus disease 2019 (COVID-19)-associated neuropathy remains unclear. Many studies have reported that SARS-CoV-2 enters the CNS through the hematogenous and neuronal routes, as well as through the main host neurological immune responses and cells involved in these responses. The neurological immune responses to COVID-19 and potential mechanisms of the extensive neuroinflammation induced by SARS-CoV-2 have been investigated. Although CNS infection with SARS-CoV-2 was shown to lead to neuronal impairment, certain aspects of this mechanism remain controversial and require further analysis. In this review, we discussed the pathway and mechanisms of SARS-CoV-2 invasion in the CNS, and associated clinical manifestations, such as anosmia, headache, and hyposmia. Moreover, the mechanism of neurological damage caused by SARS-CoV-2 may provide potential treatment methods for patients presenting with SARS-CoV-2-associated neuropathy.


Subject(s)
COVID-19 , Nervous System Diseases , COVID-19/complications , Central Nervous System/metabolism , Humans , Nervous System Diseases/etiology , Peripheral Nervous System , SARS-CoV-2
5.
Nat Rev Endocrinol ; 18(6): 333, 2022 06.
Article in English | MEDLINE | ID: covidwho-1873510
6.
Clinicoecon Outcomes Res ; 14: 293-307, 2022.
Article in English | MEDLINE | ID: covidwho-1833888

ABSTRACT

Objective: To review and qualitatively synthesize the evidence related to the economic burden of COVID-19, including healthcare resource utilization and costs. Methods: A systematic review of studies that assessed the economic burden [eg, direct costs, productivity, macroeconomic impact due to non-pharmaceutical interventions (NPIs) and equity] of COVID-19 was conducted by searches in EMBASE, MEDLINE, MEDLINE-IN-PROCESS, and The Cochrane Library, as well as manual searches of unpublished research for the period between January 2020 to February 2021. Single reviewer data extraction was confirmed independently by a second reviewer. Results: The screening process resulted in a total of 27 studies: 25 individual publications, and 2 systematic literature reviews, of narrower scopes, that fulfilled the inclusion criteria. The patients diagnosed with more severe COVID-19 were associated with higher costs. The main drivers for higher costs were consistent across countries and included ICU admission, in-hospital resource use such as mechanical ventilation, which lead to increase costs of $2082.65 ± 345.04 to $2990.76 ± 545.98. The most frequently reported indirect costs were due to productivity losses. On average, older COVID-19 patients incurred higher costs when compared to younger age groups. An estimation of a 20% COVID-19 infection rate based on a Monte Carlo simulation in the United States led to a total direct medical cost of $163.4 billion over the course of the pandemic. Conclusion: The COVID-19 pandemic has generated a considerable economic burden on patients and the general population. Preventative measures such as NPIs only have partial success in lowering the economic costs of the pandemic. Implementing additional preventative measures such as large-scale vaccination is vital in reducing direct and indirect medical costs, decreased productivity, and GDP losses.

7.
Front Psychol ; 13: 766036, 2022.
Article in English | MEDLINE | ID: covidwho-1809574

ABSTRACT

Introduction: The 2019-2020 pandemic COVID-19 has become a global health crisis. While many recent studies on COVID-19 pandemic have focused on disease epidemiology and psychological status of patients, few have explored the multi-facet influential factors or combined perspectives from both the patients and healthcare workers. The purposes of this study were to: analyze the influencing factors of psychological distress of COVID-19 patients; and describe the experience of healthcare workers relieving psychological distress. Materials and Methods: This study uses a mixed-method cross-sectional design, including a quantitative study and a qualitative study, targeting two populations: COVID-19 patient and health workers, respectively. In the quantitative part, we recruited a convenience sample of patients with COVID-19 from five hospitals in Wuhan, Hubei Province from 10 to 15 April, 2020. Besides, we collected data by using participants' socio-demographic information sheet, the Connor-Davidson Resilience Scale-10, the Herth Hope Index, the Distress Thermometer, the Revised Chinese Version of Mishel Uncertainty in Illness Scale, and the Chinese Version of Wake Forest Physician Trust Scale. In the qualitative part, the participants were healthcare workers involved in medical aid missions in Hubei Province, China. Meanwhile, we used sampling with convenient and purposive, data collection with a semi-structured online video interview, and text transcription with Colaizzi's phenomenological method. Results: The results reveal that 25.7% of patients reported higher level of psychological distress (n = 31, scoring ≥4). After controlling the sociodemographic variables, only severity of COVID-19 (ß = 0.282, P = 0.025) and uncertainty in illness (ß = 0.345, P = 0.007) shown significant effect on psychological distress in the regression model (F = 10.862, R 2 = 0.222, P < 0.001). The experience of healthcare workers emerged five themes: Particularly needed psychological care, Manifestation of negative emotion, Manifestation of proactive adaptation, Strategies relieving psychological distress, and gains of healthcare workers after delivering effective psychological care. Conclusion: The 25.7% of patients with COVID-19 still suffered from psychological distress, which should receive timely attention from healthcare workers. And the severity of the disease and disease uncertainty have a significant impact on distress. It is critical to train the healthcare workers on detecting the different manifestation of psychological distress, offering timely disease related information, and applying communication strategies.

8.
Front Public Health ; 10: 819446, 2022.
Article in English | MEDLINE | ID: covidwho-1785439

ABSTRACT

Background: Public health education is essential for epidemic prevention and control in the post-COVID-19 era. This randomized controlled trial (RCT) aims to evaluate the effect of reading leaflets during the observation period after vaccination on knowledge of COVID-19 disease and vaccines in Chinese small town residents and to provide suggestions for public health education. Methods: Residents were recruited during the observation period after getting vaccinated against COVID-19 in Xidian and were randomly divided into an education group and a control group. The education group was asked to complete the questionnaire after reading a leaflet, whereas the control group directly completed the questionnaire. The questionnaire comprised two sections on COVID-19 knowledge and vaccine knowledge, and the scores were used to assess the resident's knowledge. Results: A total of 142 participants in the education group and 154 participants in the control group were enrolled. The rates of correct knowledge in the education group and the control group were 90.7 and 83.1%, respectively. The scores of the two sections and the aggregate knowledge score of the education group were significantly higher than those of the control group (P < 0.001). The rates of correct responses to questions on clinical manifestations and transmission routes of COVID-19 and indications and contraindications of vaccines significantly increased after reading the leaflets (P < 0.05). Knowledge of different groups of genders, ages, marital statuses, education levels and occupations all improved (P < 0.05), and the 18-29-year-old and never-married group revealed a higher growth rate of correct responses. Conclusion: Chinese small town residents have a median level of knowledge regarding COVID-19 disease and vaccines. Reading leaflets during the observation period after vaccination effectively improved their knowledge. This low-cost and efficient health education approach can be widely applied.


Subject(s)
COVID-19 , Vaccines , Adolescent , Adult , COVID-19/epidemiology , COVID-19/prevention & control , China/epidemiology , Humans , SARS-CoV-2 , Vaccination , Young Adult
9.
Front Chem ; 10: 819969, 2022.
Article in English | MEDLINE | ID: covidwho-1714989

ABSTRACT

Coronavirus disease 2019 (COVID-19) is a new and severe infectious disease and new global disaster and is spreading rapidly worldwide. Natural products have a long history and have been widely used to treat various acute, chronic, and even life-threatening diseases worldwide. However, the natural products have reduced bioavailability and availability as they have poor kinetic properties, such as large molecular weight, inability to cross lipid membranes, and weak absorption ability. With the rapid development of nanotechnology, using novel nanotechnology in conjunction with natural products can effectively eliminate the molecular restriction of the entry of nanoproducts into the body and can be used to diagnose and treat various diseases, including COVID-19, bringing new strategies and directions for medicine. This article reviews the role and implementation of natural products against COVID-19 based on nanotechnology.

10.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-323625

ABSTRACT

Electric vehicles (EVs) represent a major path for global decarbonization, improvement of air quality and promotion of renewable energy. To tackle the COVID-19 pandemic, China imposed full lockdowns and thorough travel restrictions. This event represents an unprecedented inadvertent geoengineering experiment in vehicle emissions, emulating transition to EVs. Here we novelly exploited observations of air quality during the full lockdown to constrain predictions of a comprehensive chemical transport model. Large traffic flux reductions were near-linearly linked to reductions of NO 2 and PM 2.5 (correlation = 0.491 ~ 0.626). Extrapolating to a full conversion to EV results in a large reduction of PM 2.5 (30 ~ 70%) in most of central and south eastern China. A smaller reduction of PM 2.5 (10 ~ 20%) in Beijing and Tianjin was achievable due to the presence of major industrial emission sources which cause haze at a regional scale. The potential reductions in NO 2 were 40 ~ 90% in most of the megacities. At this present crossroads of policy, our findings reveal timely evidence supporting the transition towards renewable energy.Funding: This study is supported by the Department of Science and Technology of China (No. 2016YFC0202702, 2018YFC0213506 and 2018YFC0213503), National Research Program for Key Issues in Air Pollution Control in China (No. DQGG0107) and National Natural Science Foundation of China (No. 21577126, 41561144004, 21625701). Pengfei Li is supported by Initiation Fund for Introducing Talents of Hebei Agricultural University (412201904) and Youth Top Fund of Universities in Hebei Province (BJ2020032). Conflict of Interest: Authors declare no competing interests.

11.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-323527

ABSTRACT

Background: Most recent studies on the coronavirus disease (COVID-19) have focused on its epidemiology and on frontline healthcare workers’ (HCWs’) physio-psychological experiences, with few studies examining their experiences of cooperation. To assist future offsite planning for pandemics, we documented lived experiences of cooperation among HCWs during the COVID-19 pandemic.Methods: We conducted an empirical phenomenological investigation among 25 HCWs (17 nurses and eight physicians), selected through convenient and purposive sampling, who participated in a medical aid mission in China during the COVID-19 pandemic. Data were collected via semi-structured online video interviews, and the interview transcripts were analyzed using Colaizzi's phenomenological method.Findings: (1) The government-organized multi-level and multi-departmental management structure ensured appropriate arrangements of human and material resources. (2) High morale among voluntarily recruited HCWs and a supportive context entailing mutual learning encouraged cooperation among team members. (3) A continuous, streamlined workflow and communication was crucial. Adequate communication enabled HCWs, confronting shock and unfamiliar situations, to adjust quickly by drawing on their rich prior professional experience. (4) Nurse managers, who were the core internal and external team coordinators, juggling multiple roles and tasks, experienced severe stress. (5) A comprehensive person-centered care model and cooperation within multidisciplinary teams of HCWs were needed to balance infection management and patient-centered care.Interpretations: Planning for a pandemic aid mission is challenging, given the unpredictable nature of the circumstances and the political context within a specific region. We offer the following recommendations for future pandemic planning.Funding Statement: No external funding.Declaration of Interests: The authors declare no conflict of interest.Ethics Approval Statement: The study was approved by the Institutional Review Board at the researchers’ institute (IRB number: 202025).

12.
Environ Chem Lett ; 20(1): 59-69, 2022.
Article in English | MEDLINE | ID: covidwho-1680976

ABSTRACT

Despite large decreases of emissions of air pollution during the coronavirus disease 2019 (COVID-19) lockdown in 2020, an unexpected regional severe haze has still occurred over the North China Plain. To clarify the origin of this pollution, we studied air concentrations of fine particulate matter (PM2.5), NO2, O3, PM10, SO2, and CO in Beijing, Hengshui and Baoding during the lockdown period from January 24 to 29, 2020. Variations of PM2.5 composition in inorganic ions, elemental carbon and organic matter were also investigated. The HYSPLIT model was used to calculate backward trajectories and concentration weighted trajectories. Results of the cluster trajectory analysis and model simulations show that the severe haze was caused mainly by the emissions of northeastern non-stopping industries located in Inner Mongolia, Liaoning, Hebei, and Tianjin. In Beijing, Hengshui and Baoding, the mixing layer heights were about 30% lower and the maximum relative humidity was 83% higher than the annual averages, and the average wind speeds were lower than 1.5 m s-1. The concentrations of NO3 -, SO4 2-, NH4 +, organics and K+ were the main components of PM2.5 in Beijing and Hengshui, while organics, K+, NO3 -, SO4 2-, and NH4 + were the main components of PM2.5 in Baoding. Contrary to previous reports suggesting a southerly transport of air pollution, we found that northeast transport caused the haze formation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10311-021-01314-8.

13.
Resources Policy ; 76:102581, 2022.
Article in English | ScienceDirect | ID: covidwho-1665433

ABSTRACT

Indeed, natural resources are the most tradable goods across the globe and are responsible for running the industrial sector of each country. However, with the recent outbreak of Covid-19, the demand and supply chain of natural resources is greatly influence and causes economic recession, which needs to be addressed. The Covid-19 pandemic increases uncertainty in the global economic policy and natural resource commodity prices. Although the literature provides empirical outcomes in the pre-Covid-19 period, still the influence in the Covid-19 remained unexplored and needs further research. In this regard, the current study examined the US natural resources commodity price volatility and global economic uncertainty while utilizing the monthly dataset from November 01, 2007, to May 01, 2021. Using the wavelet power spectrum and wavelet coherence approaches, the empirical findings of the wavelet power spectrum reveal volatilities in the global economic policy uncertainty and crude oil price in the short run. In contrast, the oil rent, natural gas rents and total natural resources show long-run vulnerabilities. Additionally, the wavelet coherence unveils bidirectional causal association global economic policy uncertainty and other variables. However, the causal influence of global economic performance is found higher than the others. Besides, the crude oil prices and oil rents are associated with global economic policy uncertainty after the Covid-19 pandemic. These findings could have essential economic and energy implications for governors, policymakers, and researchers.

14.
Environmental Chemistry Letters ; : 1-11, 2021.
Article in English | EuropePMC | ID: covidwho-1489817

ABSTRACT

Despite large decreases of emissions of air pollution during the coronavirus disease 2019 (COVID-19) lockdown in 2020, an unexpected regional severe haze has still occurred over the North China Plain. To clarify the origin of this pollution, we studied air concentrations of fine particulate matter (PM2.5), NO2, O3, PM10, SO2, and CO in Beijing, Hengshui and Baoding during the lockdown period from January 24 to 29, 2020. Variations of PM2.5 composition in inorganic ions, elemental carbon and organic matter were also investigated. The HYSPLIT model was used to calculate backward trajectories and concentration weighted trajectories. Results of the cluster trajectory analysis and model simulations show that the severe haze was caused mainly by the emissions of northeastern non-stopping industries located in Inner Mongolia, Liaoning, Hebei, and Tianjin. In Beijing, Hengshui and Baoding, the mixing layer heights were about 30% lower and the maximum relative humidity was 83% higher than the annual averages, and the average wind speeds were lower than 1.5 m s−1. The concentrations of NO3−, SO42−, NH4+, organics and K+ were the main components of PM2.5 in Beijing and Hengshui, while organics, K+, NO3−, SO42−, and NH4+ were the main components of PM2.5 in Baoding. Contrary to previous reports suggesting a southerly transport of air pollution, we found that northeast transport caused the haze formation. Supplementary Information The online version contains supplementary material available at 10.1007/s10311-021-01314-8.

15.
Anal Chem ; 93(37): 12714-12722, 2021 09 21.
Article in English | MEDLINE | ID: covidwho-1397823

ABSTRACT

Early diagnosis, early isolation, and early treatment are efficient solutions to control the COVID-19 pandemic. To achieve the accurate early diagnosis of SARS-CoV-2, a multiplex detection strategy is required for the cross-validation to solve the problem of "false negative" of the existing gold standard assay. Here, we present a multicomponent nucleic acid assay platform for SARS-CoV-2 detection based on lanthanide nanoparticle (LnNP)-tagging strategy. For targeting SARS-CoV-2's RNA fragments ORF1ab gene, RdRp gene, and E gene, three LnNP probes can be used simultaneously to identify three sites in one sample through elemental mass spectrometry detection with limits of detection of 1.2, 1.3, and 1.3 fmol, respectively. With the multisite cross-validation, we envision that this multiplex and sensitive detection platform may provide an effective strategy for SARS-CoV-2 fast screening with a high accuracy.


Subject(s)
COVID-19 , Lanthanoid Series Elements , Nanoparticles , Humans , Pandemics , RNA, Viral/genetics , SARS-CoV-2 , Sensitivity and Specificity
16.
One Earth ; 4(7):1037-1048, 2021.
Article in English | ScienceDirect | ID: covidwho-1322298

ABSTRACT

Summary Transportation contributes to around one-fifth of global greenhouse gas emissions, while also causing severe air pollution. The conversion to electric vehicles (EVs) represents a major path to decarbonize the transport sector, with potentially significant co-benefits for human health. However, the scale of such co-benefits largely remains an empirical question and lacks observational evidence. The full lockdown in China during the coronavirus disease 2019 (COVID-19) pandemic provides an unprecedented real-world experiment to evaluate emission reduction potentials of a large-scale transition to EVs. Here, we utilize ground and satellite observations of air quality during the full lockdown to constrain predictions of a comprehensive chemical transport model and find that the substantial traffic reductions are near-linearly linked to reductions of PM2.5 (particles with an aerodynamic diameter ≤2.5 μm) and NO2. A further extrapolation of a full conversion to EVs shows a significant reduction of PM2.5 (30%–70%) and NO2 (30%–80%) in most of China. Our findings provide fact-based evidence of potential environmental benefits generated by fully switching to EVs.

17.
J Clin Nurs ; 30(17-18): 2696-2707, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1292042

ABSTRACT

AIMS AND OBJECTIVES: To assist future offsite planning for pandemics, we documented lived experiences of cooperation among healthcare workers (HCWs) during the coronavirus disease (COVID-19) pandemic. BACKGROUND: The COVID-19 pandemic poses a global health crisis. Most recent studies on the COVID-19 focus on frontline HCWs' physio-psychological experiences, with few studies examining their experiences of cooperation. DESIGN: A descriptive phenomenological design reported based on COREQ checklist. METHODS: 25 HCWs (17 nurses and eight physicians) were interviewed, selected through convenience and purposive sampling, who participated in a medical aid mission in China during the COVID-19 pandemic. Data were collected via semi-structured online video interviews, and the transcripts were analysed using Colaizzi's phenomenological method. RESULTS: The HCWs experienced stressed and anxious, but rated their overall cooperation experience as positive. We categorised the reported experiences in five themes: (1) a multi-level management structure; (2) nurse managers as internal and external team coordinators; (3) high morale and a mutual supportive context; (4) a continuous streamlined workflow; and (5) the value of multidisciplinary collaboration in care. Reasonable management structure and division of work were the basis for successful aid mission. High morale and a mutual supportive context were foundational for growth and stress mitigation. The HCWs continuously streamlined workflow through communication and met patients' individual need through multidisciplinary collaboration. CONCLUSIONS: Planning for a pandemic aid mission is challenging, given the unpredictable nature of the working circumstances. Our results underline the importance of supportive strategies for COVID-19 aid mission. RELEVANCE TO CLINICAL PRACTICE: Recommendations for future pandemic planning: (1) positive morale and supportive working text should be paid prioritised attention; (2) sufficient experienced and ancillary staff should be recruited; (3) multiple communication channels such as regular handover meetings, online chat applications and electronic recording devices are essential, and (4) multidisciplinary cooperation are is necessary in COVID-19 wards.


Subject(s)
COVID-19 , Pandemics , China , Health Personnel , Humans , SARS-CoV-2
18.
J Clin Lab Anal ; 35(2): e23685, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-1082686

ABSTRACT

BACKGROUND: Pneumonia caused by the 2019 novel Coronavirus (COVID-2019) shares overlapping signs and symptoms, laboratory findings, imaging features with influenza A pneumonia. We aimed to identify their clinical characteristics to help early diagnosis. METHODS: We retrospectively retrieved data for laboratory-confirmed patients admitted with COVID-19-induced or influenza A-induced pneumonia from electronic medical records in Ningbo First Hospital, China. We recorded patients' epidemiological and clinical features, as well as radiologic and laboratory findings. RESULTS: The median age of influenza A cohort was higher and it exhibited higher temperature and higher proportion of pleural effusion. COVID-19 cohort exhibited higher proportions of fatigue, diarrhea and ground-glass opacity and higher levels of lymphocyte percentage, absolute lymphocyte count, red-cell count, hemoglobin and albumin and presented lower levels of monocytes, c-reactive protein, aspartate aminotransferase, alkaline phosphatase, serum creatinine. Multivariate logistic regression analyses showed that fatigue, ground-glass opacity, and higher level of albumin were independent risk factors for COVID-19 pneumonia, while older age, higher temperature, and higher level of monocyte count were independent risk factors for influenza A pneumonia. CONCLUSIONS: In terms of COVID-19 pneumonia and influenza A pneumonia, fatigue, ground-glass opacity, and higher level of albumin tend to be helpful for diagnosis of COVID-19 pneumonia, while older age, higher temperature, and higher level of monocyte count tend to be helpful for the diagnosis of influenza A pneumonia.


Subject(s)
COVID-19/diagnosis , COVID-19/virology , Clinical Laboratory Techniques , Influenza A virus/physiology , Pneumonia/diagnosis , Pneumonia/virology , SARS-CoV-2/physiology , COVID-19/diagnostic imaging , Diagnosis, Differential , Female , Humans , Logistic Models , Male , Middle Aged , Multivariate Analysis , Pneumonia/diagnostic imaging , Risk Factors , Tomography, X-Ray Computed
19.
Front Pediatr ; 8: 386, 2020.
Article in English | MEDLINE | ID: covidwho-853985

ABSTRACT

Background: The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is ongoing globally. Limited data are available for children with SARS-CoV-2 infection. Methods: A retrospective case study was conducted in one designated hospital for children with SARS-CoV-2 infection in Wuhan. Results: Out of the 74 children with laboratory-confirmed SARS-CoV-2 infection, the median age was 5.8 years, with no notable variation based on gender. All of the children had had direct exposure to at least one family member with confirmed SARS-CoV-2 infection. The most common symptoms were cough in 41 (55.4%) and fever in 38 (51.4%). Typical CT patterns of viral pneumonia were exhibited in 40 (54.1%) children, including ground-glass opacity and interstitial abnormalities. However, 17 (23.0%) children were classified as asymptomatic carriers, with neither symptoms nor radiological findings. Also, 68 (91.9%) children recovered fully and showed negative results on RT-PCR assay by nasopharyngeal swabs during our observation period. In contrast to the negative result for nasopharyngeal swab, 34% of the anal swabs showed a continued positive result. The mean hospitalization days of the children discharged after full recovery was 10.0 days. Conclusion: Within family clusters that had SARS-CoV-2 infection, children had mild or even asymptomatic illness. Although CT is highly sensitive, it should be avoided in follow-up of the disease in consideration of the radiological hazards and limited clinical benefits for mild illness in children. Furthermore, it is advocated that both nasopharyngeal and anal swabs should be confirmed negative for viral load prior to declaring full recovery so as to avoid oral-fecal transmission. Asymptomatic children with family clusters are potentially a little-known source of COVID-19. This therefore warrants an urgent reassessment of the transmission dynamics of the current outbreak.

20.
SSRN; 2020.
Preprint | SSRN | ID: ppcovidwho-751

ABSTRACT

Background: The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is ongoing globally. Limited data are available for children with SARS-

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